Click here to switch to the map view.

The map label for this gene is hisC [H]

Identifier: 238916572

GI number: 238916572

Start: 638433

End: 639518

Strand: Direct

Name: hisC [H]

Synonym: EUBELI_00629

Alternate gene names: 238916572

Gene position: 638433-639518 (Clockwise)

Preceding gene: 238916571

Following gene: 238916573

Centisome position: 29.78

GC content: 36.92

Gene sequence:

>1086_bases
GTGAAAGAAGAGGACTTATATATGAAGACATGGGAGAAGAATATCAGAAGAGTTGAGCCATATGTGCCGGGAGAGCAGCC
TAAGGTTAAAGATGTTGTAAAGCTTAATACCAACGAGAATCCATATCCTCCAACACCTAAGGTGCATGAGGCAGCAGAGA
GAATGAATATCAGTGATTTAAGACTTTATCCGGATCCTGAGGTTACAGACCTTGTACATGCAATTGCAGCTTATTATGGA
ATGAATGATAATCAGGTATTCGTAGGAGTTGGTTCTGATGATGTATTGTCGATGTGTTTCCTGACATTCTTTAATTCAGA
CAAGCCAATACTGTTTCCTAATATCTCATATTCTTTCTACAGTGTATGGGCTGACCTTTACAGAATTCCATATGAGAAGC
AGCCGCTTGATAAGGATTTTAATATAATTCCAGAAGATTATTACAAGGAGAATGGCGGAGTGGTATTCCCTAACCCTAAT
GCTCCTACAGCACTTTATATGGAACTTGATAAGGTTGAAGATATTATAAAACATAATCAGGATGTAGTTGTTATTGTTGA
TGAGGCTTATATTGATTTTGGCGGAAAGTCAGCAATGGAGCTTGTCAATAAGTATGAAAATGTGTTGGTTGTACAGACAT
TTTCTAAATCACGTGCAATGGCTGGTATGAGAATAGGTTACTGTTTCGGTAATCCTGAGCTTATAAAGGCTCTTAATGAT
GTCAAATTCTCATTCAATTCGTACACAATGAACAGAACTTCAATAAGCTATGGCATTGAGTCTGTCAATGATAAGGAATA
CTTTGAAGAGTGCGTGGGTAAGATAGTTAAGACCAGAGAGAATGCTAAGGAAAGACTTTCACAGTTAGGCTTCTCATTCC
CTGACTCTAAGGCTAACTTTATATTTGCAACACACAAGAGTGTTTCGGCTAAGGAAATATTTGAAAAACTTAAAGAAAAG
AACATATTTGTCAGATATTTTAACCAGCCACTTATTGATAATTACTTAAGAATTTCAATAGGAACTGATGAGCAGATGGA
AAAGCTTTACGCTGCGTTAGAAGAGATAACAGGACAGGTTAAGTAA

Upstream 100 bases:

>100_bases
TGGATATGTTAGAATTGCATACTGTGTATCTTACGATACAATTGTTAATTCATTACCACATTTTGCAGAAGTTGCTAAAG
AGATGGGATTATAATTATTC

Downstream 100 bases:

>100_bases
TATGGGAATACCTTTTGAACAGAGAAATTTTCAGAAAGAGCTTGATAAGAAGATAGCGGGCTTCCAGAAGGACGGAATTG
TACCGACTCTGCTTCTTCAC

Product: histidinol-phosphate aminotransferase

Products: NA

Alternate protein names: Imidazole acetol-phosphate transaminase [H]

Number of amino acids: Translated: 361; Mature: 361

Protein sequence:

>361_residues
MKEEDLYMKTWEKNIRRVEPYVPGEQPKVKDVVKLNTNENPYPPTPKVHEAAERMNISDLRLYPDPEVTDLVHAIAAYYG
MNDNQVFVGVGSDDVLSMCFLTFFNSDKPILFPNISYSFYSVWADLYRIPYEKQPLDKDFNIIPEDYYKENGGVVFPNPN
APTALYMELDKVEDIIKHNQDVVVIVDEAYIDFGGKSAMELVNKYENVLVVQTFSKSRAMAGMRIGYCFGNPELIKALND
VKFSFNSYTMNRTSISYGIESVNDKEYFEECVGKIVKTRENAKERLSQLGFSFPDSKANFIFATHKSVSAKEIFEKLKEK
NIFVRYFNQPLIDNYLRISIGTDEQMEKLYAALEEITGQVK

Sequences:

>Translated_361_residues
MKEEDLYMKTWEKNIRRVEPYVPGEQPKVKDVVKLNTNENPYPPTPKVHEAAERMNISDLRLYPDPEVTDLVHAIAAYYG
MNDNQVFVGVGSDDVLSMCFLTFFNSDKPILFPNISYSFYSVWADLYRIPYEKQPLDKDFNIIPEDYYKENGGVVFPNPN
APTALYMELDKVEDIIKHNQDVVVIVDEAYIDFGGKSAMELVNKYENVLVVQTFSKSRAMAGMRIGYCFGNPELIKALND
VKFSFNSYTMNRTSISYGIESVNDKEYFEECVGKIVKTRENAKERLSQLGFSFPDSKANFIFATHKSVSAKEIFEKLKEK
NIFVRYFNQPLIDNYLRISIGTDEQMEKLYAALEEITGQVK
>Mature_361_residues
MKEEDLYMKTWEKNIRRVEPYVPGEQPKVKDVVKLNTNENPYPPTPKVHEAAERMNISDLRLYPDPEVTDLVHAIAAYYG
MNDNQVFVGVGSDDVLSMCFLTFFNSDKPILFPNISYSFYSVWADLYRIPYEKQPLDKDFNIIPEDYYKENGGVVFPNPN
APTALYMELDKVEDIIKHNQDVVVIVDEAYIDFGGKSAMELVNKYENVLVVQTFSKSRAMAGMRIGYCFGNPELIKALND
VKFSFNSYTMNRTSISYGIESVNDKEYFEECVGKIVKTRENAKERLSQLGFSFPDSKANFIFATHKSVSAKEIFEKLKEK
NIFVRYFNQPLIDNYLRISIGTDEQMEKLYAALEEITGQVK

Specific function: Histidine biosynthesis; seventh step. [C]

COG id: COG0079

COG function: function code E; Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788332, Length=352, Percent_Identity=25.2840909090909, Blast_Score=102, Evalue=5e-23,
Organism=Saccharomyces cerevisiae, GI6322075, Length=374, Percent_Identity=26.7379679144385, Blast_Score=108, Evalue=1e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR005861
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.6.1.9 [H]

Molecular weight: Translated: 41602; Mature: 41602

Theoretical pI: Translated: 4.78; Mature: 4.78

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKEEDLYMKTWEKNIRRVEPYVPGEQPKVKDVVKLNTNENPYPPTPKVHEAAERMNISDL
CCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEECCCCCCCCCCCHHHHHHHHCCCCCE
RLYPDPEVTDLVHAIAAYYGMNDNQVFVGVGSDDVLSMCFLTFFNSDKPILFPNISYSFY
EECCCCCHHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHCCCCCEEECCCCHHHH
SVWADLYRIPYEKQPLDKDFNIIPEDYYKENGGVVFPNPNAPTALYMELDKVEDIIKHNQ
HHHHHHHHCCCCCCCCCCCCCCCCHHHEECCCCEEECCCCCCEEEEEEHHHHHHHHHCCC
DVVVIVDEAYIDFGGKSAMELVNKYENVLVVQTFSKSRAMAGMRIGYCFGNPELIKALND
CEEEEEEEEEECCCCHHHHHHHHHHCCEEEEEECCCCHHHCCCEEEEEECCHHHHHHHHH
VKFSFNSYTMNRTSISYGIESVNDKEYFEECVGKIVKTRENAKERLSQLGFSFPDSKANF
HEEEECCEEEECCHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCE
IFATHKSVSAKEIFEKLKEKNIFVRYFNQPLIDNYLRISIGTDEQMEKLYAALEEITGQV
EEEECCCCCHHHHHHHHHHCCEEEEECCCCHHCCEEEEEECCHHHHHHHHHHHHHHHCCC
K
C
>Mature Secondary Structure
MKEEDLYMKTWEKNIRRVEPYVPGEQPKVKDVVKLNTNENPYPPTPKVHEAAERMNISDL
CCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEECCCCCCCCCCCHHHHHHHHCCCCCE
RLYPDPEVTDLVHAIAAYYGMNDNQVFVGVGSDDVLSMCFLTFFNSDKPILFPNISYSFY
EECCCCCHHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHCCCCCEEECCCCHHHH
SVWADLYRIPYEKQPLDKDFNIIPEDYYKENGGVVFPNPNAPTALYMELDKVEDIIKHNQ
HHHHHHHHCCCCCCCCCCCCCCCCHHHEECCCCEEECCCCCCEEEEEEHHHHHHHHHCCC
DVVVIVDEAYIDFGGKSAMELVNKYENVLVVQTFSKSRAMAGMRIGYCFGNPELIKALND
CEEEEEEEEEECCCCHHHHHHHHHHCCEEEEEECCCCHHHCCCEEEEEECCHHHHHHHHH
VKFSFNSYTMNRTSISYGIESVNDKEYFEECVGKIVKTRENAKERLSQLGFSFPDSKANF
HEEEECCEEEECCHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCE
IFATHKSVSAKEIFEKLKEKNIFVRYFNQPLIDNYLRISIGTDEQMEKLYAALEEITGQV
EEEECCCCCHHHHHHHHHHCCEEEEECCCCHHCCEEEEEECCHHHHHHHHHHHHHHHCCC
K
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA