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The map label for this gene is norM [H]

Identifier: 238916136

GI number: 238916136

Start: 198046

End: 199422

Strand: Direct

Name: norM [H]

Synonym: EUBELI_00170

Alternate gene names: 238916136

Gene position: 198046-199422 (Clockwise)

Preceding gene: 238916135

Following gene: 238916138

Centisome position: 9.24

GC content: 43.14

Gene sequence:

>1377_bases
ATGAAGGAAGATACACTTTCCTATATAAGAAATAATAAAGAGATTACATTTGAACAGAAGATAAGACTTGTAATTATGCT
GAGTCTGCCTACGATTCTGGCACAGGTGTCATCAATTATAATGCAGTATATTGATGCGTCTATGGTTGGAAGACTGGGGG
CAGGCTGTTCGGCTTCAATAGGTCTTGTATCGACAACGACATGGCTGCTTGGAAGCCTTGCTTCTGCACCATCACTTGGA
TTTTCAATTCAGGTGGCACAGCTTGTCGGGGCAAAGAAGTTTAACAGGGCAAGAAGAGTGTTCTTACAGTCATTTGGAAT
TGTTCTTCTTATATCAATTATTATTGGTGCTGCCGGAGCCATGATAAGCTGGGGACTTCCAGCATGGCTTGGTGGAGAAG
AGTCGATACAGAAGGATGCGGCAATGTATTTTCTTATAACATCATTGTCTATGCCGGCATTAGGATTTAACCGTCTTGGT
ACGAGAATGCTGCAGAGCTGCGGTAATACGAGGACGCCGGGAATTCTTAATTCTATGAATTGTTTACTTGATGTTATATT
CAATTTTATATTCATATTCAGATGGCGTGGTTTTGGCTTCGGTCTTGGAGTTATGGGTGCAGCACTCGGAACAACAGCGG
CAGAGATTGTCACTACAATTATTATGTTTTATGTTCTGATGTTCAGAACACCTATGCTATCAAAAGGTTACGGAACAGAT
TCTGATGAGAAGGCAGGTCTTGCGACAATAAAGAAGTCATTTGTTTTATCGCTTCCTGTTACATTTGAAAATGTAGTTAT
GTTCGGGGCGATGATTACAATTACAAGAATTGTTGCACCATTAGGAGTTGTGGCTGTGGCTGCCAACTCATTTGCAATAA
CTGCAGAAAGCCTGTGCTATATGCCTGCTTATGGAATTGAGGAGGCTGCAACAGCACTTGTTGGACAGAGTATCGGTGCA
GGCAGAGGAAAGCTTGCGTTGTCTTTTGGAAGAATTTCAGTTGCCTTCGGAATGGGAATAATGGCATTCACCGGACTTCT
GATGTTTATATTTGCACCATTTATGATTGGAATTCTTACACCTGATCCGGCAGTAAGAGAGCTTGGTGTAACTATACTTA
GAATTGAAGCATTTGCAGAGCCACTGTATGGCGCATCAATTGTAGTAACTGGTGTGCTTCGTGGGGCAGGAGATACTCTT
GTTTCAAGCCTTATGAATTTCTTCAGCCTGTGGGCTATTCGTGTCGTCCTTTCATTCCTGCTTGTCGGCAGATATGGACT
TGTTGGTGTGTGGATTGCGATGGCTGCAGAGCTTTGCTTCAGGGGCGCAATATTCCTTGTGCGCATGGAGCGGAAGAAGT
GGCTGAAGAAGGTGTGA

Upstream 100 bases:

>100_bases
GCATGCTGGCTTTGCAGATGAGATTGGAAGAGATAATTTCTGTGCCAACATTGATGCAGCTCTTGAGCATGCTAAAAATA
TTGTAGAAGGGTAATGCTAA

Downstream 100 bases:

>100_bases
AAATAGAGTTGTTATTACTTGCATAAATAAAATATGCATGATATAATTCAATTGAAAAAGGTGCTGCCGTGAAGCAAGAC
GGCTGCTCTGAAATAATGGT

Product: MATE family multidrug resistance protein

Products: NA

Alternate protein names: Multidrug-efflux transporter [H]

Number of amino acids: Translated: 458; Mature: 458

Protein sequence:

>458_residues
MKEDTLSYIRNNKEITFEQKIRLVIMLSLPTILAQVSSIIMQYIDASMVGRLGAGCSASIGLVSTTTWLLGSLASAPSLG
FSIQVAQLVGAKKFNRARRVFLQSFGIVLLISIIIGAAGAMISWGLPAWLGGEESIQKDAAMYFLITSLSMPALGFNRLG
TRMLQSCGNTRTPGILNSMNCLLDVIFNFIFIFRWRGFGFGLGVMGAALGTTAAEIVTTIIMFYVLMFRTPMLSKGYGTD
SDEKAGLATIKKSFVLSLPVTFENVVMFGAMITITRIVAPLGVVAVAANSFAITAESLCYMPAYGIEEAATALVGQSIGA
GRGKLALSFGRISVAFGMGIMAFTGLLMFIFAPFMIGILTPDPAVRELGVTILRIEAFAEPLYGASIVVTGVLRGAGDTL
VSSLMNFFSLWAIRVVLSFLLVGRYGLVGVWIAMAAELCFRGAIFLVRMERKKWLKKV

Sequences:

>Translated_458_residues
MKEDTLSYIRNNKEITFEQKIRLVIMLSLPTILAQVSSIIMQYIDASMVGRLGAGCSASIGLVSTTTWLLGSLASAPSLG
FSIQVAQLVGAKKFNRARRVFLQSFGIVLLISIIIGAAGAMISWGLPAWLGGEESIQKDAAMYFLITSLSMPALGFNRLG
TRMLQSCGNTRTPGILNSMNCLLDVIFNFIFIFRWRGFGFGLGVMGAALGTTAAEIVTTIIMFYVLMFRTPMLSKGYGTD
SDEKAGLATIKKSFVLSLPVTFENVVMFGAMITITRIVAPLGVVAVAANSFAITAESLCYMPAYGIEEAATALVGQSIGA
GRGKLALSFGRISVAFGMGIMAFTGLLMFIFAPFMIGILTPDPAVRELGVTILRIEAFAEPLYGASIVVTGVLRGAGDTL
VSSLMNFFSLWAIRVVLSFLLVGRYGLVGVWIAMAAELCFRGAIFLVRMERKKWLKKV
>Mature_458_residues
MKEDTLSYIRNNKEITFEQKIRLVIMLSLPTILAQVSSIIMQYIDASMVGRLGAGCSASIGLVSTTTWLLGSLASAPSLG
FSIQVAQLVGAKKFNRARRVFLQSFGIVLLISIIIGAAGAMISWGLPAWLGGEESIQKDAAMYFLITSLSMPALGFNRLG
TRMLQSCGNTRTPGILNSMNCLLDVIFNFIFIFRWRGFGFGLGVMGAALGTTAAEIVTTIIMFYVLMFRTPMLSKGYGTD
SDEKAGLATIKKSFVLSLPVTFENVVMFGAMITITRIVAPLGVVAVAANSFAITAESLCYMPAYGIEEAATALVGQSIGA
GRGKLALSFGRISVAFGMGIMAFTGLLMFIFAPFMIGILTPDPAVRELGVTILRIEAFAEPLYGASIVVTGVLRGAGDTL
VSSLMNFFSLWAIRVVLSFLLVGRYGLVGVWIAMAAELCFRGAIFLVRMERKKWLKKV

Specific function: Multidrug efflux pump [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family [H]

Homologues:

Organism=Escherichia coli, GI226510954, Length=462, Percent_Identity=25.3246753246753, Blast_Score=130, Evalue=3e-31,
Organism=Escherichia coli, GI48994890, Length=452, Percent_Identity=23.2300884955752, Blast_Score=75, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002528 [H]

Pfam domain/function: PF01554 MatE [H]

EC number: NA

Molecular weight: Translated: 49289; Mature: 49289

Theoretical pI: Translated: 10.20; Mature: 10.20

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
5.0 %Met     (Translated Protein)
6.1 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
5.0 %Met     (Mature Protein)
6.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHHHHHHHHHHHHCCHHHEEEEHHHHHHHCC
>Mature Secondary Structure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HHHHHHHHHHHHHHHHHHHHCCHHHEEEEHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10360571 [H]