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The map label for this gene is nikC [H]

Identifier: 238896949

GI number: 238896949

Start: 4923375

End: 4924208

Strand: Direct

Name: nikC [H]

Synonym: KP1_5190

Alternate gene names: 238896949

Gene position: 4923375-4924208 (Clockwise)

Preceding gene: 238896948

Following gene: 238896950

Centisome position: 93.81

GC content: 64.75

Gene sequence:

>834_bases
ATGAGAGGGCAACAAAGCTTTCGCTGGCCGGTAAAACTGGCCATGCTGGTTATCGCGCTGCTGGCGGTCATCGCCATCGG
CAGCGGCTGGTGGCTGCCCTGGGATCCAGCGGCGATTGACCTTCAGCAGCGGCTGCTGCCGCCGGGCGCAGCGCACTGGC
TCGGCACCGATCATCTCGGCCGGGATATTTTCTCACGCCTGCTGGCCGCCACCCGCGTTTCGCTGGGGGCGGTGATGGCT
TGTCTGCTGCTGGTGCTGCTGATCGGCCTGGCGGTCGGCGGCTGCGCCGGACTGCTGGGCGGCCGCGCCGACCGCGGCCT
GATGCGCATCGCCGAACTGTTTATGACCTTTCCGACCTCGATCCTGTCGTTCTTTATGGTGGGAGTGCTGGGTACCGGGC
TGACCAATGTGATCCTCGCCATTGCGCTGTCACACTGGGCCTGGTACGCCAGAATGGTGCGTAACCTGGTGGTTTCCCTG
CGCCAGCGCGAATTTATCCTCGCCGCCCGTCTGAGCGGCGCCAGCCAGTGGCGGCTGTTCAGCGACCATCTGGCCGGCGC
GGTGATCCCCTCGCTGCTGGTGCTCGCCTCGCTGGATATCGGCCATATGATGCTTCACGTAGCCGGCATGTCGTTCCTCG
GTCTCGGTGTCAGCGCACCGACGGCGGAATGGGGGGTGATGATCAACGACGCCCGGCAGTATATCTGGACCCAACCGCTG
CAAATGGTCTGGCCGGGGCTGGCGCTGTTCATCAGCGTGATGGCTTTTAACCTGCTGGGCGACGCGCTGCGCGATCGTCT
CGATCCCCACCTGATCGCGGAGCATAGCCACTGA

Upstream 100 bases:

>100_bases
CCCTGATGATGGTGACGGTGTTCGTGCTGGCTAATCTGGCGGTGGATGTGCTTAACGCGGCGCTCGACCCGCGCCTGCGC
CGCCACGAGGAGGTGAGCGC

Downstream 100 bases:

>100_bases
TGCCGCAGAAGATCCAACTGGAACAGATCTCGCTTGCCGCTGACCGACCGCTGGTCAGCGACGTCTCCTTCACCCTGCGC
CGCGGCCAGGTGCTGGCGCT

Product: nickel transporter permease NikC

Products: Ni2; [Cytoplasm]; ADP; phosphate [C]

Alternate protein names: NA

Number of amino acids: Translated: 277; Mature: 277

Protein sequence:

>277_residues
MRGQQSFRWPVKLAMLVIALLAVIAIGSGWWLPWDPAAIDLQQRLLPPGAAHWLGTDHLGRDIFSRLLAATRVSLGAVMA
CLLLVLLIGLAVGGCAGLLGGRADRGLMRIAELFMTFPTSILSFFMVGVLGTGLTNVILAIALSHWAWYARMVRNLVVSL
RQREFILAARLSGASQWRLFSDHLAGAVIPSLLVLASLDIGHMMLHVAGMSFLGLGVSAPTAEWGVMINDARQYIWTQPL
QMVWPGLALFISVMAFNLLGDALRDRLDPHLIAEHSH

Sequences:

>Translated_277_residues
MRGQQSFRWPVKLAMLVIALLAVIAIGSGWWLPWDPAAIDLQQRLLPPGAAHWLGTDHLGRDIFSRLLAATRVSLGAVMA
CLLLVLLIGLAVGGCAGLLGGRADRGLMRIAELFMTFPTSILSFFMVGVLGTGLTNVILAIALSHWAWYARMVRNLVVSL
RQREFILAARLSGASQWRLFSDHLAGAVIPSLLVLASLDIGHMMLHVAGMSFLGLGVSAPTAEWGVMINDARQYIWTQPL
QMVWPGLALFISVMAFNLLGDALRDRLDPHLIAEHSH
>Mature_277_residues
MRGQQSFRWPVKLAMLVIALLAVIAIGSGWWLPWDPAAIDLQQRLLPPGAAHWLGTDHLGRDIFSRLLAATRVSLGAVMA
CLLLVLLIGLAVGGCAGLLGGRADRGLMRIAELFMTFPTSILSFFMVGVLGTGLTNVILAIALSHWAWYARMVRNLVVSL
RQREFILAARLSGASQWRLFSDHLAGAVIPSLLVLASLDIGHMMLHVAGMSFLGLGVSAPTAEWGVMINDARQYIWTQPL
QMVWPGLALFISVMAFNLLGDALRDRLDPHLIAEHSH

Specific function: Involved in a nickel transport system, probably translocates nickel through the bacterial inner membrane [H]

COG id: COG1173

COG function: function code EP; ABC-type dipeptide/oligopeptide/nickel transport systems, permease components

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transmembrane type-1 domain [H]

Homologues:

Organism=Escherichia coli, GI1789889, Length=272, Percent_Identity=81.6176470588235, Blast_Score=417, Evalue=1e-118,
Organism=Escherichia coli, GI1787760, Length=261, Percent_Identity=40.6130268199234, Blast_Score=202, Evalue=2e-53,
Organism=Escherichia coli, GI1787054, Length=259, Percent_Identity=40.9266409266409, Blast_Score=184, Evalue=5e-48,
Organism=Escherichia coli, GI1789964, Length=254, Percent_Identity=35.4330708661417, Blast_Score=140, Evalue=6e-35,
Organism=Escherichia coli, GI1787498, Length=221, Percent_Identity=33.4841628959276, Blast_Score=125, Evalue=4e-30,
Organism=Escherichia coli, GI1787549, Length=250, Percent_Identity=31.6, Blast_Score=120, Evalue=7e-29,
Organism=Escherichia coli, GI1788505, Length=228, Percent_Identity=25, Blast_Score=72, Evalue=5e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000515
- InterPro:   IPR014157 [H]

Pfam domain/function: PF00528 BPD_transp_1 [H]

EC number: NA

Molecular weight: Translated: 30198; Mature: 30198

Theoretical pI: Translated: 10.01; Mature: 10.01

Prosite motif: PS50928 ABC_TM1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
4.7 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
4.7 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHCCCCC
>Mature Secondary Structure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HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Ni2; [Periplasm]; ATP; H2O [C]

Specific reaction: Ni2+ [Periplasm] + ATP + H2O = Ni2+ [Cytoplasm] + ADP + phosphate [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]