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The map label for this gene is lldP [H]

Identifier: 238897047

GI number: 238897047

Start: 5043072

End: 5044838

Strand: Direct

Name: lldP [H]

Synonym: KP1_5296

Alternate gene names: 238897047

Gene position: 5043072-5044838 (Clockwise)

Preceding gene: 238897046

Following gene: 238897048

Centisome position: 96.09

GC content: 59.76

Gene sequence:

>1767_bases
TTGTCATCAACCCTGATACCCTTAATTGGCCGGGCCAACTTTACCTTCGGTGGGATCGGCAATGAGCGCAGACTCAGCCC
TCCTCTCCTGGCGGCCCGATGGAGACCCTGCATGAATCTCTGGCAACAAAACTACGATCCCGCCGGTAATATCTGGCTAT
CCAGTCTTATCGCATCGCTACCGATTCTGTTTTTCTTTTTTGCGCTGATTAAGCTCAAACTGAAAGGCTACATCGCTGCC
ACCTGGACCGTCGCAATCGCGCTGGTCGTTGCCTTACTGTTCTATAAAATGCCGGTGGACCGCGCCTTAGCCTCGGTGGT
CTACGGCTTCTTCTACGGCCTGTGGCCTATCGCGTGGATTATTATCGCCGCGGTCTTCGTCTATAAAATCTCGGTGAAGA
CCGGACAGTTCGACATCATCCGCTCATCGATTCTGTCGATTACGCCGGACCAGCGCCTGCAGATGCTGATCGTCGGCTTC
TCGTTCGGCGCCTTTCTCGAAGGGGCGGCGGGTTTCGGCGCACCGGTGGCGATTACCGCCGCGCTGCTGGTTGGTCTCGG
GTTTAACCCGCTGTATGCGGCTGGCCTGTGCCTGATCGTCAACACCGCGCCGGTGGCCTTCGGCGCGATGGGCATCCCGA
TTCTGGTCGCCGGCCAGGTGACCGGTATCGATAGCTTCGCCATCGGCCAGATGGTGGGCCGCCAGCTGCCGTTCCTGACC
ATTATCGTGCTGTTCTGGATCATGGCGATTATGGATGGCTGGCGCGGCATTAAAGAGACCTGGCCGGCGGTGATAGTCGC
AGGCGGTTCGTTCGCTATTGCCCAGTACCTCAGCTCTAACTTCCTTGGCCCGGAGCTGCCGGATATCATCTCGTCGCTGG
TCTCCCTGGTCTGTCTGACCCTGTTCCTCAAACGCTGGCAGCCGGTACGCATCTTCCGCTTCGGCGATCTCGGCGCCTCG
CAGGTGGATATGACGCTGGCCCGCACACGCTACACGGCGGGACAAGTGATCCGCGCCTGGTCGCCGTTCCTGTTCCTGAC
CGCCACCGTGACCCTGTGGAGCGTGCCGCCATTCAAAGCGCTGTTCGCTCCTGGCGGCGCGATGTATGACTTCGTTATCA
ATATTTCGGTACCATTCCTCGACAAAATGGTTGCCCGTATGCCGCCGGTGGTTAGCGCCGCAACGCCCTACGCCGCGGTA
TATAAATTCGACTGGCTGTCGGCAACCGGCACCGCCATTCTGTTCGCCGCCCTGCTGTCCATCGTCTGGCTGCGCATGAA
GCCGAAAGATGCGCTGACCACCTTCGCCGGGACGCTGAAGGATCTGGCGCTGCCGATCTACTCTATCGGCATGGTGCTGG
CGTTCGCCTTTATCTCTAACTATTCCGGGCTGTCGTCGACGCTGGCCCTGGCGCTGGCCCATACCGGCCACGCGTTTACC
TTCTTCTCGCCGTTCCTTGGCTGGCTGGGGGTATTCCTGACCGGTTCGGACACCTCGTCTAACGCCCTGTTCGCCGCGCT
ACAGGCAACGGCGGCGCAGCAGATTGGCGTCTCCGATATCCTGCTGGTCGCGGCTAATACCACCGGCGGCGTTACCGGCA
AGATGATTTCCCCGCAGTCGATCGCCATCGCCTGCGCCGCGGTAGGCCTGGTGGGTAAAGAGTCGGATCTGTTCCGCTTT
ACCGTCAAACACAGCCTGATCTTCACCTGCATGGTGGGGCTGATCACCACGCTGCAGGCCTACGTTTTAACCTGGATGAT
CCCGTGA

Upstream 100 bases:

>100_bases
TGGTCCAACCAATAATTTCATCCACCCCCTGGCAGTTCACAAATCCGTCAAAACCCATCACAAAAACGTTGCTTAAGAGC
AACATCTGATTAACCATTCG

Downstream 100 bases:

>100_bases
TAGTGATGCCTAAACGCCTGGCCGACGACGTGGCGCGTCGCGTCCGGGCGCTGATTGAAGAACAACAGCTGGAGGCGGGC
ATGCGACTGCCCGCCGAGCG

Product: L-lactate permease

Products: Proton [Cytoplasm]; lactate [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 588; Mature: 587

Protein sequence:

>588_residues
MSSTLIPLIGRANFTFGGIGNERRLSPPLLAARWRPCMNLWQQNYDPAGNIWLSSLIASLPILFFFFALIKLKLKGYIAA
TWTVAIALVVALLFYKMPVDRALASVVYGFFYGLWPIAWIIIAAVFVYKISVKTGQFDIIRSSILSITPDQRLQMLIVGF
SFGAFLEGAAGFGAPVAITAALLVGLGFNPLYAAGLCLIVNTAPVAFGAMGIPILVAGQVTGIDSFAIGQMVGRQLPFLT
IIVLFWIMAIMDGWRGIKETWPAVIVAGGSFAIAQYLSSNFLGPELPDIISSLVSLVCLTLFLKRWQPVRIFRFGDLGAS
QVDMTLARTRYTAGQVIRAWSPFLFLTATVTLWSVPPFKALFAPGGAMYDFVINISVPFLDKMVARMPPVVSAATPYAAV
YKFDWLSATGTAILFAALLSIVWLRMKPKDALTTFAGTLKDLALPIYSIGMVLAFAFISNYSGLSSTLALALAHTGHAFT
FFSPFLGWLGVFLTGSDTSSNALFAALQATAAQQIGVSDILLVAANTTGGVTGKMISPQSIAIACAAVGLVGKESDLFRF
TVKHSLIFTCMVGLITTLQAYVLTWMIP

Sequences:

>Translated_588_residues
MSSTLIPLIGRANFTFGGIGNERRLSPPLLAARWRPCMNLWQQNYDPAGNIWLSSLIASLPILFFFFALIKLKLKGYIAA
TWTVAIALVVALLFYKMPVDRALASVVYGFFYGLWPIAWIIIAAVFVYKISVKTGQFDIIRSSILSITPDQRLQMLIVGF
SFGAFLEGAAGFGAPVAITAALLVGLGFNPLYAAGLCLIVNTAPVAFGAMGIPILVAGQVTGIDSFAIGQMVGRQLPFLT
IIVLFWIMAIMDGWRGIKETWPAVIVAGGSFAIAQYLSSNFLGPELPDIISSLVSLVCLTLFLKRWQPVRIFRFGDLGAS
QVDMTLARTRYTAGQVIRAWSPFLFLTATVTLWSVPPFKALFAPGGAMYDFVINISVPFLDKMVARMPPVVSAATPYAAV
YKFDWLSATGTAILFAALLSIVWLRMKPKDALTTFAGTLKDLALPIYSIGMVLAFAFISNYSGLSSTLALALAHTGHAFT
FFSPFLGWLGVFLTGSDTSSNALFAALQATAAQQIGVSDILLVAANTTGGVTGKMISPQSIAIACAAVGLVGKESDLFRF
TVKHSLIFTCMVGLITTLQAYVLTWMIP
>Mature_587_residues
SSTLIPLIGRANFTFGGIGNERRLSPPLLAARWRPCMNLWQQNYDPAGNIWLSSLIASLPILFFFFALIKLKLKGYIAAT
WTVAIALVVALLFYKMPVDRALASVVYGFFYGLWPIAWIIIAAVFVYKISVKTGQFDIIRSSILSITPDQRLQMLIVGFS
FGAFLEGAAGFGAPVAITAALLVGLGFNPLYAAGLCLIVNTAPVAFGAMGIPILVAGQVTGIDSFAIGQMVGRQLPFLTI
IVLFWIMAIMDGWRGIKETWPAVIVAGGSFAIAQYLSSNFLGPELPDIISSLVSLVCLTLFLKRWQPVRIFRFGDLGASQ
VDMTLARTRYTAGQVIRAWSPFLFLTATVTLWSVPPFKALFAPGGAMYDFVINISVPFLDKMVARMPPVVSAATPYAAVY
KFDWLSATGTAILFAALLSIVWLRMKPKDALTTFAGTLKDLALPIYSIGMVLAFAFISNYSGLSSTLALALAHTGHAFTF
FSPFLGWLGVFLTGSDTSSNALFAALQATAAQQIGVSDILLVAANTTGGVTGKMISPQSIAIACAAVGLVGKESDLFRFT
VKHSLIFTCMVGLITTLQAYVLTWMIP

Specific function: Transports L-lactate across the membrane. Can also transport D-lactate and glycolate. Seems to be driven by a proton motive force [H]

COG id: COG1620

COG function: function code C; L-lactate permease

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lactate permease family [H]

Homologues:

Organism=Escherichia coli, GI1790031, Length=551, Percent_Identity=92.9219600725953, Blast_Score=994, Evalue=0.0,
Organism=Escherichia coli, GI1789347, Length=558, Percent_Identity=64.15770609319, Blast_Score=699, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003804 [H]

Pfam domain/function: PF02652 Lactate_perm [H]

EC number: NA

Molecular weight: Translated: 63363; Mature: 63232

Theoretical pI: Translated: 9.94; Mature: 9.94

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSTLIPLIGRANFTFGGIGNERRLSPPLLAARWRPCMNLWQQNYDPAGNIWLSSLIASL
CCCCCEEHCCCCCCEECCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHH
PILFFFFALIKLKLKGYIAATWTVAIALVVALLFYKMPVDRALASVVYGFFYGLWPIAWI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHH
IIAAVFVYKISVKTGQFDIIRSSILSITPDQRLQMLIVGFSFGAFLEGAAGFGAPVAITA
HHHHHHHHHEECCCCCHHHHHHHHHHCCCCHHEEEEEEEECHHHHHCCCCCCCCHHHHHH
ALLVGLGFNPLYAAGLCLIVNTAPVAFGAMGIPILVAGQVTGIDSFAIGQMVGRQLPFLT
HHHHHCCCCHHHHCCCCEEEECCCHHHCCCCCCEEEECCCCCCCHHHHHHHHHCCCHHHH
IIVLFWIMAIMDGWRGIKETWPAVIVAGGSFAIAQYLSSNFLGPELPDIISSLVSLVCLT
HHHHHHHHHHHHHCCCHHHCCCEEEEECCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHH
LFLKRWQPVRIFRFGDLGASQVDMTLARTRYTAGQVIRAWSPFLFLTATVTLWSVPPFKA
HHHHCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCHHH
LFAPGGAMYDFVINISVPFLDKMVARMPPVVSAATPYAAVYKFDWLSATGTAILFAALLS
HHCCCCCEEEEEEEECCHHHHHHHHHCCCCCCCCCCHHHHEEEECCCCCHHHHHHHHHHH
IVWLRMKPKDALTTFAGTLKDLALPIYSIGMVLAFAFISNYSGLSSTLALALAHTGHAFT
HHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCHHH
FFSPFLGWLGVFLTGSDTSSNALFAALQATAAQQIGVSDILLVAANTTGGVTGKMISPQS
HHHHHHHHHHEEEECCCCCCCHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCHH
IAIACAAVGLVGKESDLFRFTVKHSLIFTCMVGLITTLQAYVLTWMIP
HHHHHHHHHHCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SSTLIPLIGRANFTFGGIGNERRLSPPLLAARWRPCMNLWQQNYDPAGNIWLSSLIASL
CCCCEEHCCCCCCEECCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHH
PILFFFFALIKLKLKGYIAATWTVAIALVVALLFYKMPVDRALASVVYGFFYGLWPIAWI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHH
IIAAVFVYKISVKTGQFDIIRSSILSITPDQRLQMLIVGFSFGAFLEGAAGFGAPVAITA
HHHHHHHHHEECCCCCHHHHHHHHHHCCCCHHEEEEEEEECHHHHHCCCCCCCCHHHHHH
ALLVGLGFNPLYAAGLCLIVNTAPVAFGAMGIPILVAGQVTGIDSFAIGQMVGRQLPFLT
HHHHHCCCCHHHHCCCCEEEECCCHHHCCCCCCEEEECCCCCCCHHHHHHHHHCCCHHHH
IIVLFWIMAIMDGWRGIKETWPAVIVAGGSFAIAQYLSSNFLGPELPDIISSLVSLVCLT
HHHHHHHHHHHHHCCCHHHCCCEEEEECCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHH
LFLKRWQPVRIFRFGDLGASQVDMTLARTRYTAGQVIRAWSPFLFLTATVTLWSVPPFKA
HHHHCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCHHH
LFAPGGAMYDFVINISVPFLDKMVARMPPVVSAATPYAAVYKFDWLSATGTAILFAALLS
HHCCCCCEEEEEEEECCHHHHHHHHHCCCCCCCCCCHHHHEEEECCCCCHHHHHHHHHHH
IVWLRMKPKDALTTFAGTLKDLALPIYSIGMVLAFAFISNYSGLSSTLALALAHTGHAFT
HHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCHHH
FFSPFLGWLGVFLTGSDTSSNALFAALQATAAQQIGVSDILLVAANTTGGVTGKMISPQS
HHHHHHHHHHEEEECCCCCCCHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCHH
IAIACAAVGLVGKESDLFRFTVKHSLIFTCMVGLITTLQAYVLTWMIP
HHHHHHHHHHCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; lactate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + lactate [Periplasm] = Proton [Cytoplasm] + lactate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]