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The map label for this gene is purM

Identifier: 238916492

GI number: 238916492

Start: 553764

End: 554789

Strand: Direct

Name: purM

Synonym: EUBELI_00549

Alternate gene names: 238916492

Gene position: 553764-554789 (Clockwise)

Preceding gene: 238916491

Following gene: 238916493

Centisome position: 25.83

GC content: 41.91

Gene sequence:

>1026_bases
ATGGATTACAAGAAATCTGGAGTTGATATTGAAGCAGGTTACAAGTCAGTTGAGTTAATGAAAGAGGCTGTTAAGTCTAC
TATGAGAGAAGAAGTGTTAGGCGGAATAGGCGGATTCTCAGGAGCATTTTCACTCGCTAAGATTAAGGAGATGGAAGAGC
CTGTATTACTTTCAGGAACTGACGGATGTGGAACTAAGGTTAAGTTAGCTTTCATTATGGACAAGCATGATACTATCGGT
ATTGATGCAGTTGCTATGTGTGTTAACGATGTTGTATGTGCTGGTGGAGAGCCACTCTTCTTCCTTGATTACATCGCATG
CGGCAAGAATTATCCAGAAAAGATTGCTACTATCGTTGGTGGTGTTGCAGAGGGCTGCAGACAGTCTGAATGTGCACTTA
TCGGTGGTGAGACAGCAGAGCATCCGGGACTTATGCCACAGGATGAATATGATCTTGCAGGATTTGCTGTAGGTGTTGTT
GATAAGAAGGATCTTATTACAGGCGAGAACATCAAGCCTGGTGATACTCTTATCGGTATCGCTTCAAGCGGTGTACACAG
TAACGGATTCTCACTTGTAAGAAGCGTATTTACAATGACAGAGGAATCTCTTAATACATATTACGATTCACTTGGAAAGA
CATTAGGAGAGGCATTACTTGCTCCAACTAAAATATATGTTAAGACAATGAAGGAAATCAAGAAGGCAGGCGTTAAGGTT
AAGGGCTGCAGCCATATCACAGGTGGTGGTTTCTATGAAAATGTACCTAGAATGCTTCCAGACGGTGTTAAGGCAGTAAT
TAAGAAGGACAGCTACGAAGTACCACCAATCTTTAAGATGCTTGCAGAAGATGGCAATATCGAAGAGCATATGATGTATA
ATACATTTAACATGGGTATCGGTCTTGTACTTGCTGTTGATCCTGCTGATGTTGATACAGTTATGGAAGCAGTTAAGGCT
GCAGGCGAGACTCCATATGTAATCGGAAGCATTGAAGCTGGCGAGAAGGGAGTTACTTTATGCTAA

Upstream 100 bases:

>100_bases
AGGATGCCAGACTTCAGGAAGTCGGTTATAAGAATTATTAATTAGTAACTGAATAGTTACATTAACTTACATTTATCATA
ATATTGAAGGAGAAAGAATC

Downstream 100 bases:

>100_bases
GAGTTGCAGTTATGGTTTCCGGAGGCGGAACTAATCTTCAGGCTATTATCGATGCGGTTAAGGATGGAACTATCACTAAC
ACAGAGCTTGTAGCAGTTAT

Product: phosphoribosylformylglycinamidine cyclo-ligase

Products: NA

Alternate protein names: AIR synthase; AIRS; Phosphoribosyl-aminoimidazole synthetase

Number of amino acids: Translated: 341; Mature: 341

Protein sequence:

>341_residues
MDYKKSGVDIEAGYKSVELMKEAVKSTMREEVLGGIGGFSGAFSLAKIKEMEEPVLLSGTDGCGTKVKLAFIMDKHDTIG
IDAVAMCVNDVVCAGGEPLFFLDYIACGKNYPEKIATIVGGVAEGCRQSECALIGGETAEHPGLMPQDEYDLAGFAVGVV
DKKDLITGENIKPGDTLIGIASSGVHSNGFSLVRSVFTMTEESLNTYYDSLGKTLGEALLAPTKIYVKTMKEIKKAGVKV
KGCSHITGGGFYENVPRMLPDGVKAVIKKDSYEVPPIFKMLAEDGNIEEHMMYNTFNMGIGLVLAVDPADVDTVMEAVKA
AGETPYVIGSIEAGEKGVTLC

Sequences:

>Translated_341_residues
MDYKKSGVDIEAGYKSVELMKEAVKSTMREEVLGGIGGFSGAFSLAKIKEMEEPVLLSGTDGCGTKVKLAFIMDKHDTIG
IDAVAMCVNDVVCAGGEPLFFLDYIACGKNYPEKIATIVGGVAEGCRQSECALIGGETAEHPGLMPQDEYDLAGFAVGVV
DKKDLITGENIKPGDTLIGIASSGVHSNGFSLVRSVFTMTEESLNTYYDSLGKTLGEALLAPTKIYVKTMKEIKKAGVKV
KGCSHITGGGFYENVPRMLPDGVKAVIKKDSYEVPPIFKMLAEDGNIEEHMMYNTFNMGIGLVLAVDPADVDTVMEAVKA
AGETPYVIGSIEAGEKGVTLC
>Mature_341_residues
MDYKKSGVDIEAGYKSVELMKEAVKSTMREEVLGGIGGFSGAFSLAKIKEMEEPVLLSGTDGCGTKVKLAFIMDKHDTIG
IDAVAMCVNDVVCAGGEPLFFLDYIACGKNYPEKIATIVGGVAEGCRQSECALIGGETAEHPGLMPQDEYDLAGFAVGVV
DKKDLITGENIKPGDTLIGIASSGVHSNGFSLVRSVFTMTEESLNTYYDSLGKTLGEALLAPTKIYVKTMKEIKKAGVKV
KGCSHITGGGFYENVPRMLPDGVKAVIKKDSYEVPPIFKMLAEDGNIEEHMMYNTFNMGIGLVLAVDPADVDTVMEAVKA
AGETPYVIGSIEAGEKGVTLC

Specific function: De novo purine biosynthesis; fifth step. [C]

COG id: COG0150

COG function: function code F; Phosphoribosylaminoimidazole (AIR) synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR synthase family

Homologues:

Organism=Homo sapiens, GI4503915, Length=340, Percent_Identity=44.1176470588235, Blast_Score=284, Evalue=7e-77,
Organism=Homo sapiens, GI209869995, Length=340, Percent_Identity=44.1176470588235, Blast_Score=284, Evalue=7e-77,
Organism=Homo sapiens, GI209869993, Length=340, Percent_Identity=44.1176470588235, Blast_Score=284, Evalue=7e-77,
Organism=Escherichia coli, GI1788845, Length=336, Percent_Identity=49.1071428571429, Blast_Score=325, Evalue=2e-90,
Organism=Caenorhabditis elegans, GI17567511, Length=343, Percent_Identity=39.3586005830904, Blast_Score=222, Evalue=2e-58,
Organism=Saccharomyces cerevisiae, GI6321203, Length=344, Percent_Identity=43.6046511627907, Blast_Score=270, Evalue=2e-73,
Organism=Drosophila melanogaster, GI24582400, Length=285, Percent_Identity=42.1052631578947, Blast_Score=220, Evalue=1e-57,

Paralogues:

None

Copy number: 180 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): PUR5_EUBE2 (C4Z478)

Other databases:

- EMBL:   CP001104
- RefSeq:   YP_002930009.1
- GeneID:   7958608
- GenomeReviews:   CP001104_GR
- KEGG:   eel:EUBELI_00549
- OMA:   GIDMIAM
- ProtClustDB:   CLSK2506417
- GO:   GO:0005737
- HAMAP:   MF_00741_B
- InterPro:   IPR000728
- InterPro:   IPR010918
- InterPro:   IPR004733
- InterPro:   IPR016188
- TIGRFAMs:   TIGR00878

Pfam domain/function: PF00586 AIRS; PF02769 AIRS_C; SSF56042 AIR_synth_C; SSF55326 PurM_N-like

EC number: =6.3.3.1

Molecular weight: Translated: 36215; Mature: 36215

Theoretical pI: Translated: 4.56; Mature: 4.56

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
6.7 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
6.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDYKKSGVDIEAGYKSVELMKEAVKSTMREEVLGGIGGFSGAFSLAKIKEMEEPVLLSGT
CCCCCCCCCHHCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCEEEECC
DGCGTKVKLAFIMDKHDTIGIDAVAMCVNDVVCAGGEPLFFLDYIACGKNYPEKIATIVG
CCCCCEEEEEEEECCCCCCCHHHHHHHHHHHHHCCCCCEEEHHHHHHCCCCHHHHHHHHH
GVAEGCRQSECALIGGETAEHPGLMPQDEYDLAGFAVGVVDKKDLITGENIKPGDTLIGI
HHHHHCCCCCCEEECCCCCCCCCCCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCEEEE
ASSGVHSNGFSLVRSVFTMTEESLNTYYDSLGKTLGEALLAPTKIYVKTMKEIKKAGVKV
ECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCEE
KGCSHITGGGFYENVPRMLPDGVKAVIKKDSYEVPPIFKMLAEDGNIEEHMMYNTFNMGI
ECCCCCCCCCHHHHHHHHCCHHHHHHHHCCCCCCCHHHHHHHCCCCCCHHHEEEEECCCE
GLVLAVDPADVDTVMEAVKAAGETPYVIGSIEAGEKGVTLC
EEEEEECCCCHHHHHHHHHHCCCCCEEEEEECCCCCCCCCC
>Mature Secondary Structure
MDYKKSGVDIEAGYKSVELMKEAVKSTMREEVLGGIGGFSGAFSLAKIKEMEEPVLLSGT
CCCCCCCCCHHCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCEEEECC
DGCGTKVKLAFIMDKHDTIGIDAVAMCVNDVVCAGGEPLFFLDYIACGKNYPEKIATIVG
CCCCCEEEEEEEECCCCCCCHHHHHHHHHHHHHCCCCCEEEHHHHHHCCCCHHHHHHHHH
GVAEGCRQSECALIGGETAEHPGLMPQDEYDLAGFAVGVVDKKDLITGENIKPGDTLIGI
HHHHHCCCCCCEEECCCCCCCCCCCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCEEEE
ASSGVHSNGFSLVRSVFTMTEESLNTYYDSLGKTLGEALLAPTKIYVKTMKEIKKAGVKV
ECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCEE
KGCSHITGGGFYENVPRMLPDGVKAVIKKDSYEVPPIFKMLAEDGNIEEHMMYNTFNMGI
ECCCCCCCCCHHHHHHHHCCHHHHHHHHCCCCCCCHHHHHHHCCCCCCHHHEEEEECCCE
GLVLAVDPADVDTVMEAVKAAGETPYVIGSIEAGEKGVTLC
EEEEEECCCCHHHHHHHHHHCCCCCEEEEEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA