Click here to switch to the map view.

The map label for this gene is rmlC [H]

Identifier: 238916051

GI number: 238916051

Start: 91277

End: 91888

Strand: Reverse

Name: rmlC [H]

Synonym: EUBELI_00084

Alternate gene names: 238916051

Gene position: 91888-91277 (Counterclockwise)

Preceding gene: 238916052

Following gene: 238916042

Centisome position: 4.29

GC content: 43.3

Gene sequence:

>612_bases
ATGGGACAGATTACAATTGAAAAGAATGTCGCAGGTATCGAAGGACTTTGTGTCATCACTCCTGCTGTTCACGGCGATAA
CCGTGGTTATTTTATGGAAACATACAGCCAACGTGATATGGAAGAAGCTGGTATCAATATTAACTTTGTTCAGGACAATC
AGTCTATGAGTACTAAGGGTGTTCTTCGTGGTCTTCACTTCCAGAAGCATTTCCCACAGACAAAGCTTGTAAGAGCTATC
AAGGGAGCTGTTTTTGATGTAGCTGTTGACCTTCGTACAGACTCTGAAACTTATGGAAAGTGGTACGGAATCCTTCTCAC
AGAGGAGAATAAGAAGCAGTTCCTTATCCCTAAGGGATTTGCACATGGATTCCTCGTTCTTACTGATACAGCGGAATTCT
GCTACAAGTGCGATGACTTCTATCATCCTAACGACGAGGGTGGTCTCGCATGGAATGACCCTGCAATCGGTATTGAATGG
CCAGAGCTTACAGGCACTTACAATGGCTCAGCTTCAGGCGAAGGCTATGCTTTAAGCGATGGAACAAAGCTCAACTTAAG
TGATAAGGATCAGCTTTGGGATACACTTGAGAACACATTTAAGTTTGATTAG

Upstream 100 bases:

>100_bases
TACTGCTAACGGATTCACTCCGCTTCCAACATGGCAGGATGCTCTTCACAGATTCTTAAAGGAAATCGGTGAGATTTAAT
ATTTCAAAGGAGATTTTATC

Downstream 100 bases:

>100_bases
TTATTATAATAAAAACTGCGGCTCTTATGAACCGCAGTTTTTATTATATGTACTCATTATTGCTACAAAACATATAAACA
CCGGGAAGACCTCAAATTCA

Product: dTDP-4-dehydrorhamnose 3,5-epimerase

Products: NA

Alternate protein names: Thymidine diphospho-4-keto-rhamnose 3,5-epimerase; dTDP-4-keto-6-deoxyglucose 3,5-epimerase; dTDP-6-deoxy-D-xylo-4-hexulose 3,5-epimerase; dTDP-L-rhamnose synthase [H]

Number of amino acids: Translated: 203; Mature: 202

Protein sequence:

>203_residues
MGQITIEKNVAGIEGLCVITPAVHGDNRGYFMETYSQRDMEEAGININFVQDNQSMSTKGVLRGLHFQKHFPQTKLVRAI
KGAVFDVAVDLRTDSETYGKWYGILLTEENKKQFLIPKGFAHGFLVLTDTAEFCYKCDDFYHPNDEGGLAWNDPAIGIEW
PELTGTYNGSASGEGYALSDGTKLNLSDKDQLWDTLENTFKFD

Sequences:

>Translated_203_residues
MGQITIEKNVAGIEGLCVITPAVHGDNRGYFMETYSQRDMEEAGININFVQDNQSMSTKGVLRGLHFQKHFPQTKLVRAI
KGAVFDVAVDLRTDSETYGKWYGILLTEENKKQFLIPKGFAHGFLVLTDTAEFCYKCDDFYHPNDEGGLAWNDPAIGIEW
PELTGTYNGSASGEGYALSDGTKLNLSDKDQLWDTLENTFKFD
>Mature_202_residues
GQITIEKNVAGIEGLCVITPAVHGDNRGYFMETYSQRDMEEAGININFVQDNQSMSTKGVLRGLHFQKHFPQTKLVRAIK
GAVFDVAVDLRTDSETYGKWYGILLTEENKKQFLIPKGFAHGFLVLTDTAEFCYKCDDFYHPNDEGGLAWNDPAIGIEWP
ELTGTYNGSASGEGYALSDGTKLNLSDKDQLWDTLENTFKFD

Specific function: Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4- hexulose [H]

COG id: COG1898

COG function: function code M; dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase family [H]

Homologues:

Organism=Escherichia coli, GI1788350, Length=176, Percent_Identity=49.4318181818182, Blast_Score=183, Evalue=6e-48,
Organism=Caenorhabditis elegans, GI17550412, Length=162, Percent_Identity=46.2962962962963, Blast_Score=135, Evalue=1e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011051
- InterPro:   IPR000888
- InterPro:   IPR014710
- ProDom:   PD001462 [H]

Pfam domain/function: PF00908 dTDP_sugar_isom [H]

EC number: =5.1.3.13 [H]

Molecular weight: Translated: 22738; Mature: 22606

Theoretical pI: Translated: 4.52; Mature: 4.52

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGQITIEKNVAGIEGLCVITPAVHGDNRGYFMETYSQRDMEEAGININFVQDNQSMSTKG
CCEEEEECCCCCCCEEEEEEEEEECCCCCEEEECCCCCCHHHHCCEEEEEECCCCCCHHH
VLRGLHFQKHFPQTKLVRAIKGAVFDVAVDLRTDSETYGKWYGILLTEENKKQFLIPKGF
HHHCCHHHHHCCHHHHHHHHHCCEEEEEEEEECCCCCCCEEEEEEEEECCCCEEEEECCC
AHGFLVLTDTAEFCYKCDDFYHPNDEGGLAWNDPAIGIEWPELTGTYNGSASGEGYALSD
CCEEEEEECCHHHHHHCCCCCCCCCCCCEEECCCCCCEECCCCCCCCCCCCCCCCEEECC
GTKLNLSDKDQLWDTLENTFKFD
CCEECCCCHHHHHHHHHHHCCCC
>Mature Secondary Structure 
GQITIEKNVAGIEGLCVITPAVHGDNRGYFMETYSQRDMEEAGININFVQDNQSMSTKG
CEEEEECCCCCCCEEEEEEEEEECCCCCEEEECCCCCCHHHHCCEEEEEECCCCCCHHH
VLRGLHFQKHFPQTKLVRAIKGAVFDVAVDLRTDSETYGKWYGILLTEENKKQFLIPKGF
HHHCCHHHHHCCHHHHHHHHHCCEEEEEEEEECCCCCCCEEEEEEEEECCCCEEEEECCC
AHGFLVLTDTAEFCYKCDDFYHPNDEGGLAWNDPAIGIEWPELTGTYNGSASGEGYALSD
CCEEEEEECCHHHHHHCCCCCCCCCCCCEEECCCCCCEECCCCCCCCCCCCCCCCEEECC
GTKLNLSDKDQLWDTLENTFKFD
CCEECCCCHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9371463; 10827167 [H]