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The map label for this gene is mutL [H]

Identifier: 238916922

GI number: 238916922

Start: 1009134

End: 1011011

Strand: Direct

Name: mutL [H]

Synonym: EUBELI_00991

Alternate gene names: 238916922

Gene position: 1009134-1011011 (Clockwise)

Preceding gene: 238916921

Following gene: 238916923

Centisome position: 47.06

GC content: 37.65

Gene sequence:

>1878_bases
ATGCCAATAACACTTTTAGACCAGAATACGATTAATAAGATTGCTGCAGGAGAGGTCGTCGAAAGACCTTCTTCTGTAGT
TAAGGAGCTTGTTGAAAATGCTATAGATGCCGGAGCAACTGCAATTACAGTTGAGATAAAGGAAGGTGGAATTTCATTTA
TCAGGGTTACTGATAATGGAAGTGGTATCAATAAAGATGAGATTGAGATAGCATTTAAAAGACATGCCACAAGTAAAATT
GAATCAATTGAAGATCTTATGGCTGTTTCGTCTCTGGGCTTCAGAGGTGAGGCACTAGCGAGTATAGCTGCTGTATCACA
GGTTGAACTTATTACCAAGACTGCTGACAGTCTGAGTGGTGTGCGTTATACAATTGATGGCGGAGTACCAGGTGAAGTGG
CAGAAATAGGCGCTCCGGAGGGAACTACATTTATTGTAAGAAATCTTTTCTATAATACTCCTGTTAGAAGAAAGTTCTTA
AAGACAGCGACTACCGAAGGAGGATATATTGGTTCGCTTGTGGAATATCTGGCACTTTCGCATCCTGATATTTCGTTCAG
GTTCATAAGTAATAACCAGAATAAGCTGCATACATCGGGTAATATGAATCTTAAAGATATAATATATAATGTGTATGGCA
GGGATATAACTAATAATCTGTATGAAATCAGCGGCAAGTCGCAGGATATTGAGGCTTCTGGTTTTATTGGCAAGCCTATG
GTTGTCCGCGGAAACAGGACATATGAGAATTATTATATCAACGGCAGATATATCAAGAGTAGTATTATAACTAAGGCTAT
AGAGGATGCCTATAAGGGCTTTATAATGCCACATAATTATCCGTTCAGTGCGATACATTTTAAGATTAATCCTGCAATTA
TTGATGTAAATGTACATCCAACCAAGATGGAACTGCGATTCTCGAACAATGAATATATATATAATTTTGTATATGATACA
TGTTTAAAAGCTCTTAATTCAAAAGAACTTATTGCAGAAGTTTCTGTGCCTGATCCTGTTGCAGTTAAAATGCAGGAAGA
ACCTGTTGTAAGAAATGTTATGCCGGATGTTAAGCTGCCAGAGAAGAATGTTTCGGATAGTATGCCATGTAAGACAGAGA
CAAAATCTGCAGAGTCTGCAAAAGCAGAAATTAAGCCAAAAAGACTTCCGGAGCCATTTGAAATTAAGGGTTCTCTGCAG
ATGGTTATGGAAGATAAAGTAAGATATGAAGCTGTGACAAAATCTGAACCACCAAAGCAGATGAATCTTTTTGAGAATAA
GCTTCTTGATGAGAACAGCCGTAACAAATACAGAATCATAGGGCAGCTGTTTGATACTTACTGGCTTATTGAATTTGAAG
ATAAATTCTATATGATGGATCAGCATGCGGCGCATGAGAAAGTGCTTTATGAAAGAACGATGAACAAGCTTCATAATAAG
ACGATTGGAACTCAGATGATTCTTCCACCGATTGTATTGTCGCTTAATATGCATGAGGAAGAAATATACAAGACTAATCA
GGATATATTTAAAAGATTAGGGTATGAGATTGAAGAGTTTGGCGGCAATGAATATAAGGTTACAGGAATTCCAGCAGGAC
TTCCTAAGATGGATTACAAACAGCTCCTTATTGATGTTCTGGATGGACTTTCTGAAGAAAGTGCCGGCAAAGATCCTGAT
ATTATTACTGAAAAGGTTGCAAGCATGTCATGTAAAGCGGCTGTAAAGGGCAATAACAGACTGTCATTTAATGAAGCATT
TGAACTGATGGACGAGCTTATGAAGGCAGAGAATCCATATAACTGTCCGCATGGCAGACCAACACTAATTATGATGAGCA
GATATGAGATAGAAAAGAAATTTAAACGAATAGTATAG

Upstream 100 bases:

>100_bases
ATATAAGCAATATGACACCTATTGATGCGCTGAATACACTTTATAAGCTGCAGGGAAAAGCTAAGAACCGCTGGTAAGAT
AAGCAGAATAGGAGAAATGT

Downstream 100 bases:

>100_bases
AGGCTGATATGAAAAAAGAACCTTTAATAATACTTACAGGTCCGACAGCAGTTGGAAAGACAGAGCTTTCCATAGAACTT
GCAAAGGCGGTAAATGGTGA

Product: DNA mismatch repair protein MutL

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 625; Mature: 624

Protein sequence:

>625_residues
MPITLLDQNTINKIAAGEVVERPSSVVKELVENAIDAGATAITVEIKEGGISFIRVTDNGSGINKDEIEIAFKRHATSKI
ESIEDLMAVSSLGFRGEALASIAAVSQVELITKTADSLSGVRYTIDGGVPGEVAEIGAPEGTTFIVRNLFYNTPVRRKFL
KTATTEGGYIGSLVEYLALSHPDISFRFISNNQNKLHTSGNMNLKDIIYNVYGRDITNNLYEISGKSQDIEASGFIGKPM
VVRGNRTYENYYINGRYIKSSIITKAIEDAYKGFIMPHNYPFSAIHFKINPAIIDVNVHPTKMELRFSNNEYIYNFVYDT
CLKALNSKELIAEVSVPDPVAVKMQEEPVVRNVMPDVKLPEKNVSDSMPCKTETKSAESAKAEIKPKRLPEPFEIKGSLQ
MVMEDKVRYEAVTKSEPPKQMNLFENKLLDENSRNKYRIIGQLFDTYWLIEFEDKFYMMDQHAAHEKVLYERTMNKLHNK
TIGTQMILPPIVLSLNMHEEEIYKTNQDIFKRLGYEIEEFGGNEYKVTGIPAGLPKMDYKQLLIDVLDGLSEESAGKDPD
IITEKVASMSCKAAVKGNNRLSFNEAFELMDELMKAENPYNCPHGRPTLIMMSRYEIEKKFKRIV

Sequences:

>Translated_625_residues
MPITLLDQNTINKIAAGEVVERPSSVVKELVENAIDAGATAITVEIKEGGISFIRVTDNGSGINKDEIEIAFKRHATSKI
ESIEDLMAVSSLGFRGEALASIAAVSQVELITKTADSLSGVRYTIDGGVPGEVAEIGAPEGTTFIVRNLFYNTPVRRKFL
KTATTEGGYIGSLVEYLALSHPDISFRFISNNQNKLHTSGNMNLKDIIYNVYGRDITNNLYEISGKSQDIEASGFIGKPM
VVRGNRTYENYYINGRYIKSSIITKAIEDAYKGFIMPHNYPFSAIHFKINPAIIDVNVHPTKMELRFSNNEYIYNFVYDT
CLKALNSKELIAEVSVPDPVAVKMQEEPVVRNVMPDVKLPEKNVSDSMPCKTETKSAESAKAEIKPKRLPEPFEIKGSLQ
MVMEDKVRYEAVTKSEPPKQMNLFENKLLDENSRNKYRIIGQLFDTYWLIEFEDKFYMMDQHAAHEKVLYERTMNKLHNK
TIGTQMILPPIVLSLNMHEEEIYKTNQDIFKRLGYEIEEFGGNEYKVTGIPAGLPKMDYKQLLIDVLDGLSEESAGKDPD
IITEKVASMSCKAAVKGNNRLSFNEAFELMDELMKAENPYNCPHGRPTLIMMSRYEIEKKFKRIV
>Mature_624_residues
PITLLDQNTINKIAAGEVVERPSSVVKELVENAIDAGATAITVEIKEGGISFIRVTDNGSGINKDEIEIAFKRHATSKIE
SIEDLMAVSSLGFRGEALASIAAVSQVELITKTADSLSGVRYTIDGGVPGEVAEIGAPEGTTFIVRNLFYNTPVRRKFLK
TATTEGGYIGSLVEYLALSHPDISFRFISNNQNKLHTSGNMNLKDIIYNVYGRDITNNLYEISGKSQDIEASGFIGKPMV
VRGNRTYENYYINGRYIKSSIITKAIEDAYKGFIMPHNYPFSAIHFKINPAIIDVNVHPTKMELRFSNNEYIYNFVYDTC
LKALNSKELIAEVSVPDPVAVKMQEEPVVRNVMPDVKLPEKNVSDSMPCKTETKSAESAKAEIKPKRLPEPFEIKGSLQM
VMEDKVRYEAVTKSEPPKQMNLFENKLLDENSRNKYRIIGQLFDTYWLIEFEDKFYMMDQHAAHEKVLYERTMNKLHNKT
IGTQMILPPIVLSLNMHEEEIYKTNQDIFKRLGYEIEEFGGNEYKVTGIPAGLPKMDYKQLLIDVLDGLSEESAGKDPDI
ITEKVASMSCKAAVKGNNRLSFNEAFELMDELMKAENPYNCPHGRPTLIMMSRYEIEKKFKRIV

Specific function: This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a "molecular matchmaker", a protein that promotes the formation of a stable complex between two or more DNA-bindi

COG id: COG0323

COG function: function code L; DNA mismatch repair enzyme (predicted ATPase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DNA mismatch repair mutL/hexB family [H]

Homologues:

Organism=Homo sapiens, GI4557757, Length=322, Percent_Identity=36.3354037267081, Blast_Score=209, Evalue=9e-54,
Organism=Homo sapiens, GI4505913, Length=342, Percent_Identity=29.8245614035088, Blast_Score=137, Evalue=2e-32,
Organism=Homo sapiens, GI310128478, Length=342, Percent_Identity=29.8245614035088, Blast_Score=137, Evalue=3e-32,
Organism=Homo sapiens, GI4505911, Length=398, Percent_Identity=29.3969849246231, Blast_Score=137, Evalue=4e-32,
Organism=Homo sapiens, GI189458898, Length=398, Percent_Identity=29.3969849246231, Blast_Score=135, Evalue=1e-31,
Organism=Homo sapiens, GI189458896, Length=389, Percent_Identity=29.0488431876607, Blast_Score=124, Evalue=3e-28,
Organism=Homo sapiens, GI91992160, Length=360, Percent_Identity=28.6111111111111, Blast_Score=113, Evalue=7e-25,
Organism=Homo sapiens, GI91992162, Length=360, Percent_Identity=28.6111111111111, Blast_Score=113, Evalue=7e-25,
Organism=Homo sapiens, GI263191589, Length=228, Percent_Identity=31.140350877193, Blast_Score=103, Evalue=6e-22,
Organism=Homo sapiens, GI310128480, Length=299, Percent_Identity=27.4247491638796, Blast_Score=99, Evalue=2e-20,
Organism=Escherichia coli, GI1790612, Length=562, Percent_Identity=29.3594306049822, Blast_Score=243, Evalue=3e-65,
Organism=Caenorhabditis elegans, GI71991825, Length=317, Percent_Identity=34.384858044164, Blast_Score=211, Evalue=1e-54,
Organism=Caenorhabditis elegans, GI17562796, Length=348, Percent_Identity=31.0344827586207, Blast_Score=145, Evalue=5e-35,
Organism=Saccharomyces cerevisiae, GI6323819, Length=322, Percent_Identity=35.0931677018634, Blast_Score=191, Evalue=3e-49,
Organism=Saccharomyces cerevisiae, GI6324247, Length=357, Percent_Identity=29.1316526610644, Blast_Score=125, Evalue=2e-29,
Organism=Saccharomyces cerevisiae, GI6325093, Length=301, Percent_Identity=26.578073089701, Blast_Score=91, Evalue=4e-19,
Organism=Saccharomyces cerevisiae, GI6323063, Length=202, Percent_Identity=31.1881188118812, Blast_Score=91, Evalue=6e-19,
Organism=Drosophila melanogaster, GI17136968, Length=322, Percent_Identity=32.6086956521739, Blast_Score=194, Evalue=1e-49,
Organism=Drosophila melanogaster, GI17136970, Length=359, Percent_Identity=27.2980501392758, Blast_Score=122, Evalue=8e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR002099
- InterPro:   IPR013507
- InterPro:   IPR014762
- InterPro:   IPR020667
- InterPro:   IPR014763
- InterPro:   IPR014790
- InterPro:   IPR020568
- InterPro:   IPR014721 [H]

Pfam domain/function: PF01119 DNA_mis_repair; PF02518 HATPase_c; PF08676 MutL_C [H]

