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The map label for this gene is lexA [H]

Identifier: 238916939

GI number: 238916939

Start: 1026151

End: 1026786

Strand: Direct

Name: lexA [H]

Synonym: EUBELI_01008

Alternate gene names: 238916939

Gene position: 1026151-1026786 (Clockwise)

Preceding gene: 238916935

Following gene: 238916964

Centisome position: 47.86

GC content: 38.36

Gene sequence:

>636_bases
ATGGAGGTTCGTAATATGGCATATGGCAGAATAACTCAGAAACAATCTGAGATTCTTGAATATATTAAATCACAGATTCT
TAATAAGGGATATCCACCATCAGTAAGGGATATATGCCAGGCAGTTAATCTTAAGTCTACATCATCTGTTCATGCACATC
TTGAGTCATTAGAGAAGAATGGATATATAAGAAGAGACCCGACTAAGTCGCGTACAATAGAGATAATTGATGATAATTTT
AATCTTTCAAGAAGAGAGGTTGTTAATATTCCGTTATTAGGTCAGGTTGCCGCAGGACAGCCACTTCTTGCTGTTGAGAA
TATAACAGAGTACTTCCCTATTCCATCAGAATATATGCCAGGCGGCGAAGTATTCATGTTAAAGGTCAAAGGCGACAGCA
TGATTAATATGGGAATTTACGAAGGCGACCAGATAATAGTAAGAAAGCAGAATACAGCTTCTAATGGAGAAGTAATTGTT
GCACTTGTAGACGATTCCGCAACAGTTAAGCGTTTTTACAAGGAGAATGGACACATAAGACTCCAGCCAGAGAACGATTT
CATGGACCCAATCATCGTAGACGACTGCGAGATACTGGGAAAAGTAATCGGACTTATAAGATTAGGTATTGACTAA

Upstream 100 bases:

>100_bases
GCGTTTGTCAATAAAAATCGAACAAATTTTCCGAACATTTTTTCAGAAATTATGTTTGCACATAGTGTATAAATGTGGTA
AAATTATTTAAAAGAAATTA

Downstream 100 bases:

>100_bases
TAAAAATTATTATTATTGATTGTAAAAATCCAGCCATAGATATACAAGAAATCAAAAATGGAAGCTATATTACTTGTAAG
CTGCAAAGCAGCAAAACAAG

Product: repressor LexA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 211; Mature: 211

Protein sequence:

>211_residues
MEVRNMAYGRITQKQSEILEYIKSQILNKGYPPSVRDICQAVNLKSTSSVHAHLESLEKNGYIRRDPTKSRTIEIIDDNF
NLSRREVVNIPLLGQVAAGQPLLAVENITEYFPIPSEYMPGGEVFMLKVKGDSMINMGIYEGDQIIVRKQNTASNGEVIV
ALVDDSATVKRFYKENGHIRLQPENDFMDPIIVDDCEILGKVIGLIRLGID

Sequences:

>Translated_211_residues
MEVRNMAYGRITQKQSEILEYIKSQILNKGYPPSVRDICQAVNLKSTSSVHAHLESLEKNGYIRRDPTKSRTIEIIDDNF
NLSRREVVNIPLLGQVAAGQPLLAVENITEYFPIPSEYMPGGEVFMLKVKGDSMINMGIYEGDQIIVRKQNTASNGEVIV
ALVDDSATVKRFYKENGHIRLQPENDFMDPIIVDDCEILGKVIGLIRLGID
>Mature_211_residues
MEVRNMAYGRITQKQSEILEYIKSQILNKGYPPSVRDICQAVNLKSTSSVHAHLESLEKNGYIRRDPTKSRTIEIIDDNF
NLSRREVVNIPLLGQVAAGQPLLAVENITEYFPIPSEYMPGGEVFMLKVKGDSMINMGIYEGDQIIVRKQNTASNGEVIV
ALVDDSATVKRFYKENGHIRLQPENDFMDPIIVDDCEILGKVIGLIRLGID

Specific function: Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, recA interacts with lexA causing an autocatalytic cleavage which disrupts the DNA-binding part of lexA, lea

COG id: COG1974

COG function: function code KT; SOS-response transcriptional repressors (RecA-mediated autopeptidases)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S24 family [H]

Homologues:

Organism=Escherichia coli, GI1790476, Length=204, Percent_Identity=35.7843137254902, Blast_Score=127, Evalue=5e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006199
- InterPro:   IPR006200
- InterPro:   IPR006197
- InterPro:   IPR019759
- InterPro:   IPR015927
- InterPro:   IPR011056
- InterPro:   IPR011991 [H]

Pfam domain/function: PF01726 LexA_DNA_bind; PF00717 Peptidase_S24 [H]

EC number: =3.4.21.88 [H]

Molecular weight: Translated: 23725; Mature: 23725

Theoretical pI: Translated: 5.13; Mature: 5.13

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEVRNMAYGRITQKQSEILEYIKSQILNKGYPPSVRDICQAVNLKSTSSVHAHLESLEKN
CCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCCCCCHHHHHHHHHHHHC
GYIRRDPTKSRTIEIIDDNFNLSRREVVNIPLLGQVAAGQPLLAVENITEYFPIPSEYMP
CCEEECCCCCCEEEEEECCCCCCCCEEECCCCCCCCCCCCCEEEHHHHHHHCCCCHHHCC
GGEVFMLKVKGDSMINMGIYEGDQIIVRKQNTASNGEVIVALVDDSATVKRFYKENGHIR
CCCEEEEEECCCCEEEEEEECCCEEEEEECCCCCCCCEEEEEECCCHHHHHHHHCCCEEE
LQPENDFMDPIIVDDCEILGKVIGLIRLGID
EECCCCCCCCEEEHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MEVRNMAYGRITQKQSEILEYIKSQILNKGYPPSVRDICQAVNLKSTSSVHAHLESLEKN
CCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCCCCCHHHHHHHHHHHHC
GYIRRDPTKSRTIEIIDDNFNLSRREVVNIPLLGQVAAGQPLLAVENITEYFPIPSEYMP
CCEEECCCCCCEEEEEECCCCCCCCEEECCCCCCCCCCCCCEEEHHHHHHHCCCCHHHCC
GGEVFMLKVKGDSMINMGIYEGDQIIVRKQNTASNGEVIVALVDDSATVKRFYKENGHIR
CCCEEEEEECCCCEEEEEEECCCEEEEEECCCCCCCCEEEEEECCCHHHHHHHHCCCEEE
LQPENDFMDPIIVDDCEILGKVIGLIRLGID
EECCCCCCCCEEEHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA