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The map label for this gene is uhpA [H]

Identifier: 238897178

GI number: 238897178

Start: 5178152

End: 5178745

Strand: Reverse

Name: uhpA [H]

Synonym: KP1_5447

Alternate gene names: 238897178

Gene position: 5178745-5178152 (Counterclockwise)

Preceding gene: 238897179

Following gene: 238897177

Centisome position: 98.67

GC content: 62.46

Gene sequence:

>594_bases
ATGACCACCATCGCCCTTATTGACGATCATTTGATTGTCCGCTCCGGCTTTGCTCAGCTGCTGGGGCTGGAAGCTGATTT
TCAGGTTGTCGCCGAATTTGGTAGCGGCCGCGAGGCGCTGACGGGGCTACCGGGGCGCGGCGTGCAGGTCTGTATCTGCG
ATATCTCCATGCCGGATATTTCCGGGCTGGAGCTGCTCAGCCAGCTGCCGAAGGGGATGGCGACCATCATGTTGTCGGTA
CACGATAGCCCGGCGCTGATCGAGCAAGCGTTGAACGCCGGCGCGCGCGGCTTCCTGTCGAAACGCTGCAGCCCCGATGA
ACTTATCGCCGCGGTACGCACGGTGGCGGCGGGAGGTTGCTATCTCACGCCGGATATCGCCATGAAGTTGGCCGCCGGGC
GCCAGGATCCACTCACCAAACGCGAGCGTCAGGTGGCGGAAAAGCTGGCGCAGGGCATGGCGGTGAAAGAGATTGCCGCC
GAGCTCGGTCTGTCGCCGAAAACCGTCCACGTACACCGCGCCAACCTGCTGGAAAAGCTGGGCGTCAGCAACGACGTTGA
GCTGGCGCGCCGCATGTTCGATAGCTGGCAATGA

Upstream 100 bases:

>100_bases
CCGGATGACGCTGCGCTTATCCGGCCTACAAGCAGTGAATCCGTAGGCCGGATAAGGCGTTTACGCCGCCATCCGGCGTT
TTCAGGCACCAGGACACACC

Downstream 100 bases:

>100_bases
AGGCCGTCGTCTCACGATTGCTGTCGGTCATCGGCTGCGCCTTTATCTTCGCGGCCGCCTGGTTCTGCCTGTGGAGCATC
AGTCTGCATCTGGTGGAACG

Product: DNA-binding transcriptional activator UhpA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 197; Mature: 196

Protein sequence:

>197_residues
MTTIALIDDHLIVRSGFAQLLGLEADFQVVAEFGSGREALTGLPGRGVQVCICDISMPDISGLELLSQLPKGMATIMLSV
HDSPALIEQALNAGARGFLSKRCSPDELIAAVRTVAAGGCYLTPDIAMKLAAGRQDPLTKRERQVAEKLAQGMAVKEIAA
ELGLSPKTVHVHRANLLEKLGVSNDVELARRMFDSWQ

Sequences:

>Translated_197_residues
MTTIALIDDHLIVRSGFAQLLGLEADFQVVAEFGSGREALTGLPGRGVQVCICDISMPDISGLELLSQLPKGMATIMLSV
HDSPALIEQALNAGARGFLSKRCSPDELIAAVRTVAAGGCYLTPDIAMKLAAGRQDPLTKRERQVAEKLAQGMAVKEIAA
ELGLSPKTVHVHRANLLEKLGVSNDVELARRMFDSWQ
>Mature_196_residues
TTIALIDDHLIVRSGFAQLLGLEADFQVVAEFGSGREALTGLPGRGVQVCICDISMPDISGLELLSQLPKGMATIMLSVH
DSPALIEQALNAGARGFLSKRCSPDELIAAVRTVAAGGCYLTPDIAMKLAAGRQDPLTKRERQVAEKLAQGMAVKEIAAE
LGLSPKTVHVHRANLLEKLGVSNDVELARRMFDSWQ

Specific function: Appears to be the positive activator of uhpT transcription [H]

COG id: COG2197

COG function: function code TK; Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1790102, Length=196, Percent_Identity=93.8775510204082, Blast_Score=377, Evalue=1e-106,
Organism=Escherichia coli, GI1788222, Length=200, Percent_Identity=36, Blast_Score=126, Evalue=8e-31,
Organism=Escherichia coli, GI1788521, Length=194, Percent_Identity=35.5670103092784, Blast_Score=102, Evalue=2e-23,
Organism=Escherichia coli, GI1787473, Length=183, Percent_Identity=34.4262295081967, Blast_Score=87, Evalue=9e-19,
Organism=Escherichia coli, GI1786747, Length=197, Percent_Identity=28.4263959390863, Blast_Score=85, Evalue=4e-18,
Organism=Escherichia coli, GI1788546, Length=202, Percent_Identity=28.7128712871287, Blast_Score=76, Evalue=1e-15,
Organism=Escherichia coli, GI1788712, Length=183, Percent_Identity=27.8688524590164, Blast_Score=76, Evalue=1e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR016032
- InterPro:   IPR001789
- InterPro:   IPR000792
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00196 GerE; PF00072 Response_reg [H]

EC number: NA

Molecular weight: Translated: 21075; Mature: 20944

Theoretical pI: Translated: 6.11; Mature: 6.11

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00622 HTH_LUXR_1 ; PS50043 HTH_LUXR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTIALIDDHLIVRSGFAQLLGLEADFQVVAEFGSGREALTGLPGRGVQVCICDISMPDI
CCEEEEECCHHHHHHHHHHHHCCCCHHHHHHHHCCCHHHHCCCCCCCCEEEEEECCCCCC
SGLELLSQLPKGMATIMLSVHDSPALIEQALNAGARGFLSKRCSPDELIAAVRTVAAGGC
HHHHHHHHCCHHHHHHHEECCCCHHHHHHHHHHCHHHHHHCCCCHHHHHHHHHHHHCCCC
YLTPDIAMKLAAGRQDPLTKRERQVAEKLAQGMAVKEIAAELGLSPKTVHVHRANLLEKL
EECHHHHHHHHCCCCCCCHHHHHHHHHHHHHCHHHHHHHHHHCCCCCEEEHHHHHHHHHH
GVSNDVELARRMFDSWQ
CCCCHHHHHHHHHHCCC
>Mature Secondary Structure 
TTIALIDDHLIVRSGFAQLLGLEADFQVVAEFGSGREALTGLPGRGVQVCICDISMPDI
CEEEEECCHHHHHHHHHHHHCCCCHHHHHHHHCCCHHHHCCCCCCCCEEEEEECCCCCC
SGLELLSQLPKGMATIMLSVHDSPALIEQALNAGARGFLSKRCSPDELIAAVRTVAAGGC
HHHHHHHHCCHHHHHHHEECCCCHHHHHHHHHHCHHHHHHCCCCHHHHHHHHHHHHCCCC
YLTPDIAMKLAAGRQDPLTKRERQVAEKLAQGMAVKEIAAELGLSPKTVHVHRANLLEKL
EECHHHHHHHHCCCCCCCHHHHHHHHHHHHHCHHHHHHHHHHCCCCCEEEHHHHHHHHHH
GVSNDVELARRMFDSWQ
CCCCHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]