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The map label for this gene is gltA [H]

Identifier: 238916322

GI number: 238916322

Start: 383058

End: 384461

Strand: Direct

Name: gltA [H]

Synonym: EUBELI_00356

Alternate gene names: 238916322

Gene position: 383058-384461 (Clockwise)

Preceding gene: 238916321

Following gene: 238916323

Centisome position: 17.86

GC content: 37.61

Gene sequence:

>1404_bases
ATGCGGGAAATAATCAGGAGGAGGAAAGCCATGAACAATCAGGAAATGATGGAACTTTCAACAGTAGATAAGAGCGATTT
TGAGGAACTTGTAAAAGAATGTACAGCCTCAGGTATAATCGATCAGAATCTGTATACAGAGTATGATGTAAAGAGAGGTC
TTCGTGACAGCAATGGTAACGGCGTACTTACAGGTCTCACAGAGATATCAGATGTATTAGGTAACCAGAGTGTTCACGGA
AGAAAGATACCTGTAGATGGAGAATTATATTTTCAGGGATATAATGTTGAGGAGCTTATCAAGAGAAGCAGCCTTGATAG
ATTCAGATTTGAAGAAGCGACATATCTTCTGTTATTCGGAGTACTTCCAGACAAGGATCAGTTAGACAGATTTATAAGAA
TCTTAACAGACCTTCAGGAACTTTCAGGGGCATTCATCAGAGATGTTATTATGAAAGCTACAAGTACTAATCTTATGAAT
TCGCTTATGAAGAGTATCTTAAGTCTTTATTCATATGATGAGAAACCGGATGATATTTCAATTCCTAATGTATTAAGACA
GAGTCTTCAGCTTATAGCCAAGATGCCTCTTCTTTCAGTATATGCTTATCAGTCATACAGACATTTTAAGCTTGATGGAA
CACTTATGATAAAGAATCCTAAGAAGGGTTATTCAACAGCCGAGAATATCCTCTATATGTTAAGAGATGACGGAGACTTT
ACAGAACTTGAAGCAAAGGTACTTGATATTTGTCTTGTTCTTCATGCAGAGCATGGTGGTGGTAATAACTCAACATTTAC
AACTCATGTTGTTACTTCATCAGGAACAGATACATATTCAGCAATTGCTTCATCAATCGCATCCCTTAAAGGACCTAAGC
ATGGTGGTGCTAACTTAAAGGTTCAGGAAATGTTTACAGATATTAAGGCACATTGCAGCGATTGGGACAATAAAGATGAG
ATATGTACATATCTTAACAAGATCCTTGACAAAGAAGCATTTGACCATGCAGGACTTATCTATGGTATGGGTCATGCGGT
ATATACTAACTCAGATCCTAGAGCAGTTATTCTTAAGAAATTTGCGAAACAGCTTTCAGAAGAGAAGGGAATGCAGAAAG
AATTTGCATTATATGAGCTTGTTGAAAGCGAGGCAGGACAGCTTATCATGAACAAGAGAAAGATGTTTAAGCCAGTCTGT
GCCAATGTCGATTTCTATAGTGGATTTGTATACACAATGCTTGGTATTCCAGAAGAAATGTTTACACCAATGTTTGCAAC
TTCTAGAATTTCAGGCTGGTGTGCACACAGACTTGAGGAACTTGTTAATGCAGGAAAGATTATCCGTCCTGCATACAAAT
ATGTTGGACATCACAGACCATATGTTGATATGGACGAGAGATAA

Upstream 100 bases:

>100_bases
TGATGCTGTAATCGGGATGAGAAATGAGACAGAAAACAGCCAGCAGTAAATTGACAAACACTATTAGTAGCAGATATAAT
ATCTTCATCTGCGTTTAGCT

Downstream 100 bases:

>100_bases
TTACGTTTAATGGAGTAGTAAAATTATGTCACAGTACAAGGTTAAGAAGCTGGACCACCCGATTCACTGTACAGTTGAAG
TGCCTGGTTCAAAGAGTATT

Product: citrate synthase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 467; Mature: 467

Protein sequence:

>467_residues
MREIIRRRKAMNNQEMMELSTVDKSDFEELVKECTASGIIDQNLYTEYDVKRGLRDSNGNGVLTGLTEISDVLGNQSVHG
RKIPVDGELYFQGYNVEELIKRSSLDRFRFEEATYLLLFGVLPDKDQLDRFIRILTDLQELSGAFIRDVIMKATSTNLMN
SLMKSILSLYSYDEKPDDISIPNVLRQSLQLIAKMPLLSVYAYQSYRHFKLDGTLMIKNPKKGYSTAENILYMLRDDGDF
TELEAKVLDICLVLHAEHGGGNNSTFTTHVVTSSGTDTYSAIASSIASLKGPKHGGANLKVQEMFTDIKAHCSDWDNKDE
ICTYLNKILDKEAFDHAGLIYGMGHAVYTNSDPRAVILKKFAKQLSEEKGMQKEFALYELVESEAGQLIMNKRKMFKPVC
ANVDFYSGFVYTMLGIPEEMFTPMFATSRISGWCAHRLEELVNAGKIIRPAYKYVGHHRPYVDMDER

Sequences:

>Translated_467_residues
MREIIRRRKAMNNQEMMELSTVDKSDFEELVKECTASGIIDQNLYTEYDVKRGLRDSNGNGVLTGLTEISDVLGNQSVHG
RKIPVDGELYFQGYNVEELIKRSSLDRFRFEEATYLLLFGVLPDKDQLDRFIRILTDLQELSGAFIRDVIMKATSTNLMN
SLMKSILSLYSYDEKPDDISIPNVLRQSLQLIAKMPLLSVYAYQSYRHFKLDGTLMIKNPKKGYSTAENILYMLRDDGDF
TELEAKVLDICLVLHAEHGGGNNSTFTTHVVTSSGTDTYSAIASSIASLKGPKHGGANLKVQEMFTDIKAHCSDWDNKDE
ICTYLNKILDKEAFDHAGLIYGMGHAVYTNSDPRAVILKKFAKQLSEEKGMQKEFALYELVESEAGQLIMNKRKMFKPVC
ANVDFYSGFVYTMLGIPEEMFTPMFATSRISGWCAHRLEELVNAGKIIRPAYKYVGHHRPYVDMDER
>Mature_467_residues
MREIIRRRKAMNNQEMMELSTVDKSDFEELVKECTASGIIDQNLYTEYDVKRGLRDSNGNGVLTGLTEISDVLGNQSVHG
RKIPVDGELYFQGYNVEELIKRSSLDRFRFEEATYLLLFGVLPDKDQLDRFIRILTDLQELSGAFIRDVIMKATSTNLMN
SLMKSILSLYSYDEKPDDISIPNVLRQSLQLIAKMPLLSVYAYQSYRHFKLDGTLMIKNPKKGYSTAENILYMLRDDGDF
TELEAKVLDICLVLHAEHGGGNNSTFTTHVVTSSGTDTYSAIASSIASLKGPKHGGANLKVQEMFTDIKAHCSDWDNKDE
ICTYLNKILDKEAFDHAGLIYGMGHAVYTNSDPRAVILKKFAKQLSEEKGMQKEFALYELVESEAGQLIMNKRKMFKPVC
ANVDFYSGFVYTMLGIPEEMFTPMFATSRISGWCAHRLEELVNAGKIIRPAYKYVGHHRPYVDMDER

Specific function: Catalyzes The Synthesis Of 2-Methylcitrate From Propionyl-CoA And Oxaloacetate. Also Catalyzes The Condensation Of Oxaloacetate With Acetyl-CoA But With A Lower Specificity. [C]

COG id: COG0372

COG function: function code C; Citrate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the citrate synthase family [H]

Homologues:

Organism=Homo sapiens, GI38327625, Length=366, Percent_Identity=26.2295081967213, Blast_Score=86, Evalue=1e-16,
Organism=Escherichia coli, GI1786527, Length=388, Percent_Identity=31.1855670103093, Blast_Score=176, Evalue=3e-45,
Organism=Escherichia coli, GI1786939, Length=389, Percent_Identity=28.5347043701799, Blast_Score=136, Evalue=2e-33,
Organism=Caenorhabditis elegans, GI17555174, Length=270, Percent_Identity=29.2592592592593, Blast_Score=89, Evalue=4e-18,
Organism=Saccharomyces cerevisiae, GI6319850, Length=415, Percent_Identity=28.433734939759, Blast_Score=110, Evalue=5e-25,
Organism=Saccharomyces cerevisiae, GI6324328, Length=268, Percent_Identity=29.4776119402985, Blast_Score=94, Evalue=4e-20,
Organism=Saccharomyces cerevisiae, GI6325257, Length=449, Percent_Identity=26.7260579064588, Blast_Score=94, Evalue=5e-20,
Organism=Drosophila melanogaster, GI24640124, Length=349, Percent_Identity=27.2206303724928, Blast_Score=100, Evalue=2e-21,
Organism=Drosophila melanogaster, GI24640126, Length=349, Percent_Identity=27.2206303724928, Blast_Score=100, Evalue=3e-21,
Organism=Drosophila melanogaster, GI21356863, Length=214, Percent_Identity=28.5046728971963, Blast_Score=79, Evalue=9e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011278
- InterPro:   IPR016142
- InterPro:   IPR016143
- InterPro:   IPR002020
- InterPro:   IPR016141
- InterPro:   IPR019810 [H]

Pfam domain/function: PF00285 Citrate_synt [H]

EC number: =2.3.3.1 [H]

Molecular weight: Translated: 53016; Mature: 53016

Theoretical pI: Translated: 6.11; Mature: 6.11

Prosite motif: PS00228 TUBULIN_B_AUTOREG

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MREIIRRRKAMNNQEMMELSTVDKSDFEELVKECTASGIIDQNLYTEYDVKRGLRDSNGN
CHHHHHHHHHCCCHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCCCCC
GVLTGLTEISDVLGNQSVHGRKIPVDGELYFQGYNVEELIKRSSLDRFRFEEATYLLLFG
EEEEHHHHHHHHHCCCCCCCCCCCCCCEEEEECCCHHHHHHHHCCHHHHHHHHEEEEEEE
VLPDKDQLDRFIRILTDLQELSGAFIRDVIMKATSTNLMNSLMKSILSLYSYDEKPDDIS
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
IPNVLRQSLQLIAKMPLLSVYAYQSYRHFKLDGTLMIKNPKKGYSTAENILYMLRDDGDF
HHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCEEEEECCCCCCCHHHHHEEEEECCCCH
TELEAKVLDICLVLHAEHGGGNNSTFTTHVVTSSGTDTYSAIASSIASLKGPKHGGANLK
HHHHHHHHHHHHHEEECCCCCCCCEEEEEEEECCCCHHHHHHHHHHHHHCCCCCCCCCCC
VQEMFTDIKAHCSDWDNKDEICTYLNKILDKEAFDHAGLIYGMGHAVYTNSDPRAVILKK
HHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCHHEECCCEEEECCCCHHHHHHH
FAKQLSEEKGMQKEFALYELVESEAGQLIMNKRKMFKPVCANVDFYSGFVYTMLGIPEEM
HHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCHHH
FTPMFATSRISGWCAHRLEELVNAGKIIRPAYKYVGHHRPYVDMDER
HCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure
MREIIRRRKAMNNQEMMELSTVDKSDFEELVKECTASGIIDQNLYTEYDVKRGLRDSNGN
CHHHHHHHHHCCCHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCCCCC
GVLTGLTEISDVLGNQSVHGRKIPVDGELYFQGYNVEELIKRSSLDRFRFEEATYLLLFG
EEEEHHHHHHHHHCCCCCCCCCCCCCCEEEEECCCHHHHHHHHCCHHHHHHHHEEEEEEE
VLPDKDQLDRFIRILTDLQELSGAFIRDVIMKATSTNLMNSLMKSILSLYSYDEKPDDIS
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
IPNVLRQSLQLIAKMPLLSVYAYQSYRHFKLDGTLMIKNPKKGYSTAENILYMLRDDGDF
HHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCEEEEECCCCCCCHHHHHEEEEECCCCH
TELEAKVLDICLVLHAEHGGGNNSTFTTHVVTSSGTDTYSAIASSIASLKGPKHGGANLK
HHHHHHHHHHHHHEEECCCCCCCCEEEEEEEECCCCHHHHHHHHHHHHHCCCCCCCCCCC
VQEMFTDIKAHCSDWDNKDEICTYLNKILDKEAFDHAGLIYGMGHAVYTNSDPRAVILKK
HHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCHHEECCCEEEECCCCHHHHHHH
FAKQLSEEKGMQKEFALYELVESEAGQLIMNKRKMFKPVCANVDFYSGFVYTMLGIPEEM
HHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCHHH
FTPMFATSRISGWCAHRLEELVNAGKIIRPAYKYVGHHRPYVDMDER
HCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8590279; 8905231 [H]