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The map label for this gene is hemN [H]

Identifier: 238916676

GI number: 238916676

Start: 743852

End: 745009

Strand: Direct

Name: hemN [H]

Synonym: EUBELI_00738

Alternate gene names: 238916676

Gene position: 743852-745009 (Clockwise)

Preceding gene: 238916675

Following gene: 238916678

Centisome position: 34.69

GC content: 39.9

Gene sequence:

>1158_bases
ATGATGAATAAAACATATGAAAAAGGGATATATATACATATCCCTTTTTGTGTACACAAATGTATATATTGTGATTTCCT
GTCTGCTCCGGCTGGTGATGCTGTAAAATATGCATACACTAGGGCACTTATTAATGAAATCAGAAATACAGCGGACAGGC
AGGTAAAGGATAAGATAACATCCATATTCTTTGGCGGAGGTACTCCGTCTGTACTGCCTGATGGCTGTATAGCTGACATA
TTATCGGCTGTCAGGGATTGCTTTGATATTTCGGATGATGCCGAGATAACAATGGAATGTAATCCGGGAACTGTTAATGA
AAGCAGGCTTTCAGAATACAGAGCCGCAGGAGTGAACAGGTTAAGCTTTGGCTTACAGTCTGCTGATAATAATGAATTAA
AAATGCTTGGGCGAATACACACATTTGAACAGTTTGAAGAAAGCTTCAGACTGGCAAGGGATGCAGGCTTTAATAATATT
AATGTTGACCTTATGTCGGCTATTCCGGGGCAGACTGAAGCAACTCTTGAAAATACATTTGACAAGGTGATGGCATTACA
GCCGGAGCATATATCGGTGTATAGCCTTATTCTTGAGGAAGGCACTTATCTGGCTGATAATATTGATAAGTTTCCGCCGG
TTCCTGATGAGGAAGAGGACAGGCGTATGTACCATATAACGAAGCAGATTCTTGAGAATGCAGGGTATGAAAGATACGAA
ATATCCAATTACAGCAGACCGGGCTTCGAATGCAGGCATAATCTTCTGTATTGGAACAGAGGAGAGTATTATGGCTTTGG
GTGTTCGGCAGCAGGATTTACAGGGAATGAGCGGTATTCTGACATAAGGGATGTCAGGGAGTATATAGAGCTTAACGGTG
ATATAGGAAAACTTCATGAAAATATTGAAATTCTGACGAAAGAAGATGCAATGGAAGAATTCATGTTTCTCGGCCTTAGA
AAGGTGGCAGGAGTTGATGTGAAGGATTTTCAGAACAGGTTCGGAGTTTCAATTAATGATGTCTATGCGAAAGAAACAGA
GCGGAATATTAATAAAGGTCTTCTTGTAAAGCGGGGAGATATGTTAAGGCTTACTGAATATGGCATGGATATATGTAATA
CAGTGATGAGTGATTTTATATTAACTGATGGAGATTAA

Upstream 100 bases:

>100_bases
AAGAAACTTCTTGAGAAGCAGAAGGAAGGAAAGAAGCGTATGCGCCAGATTGGTAATGTAGAGATTCCACAGAAGGCGTT
TATGAGCGTATTAAAGTTAG

Downstream 100 bases:

>100_bases
GAAAAGCAGGTGGTAGTCTGATTGTAAAGATTGTCACCTGCTTTAGTGTGTATATCAGAAATTCTTAATGAGTTTTATGT
ACTGCTTAGGAGTCATTCCC

Product: oxygen-independent coproporphyrinogen III oxidase

Products: NA

Alternate protein names: Coprogen oxidase; Coproporphyrinogenase [H]

Number of amino acids: Translated: 385; Mature: 385

Protein sequence:

>385_residues
MMNKTYEKGIYIHIPFCVHKCIYCDFLSAPAGDAVKYAYTRALINEIRNTADRQVKDKITSIFFGGGTPSVLPDGCIADI
LSAVRDCFDISDDAEITMECNPGTVNESRLSEYRAAGVNRLSFGLQSADNNELKMLGRIHTFEQFEESFRLARDAGFNNI
NVDLMSAIPGQTEATLENTFDKVMALQPEHISVYSLILEEGTYLADNIDKFPPVPDEEEDRRMYHITKQILENAGYERYE
ISNYSRPGFECRHNLLYWNRGEYYGFGCSAAGFTGNERYSDIRDVREYIELNGDIGKLHENIEILTKEDAMEEFMFLGLR
KVAGVDVKDFQNRFGVSINDVYAKETERNINKGLLVKRGDMLRLTEYGMDICNTVMSDFILTDGD

Sequences:

>Translated_385_residues
MMNKTYEKGIYIHIPFCVHKCIYCDFLSAPAGDAVKYAYTRALINEIRNTADRQVKDKITSIFFGGGTPSVLPDGCIADI
LSAVRDCFDISDDAEITMECNPGTVNESRLSEYRAAGVNRLSFGLQSADNNELKMLGRIHTFEQFEESFRLARDAGFNNI
NVDLMSAIPGQTEATLENTFDKVMALQPEHISVYSLILEEGTYLADNIDKFPPVPDEEEDRRMYHITKQILENAGYERYE
ISNYSRPGFECRHNLLYWNRGEYYGFGCSAAGFTGNERYSDIRDVREYIELNGDIGKLHENIEILTKEDAMEEFMFLGLR
KVAGVDVKDFQNRFGVSINDVYAKETERNINKGLLVKRGDMLRLTEYGMDICNTVMSDFILTDGD
>Mature_385_residues
MMNKTYEKGIYIHIPFCVHKCIYCDFLSAPAGDAVKYAYTRALINEIRNTADRQVKDKITSIFFGGGTPSVLPDGCIADI
LSAVRDCFDISDDAEITMECNPGTVNESRLSEYRAAGVNRLSFGLQSADNNELKMLGRIHTFEQFEESFRLARDAGFNNI
NVDLMSAIPGQTEATLENTFDKVMALQPEHISVYSLILEEGTYLADNIDKFPPVPDEEEDRRMYHITKQILENAGYERYE
ISNYSRPGFECRHNLLYWNRGEYYGFGCSAAGFTGNERYSDIRDVREYIELNGDIGKLHENIEILTKEDAMEEFMFLGLR
KVAGVDVKDFQNRFGVSINDVYAKETERNINKGLLVKRGDMLRLTEYGMDICNTVMSDFILTDGD

Specific function: Anaerobic transformation of coproporphyrinogen-III into protoporphyrinogen-IX [H]

COG id: COG0635

COG function: function code H; Coproporphyrinogen III oxidase and related Fe-S oxidoreductases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anaerobic coproporphyrinogen-III oxidase family [H]

Homologues:

Organism=Homo sapiens, GI8922911, Length=311, Percent_Identity=33.4405144694534, Blast_Score=186, Evalue=4e-47,
Organism=Escherichia coli, GI1789325, Length=386, Percent_Identity=34.4559585492228, Blast_Score=224, Evalue=5e-60,
Organism=Escherichia coli, GI87082341, Length=352, Percent_Identity=24.4318181818182, Blast_Score=116, Evalue=3e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006638
- InterPro:   IPR004559
- InterPro:   IPR010723
- InterPro:   IPR007197 [H]

Pfam domain/function: PF06969 HemN_C; PF04055 Radical_SAM [H]

EC number: =1.3.99.22 [H]

Molecular weight: Translated: 43795; Mature: 43795

Theoretical pI: Translated: 4.49; Mature: 4.49

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMNKTYEKGIYIHIPFCVHKCIYCDFLSAPAGDAVKYAYTRALINEIRNTADRQVKDKIT
CCCCCHHCCEEEEEHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
SIFFGGGTPSVLPDGCIADILSAVRDCFDISDDAEITMECNPGTVNESRLSEYRAAGVNR
EEEECCCCCCCCCCHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCHHHHHHHHHHCCHH
LSFGLQSADNNELKMLGRIHTFEQFEESFRLARDAGFNNINVDLMSAIPGQTEATLENTF
HHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEHHCCCCCCCHHHHHHHH
DKVMALQPEHISVYSLILEEGTYLADNIDKFPPVPDEEEDRRMYHITKQILENAGYERYE
HHHHHCCCCHHHHHHHHHHCCCEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEE
ISNYSRPGFECRHNLLYWNRGEYYGFGCSAAGFTGNERYSDIRDVREYIELNGDIGKLHE
CCCCCCCCHHHHCCCEEEECCCEEECCCCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHC
NIEILTKEDAMEEFMFLGLRKVAGVDVKDFQNRFGVSINDVYAKETERNINKGLLVKRGD
CHHEEEHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCHHHHHHHHHHCCCCCCEEEECCC
MLRLTEYGMDICNTVMSDFILTDGD
EEEHHHHHHHHHHHHHHHHEECCCC
>Mature Secondary Structure
MMNKTYEKGIYIHIPFCVHKCIYCDFLSAPAGDAVKYAYTRALINEIRNTADRQVKDKIT
CCCCCHHCCEEEEEHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
SIFFGGGTPSVLPDGCIADILSAVRDCFDISDDAEITMECNPGTVNESRLSEYRAAGVNR
EEEECCCCCCCCCCHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCHHHHHHHHHHCCHH
LSFGLQSADNNELKMLGRIHTFEQFEESFRLARDAGFNNINVDLMSAIPGQTEATLENTF
HHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEHHCCCCCCCHHHHHHHH
DKVMALQPEHISVYSLILEEGTYLADNIDKFPPVPDEEEDRRMYHITKQILENAGYERYE
HHHHHCCCCHHHHHHHHHHCCCEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEE
ISNYSRPGFECRHNLLYWNRGEYYGFGCSAAGFTGNERYSDIRDVREYIELNGDIGKLHE
CCCCCCCCHHHHCCCEEEECCCEEECCCCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHC
NIEILTKEDAMEEFMFLGLRKVAGVDVKDFQNRFGVSINDVYAKETERNINKGLLVKRGD
CHHEEEHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCHHHHHHHHHHCCCCCCEEEECCC
MLRLTEYGMDICNTVMSDFILTDGD
EEEHHHHHHHHHHHHHHHHEECCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8757728; 8969508; 9384377; 1339421 [H]