EC number: NA

Molecular weight: Translated: 70461; Mature: 70329

Theoretical pI: Translated: 5.75; Mature: 5.75

Prosite motif: PS00058 DNA_MISMATCH_REPAIR_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPITLLDQNTINKIAAGEVVERPSSVVKELVENAIDAGATAITVEIKEGGISFIRVTDNG
CCEEEECCCHHHHHHHHHHHHCHHHHHHHHHHHHHCCCCEEEEEEEECCCEEEEEEECCC
SGINKDEIEIAFKRHATSKIESIEDLMAVSSLGFRGEALASIAAVSQVELITKTADSLSG
CCCCCHHEEEEEHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCC
VRYTIDGGVPGEVAEIGAPEGTTFIVRNLFYNTPVRRKFLKTATTEGGYIGSLVEYLALS
EEEEECCCCCCCHHHCCCCCCCHHHHHHHHHCCHHHHHHHHHHCCCCCHHHHHHHHHHCC
HPDISFRFISNNQNKLHTSGNMNLKDIIYNVYGRDITNNLYEISGKSQDIEASGFIGKPM
CCCEEEEEECCCCCEEECCCCCCHHHHHHHHHCCCCCCCEEEECCCCCCCCCCCCCCCCE
VVRGNRTYENYYINGRYIKSSIITKAIEDAYKGFIMPHNYPFSAIHFKINPAIIDVNVHP
EEECCCEEEEEEEECEEEHHHHHHHHHHHHHCCEECCCCCCCEEEEEEECCEEEEEEECC
TKMELRFSNNEYIYNFVYDTCLKALNSKELIAEVSVPDPVAVKMQEEPVVRNVMPDVKLP
CEEEEEECCCCEEEHHHHHHHHHHCCCCCEEEEECCCCCEEEEECCCCHHHHCCCCCCCC
EKNVSDSMPCKTETKSAESAKAEIKPKRLPEPFEIKGSLQMVMEDKVRYEAVTKSEPPKQ
CCCCCCCCCCCCCCCCCCCHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCHH
MNLFENKLLDENSRNKYRIIGQLFDTYWLIEFEDKFYMMDQHAAHEKVLYERTMNKLHNK
HHHHHHHHCCCCCCCCEEHHEEHHCEEEEEEECCCEEEECCHHHHHHHHHHHHHHHHHCC
TIGTQMILPPIVLSLNMHEEEIYKTNQDIFKRLGYEIEEFGGNEYKVTGIPAGLPKMDYK
CCCCHHCCCCCEEEECCCHHHHHHCCHHHHHHCCCCHHHCCCCEEEEEECCCCCCCCCHH
QLLIDVLDGLSEESAGKDPDIITEKVASMSCKAAVKGNNRLSFNEAFELMDELMKAENPY
HHHHHHHHCCCCCCCCCCCHHHHHHHHHCCEEEEECCCCEECHHHHHHHHHHHHHCCCCC
NCPHGRPTLIMMSRYEIEKKFKRIV
CCCCCCCEEEEEHHHHHHHHHHHCC
>Mature Secondary Structure 
PITLLDQNTINKIAAGEVVERPSSVVKELVENAIDAGATAITVEIKEGGISFIRVTDNG
CEEEECCCHHHHHHHHHHHHCHHHHHHHHHHHHHCCCCEEEEEEEECCCEEEEEEECCC
SGINKDEIEIAFKRHATSKIESIEDLMAVSSLGFRGEALASIAAVSQVELITKTADSLSG
CCCCCHHEEEEEHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCC
VRYTIDGGVPGEVAEIGAPEGTTFIVRNLFYNTPVRRKFLKTATTEGGYIGSLVEYLALS
EEEEECCCCCCCHHHCCCCCCCHHHHHHHHHCCHHHHHHHHHHCCCCCHHHHHHHHHHCC
HPDISFRFISNNQNKLHTSGNMNLKDIIYNVYGRDITNNLYEISGKSQDIEASGFIGKPM
CCCEEEEEECCCCCEEECCCCCCHHHHHHHHHCCCCCCCEEEECCCCCCCCCCCCCCCCE
VVRGNRTYENYYINGRYIKSSIITKAIEDAYKGFIMPHNYPFSAIHFKINPAIIDVNVHP
EEECCCEEEEEEEECEEEHHHHHHHHHHHHHCCEECCCCCCCEEEEEEECCEEEEEEECC
TKMELRFSNNEYIYNFVYDTCLKALNSKELIAEVSVPDPVAVKMQEEPVVRNVMPDVKLP
CEEEEEECCCCEEEHHHHHHHHHHCCCCCEEEEECCCCCEEEEECCCCHHHHCCCCCCCC
EKNVSDSMPCKTETKSAESAKAEIKPKRLPEPFEIKGSLQMVMEDKVRYEAVTKSEPPKQ
CCCCCCCCCCCCCCCCCCCHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCHH
MNLFENKLLDENSRNKYRIIGQLFDTYWLIEFEDKFYMMDQHAAHEKVLYERTMNKLHNK
HHHHHHHHCCCCCCCCEEHHEEHHCEEEEEEECCCEEEECCHHHHHHHHHHHHHHHHHCC
TIGTQMILPPIVLSLNMHEEEIYKTNQDIFKRLGYEIEEFGGNEYKVTGIPAGLPKMDYK
CCCCHHCCCCCEEEECCCHHHHHHCCHHHHHHCCCCHHHCCCCEEEEEECCCCCCCCCHH
QLLIDVLDGLSEESAGKDPDIITEKVASMSCKAAVKGNNRLSFNEAFELMDELMKAENPY
HHHHHHHHCCCCCCCCCCCHHHHHHHHHCCEEEEECCCCEECHHHHHHHHHHHHHCCCCC
NCPHGRPTLIMMSRYEIEKKFKRIV
CCCCCCCEEEEEHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA