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The map label for this gene is purE [H]

Identifier: 238916491

GI number: 238916491

Start: 553204

End: 553704

Strand: Direct

Name: purE [H]

Synonym: EUBELI_00548

Alternate gene names: 238916491

Gene position: 553204-553704 (Clockwise)

Preceding gene: 238916490

Following gene: 238916492

Centisome position: 25.8

GC content: 41.32

Gene sequence:

>501_bases
ATGGCTTTAGTAGGAATTGTTATGGGAAGTGACTCTGATATGCCTGTTATGGCAAAGGCAGCAGACATTCTTGAGCAGTT
AGGAATTTCGTATGAGATGACAATTATCTCAGCACACAGAGAGCCTGACGTATTCTTTGAATATGCTAAGAGTGCAGAGG
AGAAGGGATTTAAGGTTATTATTGCAGGTGCAGGTATGGCAGCACATCTTCCGGGTATGTGCGCAGCTATTTTCCCAATG
CCTGTTATTGGTATTCCAATGCACACAACATCACTAGGCGGTAGAGATTCATTATATTCAATAGTACAGATGCCTACAGG
TATTCCTGTTGCAACTGTTGCTATTAACGGTGGTGCCAATGCAGGTATTCTTGCAGCCAAGATTCTTGCAACATCTGATG
CAGCACTTCTTGAAAGGCTTAAGGATTATACTAAGAATCTTAAGGAAAGTGTTCAGAAGAAGGATGCCAGACTTCAGGAA
GTCGGTTATAAGAATTATTAA

Upstream 100 bases:

>100_bases
AAACAGGCTTTATCTTGACGCAAAGTTTAAAACAAAGTACAATGATAATTAGTGTTTTCACTAATTTTAATATTATATCT
ATCGGACATAGGAGGTTAAT

Downstream 100 bases:

>100_bases
TTAGTAACTGAATAGTTACATTAACTTACATTTATCATAATATTGAAGGAGAAAGAATCATGGATTACAAGAAATCTGGA
GTTGATATTGAAGCAGGTTA

Product: phosphoribosylaminoimidazole carboxylase

Products: NA

Alternate protein names: N5-CAIR mutase; 5-(carboxyamino)imidazole ribonucleotide mutase [H]

Number of amino acids: Translated: 166; Mature: 165

Protein sequence:

>166_residues
MALVGIVMGSDSDMPVMAKAADILEQLGISYEMTIISAHREPDVFFEYAKSAEEKGFKVIIAGAGMAAHLPGMCAAIFPM
PVIGIPMHTTSLGGRDSLYSIVQMPTGIPVATVAINGGANAGILAAKILATSDAALLERLKDYTKNLKESVQKKDARLQE
VGYKNY

Sequences:

>Translated_166_residues
MALVGIVMGSDSDMPVMAKAADILEQLGISYEMTIISAHREPDVFFEYAKSAEEKGFKVIIAGAGMAAHLPGMCAAIFPM
PVIGIPMHTTSLGGRDSLYSIVQMPTGIPVATVAINGGANAGILAAKILATSDAALLERLKDYTKNLKESVQKKDARLQE
VGYKNY
>Mature_165_residues
ALVGIVMGSDSDMPVMAKAADILEQLGISYEMTIISAHREPDVFFEYAKSAEEKGFKVIIAGAGMAAHLPGMCAAIFPMP
VIGIPMHTTSLGGRDSLYSIVQMPTGIPVATVAINGGANAGILAAKILATSDAALLERLKDYTKNLKESVQKKDARLQEV
GYKNY

Specific function: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) [H]

COG id: COG0041

COG function: function code F; Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR carboxylase family [H]

Homologues:

Organism=Escherichia coli, GI1786734, Length=159, Percent_Identity=53.4591194968553, Blast_Score=137, Evalue=3e-34,
Organism=Saccharomyces cerevisiae, GI6324702, Length=164, Percent_Identity=51.8292682926829, Blast_Score=175, Evalue=4e-45,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000031 [H]

Pfam domain/function: PF00731 AIRC [H]

EC number: =5.4.99.18 [H]

Molecular weight: Translated: 17604; Mature: 17473

Theoretical pI: Translated: 6.26; Mature: 6.26

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
6.0 %Met     (Translated Protein)
6.6 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
5.5 %Met     (Mature Protein)
6.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALVGIVMGSDSDMPVMAKAADILEQLGISYEMTIISAHREPDVFFEYAKSAEEKGFKVI
CEEEEEEECCCCCCCHHHHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHHCCCCEEE
IAGAGMAAHLPGMCAAIFPMPVIGIPMHTTSLGGRDSLYSIVQMPTGIPVATVAINGGAN
EECCCHHHHCCHHHHHHHCCCEECCCCCCCCCCCHHHHHHHHHCCCCCCEEEEEECCCCC
AGILAAKILATSDAALLERLKDYTKNLKESVQKKDARLQEVGYKNY
CHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
ALVGIVMGSDSDMPVMAKAADILEQLGISYEMTIISAHREPDVFFEYAKSAEEKGFKVI
EEEEEEECCCCCCCHHHHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHHCCCCEEE
IAGAGMAAHLPGMCAAIFPMPVIGIPMHTTSLGGRDSLYSIVQMPTGIPVATVAINGGAN
EECCCHHHHCCHHHHHHHCCCEECCCCCCCCCCCHHHHHHHHHCCCCCCEEEEEECCCCC
AGILAAKILATSDAALLERLKDYTKNLKESVQKKDARLQEVGYKNY
CHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10360571 [H]