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The map label for this gene is pyrC [H]

Identifier: 238916474

GI number: 238916474

Start: 537740

End: 539062

Strand: Direct

Name: pyrC [H]

Synonym: EUBELI_00531

Alternate gene names: 238916474

Gene position: 537740-539062 (Clockwise)

Preceding gene: 238916473

Following gene: 238916475

Centisome position: 25.08

GC content: 42.03

Gene sequence:

>1323_bases
ATGAACATACTGATTAAAGAAGGCAGGGTGCTTGACCCTGCAAGTAAGACGGACAAAGTGATGGACGTGCTTATTAAGGA
CGGATTTATTGCGGCTATGGAAGAGAACATTGATGAGTCTCAGGCAGATGATGTCATTGATGCATCAGGCTGTATGGTTA
TGCCGGGACTGATTGACCTTAATGCACATTTCAGGGAACCGGGACTTGAGCATAAGGAAACTATAAGAACCGGATCAAGA
GCTGCAGCAAGAGGCGGATACACAACAGTGTGCATGATGCCTAATACTAAACCTGTAATTGATAATGTTGAGATGTTACA
GTATGTAACTGATAAGGCTGAAGAGGTAACAGATATTAATCTGTATACTATAGCTGCCATGACAGCAGGTCAGGAGGGTG
AGTATCTTACTGATTTTGAGGCACTTAAGGATGCAGGTGCTGTTGCAGTCAGTGACAATGGCGGAACTATTATGAATGCA
AGAACTGCAAGGCAGGCTATGAGGCAGGCAGCAGAGGTTGACATTCCGGTATTTGCACATTGTGAAGATACTAACTTGGC
TGCAAGAGGTGTTATGAATGCCGGAGAGAGAGCCAAGGAACTTGGTCTTTTCGGAATAATGGATGCCGTTGAGGATGTTA
TTGTTGCAAGAGATATTCTTCTTGCAAAGAATACAGGTGCAAAGCTGCATATAAGTCATGTGTCTAATAAGGAATCAGCA
TTTATTATAAAGATTGCCAAGGAACAGGGAATTCCAGTGACAGCAGAGGTTGCCCCACATCATTTCACACTGACAGAGGA
TGCGGTGAACGGGGATGATGCAAACTTTAAGATTAACCCTCCTTTAAGAAAGGCAGATGATGTAAAGGCTCTTAAAGAAG
CGCTTGCATCAGGGGTTATTGATGTTATTGCAACAGACCATGCTCCACATCATCCTACTGAGAAGGAAAGACCTTTTGAC
GAAGCACCGTTTGGTGTAGTAGGTCTTGAAACAGCAGTTCCGGTTACTATTACTGTGCTTGTAAGAACAGGAGTGCTTAC
TCCGTTACAGATGGTTGAGAAAATGAGTTATAATCCGGCTAAGATACTTGGAATTGACAGAGGAGTTCTTGCACCGGGAA
AAGTTGCTGATATAACAGTTGTTAATCCTACAGAAGAGTATGATATTGACAGCAACAGATTTGCTTCAAAGGGAAAGAAT
ACTCCATTTGAAGGAAAGCATGTGTATGGAAAGGTTTTATATACGCTTGTTAATGGAAGAGTTGTGTATTCAGACCATAA
TGGAACAGAAATTCTTATTGAAAGAGAAGTTCCAAAGTTGTAG

Upstream 100 bases:

>100_bases
TTAAAAGTCTTGGTGTGGATTATATACAGGGATATTACTTTGGAAAGCCTGTTCCAGCCAATATTTTTGAAGAGAAAAAC
TTAGAGGGGAGATTGGGCAA

Downstream 100 bases:

>100_bases
AATAAAGTGATTTTGCGTATGAATTAAGGAGGCTAAAGTAGATTAATGATTAAGAAGCTTGTTGATAAGATTGTAGAGAC
TAATGCACCAATAGTTGTAG

Product: dihydroorotase

Products: NA

Alternate protein names: DHOase [H]

Number of amino acids: Translated: 440; Mature: 440

Protein sequence:

>440_residues
MNILIKEGRVLDPASKTDKVMDVLIKDGFIAAMEENIDESQADDVIDASGCMVMPGLIDLNAHFREPGLEHKETIRTGSR
AAARGGYTTVCMMPNTKPVIDNVEMLQYVTDKAEEVTDINLYTIAAMTAGQEGEYLTDFEALKDAGAVAVSDNGGTIMNA
RTARQAMRQAAEVDIPVFAHCEDTNLAARGVMNAGERAKELGLFGIMDAVEDVIVARDILLAKNTGAKLHISHVSNKESA
FIIKIAKEQGIPVTAEVAPHHFTLTEDAVNGDDANFKINPPLRKADDVKALKEALASGVIDVIATDHAPHHPTEKERPFD
EAPFGVVGLETAVPVTITVLVRTGVLTPLQMVEKMSYNPAKILGIDRGVLAPGKVADITVVNPTEEYDIDSNRFASKGKN
TPFEGKHVYGKVLYTLVNGRVVYSDHNGTEILIEREVPKL

Sequences:

>Translated_440_residues
MNILIKEGRVLDPASKTDKVMDVLIKDGFIAAMEENIDESQADDVIDASGCMVMPGLIDLNAHFREPGLEHKETIRTGSR
AAARGGYTTVCMMPNTKPVIDNVEMLQYVTDKAEEVTDINLYTIAAMTAGQEGEYLTDFEALKDAGAVAVSDNGGTIMNA
RTARQAMRQAAEVDIPVFAHCEDTNLAARGVMNAGERAKELGLFGIMDAVEDVIVARDILLAKNTGAKLHISHVSNKESA
FIIKIAKEQGIPVTAEVAPHHFTLTEDAVNGDDANFKINPPLRKADDVKALKEALASGVIDVIATDHAPHHPTEKERPFD
EAPFGVVGLETAVPVTITVLVRTGVLTPLQMVEKMSYNPAKILGIDRGVLAPGKVADITVVNPTEEYDIDSNRFASKGKN
TPFEGKHVYGKVLYTLVNGRVVYSDHNGTEILIEREVPKL
>Mature_440_residues
MNILIKEGRVLDPASKTDKVMDVLIKDGFIAAMEENIDESQADDVIDASGCMVMPGLIDLNAHFREPGLEHKETIRTGSR
AAARGGYTTVCMMPNTKPVIDNVEMLQYVTDKAEEVTDINLYTIAAMTAGQEGEYLTDFEALKDAGAVAVSDNGGTIMNA
RTARQAMRQAAEVDIPVFAHCEDTNLAARGVMNAGERAKELGLFGIMDAVEDVIVARDILLAKNTGAKLHISHVSNKESA
FIIKIAKEQGIPVTAEVAPHHFTLTEDAVNGDDANFKINPPLRKADDVKALKEALASGVIDVIATDHAPHHPTEKERPFD
EAPFGVVGLETAVPVTITVLVRTGVLTPLQMVEKMSYNPAKILGIDRGVLAPGKVADITVVNPTEEYDIDSNRFASKGKN
TPFEGKHVYGKVLYTLVNGRVVYSDHNGTEILIEREVPKL

Specific function: Involved In The Anaerobic Utilization Of Allantoin. [C]

COG id: COG0044

COG function: function code F; Dihydroorotase and related cyclic amidohydrolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHOase family. Type 2 subfamily [H]

Homologues:

Organism=Homo sapiens, GI18105007, Length=384, Percent_Identity=32.03125, Blast_Score=160, Evalue=3e-39,
Organism=Homo sapiens, GI4503051, Length=457, Percent_Identity=24.72647702407, Blast_Score=100, Evalue=3e-21,
Organism=Homo sapiens, GI62422571, Length=457, Percent_Identity=24.72647702407, Blast_Score=99, Evalue=6e-21,
Organism=Homo sapiens, GI19923821, Length=450, Percent_Identity=25.5555555555556, Blast_Score=95, Evalue=1e-19,
Organism=Homo sapiens, GI4503375, Length=457, Percent_Identity=24.945295404814, Blast_Score=86, Evalue=6e-17,
Organism=Escherichia coli, GI1786722, Length=448, Percent_Identity=29.2410714285714, Blast_Score=180, Evalue=1e-46,
Organism=Escherichia coli, GI87082175, Length=445, Percent_Identity=27.8651685393258, Blast_Score=146, Evalue=3e-36,
Organism=Caenorhabditis elegans, GI193204318, Length=410, Percent_Identity=29.2682926829268, Blast_Score=150, Evalue=2e-36,
Organism=Caenorhabditis elegans, GI71989490, Length=435, Percent_Identity=24.5977011494253, Blast_Score=88, Evalue=8e-18,
Organism=Caenorhabditis elegans, GI17539558, Length=467, Percent_Identity=25.4817987152034, Blast_Score=87, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6322218, Length=436, Percent_Identity=26.605504587156, Blast_Score=130, Evalue=3e-31,
Organism=Drosophila melanogaster, GI24642586, Length=389, Percent_Identity=32.3907455012853, Blast_Score=152, Evalue=5e-37,
Organism=Drosophila melanogaster, GI18859883, Length=438, Percent_Identity=27.3972602739726, Blast_Score=100, Evalue=3e-21,
Organism=Drosophila melanogaster, GI17137462, Length=449, Percent_Identity=25.1670378619154, Blast_Score=87, Evalue=3e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006680
- InterPro:   IPR004722
- InterPro:   IPR002195
- InterPro:   IPR011059 [H]

Pfam domain/function: PF01979 Amidohydro_1 [H]

EC number: =3.5.2.3 [H]

Molecular weight: Translated: 47608; Mature: 47608

Theoretical pI: Translated: 4.76; Mature: 4.76

Prosite motif: PS00483 DIHYDROOROTASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNILIKEGRVLDPASKTDKVMDVLIKDGFIAAMEENIDESQADDVIDASGCMVMPGLIDL
CCEEECCCCEECCCCHHHHHHHHHHCCCCCEEHHHCCCHHHHCCCCCCCCCEEECCEEEC
NAHFREPGLEHKETIRTGSRAAARGGYTTVCMMPNTKPVIDNVEMLQYVTDKAEEVTDIN
CCCCCCCCCCHHHHHHCCCCHHCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHCCCE
LYTIAAMTAGQEGEYLTDFEALKDAGAVAVSDNGGTIMNARTARQAMRQAAEVDIPVFAH
EEEEEEEECCCCCCEEHHHHHHHCCCCEEEECCCCEEECHHHHHHHHHHHHHCCCCEEEE
CEDTNLAARGVMNAGERAKELGLFGIMDAVEDVIVARDILLAKNTGAKLHISHVSNKESA
CCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCEEEEEECCCCCCE
FIIKIAKEQGIPVTAEVAPHHFTLTEDAVNGDDANFKINPPLRKADDVKALKEALASGVI
EEEEEECCCCCEEEEECCCCEEEEECCCCCCCCCCEEECCCCCCCHHHHHHHHHHHCCCE
DVIATDHAPHHPTEKERPFDEAPFGVVGLETAVPVTITVLVRTGVLTPLQMVEKMSYNPA
EEEECCCCCCCCCCCCCCCCCCCCCEEEECCCCCEEEEEEEHHCCCCHHHHHHHCCCCCE
KILGIDRGVLAPGKVADITVVNPTEEYDIDSNRFASKGKNTPFEGKHVYGKVLYTLVNGR
EEEEECCCCCCCCCEEEEEEECCCHHCCCCCCHHHCCCCCCCCCCCHHHHHHHHHHHCCE
VVYSDHNGTEILIEREVPKL
EEEECCCCCEEEEECCCCCC
>Mature Secondary Structure
MNILIKEGRVLDPASKTDKVMDVLIKDGFIAAMEENIDESQADDVIDASGCMVMPGLIDL
CCEEECCCCEECCCCHHHHHHHHHHCCCCCEEHHHCCCHHHHCCCCCCCCCEEECCEEEC
NAHFREPGLEHKETIRTGSRAAARGGYTTVCMMPNTKPVIDNVEMLQYVTDKAEEVTDIN
CCCCCCCCCCHHHHHHCCCCHHCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHCCCE
LYTIAAMTAGQEGEYLTDFEALKDAGAVAVSDNGGTIMNARTARQAMRQAAEVDIPVFAH
EEEEEEEECCCCCCEEHHHHHHHCCCCEEEECCCCEEECHHHHHHHHHHHHHCCCCEEEE
CEDTNLAARGVMNAGERAKELGLFGIMDAVEDVIVARDILLAKNTGAKLHISHVSNKESA
CCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCEEEEEECCCCCCE
FIIKIAKEQGIPVTAEVAPHHFTLTEDAVNGDDANFKINPPLRKADDVKALKEALASGVI
EEEEEECCCCCEEEEECCCCEEEEECCCCCCCCCCEEECCCCCCCHHHHHHHHHHHCCCE
DVIATDHAPHHPTEKERPFDEAPFGVVGLETAVPVTITVLVRTGVLTPLQMVEKMSYNPA
EEEECCCCCCCCCCCCCCCCCCCCCEEEECCCCCEEEEEEEHHCCCCHHHHHHHCCCCCE
KILGIDRGVLAPGKVADITVVNPTEEYDIDSNRFASKGKNTPFEGKHVYGKVLYTLVNGR
EEEEECCCCCCCCCEEEEEEECCCHHCCCCCCHHHCCCCCCCCCCCHHHHHHHHHHHCCE
VVYSDHNGTEILIEREVPKL
EEEECCCCCEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA