The gene/protein map for NC_012778 is currently unavailable.
Definition Eubacterium eligens ATCC 27750 chromosome, complete genome.
Accession NC_012778
Length 2,144,190

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The map label for this gene is kduD [H]

Identifier: 238916471

GI number: 238916471

Start: 534079

End: 534843

Strand: Direct

Name: kduD [H]

Synonym: EUBELI_00528

Alternate gene names: 238916471

Gene position: 534079-534843 (Clockwise)

Preceding gene: 238916470

Following gene: 238916473

Centisome position: 24.91

GC content: 41.31

Gene sequence:

>765_bases
ATGTCTATAATTGATGCATTCAGACTTGATGGAAAGGTTGCAGTAGTCACAGGTGCCAATACAGGTCTTGGACAGGGAAT
GTCCGTTGCACTTGCGCAGGCAGGTGCTAAGGTTGTAGGTGTTGCAAGAAGATCTTGCGAGGATACTAAGAAGCTTGTTG
AAGCTGATGGAGGAGAATTTGCTGAGGTTATAGCAGATCTTTCAGATATGTCAGCTATAGATGTTATTGTGAACGGTGCA
CTCGCAGCTTTTGGAAAAGTTGATATTCTTGTTAATAATGCAGGACTTATTAAGCGAAATGATGCTATTGATTTCACGGA
AGATGAATGGGATAGTGTTATTCAGGTTAATCAGAAGATGGTATTCTTCTTAAGCCAGGCATTTGCAAAGCAGTATATTA
AGCAGGGACATGGTGGCAAGATTATTAATATCAATTCCATGCTTTCATATCAGGGAGGCATAAGAGTTCCTTCTTATACA
GCAAGTAAGAGTGCTGGTATGGGACTTACAAAAGCTATGTGTAATGAGTGGGCATGCCATAACATTAATGTTAATGCTAT
TGCACCAGGATATATGGCTACTAATAATACGGCACAATTAAGGAGTGATTCTGACAGAAGTGAAGCTATTATAGACAGAA
TTCCTGCAGGACGCTGGGGAACTCCTGATGATATGAAGGGAGCGGTTGTGTTCCTTGCATCAGCAGCATCTGATTATGTT
AATGGATTTACACTGGCTGTCGATGGCGGATGGCTCGCAAGATAA

Upstream 100 bases:

>100_bases
TATCCCTACATCTGCAGGAAGATGGATATCTAAGCAGGGATACAAGGTAGCTAATAATATAATAGGTTTTAATTAAACAG
ATTTAGAAGGAGAAGAATAT

Downstream 100 bases:

>100_bases
ACAGAATATTTAAGTGACAATAAAAATGCGTTTCAACTTTAACCGGTTGAAACGCATTTTGTGTATTACTGTTAAAAATT
AATTTTACAAATGTTTCTGT

Product: 2-deoxy-D-gluconate 3-dehydrogenase

Products: NA

Alternate protein names: 2-keto-3-deoxygluconate 5-dehydrogenase; 2-keto-3-deoxygluconate oxidoreductase; KDG oxidoreductase [H]

Number of amino acids: Translated: 254; Mature: 253

Protein sequence:

>254_residues
MSIIDAFRLDGKVAVVTGANTGLGQGMSVALAQAGAKVVGVARRSCEDTKKLVEADGGEFAEVIADLSDMSAIDVIVNGA
LAAFGKVDILVNNAGLIKRNDAIDFTEDEWDSVIQVNQKMVFFLSQAFAKQYIKQGHGGKIININSMLSYQGGIRVPSYT
ASKSAGMGLTKAMCNEWACHNINVNAIAPGYMATNNTAQLRSDSDRSEAIIDRIPAGRWGTPDDMKGAVVFLASAASDYV
NGFTLAVDGGWLAR

Sequences:

>Translated_254_residues
MSIIDAFRLDGKVAVVTGANTGLGQGMSVALAQAGAKVVGVARRSCEDTKKLVEADGGEFAEVIADLSDMSAIDVIVNGA
LAAFGKVDILVNNAGLIKRNDAIDFTEDEWDSVIQVNQKMVFFLSQAFAKQYIKQGHGGKIININSMLSYQGGIRVPSYT
ASKSAGMGLTKAMCNEWACHNINVNAIAPGYMATNNTAQLRSDSDRSEAIIDRIPAGRWGTPDDMKGAVVFLASAASDYV
NGFTLAVDGGWLAR
>Mature_253_residues
SIIDAFRLDGKVAVVTGANTGLGQGMSVALAQAGAKVVGVARRSCEDTKKLVEADGGEFAEVIADLSDMSAIDVIVNGAL
AAFGKVDILVNNAGLIKRNDAIDFTEDEWDSVIQVNQKMVFFLSQAFAKQYIKQGHGGKIININSMLSYQGGIRVPSYTA
SKSAGMGLTKAMCNEWACHNINVNAIAPGYMATNNTAQLRSDSDRSEAIIDRIPAGRWGTPDDMKGAVVFLASAASDYVN
GFTLAVDGGWLAR

Specific function: Catalyzes the reduction of 2,5-diketo-3-deoxygluconate (DKII or 4,6-dihydroxy-2,5-dioxohexanoate) into 2-keto-3- deoxygluconate (KDG or 2-dehydro-3-deoxygluconate) with a concomitant oxidation of NADH [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI15277342, Length=255, Percent_Identity=33.7254901960784, Blast_Score=134, Evalue=1e-31,
Organism=Homo sapiens, GI7705925, Length=245, Percent_Identity=33.8775510204082, Blast_Score=124, Evalue=6e-29,
Organism=Homo sapiens, GI19923817, Length=253, Percent_Identity=29.6442687747036, Blast_Score=120, Evalue=1e-27,
Organism=Homo sapiens, GI32483357, Length=250, Percent_Identity=32.4, Blast_Score=118, Evalue=5e-27,
Organism=Homo sapiens, GI126723750, Length=253, Percent_Identity=29.6442687747036, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI66933014, Length=249, Percent_Identity=30.5220883534137, Blast_Score=99, Evalue=4e-21,
Organism=Homo sapiens, GI40254992, Length=241, Percent_Identity=30.7053941908714, Blast_Score=96, Evalue=4e-20,
Organism=Homo sapiens, GI10190704, Length=253, Percent_Identity=28.4584980237154, Blast_Score=93, Evalue=2e-19,
Organism=Homo sapiens, GI4504505, Length=258, Percent_Identity=28.2945736434109, Blast_Score=92, Evalue=4e-19,
Organism=Homo sapiens, GI5031737, Length=245, Percent_Identity=29.3877551020408, Blast_Score=92, Evalue=4e-19,
Organism=Homo sapiens, GI20149619, Length=200, Percent_Identity=34, Blast_Score=80, Evalue=1e-15,
Organism=Homo sapiens, GI7706318, Length=202, Percent_Identity=30.6930693069307, Blast_Score=79, Evalue=4e-15,
Organism=Homo sapiens, GI4503301, Length=249, Percent_Identity=28.5140562248996, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI59889578, Length=202, Percent_Identity=28.2178217821782, Blast_Score=75, Evalue=4e-14,
Organism=Homo sapiens, GI33667109, Length=197, Percent_Identity=29.4416243654822, Blast_Score=75, Evalue=6e-14,
Organism=Homo sapiens, GI109715829, Length=250, Percent_Identity=29.2, Blast_Score=73, Evalue=2e-13,
Organism=Homo sapiens, GI31542939, Length=210, Percent_Identity=30.952380952381, Blast_Score=72, Evalue=7e-13,
Organism=Homo sapiens, GI40254986, Length=152, Percent_Identity=30.9210526315789, Blast_Score=70, Evalue=1e-12,
Organism=Homo sapiens, GI126723191, Length=183, Percent_Identity=29.5081967213115, Blast_Score=69, Evalue=4e-12,
Organism=Homo sapiens, GI142976729, Length=220, Percent_Identity=24.5454545454545, Blast_Score=69, Evalue=6e-12,
Organism=Escherichia coli, GI1789208, Length=252, Percent_Identity=64.2857142857143, Blast_Score=335, Evalue=2e-93,
Organism=Escherichia coli, GI87082160, Length=252, Percent_Identity=46.8253968253968, Blast_Score=213, Evalue=1e-56,
Organism=Escherichia coli, GI1790717, Length=251, Percent_Identity=40.6374501992032, Blast_Score=175, Evalue=3e-45,
Organism=Escherichia coli, GI1787335, Length=243, Percent_Identity=36.6255144032922, Blast_Score=151, Evalue=5e-38,
Organism=Escherichia coli, GI1788459, Length=245, Percent_Identity=35.5102040816327, Blast_Score=136, Evalue=1e-33,
Organism=Escherichia coli, GI87082100, Length=256, Percent_Identity=30.46875, Blast_Score=107, Evalue=8e-25,
Organism=Escherichia coli, GI1787905, Length=252, Percent_Identity=32.9365079365079, Blast_Score=106, Evalue=2e-24,
Organism=Escherichia coli, GI1789378, Length=248, Percent_Identity=29.0322580645161, Blast_Score=97, Evalue=1e-21,
Organism=Escherichia coli, GI1786812, Length=250, Percent_Identity=27.2, Blast_Score=89, Evalue=4e-19,
Organism=Escherichia coli, GI1789057, Length=256, Percent_Identity=28.125, Blast_Score=86, Evalue=3e-18,
Organism=Escherichia coli, GI2367175, Length=252, Percent_Identity=28.1746031746032, Blast_Score=76, Evalue=3e-15,
Organism=Escherichia coli, GI2367365, Length=247, Percent_Identity=26.3157894736842, Blast_Score=74, Evalue=9e-15,
Organism=Escherichia coli, GI1787820, Length=239, Percent_Identity=26.7782426778243, Blast_Score=69, Evalue=4e-13,
Organism=Escherichia coli, GI1787526, Length=229, Percent_Identity=25.764192139738, Blast_Score=61, Evalue=6e-11,
Organism=Caenorhabditis elegans, GI25147288, Length=246, Percent_Identity=34.1463414634146, Blast_Score=124, Evalue=4e-29,
Organism=Caenorhabditis elegans, GI17555706, Length=245, Percent_Identity=31.0204081632653, Blast_Score=122, Evalue=3e-28,
Organism=Caenorhabditis elegans, GI17561402, Length=258, Percent_Identity=32.5581395348837, Blast_Score=112, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI115534694, Length=241, Percent_Identity=31.5352697095436, Blast_Score=110, Evalue=6e-25,
Organism=Caenorhabditis elegans, GI17560676, Length=250, Percent_Identity=30.8, Blast_Score=109, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI17560150, Length=259, Percent_Identity=30.5019305019305, Blast_Score=106, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI17544670, Length=267, Percent_Identity=29.5880149812734, Blast_Score=106, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI17551412, Length=262, Percent_Identity=30.9160305343511, Blast_Score=103, Evalue=6e-23,
Organism=Caenorhabditis elegans, GI17562906, Length=261, Percent_Identity=29.8850574712644, Blast_Score=102, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI17562910, Length=261, Percent_Identity=29.5019157088123, Blast_Score=101, Evalue=3e-22,
Organism=Caenorhabditis elegans, GI17559104, Length=261, Percent_Identity=29.8850574712644, Blast_Score=100, Evalue=9e-22,
Organism=Caenorhabditis elegans, GI17560332, Length=262, Percent_Identity=29.7709923664122, Blast_Score=99, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI17562990, Length=260, Percent_Identity=30, Blast_Score=99, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI17538480, Length=263, Percent_Identity=30.7984790874525, Blast_Score=98, Evalue=4e-21,
Organism=Caenorhabditis elegans, GI17562908, Length=263, Percent_Identity=30.0380228136882, Blast_Score=97, Evalue=6e-21,
Organism=Caenorhabditis elegans, GI72000259, Length=262, Percent_Identity=29.7709923664122, Blast_Score=97, Evalue=9e-21,
Organism=Caenorhabditis elegans, GI17565030, Length=264, Percent_Identity=29.9242424242424, Blast_Score=97, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI17531453, Length=261, Percent_Identity=29.5019157088123, Blast_Score=95, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI71994600, Length=248, Percent_Identity=28.6290322580645, Blast_Score=95, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI17568967, Length=192, Percent_Identity=32.2916666666667, Blast_Score=95, Evalue=4e-20,
Organism=Caenorhabditis elegans, GI193204405, Length=266, Percent_Identity=31.5789473684211, Blast_Score=94, Evalue=5e-20,
Organism=Caenorhabditis elegans, GI71994604, Length=248, Percent_Identity=29.0322580645161, Blast_Score=94, Evalue=5e-20,
Organism=Caenorhabditis elegans, GI17563726, Length=260, Percent_Identity=27.6923076923077, Blast_Score=94, Evalue=6e-20,
Organism=Caenorhabditis elegans, GI17560220, Length=265, Percent_Identity=28.3018867924528, Blast_Score=92, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI17536025, Length=251, Percent_Identity=28.2868525896414, Blast_Score=91, Evalue=4e-19,
Organism=Caenorhabditis elegans, GI17538486, Length=262, Percent_Identity=28.6259541984733, Blast_Score=89, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI17536651, Length=251, Percent_Identity=27.4900398406374, Blast_Score=87, Evalue=7e-18,
Organism=Caenorhabditis elegans, GI17562904, Length=262, Percent_Identity=27.0992366412214, Blast_Score=86, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17561272, Length=254, Percent_Identity=27.9527559055118, Blast_Score=82, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI17564282, Length=191, Percent_Identity=26.7015706806283, Blast_Score=80, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17538182, Length=256, Percent_Identity=28.90625, Blast_Score=75, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI193203117, Length=192, Percent_Identity=26.5625, Blast_Score=74, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI193203115, Length=188, Percent_Identity=27.1276595744681, Blast_Score=73, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI71982365, Length=194, Percent_Identity=27.319587628866, Blast_Score=73, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17558628, Length=196, Percent_Identity=29.0816326530612, Blast_Score=66, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17508895, Length=196, Percent_Identity=27.0408163265306, Blast_Score=65, Evalue=4e-11,
Organism=Saccharomyces cerevisiae, GI6322861, Length=190, Percent_Identity=32.6315789473684, Blast_Score=79, Evalue=9e-16,
Organism=Saccharomyces cerevisiae, GI6324126, Length=255, Percent_Identity=27.0588235294118, Blast_Score=68, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24639444, Length=246, Percent_Identity=34.5528455284553, Blast_Score=130, Evalue=1e-30,
Organism=Drosophila melanogaster, GI23397609, Length=248, Percent_Identity=32.258064516129, Blast_Score=117, Evalue=6e-27,
Organism=Drosophila melanogaster, GI21355319, Length=258, Percent_Identity=31.7829457364341, Blast_Score=115, Evalue=3e-26,
Organism=Drosophila melanogaster, GI24643142, Length=243, Percent_Identity=33.3333333333333, Blast_Score=110, Evalue=1e-24,
Organism=Drosophila melanogaster, GI21357041, Length=252, Percent_Identity=31.3492063492063, Blast_Score=108, Evalue=3e-24,
Organism=Drosophila melanogaster, GI28571526, Length=249, Percent_Identity=28.9156626506024, Blast_Score=102, Evalue=3e-22,
Organism=Drosophila melanogaster, GI24644339, Length=251, Percent_Identity=27.4900398406374, Blast_Score=96, Evalue=2e-20,
Organism=Drosophila melanogaster, GI18859837, Length=194, Percent_Identity=34.5360824742268, Blast_Score=94, Evalue=7e-20,
Organism=Drosophila melanogaster, GI21358495, Length=227, Percent_Identity=31.2775330396476, Blast_Score=92, Evalue=3e-19,
Organism=Drosophila melanogaster, GI21357673, Length=199, Percent_Identity=28.1407035175879, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24641232, Length=219, Percent_Identity=27.8538812785388, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI116007236, Length=195, Percent_Identity=27.6923076923077, Blast_Score=71, Evalue=7e-13,
Organism=Drosophila melanogaster, GI24644337, Length=205, Percent_Identity=26.8292682926829, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI21355631, Length=205, Percent_Identity=27.3170731707317, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24584748, Length=202, Percent_Identity=29.7029702970297, Blast_Score=69, Evalue=4e-12,
Organism=Drosophila melanogaster, GI161076933, Length=202, Percent_Identity=29.7029702970297, Blast_Score=68, Evalue=5e-12,
Organism=Drosophila melanogaster, GI28571387, Length=258, Percent_Identity=24.8062015503876, Blast_Score=68, Evalue=5e-12,
Organism=Drosophila melanogaster, GI24640492, Length=227, Percent_Identity=24.2290748898678, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI17737361, Length=252, Percent_Identity=25.7936507936508, Blast_Score=66, Evalue=2e-11,
Organism=Drosophila melanogaster, GI116007238, Length=175, Percent_Identity=28, Blast_Score=66, Evalue=2e-11,
Organism=Drosophila melanogaster, GI22024069, Length=200, Percent_Identity=27, Blast_Score=64, Evalue=8e-11,
Organism=Drosophila melanogaster, GI19921754, Length=200, Percent_Identity=26.5, Blast_Score=64, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011286
- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: =1.1.1.127 [H]

Molecular weight: Translated: 26860; Mature: 26729

Theoretical pI: Translated: 5.06; Mature: 5.06

Prosite motif: PS00061 ADH_SHORT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure: 

>Translated Secondary Structure
MSIIDAFRLDGKVAVVTGANTGLGQGMSVALAQAGAKVVGVARRSCEDTKKLVEADGGEF
CCCCCCEECCCEEEEEECCCCCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCHH
AEVIADLSDMSAIDVIVNGALAAFGKVDILVNNAGLIKRNDAIDFTEDEWDSVIQVNQKM
HHHHHHHHCCHHHHHHHHHHHHHCCEEEEEECCCCEEEECCCCCCCHHHHHHHHHHHHHH
VFFLSQAFAKQYIKQGHGGKIININSMLSYQGGIRVPSYTASKSAGMGLTKAMCNEWACH
HHHHHHHHHHHHHHCCCCCEEEEECCEEECCCCCCCCCCCCCCCCCCCHHHHHHCCCCCC
NINVNAIAPGYMATNNTAQLRSDSDRSEAIIDRIPAGRWGTPDDMKGAVVFLASAASDYV
CCCCCEECCCEEECCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCEEEEEEEHHHHHH
NGFTLAVDGGWLAR
CCEEEEECCCCCCC
>Mature Secondary Structure 
SIIDAFRLDGKVAVVTGANTGLGQGMSVALAQAGAKVVGVARRSCEDTKKLVEADGGEF
CCCCCEECCCEEEEEECCCCCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCHH
AEVIADLSDMSAIDVIVNGALAAFGKVDILVNNAGLIKRNDAIDFTEDEWDSVIQVNQKM
HHHHHHHHCCHHHHHHHHHHHHHCCEEEEEECCCCEEEECCCCCCCHHHHHHHHHHHHHH
VFFLSQAFAKQYIKQGHGGKIININSMLSYQGGIRVPSYTASKSAGMGLTKAMCNEWACH
HHHHHHHHHHHHHHCCCCCEEEEECCEEECCCCCCCCCCCCCCCCCCCHHHHHHCCCCCC
NINVNAIAPGYMATNNTAQLRSDSDRSEAIIDRIPAGRWGTPDDMKGAVVFLASAASDYV
CCCCCEECCCEEECCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCEEEEEEEHHHHHH
NGFTLAVDGGWLAR
CCEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1766386 [H]