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The map label for this gene is ung [H]

Identifier: 238916820

GI number: 238916820

Start: 899982

End: 900662

Strand: Direct

Name: ung [H]

Synonym: EUBELI_00887

Alternate gene names: 238916820

Gene position: 899982-900662 (Clockwise)

Preceding gene: 238916819

Following gene: 238916821

Centisome position: 41.97

GC content: 40.09

Gene sequence:

>681_bases
ATGGATATGTCAATGATAGATAATGACTGGCTTCCTGCTATTAAGGAGGAATATTCCAAGCCATATTACAAGGAATTATT
TACATTTGTTAAGAATGAATACAGCAAATATGTTGTATATCCTCCGGCAGATGATATATTTAATGCGTTTCATTTTACAC
CGCTTAGTAAGGTTAAGGTACTGATACTTGGTCAGGATCCTTATCATAATGTACATCAGGCACATGGACTGTCTTTTTCA
GTACTTCCGGGAGAGGAAGCACCGCCTTCACTTAAGAATATATATAAAGAACTGCATGATGACTGTGGATGTTATATTCC
TAATAACGGATATCTTAAGAAATGGGCCGACCAGGGAGTGCTTCTGCTTAACACAGTGCTTACTGTAAGAGCACATCAGG
CTAATTCACATCAGGGACACGGCTGGGAGCAGTTTACGGATGCAGTTATTAATGCTGTCAATATGCAGGACAGACCTATT
GTGTATATGCTGTGGGGTTCGCCTGCACAGAGAAAGGCATCAATGCTTAATAATCCGAAACATCTTATTCTTAAAGCACC
ACATCCGAGTCCGTTATCTGCGTACAGAGGCTTTTTTGGCTGCAGACATTTCAGCCAGTGCAATGAATTTTTAAAGGCTA
ATGGGGTAGAACCGATTGACTGGCAGATTGAGAATATATAA

Upstream 100 bases:

>100_bases
AGCACTTGCAGCTTCACTATTCCATTATAAGGAACTTGATATTATGGAGCTTAAGAAATACCTTGCAGATAATGGTATTC
CTATGCGTATGTAGGAGGAT

Downstream 100 bases:

>100_bases
TACACTTGATTTTTTAACAAATATTATGTATTATCAATTCTGTTTATTATTAAATTAAATAGGAGATAGTATGTTAAAAA
AGTATTTGTATATTTTTCTT

Product: uracil-DNA glycosylase

Products: NA

Alternate protein names: UDG [H]

Number of amino acids: Translated: 226; Mature: 226

Protein sequence:

>226_residues
MDMSMIDNDWLPAIKEEYSKPYYKELFTFVKNEYSKYVVYPPADDIFNAFHFTPLSKVKVLILGQDPYHNVHQAHGLSFS
VLPGEEAPPSLKNIYKELHDDCGCYIPNNGYLKKWADQGVLLLNTVLTVRAHQANSHQGHGWEQFTDAVINAVNMQDRPI
VYMLWGSPAQRKASMLNNPKHLILKAPHPSPLSAYRGFFGCRHFSQCNEFLKANGVEPIDWQIENI

Sequences:

>Translated_226_residues
MDMSMIDNDWLPAIKEEYSKPYYKELFTFVKNEYSKYVVYPPADDIFNAFHFTPLSKVKVLILGQDPYHNVHQAHGLSFS
VLPGEEAPPSLKNIYKELHDDCGCYIPNNGYLKKWADQGVLLLNTVLTVRAHQANSHQGHGWEQFTDAVINAVNMQDRPI
VYMLWGSPAQRKASMLNNPKHLILKAPHPSPLSAYRGFFGCRHFSQCNEFLKANGVEPIDWQIENI
>Mature_226_residues
MDMSMIDNDWLPAIKEEYSKPYYKELFTFVKNEYSKYVVYPPADDIFNAFHFTPLSKVKVLILGQDPYHNVHQAHGLSFS
VLPGEEAPPSLKNIYKELHDDCGCYIPNNGYLKKWADQGVLLLNTVLTVRAHQANSHQGHGWEQFTDAVINAVNMQDRPI
VYMLWGSPAQRKASMLNNPKHLILKAPHPSPLSAYRGFFGCRHFSQCNEFLKANGVEPIDWQIENI

Specific function: Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine [H]

COG id: COG0692

COG function: function code L; Uracil DNA glycosylase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uracil-DNA glycosylase family [H]

Homologues:

Organism=Homo sapiens, GI19718751, Length=216, Percent_Identity=53.2407407407407, Blast_Score=237, Evalue=5e-63,
Organism=Homo sapiens, GI6224979, Length=216, Percent_Identity=53.2407407407407, Blast_Score=237, Evalue=6e-63,
Organism=Escherichia coli, GI1788934, Length=214, Percent_Identity=55.607476635514, Blast_Score=244, Evalue=5e-66,
Organism=Caenorhabditis elegans, GI17556304, Length=220, Percent_Identity=46.8181818181818, Blast_Score=211, Evalue=2e-55,
Organism=Saccharomyces cerevisiae, GI6323620, Length=241, Percent_Identity=47.7178423236515, Blast_Score=221, Evalue=5e-59,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002043
- InterPro:   IPR018085
- InterPro:   IPR005122 [H]

Pfam domain/function: PF03167 UDG [H]

EC number: =3.2.2.27 [H]

Molecular weight: Translated: 25895; Mature: 25895

Theoretical pI: Translated: 6.91; Mature: 6.91

Prosite motif: PS00130 U_DNA_GLYCOSYLASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDMSMIDNDWLPAIKEEYSKPYYKELFTFVKNEYSKYVVYPPADDIFNAFHFTPLSKVKV
CCCCCCCCCCCHHHHHHHCCHHHHHHHHHHHHCCCCEEEECCHHHHHHHHHCCCHHHEEE
LILGQDPYHNVHQAHGLSFSVLPGEEAPPSLKNIYKELHDDCGCYIPNNGYLKKWADQGV
EEECCCCCCHHHHHCCCEEEECCCCCCCCHHHHHHHHHHHCCCEEECCCCCHHHHHCCCE
LLLNTVLTVRAHQANSHQGHGWEQFTDAVINAVNMQDRPIVYMLWGSPAQRKASMLNNPK
EEEHHHHHHHCCCCCCCCCCCHHHHHHHHHHHCCCCCCCEEEEEECCCHHHHHHHHCCCC
HLILKAPHPSPLSAYRGFFGCRHFSQCNEFLKANGVEPIDWQIENI
EEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCC
>Mature Secondary Structure
MDMSMIDNDWLPAIKEEYSKPYYKELFTFVKNEYSKYVVYPPADDIFNAFHFTPLSKVKV
CCCCCCCCCCCHHHHHHHCCHHHHHHHHHHHHCCCCEEEECCHHHHHHHHHCCCHHHEEE
LILGQDPYHNVHQAHGLSFSVLPGEEAPPSLKNIYKELHDDCGCYIPNNGYLKKWADQGV
EEECCCCCCHHHHHCCCEEEECCCCCCCCHHHHHHHHHHHCCCEEECCCCCHHHHHCCCE
LLLNTVLTVRAHQANSHQGHGWEQFTDAVINAVNMQDRPIVYMLWGSPAQRKASMLNNPK
EEEHHHHHHHCCCCCCCCCCCHHHHHHHHHHHCCCCCCCEEEEEECCCHHHHHHHHCCCC
HLILKAPHPSPLSAYRGFFGCRHFSQCNEFLKANGVEPIDWQIENI
EEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA