Click here to switch to the map view.

The map label for this gene is fkpA [H]

Identifier: 238896829

GI number: 238896829

Start: 4792975

End: 4793805

Strand: Reverse

Name: fkpA [H]

Synonym: KP1_5059

Alternate gene names: 238896829

Gene position: 4793805-4792975 (Counterclockwise)

Preceding gene: 238896831

Following gene: 238896828

Centisome position: 91.34

GC content: 54.15

Gene sequence:

>831_bases
ATGAAATCACTGTTTAAAGTAACGCTGCTGGCGACCACAATGGCCGTCGCCCTGAATGCACCGCTGACCTTCGCTGCAGA
TACGGCAACGAAGGCAGCCCCGGCGGCTGAGAGTAAATCGGCATTTAAAAATGACGATCAGAAATCGGCCTATGCGCTGG
GCGCGTCCCTGGGGCGTTACATGGAAAACTCCCTGAAAGAACAAGAGAAGCTGGGCATTAAGCTGGATAAATCCCAGCTG
ATCGCCGGCGTACAGGACGCGTTTGCCGATAAGAGCAAACTGTCCGACCAGGAGATCGAACAGACTCTGCAGGCCTTTGA
AACGCGCGTGAAGACCGCGGCTCAGCAGAAAATGGAAAAAGACGCCACTGAGAACGAAGCCAAAGGCAAAGCTTTCCGTG
ACAACTTTGCCAAAGAGAAGGGCGTGAAAACCTCAAAAACTGGCCTGCTGTATAAAGTCGAGAAAGAAGGCGCTGGCGAT
GCGCCGAAAGATAGCGATACCGTGGTGGTAAACTACAAAGGTACCCTGATCGACGGTAAAGAGTTTGATAACTCTTATAC
TCGCGGCGAGCCGCTCTCTTTCCGTCTCGACGGTGTGATCCCGGGCTGGACTGAAGGCCTGAAGAACATCAAGAAAGGCG
GCAAAATCAAGCTGGTTATTCCGCCGGACCTGGCCTACGGTAAAACTGGCGTCCCGGGCATCCCGGCCAACTCTACGCTG
GTCTTTGATGTAGAACTGCTGGATATCAAACCGGCGCCGAAGGCAGATGCACAGCCGGAAGCCGCAGGCGATGCGAAAGC
CGCGGACGCGAAAGCTGACGCTAAGAAGTAA

Upstream 100 bases:

>100_bases
AGGAACGTCCGTATGTAGATTTTAACGGCAACGTTCTATAGTACGTTTTTTGCTTTTTACGATAACCCTGGGGCGAGAGG
CCCCGGCCCTGGAGAAATGG

Downstream 100 bases:

>100_bases
TCAGGTTCAGGCCGCCGTCTCGTCAGAGGCGGCGGCTTTTTTATTGAGCGCAGATATAATTAAAACTGGAAAGATCCTCA
GGCGCTGTATTACTTTAGAT

Product: FKBP-type peptidyl-prolyl cis-trans isomerase

Products: NA

Alternate protein names: PPIase; Rotamase [H]

Number of amino acids: Translated: 276; Mature: 276

Protein sequence:

>276_residues
MKSLFKVTLLATTMAVALNAPLTFAADTATKAAPAAESKSAFKNDDQKSAYALGASLGRYMENSLKEQEKLGIKLDKSQL
IAGVQDAFADKSKLSDQEIEQTLQAFETRVKTAAQQKMEKDATENEAKGKAFRDNFAKEKGVKTSKTGLLYKVEKEGAGD
APKDSDTVVVNYKGTLIDGKEFDNSYTRGEPLSFRLDGVIPGWTEGLKNIKKGGKIKLVIPPDLAYGKTGVPGIPANSTL
VFDVELLDIKPAPKADAQPEAAGDAKAADAKADAKK

Sequences:

>Translated_276_residues
MKSLFKVTLLATTMAVALNAPLTFAADTATKAAPAAESKSAFKNDDQKSAYALGASLGRYMENSLKEQEKLGIKLDKSQL
IAGVQDAFADKSKLSDQEIEQTLQAFETRVKTAAQQKMEKDATENEAKGKAFRDNFAKEKGVKTSKTGLLYKVEKEGAGD
APKDSDTVVVNYKGTLIDGKEFDNSYTRGEPLSFRLDGVIPGWTEGLKNIKKGGKIKLVIPPDLAYGKTGVPGIPANSTL
VFDVELLDIKPAPKADAQPEAAGDAKAADAKADAKK
>Mature_276_residues
MKSLFKVTLLATTMAVALNAPLTFAADTATKAAPAAESKSAFKNDDQKSAYALGASLGRYMENSLKEQEKLGIKLDKSQL
IAGVQDAFADKSKLSDQEIEQTLQAFETRVKTAAQQKMEKDATENEAKGKAFRDNFAKEKGVKTSKTGLLYKVEKEGAGD
APKDSDTVVVNYKGTLIDGKEFDNSYTRGEPLSFRLDGVIPGWTEGLKNIKKGGKIKLVIPPDLAYGKTGVPGIPANSTL
VFDVELLDIKPAPKADAQPEAAGDAKAADAKADAKK

Specific function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides [H]

COG id: COG0545

COG function: function code O; FKBP-type peptidyl-prolyl cis-trans isomerases 1

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase FKBP-type domain [H]

Homologues:

Organism=Homo sapiens, GI17149836, Length=105, Percent_Identity=49.5238095238095, Blast_Score=91, Evalue=1e-18,
Organism=Homo sapiens, GI4503725, Length=105, Percent_Identity=49.5238095238095, Blast_Score=91, Evalue=1e-18,
Organism=Homo sapiens, GI224809329, Length=107, Percent_Identity=44.8598130841121, Blast_Score=89, Evalue=6e-18,
Organism=Homo sapiens, GI224809327, Length=107, Percent_Identity=44.8598130841121, Blast_Score=89, Evalue=6e-18,
Organism=Homo sapiens, GI4758384, Length=107, Percent_Identity=44.8598130841121, Blast_Score=89, Evalue=6e-18,
Organism=Homo sapiens, GI4758380, Length=105, Percent_Identity=45.7142857142857, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI224809331, Length=107, Percent_Identity=44.8598130841121, Blast_Score=85, Evalue=7e-17,
Organism=Homo sapiens, GI4503729, Length=107, Percent_Identity=40.1869158878505, Blast_Score=78, Evalue=1e-14,
Organism=Homo sapiens, GI206725530, Length=91, Percent_Identity=46.1538461538462, Blast_Score=77, Evalue=1e-14,
Organism=Homo sapiens, GI17149844, Length=91, Percent_Identity=46.1538461538462, Blast_Score=77, Evalue=1e-14,
Organism=Homo sapiens, GI17149842, Length=91, Percent_Identity=46.1538461538462, Blast_Score=77, Evalue=1e-14,
Organism=Homo sapiens, GI8923659, Length=99, Percent_Identity=41.4141414141414, Blast_Score=75, Evalue=9e-14,
Organism=Homo sapiens, GI4503727, Length=99, Percent_Identity=44.4444444444444, Blast_Score=73, Evalue=3e-13,
Organism=Homo sapiens, GI33469985, Length=101, Percent_Identity=37.6237623762376, Blast_Score=72, Evalue=4e-13,
Organism=Homo sapiens, GI146229346, Length=137, Percent_Identity=31.3868613138686, Blast_Score=69, Evalue=5e-12,
Organism=Escherichia coli, GI1789745, Length=260, Percent_Identity=86.9230769230769, Blast_Score=420, Evalue=1e-119,
Organism=Escherichia coli, GI87082390, Length=210, Percent_Identity=36.1904761904762, Blast_Score=127, Evalue=5e-31,
Organism=Caenorhabditis elegans, GI17540882, Length=90, Percent_Identity=48.8888888888889, Blast_Score=85, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI71993519, Length=91, Percent_Identity=48.3516483516484, Blast_Score=78, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI17561782, Length=113, Percent_Identity=41.5929203539823, Blast_Score=74, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17561778, Length=185, Percent_Identity=29.7297297297297, Blast_Score=67, Evalue=7e-12,
Organism=Saccharomyces cerevisiae, GI6320727, Length=111, Percent_Identity=44.1441441441441, Blast_Score=84, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6324194, Length=105, Percent_Identity=44.7619047619048, Blast_Score=81, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6323482, Length=105, Percent_Identity=41.9047619047619, Blast_Score=75, Evalue=9e-15,
Organism=Saccharomyces cerevisiae, GI6323566, Length=102, Percent_Identity=43.1372549019608, Blast_Score=75, Evalue=1e-14,
Organism=Drosophila melanogaster, GI281363946, Length=95, Percent_Identity=48.4210526315789, Blast_Score=87, Evalue=9e-18,
Organism=Drosophila melanogaster, GI17352457, Length=95, Percent_Identity=48.4210526315789, Blast_Score=87, Evalue=9e-18,
Organism=Drosophila melanogaster, GI24655568, Length=92, Percent_Identity=48.9130434782609, Blast_Score=84, Evalue=9e-17,
Organism=Drosophila melanogaster, GI21356629, Length=93, Percent_Identity=50.5376344086022, Blast_Score=81, Evalue=9e-16,
Organism=Drosophila melanogaster, GI24583150, Length=107, Percent_Identity=40.1869158878505, Blast_Score=79, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24647110, Length=93, Percent_Identity=43.010752688172, Blast_Score=67, Evalue=1e-11,

Paralogues:

None

Copy number: 200 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001179
- InterPro:   IPR000774 [H]

Pfam domain/function: PF00254 FKBP_C; PF01346 FKBP_N [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 29477; Mature: 29477

Theoretical pI: Translated: 9.34; Mature: 9.34

Prosite motif: PS50059 FKBP_PPIASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKSLFKVTLLATTMAVALNAPLTFAADTATKAAPAAESKSAFKNDDQKSAYALGASLGRY
CCHHHHHHHHHHHHHHHHCCCEEEECCCCHHCCCCCHHHHHHCCCCHHHHHHHHHHHHHH
MENSLKEQEKLGIKLDKSQLIAGVQDAFADKSKLSDQEIEQTLQAFETRVKTAAQQKMEK
HHHHHHHHHHCCCEECHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHH
DATENEAKGKAFRDNFAKEKGVKTSKTGLLYKVEKEGAGDAPKDSDTVVVNYKGTLIDGK
HCCCCHHCCCHHHHHHHHHHCCCCCCCCEEEEEECCCCCCCCCCCCEEEEEECCEEECCH
EFDNSYTRGEPLSFRLDGVIPGWTEGLKNIKKGGKIKLVIPPDLAYGKTGVPGIPANSTL
HCCCCCCCCCCCEEEECCCCCCHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCCCCCEE
VFDVELLDIKPAPKADAQPEAAGDAKAADAKADAKK
EEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MKSLFKVTLLATTMAVALNAPLTFAADTATKAAPAAESKSAFKNDDQKSAYALGASLGRY
CCHHHHHHHHHHHHHHHHCCCEEEECCCCHHCCCCCHHHHHHCCCCHHHHHHHHHHHHHH
MENSLKEQEKLGIKLDKSQLIAGVQDAFADKSKLSDQEIEQTLQAFETRVKTAAQQKMEK
HHHHHHHHHHCCCEECHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHH
DATENEAKGKAFRDNFAKEKGVKTSKTGLLYKVEKEGAGDAPKDSDTVVVNYKGTLIDGK
HCCCCHHCCCHHHHHHHHHHCCCCCCCCEEEEEECCCCCCCCCCCCEEEEEECCEEECCH
EFDNSYTRGEPLSFRLDGVIPGWTEGLKNIKKGGKIKLVIPPDLAYGKTGVPGIPANSTL
HCCCCCCCCCCCEEEECCCCCCHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCCCCCEE
VFDVELLDIKPAPKADAQPEAAGDAKAADAKADAKK
EEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]