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The map label for this gene is pbpA [H]

Identifier: 238916878

GI number: 238916878

Start: 964477

End: 965970

Strand: Direct

Name: pbpA [H]

Synonym: EUBELI_00947

Alternate gene names: 238916878

Gene position: 964477-965970 (Clockwise)

Preceding gene: 238916877

Following gene: 238916879

Centisome position: 44.98

GC content: 37.28

Gene sequence:

>1494_bases
ATGGCAGAAAACAAAAAGCAGGTCAGACAAAGAAAAAACAAAAATGCACAGAACGATATAGTAGATAATGAAAAGAAGGA
TTTAAGAAATAAGGAAACTAATATAATAGCATTCTTTTTTGTAGGACTTTTTATGGCTACAATTGTTTATCTGTGCGTAT
TCAATATAAAGGATGCCGGCAAGGTTGTTAATAATCCATATAATAAAAGAGTTGACAGTCAGGAAGCAAAGGTTATAAGA
GGAGATATTCTGTCAGATGATGGAACTGTACTTGCGACAACGCTGCTTGATGAAGATGGCAATGAAAAAAGATATTATCC
ATTTGATGATTTGTTCTGTCATTCTGTTGGATTCACTTCTCTTACCGGAATGAAAACAGGACTTGAACAGTCACAGAATT
TCTATCTTCTTAAGGAAACTGACAATGTGCTTGACCAGATTGGAAATGATATATCAGGAGGTAAGGCAAAGGGACATAAT
GTCACAACAACACTTGATTTAGAGCTTACTCAGGCAGCATATAAGGCACTTGGTAATAATAAGGGCGCAGTTATAGCAAT
GGAACCATCTACGGGTAAGATTCTTGCAATGGTATCTAATCCAACATTTGATGCAAATGTAGTAAATACCGATTATGATG
AATGGCTTACTTATGACAGCTCTGATTCGGTACTTTTAAACAGGGCTACACAGGGATTGTATCCTCCGGGTTCAACATTC
AAGATAATTACAGCTCTTGCATATATAAGGCAGAATCAGAATGATTATTATAATTATTCATATAACTGTGATGGACAGGC
ATATATATCAGGTGGAACGACTATTGCATGTTTTGACCATACGGCACATGGATATGAGGATTTAAGAAAAGCATTTGCTA
ATTCCTGCAATTCAGCGTTTTCTACGATTGGAGCAGGGCTTAATAAAACCTCATTTATTAATCTGTGTAATACTTTCCTG
TTTAATTCTAATCTTCCTGTTGGATTCGAGTACTCAAAGAGTACAATGTCAGTGACTAAAGATTCGTCAGTCAGTGAAAT
GCAGGAAACAGGCATAGGACAGGGAAAAACAATGATGTCACCTCTTCATAATCTTATGATTGCAGCAAGTGTTGCCAATG
ACGGGGTTATGATGACACCTTATATGGTCGATAACATCAGTGACAGTGAGGGAAGAGTTGTTGTAAAGAACCAGCCTTCA
GCAATAGATACAGTAATGTCAGCAGAAGAGGCTGAATATCTTACGGAATGCATGAGAGCAGTTGTTACTTCAGGAACCGG
TTATGCAATGAAGAATTCTTCGTATGAAGCGGCAGGAAAGACAGGTTCGGCACAGTATGATGATTCAGAAAAATATCATA
GCTGGTTTACAGGATTTGCACCATATGATAATCCGCAGATAGCGGTATGTGTTATTCTTGAAGGTGGATATTCAGGAGTC
TCAAGTGCACAGTATGTAGCTAAAGCTGTATTTGATACTTATTTTGGCTATTGA

Upstream 100 bases:

>100_bases
TTTGTAAGTTACGGAGGAAGCTCAATATTAAGCTCACTGATAATGTTTGCATTAATAAATGGAATGTATACTATGAGACA
GGATGAAGGTGACAGGAAAG

Downstream 100 bases:

>100_bases
TATTCTGTCACACAGTATGTATAATTTTATTGATGAATTACTAATTTTTAAGAAGGAAATATAATGAGTACAGTTAACAA
TATTAGTCCGATAGATGGCA

Product: peptidoglycan glycosyltransferase

Products: NA

Alternate protein names: PBPA [H]

Number of amino acids: Translated: 497; Mature: 496

Protein sequence:

>497_residues
MAENKKQVRQRKNKNAQNDIVDNEKKDLRNKETNIIAFFFVGLFMATIVYLCVFNIKDAGKVVNNPYNKRVDSQEAKVIR
GDILSDDGTVLATTLLDEDGNEKRYYPFDDLFCHSVGFTSLTGMKTGLEQSQNFYLLKETDNVLDQIGNDISGGKAKGHN
VTTTLDLELTQAAYKALGNNKGAVIAMEPSTGKILAMVSNPTFDANVVNTDYDEWLTYDSSDSVLLNRATQGLYPPGSTF
KIITALAYIRQNQNDYYNYSYNCDGQAYISGGTTIACFDHTAHGYEDLRKAFANSCNSAFSTIGAGLNKTSFINLCNTFL
FNSNLPVGFEYSKSTMSVTKDSSVSEMQETGIGQGKTMMSPLHNLMIAASVANDGVMMTPYMVDNISDSEGRVVVKNQPS
AIDTVMSAEEAEYLTECMRAVVTSGTGYAMKNSSYEAAGKTGSAQYDDSEKYHSWFTGFAPYDNPQIAVCVILEGGYSGV
SSAQYVAKAVFDTYFGY

Sequences:

>Translated_497_residues
MAENKKQVRQRKNKNAQNDIVDNEKKDLRNKETNIIAFFFVGLFMATIVYLCVFNIKDAGKVVNNPYNKRVDSQEAKVIR
GDILSDDGTVLATTLLDEDGNEKRYYPFDDLFCHSVGFTSLTGMKTGLEQSQNFYLLKETDNVLDQIGNDISGGKAKGHN
VTTTLDLELTQAAYKALGNNKGAVIAMEPSTGKILAMVSNPTFDANVVNTDYDEWLTYDSSDSVLLNRATQGLYPPGSTF
KIITALAYIRQNQNDYYNYSYNCDGQAYISGGTTIACFDHTAHGYEDLRKAFANSCNSAFSTIGAGLNKTSFINLCNTFL
FNSNLPVGFEYSKSTMSVTKDSSVSEMQETGIGQGKTMMSPLHNLMIAASVANDGVMMTPYMVDNISDSEGRVVVKNQPS
AIDTVMSAEEAEYLTECMRAVVTSGTGYAMKNSSYEAAGKTGSAQYDDSEKYHSWFTGFAPYDNPQIAVCVILEGGYSGV
SSAQYVAKAVFDTYFGY
>Mature_496_residues
AENKKQVRQRKNKNAQNDIVDNEKKDLRNKETNIIAFFFVGLFMATIVYLCVFNIKDAGKVVNNPYNKRVDSQEAKVIRG
DILSDDGTVLATTLLDEDGNEKRYYPFDDLFCHSVGFTSLTGMKTGLEQSQNFYLLKETDNVLDQIGNDISGGKAKGHNV
TTTLDLELTQAAYKALGNNKGAVIAMEPSTGKILAMVSNPTFDANVVNTDYDEWLTYDSSDSVLLNRATQGLYPPGSTFK
IITALAYIRQNQNDYYNYSYNCDGQAYISGGTTIACFDHTAHGYEDLRKAFANSCNSAFSTIGAGLNKTSFINLCNTFLF
NSNLPVGFEYSKSTMSVTKDSSVSEMQETGIGQGKTMMSPLHNLMIAASVANDGVMMTPYMVDNISDSEGRVVVKNQPSA
IDTVMSAEEAEYLTECMRAVVTSGTGYAMKNSSYEAAGKTGSAQYDDSEKYHSWFTGFAPYDNPQIAVCVILEGGYSGVS
SAQYVAKAVFDTYFGY

Specific function: Cell wall formation. Plays an important role in cell division and cell shape maintenance by cross-linking adjacent peptidoglycan chains through transpeptidation [H]

COG id: COG0768

COG function: function code M; Cell division protein FtsI/penicillin-binding protein 2

Gene ontology:

Cell location: Cell membrane; Single-pass type II membrane protein (Probable). Note=Localized to the division site (septum) along with newly synthesized peptidoglycan, between segregated nucleoids (Probable) [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transpeptidase family [H]

Homologues:

Organism=Escherichia coli, GI1786854, Length=442, Percent_Identity=23.7556561085973, Blast_Score=114, Evalue=2e-26,
Organism=Escherichia coli, GI1786272, Length=421, Percent_Identity=22.3277909738717, Blast_Score=70, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR001460 [H]

Pfam domain/function: PF00905 Transpeptidase [H]

EC number: NA

Molecular weight: Translated: 54526; Mature: 54395

Theoretical pI: Translated: 4.66; Mature: 4.66

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAENKKQVRQRKNKNAQNDIVDNEKKDLRNKETNIIAFFFVGLFMATIVYLCVFNIKDAG
CCCCHHHHHHHHCCCCCCCCCCCCHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCH
KVVNNPYNKRVDSQEAKVIRGDILSDDGTVLATTLLDEDGNEKRYYPFDDLFCHSVGFTS
HHHCCCHHCCCCCHHHHHHCCCEECCCCCEEEEEEECCCCCCCCCCCHHHHHHHHCCCHH
LTGMKTGLEQSQNFYLLKETDNVLDQIGNDISGGKAKGHNVTTTLDLELTQAAYKALGNN
HHHHHHHHHCCCCEEEEECHHHHHHHHCCCCCCCCCCCCCEEEEEEHHHHHHHHHHHCCC
KGAVIAMEPSTGKILAMVSNPTFDANVVNTDYDEWLTYDSSDSVLLNRATQGLYPPGSTF
CCEEEEECCCCCEEEEEEECCCCCCEEECCCHHHHEEECCCCCEEEEHHHCCCCCCCCHH
KIITALAYIRQNQNDYYNYSYNCDGQAYISGGTTIACFDHTAHGYEDLRKAFANSCNSAF
HHHHHHHHHHCCCCCCEEEEECCCCEEEEECCCEEEEECCCCCCHHHHHHHHHHHHHHHH
STIGAGLNKTSFINLCNTFLFNSNLPVGFEYSKSTMSVTKDSSVSEMQETGIGQGKTMMS
HHHHCCCCCHHHHHHHHHHHCCCCCCCCEEECCCEEEECCCCCHHHHHHCCCCCCHHHHH
PLHNLMIAASVANDGVMMTPYMVDNISDSEGRVVVKNQPSAIDTVMSAEEAEYLTECMRA
HHHHHHEEEEECCCCEEECCEEECCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHH
VVTSGTGYAMKNSSYEAAGKTGSAQYDDSEKYHSWFTGFAPYDNPQIAVCVILEGGYSGV
HHCCCCCEEEECCCCCCCCCCCCCCCCCCHHHHHHHCCCCCCCCCCEEEEEEEECCCCCC
SSAQYVAKAVFDTYFGY
HHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
AENKKQVRQRKNKNAQNDIVDNEKKDLRNKETNIIAFFFVGLFMATIVYLCVFNIKDAG
CCCHHHHHHHHCCCCCCCCCCCCHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCH
KVVNNPYNKRVDSQEAKVIRGDILSDDGTVLATTLLDEDGNEKRYYPFDDLFCHSVGFTS
HHHCCCHHCCCCCHHHHHHCCCEECCCCCEEEEEEECCCCCCCCCCCHHHHHHHHCCCHH
LTGMKTGLEQSQNFYLLKETDNVLDQIGNDISGGKAKGHNVTTTLDLELTQAAYKALGNN
HHHHHHHHHCCCCEEEEECHHHHHHHHCCCCCCCCCCCCCEEEEEEHHHHHHHHHHHCCC
KGAVIAMEPSTGKILAMVSNPTFDANVVNTDYDEWLTYDSSDSVLLNRATQGLYPPGSTF
CCEEEEECCCCCEEEEEEECCCCCCEEECCCHHHHEEECCCCCEEEEHHHCCCCCCCCHH
KIITALAYIRQNQNDYYNYSYNCDGQAYISGGTTIACFDHTAHGYEDLRKAFANSCNSAF
HHHHHHHHHHCCCCCCEEEEECCCCEEEEECCCEEEEECCCCCCHHHHHHHHHHHHHHHH
STIGAGLNKTSFINLCNTFLFNSNLPVGFEYSKSTMSVTKDSSVSEMQETGIGQGKTMMS
HHHHCCCCCHHHHHHHHHHHCCCCCCCCEEECCCEEEECCCCCHHHHHHCCCCCCHHHHH
PLHNLMIAASVANDGVMMTPYMVDNISDSEGRVVVKNQPSAIDTVMSAEEAEYLTECMRA
HHHHHHEEEEECCCCEEECCEEECCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHH
VVTSGTGYAMKNSSYEAAGKTGSAQYDDSEKYHSWFTGFAPYDNPQIAVCVILEGGYSGV
HHCCCCCEEEECCCCCCCCCCCCCCCCCCHHHHHHHCCCCCCCCCCEEEEEEEECCCCCC
SSAQYVAKAVFDTYFGY
HHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA