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The map label for this gene is ypnP [H]

Identifier: 238916411

GI number: 238916411

Start: 478189

End: 479526

Strand: Direct

Name: ypnP [H]

Synonym: EUBELI_00467

Alternate gene names: 238916411

Gene position: 478189-479526 (Clockwise)

Preceding gene: 238916410

Following gene: 238916412

Centisome position: 22.3

GC content: 39.61

Gene sequence:

>1338_bases
ATGAAATCAAATGAAATAGATATGACGACAGGTTCCCTGCCAAAGAAAATATTAATGTATTCAGTTCCGCTTATGTTGTC
AAATGTACTGCAGGTTATGTTCAACCTGTGTGATGTGGCGGTAGTTGGTAAATTTGTAGGACCACTGGCACTTGGTGCGG
TAGGTTCAACGAGTATAATTATTACATTGACAACCGGAATCCTGCTAGGACTAGCAGGTGGTGTCAATGCTGTAGTCGCG
CTGTTTGTGGGGGCTAAGAATAGTGCAAATGTAAAGAAAGCAGTCCACACTTCAATTGTAATATGTATGATTGCGGGACT
GCTGTTGCTTTTGTCTGGGCTGTTCCTTTCAAGACCGGTGCTGAATCTTATAGGAACTAAGAAAGAACTGATAGATGGTG
CAGTTATATATCTTACAATATATCTTCTTGGTTCACCGGCACTTGCAATGTATAACTATGGTAACGCCGTGTTAAGTGCA
GTTGGAGATACTAAAAGGCCACTTATGTATCTTATTACAGCAGGTATAATTAATGTGGTACTTAATCTGTTCTTTGTAAT
AGTATGCAGGCTTGGGGTTGTCGGTGTTGCACTGGCAAGTATAATATCACAGTATATATCAGCATTTCTGATACTTAAAT
TCCTGTTTGGCTGTGGCAAGGATTACGGACTTTATATAACAAATATAGGAATGGACTCGCATATAGCAGCGAGAGTTTTA
AGGATTGGCCTGCCGGCAGCAGTACAGTATTCACTTTTTGCAGTTGCCAATCTGTACATACAGTCGGCAGTTAATTCATT
TGACCATGTAGTTGTTGAGGGCAATTCGGCTGCGGCTAATGCTGATAACATTGTGTATGATATGATGGCGGCATTCTATA
CTGCATGTACAAGCTTTATAGCACAGAATCTTGGAGCAAGAAAGCGTGACAGAATTAAGAAAGCATATCTTGTTACACAG
ATGTATTCATTTATTATAGGAGCAGTGCTTGGTGCATTGCTTGTAGTTTTCAGGACACAGTTTCTTAGCATATTTACAAG
TGATCCGGATGTGATGCATTACGGCTCAATAAGACTTGGAATAATGGGATGCTCTTATTTTATATCCGCATTTATGGATA
ATGCGGCAGCAGGAGCAAGAGGACTTGGCAGAAGCGTTATACCTACAATAATAGTAATAATGGGTTCTGTTGTGTTCAGA
ATCGTGTGGGTGTGTACAATATTTGCAAGTATACATACGCTGATGTCACTCTATCTTGTGTATGCGAGTGCGTGGGCATT
TACATCTATTATAGGAACGGTGTATTTTATAATAATATTCAGAAAGACTTTGAGATAA

Upstream 100 bases:

>100_bases
CTTTCTGAATGGGTACACAGAAAGTCAATACAGAAGGCTGTAGAGAGTTACCGCATTACACCAGAGCAGAAGGATTATTT
AAAGGGTTTAAGATAAGGTT

Downstream 100 bases:

>100_bases
TCACATACATTTTACAAAAACTTTACGAACACGAGATTATGCATTTTACATAACATTGATAACATACCCTCTGCAAGCAG
ATGCAGAGGGTTTTCTTTTT

Product: MATE family multidrug resistance protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 445; Mature: 445

Protein sequence:

>445_residues
MKSNEIDMTTGSLPKKILMYSVPLMLSNVLQVMFNLCDVAVVGKFVGPLALGAVGSTSIIITLTTGILLGLAGGVNAVVA
LFVGAKNSANVKKAVHTSIVICMIAGLLLLLSGLFLSRPVLNLIGTKKELIDGAVIYLTIYLLGSPALAMYNYGNAVLSA
VGDTKRPLMYLITAGIINVVLNLFFVIVCRLGVVGVALASIISQYISAFLILKFLFGCGKDYGLYITNIGMDSHIAARVL
RIGLPAAVQYSLFAVANLYIQSAVNSFDHVVVEGNSAAANADNIVYDMMAAFYTACTSFIAQNLGARKRDRIKKAYLVTQ
MYSFIIGAVLGALLVVFRTQFLSIFTSDPDVMHYGSIRLGIMGCSYFISAFMDNAAAGARGLGRSVIPTIIVIMGSVVFR
IVWVCTIFASIHTLMSLYLVYASAWAFTSIIGTVYFIIIFRKTLR

Sequences:

>Translated_445_residues
MKSNEIDMTTGSLPKKILMYSVPLMLSNVLQVMFNLCDVAVVGKFVGPLALGAVGSTSIIITLTTGILLGLAGGVNAVVA
LFVGAKNSANVKKAVHTSIVICMIAGLLLLLSGLFLSRPVLNLIGTKKELIDGAVIYLTIYLLGSPALAMYNYGNAVLSA
VGDTKRPLMYLITAGIINVVLNLFFVIVCRLGVVGVALASIISQYISAFLILKFLFGCGKDYGLYITNIGMDSHIAARVL
RIGLPAAVQYSLFAVANLYIQSAVNSFDHVVVEGNSAAANADNIVYDMMAAFYTACTSFIAQNLGARKRDRIKKAYLVTQ
MYSFIIGAVLGALLVVFRTQFLSIFTSDPDVMHYGSIRLGIMGCSYFISAFMDNAAAGARGLGRSVIPTIIVIMGSVVFR
IVWVCTIFASIHTLMSLYLVYASAWAFTSIIGTVYFIIIFRKTLR
>Mature_445_residues
MKSNEIDMTTGSLPKKILMYSVPLMLSNVLQVMFNLCDVAVVGKFVGPLALGAVGSTSIIITLTTGILLGLAGGVNAVVA
LFVGAKNSANVKKAVHTSIVICMIAGLLLLLSGLFLSRPVLNLIGTKKELIDGAVIYLTIYLLGSPALAMYNYGNAVLSA
VGDTKRPLMYLITAGIINVVLNLFFVIVCRLGVVGVALASIISQYISAFLILKFLFGCGKDYGLYITNIGMDSHIAARVL
RIGLPAAVQYSLFAVANLYIQSAVNSFDHVVVEGNSAAANADNIVYDMMAAFYTACTSFIAQNLGARKRDRIKKAYLVTQ
MYSFIIGAVLGALLVVFRTQFLSIFTSDPDVMHYGSIRLGIMGCSYFISAFMDNAAAGARGLGRSVIPTIIVIMGSVVFR
IVWVCTIFASIHTLMSLYLVYASAWAFTSIIGTVYFIIIFRKTLR

Specific function: Unknown

COG id: COG0534

COG function: function code V; Na+-driven multidrug efflux pump

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family [H]

Homologues:

Organism=Escherichia coli, GI226510954, Length=353, Percent_Identity=23.2294617563739, Blast_Score=64, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002528
- InterPro:   IPR015522 [H]

Pfam domain/function: PF01554 MatE [H]

EC number: NA

Molecular weight: Translated: 47780; Mature: 47780

Theoretical pI: Translated: 9.74; Mature: 9.74

Prosite motif: PS00177 TOPOISOMERASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKSNEIDMTTGSLPKKILMYSVPLMLSNVLQVMFNLCDVAVVGKFVGPLALGAVGSTSII
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEE
ITLTTGILLGLAGGVNAVVALFVGAKNSANVKKAVHTSIVICMIAGLLLLLSGLFLSRPV
EHHHHHHHHHHCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LNLIGTKKELIDGAVIYLTIYLLGSPALAMYNYGNAVLSAVGDTKRPLMYLITAGIINVV
HHHHCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHH
LNLFFVIVCRLGVVGVALASIISQYISAFLILKFLFGCGKDYGLYITNIGMDSHIAARVL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCHHHHHHHH
RIGLPAAVQYSLFAVANLYIQSAVNSFDHVVVEGNSAAANADNIVYDMMAAFYTACTSFI
HHCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHH
AQNLGARKRDRIKKAYLVTQMYSFIIGAVLGALLVVFRTQFLSIFTSDPDVMHYGSIRLG
HHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCHHH
IMGCSYFISAFMDNAAAGARGLGRSVIPTIIVIMGSVVFRIVWVCTIFASIHTLMSLYLV
HHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YASAWAFTSIIGTVYFIIIFRKTLR
HHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKSNEIDMTTGSLPKKILMYSVPLMLSNVLQVMFNLCDVAVVGKFVGPLALGAVGSTSII
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEE
ITLTTGILLGLAGGVNAVVALFVGAKNSANVKKAVHTSIVICMIAGLLLLLSGLFLSRPV
EHHHHHHHHHHCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LNLIGTKKELIDGAVIYLTIYLLGSPALAMYNYGNAVLSAVGDTKRPLMYLITAGIINVV
HHHHCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHH
LNLFFVIVCRLGVVGVALASIISQYISAFLILKFLFGCGKDYGLYITNIGMDSHIAARVL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCHHHHHHHH
RIGLPAAVQYSLFAVANLYIQSAVNSFDHVVVEGNSAAANADNIVYDMMAAFYTACTSFI
HHCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHH
AQNLGARKRDRIKKAYLVTQMYSFIIGAVLGALLVVFRTQFLSIFTSDPDVMHYGSIRLG
HHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCHHH
IMGCSYFISAFMDNAAAGARGLGRSVIPTIIVIMGSVVFRIVWVCTIFASIHTLMSLYLV
HHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YASAWAFTSIIGTVYFIIIFRKTLR
HHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]