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The map label for this gene is aroA [H]

Identifier: 238916323

GI number: 238916323

Start: 384487

End: 385782

Strand: Direct

Name: aroA [H]

Synonym: EUBELI_00357

Alternate gene names: 238916323

Gene position: 384487-385782 (Clockwise)

Preceding gene: 238916322

Following gene: 238916324

Centisome position: 17.93

GC content: 40.82

Gene sequence:

>1296_bases
ATGTCACAGTACAAGGTTAAGAAGCTGGACCACCCGATTCACTGTACAGTTGAAGTGCCTGGTTCAAAGAGTATTACTAA
CAGAGCGCTGCTTATGGCAGCTTTATCACAGGGTGAATGTACCCTTAAAGGAGTTTTGTTCAGTGACGATTCGAGACATT
TTCTTTTAAGTCTTATCGCACTTGGATATATTATCGAAGTAAACGAAGTTGAACGATATGTTATCATTCATGGACATGGA
AGAGATATTCCAAAGAAGAGAGCAACAATCAATGTAGGAAGTGCCGGAACAGCGGCAAGATTCCTTACAGCCATGCTTGC
GTTATCAGATGGTGAGTACACAATTGAAGCTTCTGAACAGATGAAGAAAAGACCTATGCTTCCGCTTTTTGAAGCATTAC
AGAGTATGGGAGCAGAGATTGAGTTTCTAGAGAAAGACGGACATCTTCCGGTTAATGTAAAAGGTGCAGCGTATGGTGGG
AAGAAGCCACAGAATCATGTTTCAATAAGTATAAGTGAAAGCACACAATTCTTAAGCGCGCTTATGATGACATCTCCGAT
GCTTGAAGAAGGAATACATGTTCATATTACAAGTAATAAAACAGAAGGATCATATGTGCGTATAACAGCTAAGATGATGG
AACAGTTTGGATGTGTGGTAGACCATAAAGGGGCAGAATATGTAGTCCCTGCGGGTTCGGGTTACTATCCACAGACATAT
TATATTGAACCGGATGTTTCAGCAGCCTGCTATTTTTATGCAGCAGCAGCTCTTATAGGCGGAACAGCTATTGTCAAAGG
TGTACATTCAAATTCAATGCAGGGTGACCTTAAGTTCATAGATGTGCTTAAGCAGATGGGTTGTGCTGTGACAGAGGAAC
GCGAGGGTATATGCGTCAGCGGACCTAAGGATGGAGAATATTGCGGTGTGGATGTTGATATGAATGATTTCTCAGACCAG
TCAATGACACTTGCAGCTATTGCTCCATTTGCAAAGACTACTACAGTTATCAAGAATATTGAACATATACGATTACAGGA
GTCAGACAGAATTGAGGCTATGGTCAACGAGCTTAACAATCTTGGTGTTGATGTCAAAGAGGGAAGAGACCGTATAGAGA
TATCTCCAGCCAATGTTAAGCCAGGTGTAGTTGACACATATAATGACCATAGAATGGCAATGTCTTTCGCACTAATCGGC
CTGCGTGTTGATGGAATAATAATTGATAATTATGAATGCTGTTGTAAAACATTTGAGAACTATTTTGAAGTACTTGAAAA
GGCATGTGCACAATGA

Upstream 100 bases:

>100_bases
GCAGGAAAGATTATCCGTCCTGCATACAAATATGTTGGACATCACAGACCATATGTTGATATGGACGAGAGATAATTACG
TTTAATGGAGTAGTAAAATT

Downstream 100 bases:

>100_bases
GAATACTTTTATACAGATGGAAGGTGTTCAATCAGGATGATGTAAAGTCTGCGATTGAATATTTCGGACATGAAGTACAT
GATTACACAGAAACAGTAAT

Product: 3-phosphoshikimate 1-carboxyvinyltransferase

Products: NA

Alternate protein names: 5-enolpyruvylshikimate-3-phosphate synthase; EPSP synthase; EPSPS [H]

Number of amino acids: Translated: 431; Mature: 430

Protein sequence:

>431_residues
MSQYKVKKLDHPIHCTVEVPGSKSITNRALLMAALSQGECTLKGVLFSDDSRHFLLSLIALGYIIEVNEVERYVIIHGHG
RDIPKKRATINVGSAGTAARFLTAMLALSDGEYTIEASEQMKKRPMLPLFEALQSMGAEIEFLEKDGHLPVNVKGAAYGG
KKPQNHVSISISESTQFLSALMMTSPMLEEGIHVHITSNKTEGSYVRITAKMMEQFGCVVDHKGAEYVVPAGSGYYPQTY
YIEPDVSAACYFYAAAALIGGTAIVKGVHSNSMQGDLKFIDVLKQMGCAVTEEREGICVSGPKDGEYCGVDVDMNDFSDQ
SMTLAAIAPFAKTTTVIKNIEHIRLQESDRIEAMVNELNNLGVDVKEGRDRIEISPANVKPGVVDTYNDHRMAMSFALIG
LRVDGIIIDNYECCCKTFENYFEVLEKACAQ

Sequences:

>Translated_431_residues
MSQYKVKKLDHPIHCTVEVPGSKSITNRALLMAALSQGECTLKGVLFSDDSRHFLLSLIALGYIIEVNEVERYVIIHGHG
RDIPKKRATINVGSAGTAARFLTAMLALSDGEYTIEASEQMKKRPMLPLFEALQSMGAEIEFLEKDGHLPVNVKGAAYGG
KKPQNHVSISISESTQFLSALMMTSPMLEEGIHVHITSNKTEGSYVRITAKMMEQFGCVVDHKGAEYVVPAGSGYYPQTY
YIEPDVSAACYFYAAAALIGGTAIVKGVHSNSMQGDLKFIDVLKQMGCAVTEEREGICVSGPKDGEYCGVDVDMNDFSDQ
SMTLAAIAPFAKTTTVIKNIEHIRLQESDRIEAMVNELNNLGVDVKEGRDRIEISPANVKPGVVDTYNDHRMAMSFALIG
LRVDGIIIDNYECCCKTFENYFEVLEKACAQ
>Mature_430_residues
SQYKVKKLDHPIHCTVEVPGSKSITNRALLMAALSQGECTLKGVLFSDDSRHFLLSLIALGYIIEVNEVERYVIIHGHGR
DIPKKRATINVGSAGTAARFLTAMLALSDGEYTIEASEQMKKRPMLPLFEALQSMGAEIEFLEKDGHLPVNVKGAAYGGK
KPQNHVSISISESTQFLSALMMTSPMLEEGIHVHITSNKTEGSYVRITAKMMEQFGCVVDHKGAEYVVPAGSGYYPQTYY
IEPDVSAACYFYAAAALIGGTAIVKGVHSNSMQGDLKFIDVLKQMGCAVTEEREGICVSGPKDGEYCGVDVDMNDFSDQS
MTLAAIAPFAKTTTVIKNIEHIRLQESDRIEAMVNELNNLGVDVKEGRDRIEISPANVKPGVVDTYNDHRMAMSFALIGL
RVDGIIIDNYECCCKTFENYFEVLEKACAQ

Specific function: Aromatic amino acids biosynthesis; shikimate pathway; sixth step. [C]

COG id: COG0128

COG function: function code E; 5-enolpyruvylshikimate-3-phosphate synthase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the EPSP synthase family [H]

Homologues:

Organism=Escherichia coli, GI1787137, Length=419, Percent_Identity=39.618138424821, Blast_Score=276, Evalue=1e-75,
Organism=Saccharomyces cerevisiae, GI6320332, Length=448, Percent_Identity=35.0446428571429, Blast_Score=231, Evalue=2e-61,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001986
- InterPro:   IPR006264
- InterPro:   IPR023193
- InterPro:   IPR013792 [H]

Pfam domain/function: PF00275 EPSP_synthase [H]

EC number: =2.5.1.19 [H]

Molecular weight: Translated: 47266; Mature: 47135

Theoretical pI: Translated: 5.44; Mature: 5.44

Prosite motif: PS00290 IG_MHC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
6.7 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
6.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQYKVKKLDHPIHCTVEVPGSKSITNRALLMAALSQGECTLKGVLFSDDSRHFLLSLIA
CCCCCCHHCCCCEEEEEECCCCCCHHHHHHHHHHHCCCCEEEEEEEECCCCHHHHHHHHH
LGYIIEVNEVERYVIIHGHGRDIPKKRATINVGSAGTAARFLTAMLALSDGEYTIEASEQ
HHEEEEEECCEEEEEEECCCCCCCCCCCEEEECCCCHHHHHHHHHHHCCCCCEEEECHHH
MKKRPMLPLFEALQSMGAEIEFLEKDGHLPVNVKGAAYGGKKPQNHVSISISESTQFLSA
HHHCCCCHHHHHHHHCCCEEEEEECCCCCEEEEEECCCCCCCCCCCEEEEECHHHHHHHH
LMMTSPMLEEGIHVHITSNKTEGSYVRITAKMMEQFGCVVDHKGAEYVVPAGSGYYPQTY
HHHHCHHHHCCEEEEEECCCCCCCEEEEEHHHHHHCCCEEECCCCCEEEECCCCCCCEEE
YIEPDVSAACYFYAAAALIGGTAIVKGVHSNSMQGDLKFIDVLKQMGCAVTEEREGICVS
EECCCCCHHHHHHHHHHHHCCHHHEEECCCCCCCCCHHHHHHHHHHCCEECCCCCCEEEE
GPKDGEYCGVDVDMNDFSDQSMTLAAIAPFAKTTTVIKNIEHIRLQESDRIEAMVNELNN
CCCCCCEEEEECCCCCCCCCCEEEEECCCHHHHHHHHHCHHHEEECCCHHHHHHHHHHHH
LGVDVKEGRDRIEISPANVKPGVVDTYNDHRMAMSFALIGLRVDGIIIDNYECCCKTFEN
CCCCCCCCCCEEEEECCCCCCCEEECCCCCHHHEEEEEEEEEECCEEECCHHHHHHHHHH
YFEVLEKACAQ
HHHHHHHHHCC
>Mature Secondary Structure 
SQYKVKKLDHPIHCTVEVPGSKSITNRALLMAALSQGECTLKGVLFSDDSRHFLLSLIA
CCCCCHHCCCCEEEEEECCCCCCHHHHHHHHHHHCCCCEEEEEEEECCCCHHHHHHHHH
LGYIIEVNEVERYVIIHGHGRDIPKKRATINVGSAGTAARFLTAMLALSDGEYTIEASEQ
HHEEEEEECCEEEEEEECCCCCCCCCCCEEEECCCCHHHHHHHHHHHCCCCCEEEECHHH
MKKRPMLPLFEALQSMGAEIEFLEKDGHLPVNVKGAAYGGKKPQNHVSISISESTQFLSA
HHHCCCCHHHHHHHHCCCEEEEEECCCCCEEEEEECCCCCCCCCCCEEEEECHHHHHHHH
LMMTSPMLEEGIHVHITSNKTEGSYVRITAKMMEQFGCVVDHKGAEYVVPAGSGYYPQTY
HHHHCHHHHCCEEEEEECCCCCCCEEEEEHHHHHHCCCEEECCCCCEEEECCCCCCCEEE
YIEPDVSAACYFYAAAALIGGTAIVKGVHSNSMQGDLKFIDVLKQMGCAVTEEREGICVS
EECCCCCHHHHHHHHHHHHCCHHHEEECCCCCCCCCHHHHHHHHHHCCEECCCCCCEEEE
GPKDGEYCGVDVDMNDFSDQSMTLAAIAPFAKTTTVIKNIEHIRLQESDRIEAMVNELNN
CCCCCCEEEEECCCCCCCCCCEEEEECCCHHHHHHHHHCHHHEEECCCHHHHHHHHHHHH
LGVDVKEGRDRIEISPANVKPGVVDTYNDHRMAMSFALIGLRVDGIIIDNYECCCKTFEN
CCCCCCCCCCEEEEECCCCCCCEEECCCCCHHHEEEEEEEEEECCEEECCHHHHHHHHHH
YFEVLEKACAQ
HHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA