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The map label for this gene is rmlA1 [H]

Identifier: 238916054

GI number: 238916054

Start: 93944

End: 94843

Strand: Reverse

Name: rmlA1 [H]

Synonym: EUBELI_00087

Alternate gene names: 238916054

Gene position: 94843-93944 (Counterclockwise)

Preceding gene: 238916110

Following gene: 238916053

Centisome position: 4.42

GC content: 40.33

Gene sequence:

>900_bases
ATGAAGGGTATTATTTTAGCTGGTGGTTCTGGCACACGCCTTTACCCACTCACAATGGTAACTAGTAAACAGCTTCTTCC
AATCTATGATAAGCCAATGATTTATTATCCACTCTCAGTTCTTATGAGTGCTGGTATCAGAGATATTCTTATCATCTCTA
CACCACAGGATACTCCTAGATTCAAAGAGCTTTTAAAGGACGGAAGCCAGTTCGGTGTCAACCTTACTTACGCTGTACAG
CCAAGCCCGGACGGACTTGCACAGGCATTTATTATCGGTGAGGAATTCATCGGTGATGACACTGTTGCCATGGTTCTTGG
TGATAATATATTTGCAGGTCACGGTCTTAAGAAGAGACTTAAGGCAGCTGTTGAGAATGCTGAATCAGGAAAGGGTGCAA
CAGTATTTGGTTACTATGTTGATGATCCTGAAAGATTTGGTATTGTTGAATTTAATAATGAAGGAAAGGCCGTATCTATC
GAGGAAAAGCCAGCACAGCCTAAGAGCAACTACTGTGTAACAGGTCTTTACTTCTATGACAACAAGGTTGTTGAATACGC
TAAGAACTTAAAGCCATCTGCAAGAGGCGAGCTTGAGATTACTGATCTTAACCGTATCTACTTAGATAAGGGTACTTTAA
ATGTAGAGCTTCTCGGTCAGGGATTTACATGGCTTGATACAGGAACACATGAAAGTCTTGTAGAAGCTACTAACTTTGTT
AAGACTGTTGAGACTCATCAGCACAGAAAGATTGCATGTCTTGAAGAAATCGCTTACTTAAACGGCTGGATTAACAAAGA
TGACGTCCTCAAGGTATATGAAGTATTAAAGAAGAACCAGTATGGTCAGTACTTAAAGGATGTCTTAGACGGCAAATATG
TCGACAAGCTTCATGAATAA

Upstream 100 bases:

>100_bases
TGAAGGTGACGCTGCGTCACCTTTTATTATATACATGACTTAAAAAATGTCTACTTGAAAATTAACATAACATTTTAACA
AACAAGGAGGAACTTCAATT

Downstream 100 bases:

>100_bases
TTAAGTACATTTAGTTAAAACATTTTTCATATAAGAACACATTTTAAATATTAAGGAGATTAATTATGACAATTATTGTT
ACCGGTGGAGCCGGATTTAT

Product: glucose-1-phosphate thymidylyltransferase

Products: NA

Alternate protein names: G1P-TT 1; dTDP-glucose pyrophosphorylase 1; dTDP-glucose synthase 1 [H]

Number of amino acids: Translated: 299; Mature: 299

Protein sequence:

>299_residues
MKGIILAGGSGTRLYPLTMVTSKQLLPIYDKPMIYYPLSVLMSAGIRDILIISTPQDTPRFKELLKDGSQFGVNLTYAVQ
PSPDGLAQAFIIGEEFIGDDTVAMVLGDNIFAGHGLKKRLKAAVENAESGKGATVFGYYVDDPERFGIVEFNNEGKAVSI
EEKPAQPKSNYCVTGLYFYDNKVVEYAKNLKPSARGELEITDLNRIYLDKGTLNVELLGQGFTWLDTGTHESLVEATNFV
KTVETHQHRKIACLEEIAYLNGWINKDDVLKVYEVLKKNQYGQYLKDVLDGKYVDKLHE

Sequences:

>Translated_299_residues
MKGIILAGGSGTRLYPLTMVTSKQLLPIYDKPMIYYPLSVLMSAGIRDILIISTPQDTPRFKELLKDGSQFGVNLTYAVQ
PSPDGLAQAFIIGEEFIGDDTVAMVLGDNIFAGHGLKKRLKAAVENAESGKGATVFGYYVDDPERFGIVEFNNEGKAVSI
EEKPAQPKSNYCVTGLYFYDNKVVEYAKNLKPSARGELEITDLNRIYLDKGTLNVELLGQGFTWLDTGTHESLVEATNFV
KTVETHQHRKIACLEEIAYLNGWINKDDVLKVYEVLKKNQYGQYLKDVLDGKYVDKLHE
>Mature_299_residues
MKGIILAGGSGTRLYPLTMVTSKQLLPIYDKPMIYYPLSVLMSAGIRDILIISTPQDTPRFKELLKDGSQFGVNLTYAVQ
PSPDGLAQAFIIGEEFIGDDTVAMVLGDNIFAGHGLKKRLKAAVENAESGKGATVFGYYVDDPERFGIVEFNNEGKAVSI
EEKPAQPKSNYCVTGLYFYDNKVVEYAKNLKPSARGELEITDLNRIYLDKGTLNVELLGQGFTWLDTGTHESLVEATNFV
KTVETHQHRKIACLEEIAYLNGWINKDDVLKVYEVLKKNQYGQYLKDVLDGKYVDKLHE

Specific function: Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis [H]

COG id: COG1209

COG function: function code M; dTDP-glucose pyrophosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucose-1-phosphate thymidylyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI11761621, Length=260, Percent_Identity=22.6923076923077, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI11761619, Length=260, Percent_Identity=22.6923076923077, Blast_Score=67, Evalue=2e-11,
Organism=Escherichia coli, GI1788351, Length=284, Percent_Identity=71.1267605633803, Blast_Score=417, Evalue=1e-118,
Organism=Escherichia coli, GI1790224, Length=292, Percent_Identity=64.7260273972603, Blast_Score=391, Evalue=1e-110,
Organism=Escherichia coli, GI1787488, Length=245, Percent_Identity=24.4897959183673, Blast_Score=63, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI133931050, Length=195, Percent_Identity=26.6666666666667, Blast_Score=83, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6320148, Length=256, Percent_Identity=27.734375, Blast_Score=92, Evalue=9e-20,
Organism=Drosophila melanogaster, GI21355443, Length=230, Percent_Identity=25.6521739130435, Blast_Score=84, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24644084, Length=230, Percent_Identity=25.6521739130435, Blast_Score=84, Evalue=1e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005907
- InterPro:   IPR005835 [H]

Pfam domain/function: PF00483 NTP_transferase [H]

EC number: =2.7.7.24 [H]

Molecular weight: Translated: 33363; Mature: 33363

Theoretical pI: Translated: 5.24; Mature: 5.24

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKGIILAGGSGTRLYPLTMVTSKQLLPIYDKPMIYYPLSVLMSAGIRDILIISTPQDTPR
CCCEEEECCCCCEEEEEEEECCCCCCCCCCCCEEEHHHHHHHHCCCCEEEEEECCCCCHH
FKELLKDGSQFGVNLTYAVQPSPDGLAQAFIIGEEFIGDDTVAMVLGDNIFAGHGLKKRL
HHHHHHCCHHCCEEEEEEECCCCCCHHEEEEECHHHCCCCEEEEEECCCEEECCCHHHHH
KAAVENAESGKGATVFGYYVDDPERFGIVEFNNEGKAVSIEEKPAQPKSNYCVTGLYFYD
HHHHHCCCCCCCCEEEEEEECCCCCEEEEEECCCCCEEEECCCCCCCCCCEEEEEEEEEC
NKVVEYAKNLKPSARGELEITDLNRIYLDKGTLNVELLGQGFTWLDTGTHESLVEATNFV
CHHHHHHHCCCCCCCCCEEEEECCEEEEECCEEEEEEEECCCEEEECCCHHHHHHHHHHH
KTVETHQHRKIACLEEIAYLNGWINKDDVLKVYEVLKKNQYGQYLKDVLDGKYVDKLHE
HHHHHHCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCHHHHHHHHHCCHHHHHHCC
>Mature Secondary Structure
MKGIILAGGSGTRLYPLTMVTSKQLLPIYDKPMIYYPLSVLMSAGIRDILIISTPQDTPR
CCCEEEECCCCCEEEEEEEECCCCCCCCCCCCEEEHHHHHHHHCCCCEEEEEECCCCCHH
FKELLKDGSQFGVNLTYAVQPSPDGLAQAFIIGEEFIGDDTVAMVLGDNIFAGHGLKKRL
HHHHHHCCHHCCEEEEEEECCCCCCHHEEEEECHHHCCCCEEEEEECCCEEECCCHHHHH
KAAVENAESGKGATVFGYYVDDPERFGIVEFNNEGKAVSIEEKPAQPKSNYCVTGLYFYD
HHHHHCCCCCCCCEEEEEEECCCCCEEEEEECCCCCEEEECCCCCCCCCCEEEEEEEEEC
NKVVEYAKNLKPSARGELEITDLNRIYLDKGTLNVELLGQGFTWLDTGTHESLVEATNFV
CHHHHHHHCCCCCCCCCEEEEECCEEEEECCEEEEEEEECCCEEEECCCHHHHHHHHHHH
KTVETHQHRKIACLEEIAYLNGWINKDDVLKVYEVLKKNQYGQYLKDVLDGKYVDKLHE
HHHHHHCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCHHHHHHHHHCCHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7517391; 9097040; 9278503; 7517390 [H]