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The map label for this gene is rrmB [H]

Identifier: 238896785

GI number: 238896785

Start: 4766662

End: 4767957

Strand: Direct

Name: rrmB [H]

Synonym: KP1_5007

Alternate gene names: 238896785

Gene position: 4766662-4767957 (Clockwise)

Preceding gene: 238896784

Following gene: 238896786

Centisome position: 90.82

GC content: 57.41

Gene sequence:

>1296_bases
ATGAAAAAGAATATAAATTTACGCAGCCTGGCCGCCCAGGCTATCGAACAAGTTGTTGAAAAAGGGCAGTCTTTAAGCAA
CGTACTGCCCCCTCTACAGCAGAAAGTCAGCGATAAAGATAAAGCGCTACTGCAGGAGTTGTGCTTTGGTGTACTACGTA
CTCTAAGCCAGCTGGAGTGGCTTATCAGCAAGCTGATGGCGCGTCCGATGACCGGCAAACAGCGCACCGTGCACTTTCTG
ATCATGGTTGGTCTCTATCAGTTACTCTACACCCGCATTCCACCACACGCCGCGCTGGCGGAAACGGTAGAAGGCGCGGT
GGCCATTAAACGCCCGCAGCTTAAAGGGCTAATCAACGGCGTGCTACGCCAGTTCCAGCGCCAGCAGGAAGCGTTGTTAG
CCGAATTTGCTGAGCATGAAAACCGCTATCTTCATCCCAAATGGCTGCTGAAACGCCTGCAGCAGGCCTGGCCGCAGCAG
TGGCAGGAGATCGTCGAGGCGAACAACCAGCGCCCGCCGATGTGGCTGCGCGTTAACCGCAACCATCATTCCCGGGATGA
GTGGCTTGCCCTGCTTAACGAGACCGGTTTAGAGGGCTTTACCCACCCTGATTATCCGGACGCCGTACGCCTGGCCACCC
CTGCTCCGGTCCACGCGTTACCAGGCTTTGCCGAAGGCTGGGTGACCGTCCAGGATGCCTCGGCTCAGGGCTGTATGCGC
TACCTGCAACCGGAAAATGGCGAACGCATTCTCGATCTCTGCGCGGCGCCGGGCGGGAAGACGACGCATATTCTGGAAGT
CGCTCCCCAGGCTCAGGTTATGGCGGTGGATATTGATGAACAGCGTCTGTCCCGCGTCTATGACAACCTGAAGCGTCTGG
GTGTAAAAGCGGAAGTAAAACAGGGCGATGGCCGCTTCCCTGAGCAGTGGTGTGGCAATGAGCAGTTCGATCGTATTCTG
CTGGATGCTCCCTGCTCCGCAACCGGCGTTATTCGCCGCCATCCGGATATCAAATGGCTGCGCCGGGATCGGGATATCGC
CGAGTTAGCCCAGCTGCAGGCCGAGATCCTCAATGCCACCTGGACGCACCTGAAGCCTGGCGGCACGCTGGTTTACGCAA
CCTGTTCTATTCTGCCGGAAGAGAACAGTCAGCAAATTGCCGCCTTCCTCGCGCGAACCCCGGATGCAGAACTTCACGCC
ACCGGCACGCCGGCGAGCCCCGGGCAGCAAAATCTGCCGGGCGTGGAAGAAGGTGATGGCTTCTTTTACGCTAAGCTAAT
CAAACGTCGGAACTAA

Upstream 100 bases:

>100_bases
CTCAATTCCCGCCGGGAGTGGTTTATCCCTGGCACCCGTCTCGCCTGACGGTCGTCTCTTCTGAAGCCCGGGTTCGCCGG
GCATTTTTATTTTTGCGCTT

Downstream 100 bases:

>100_bases
TGGGTCACTGCAGATGAAGATTATTATTCTGGGCGCCGGCCAGGTCGGCGGCACGCTGGCGGAAAACCTCGTCGGCGAGA
ACAATGATATTACGCTGGTT

Product: 16S rRNA methyltransferase B

Products: NA

Alternate protein names: 16S rRNA m5C967 methyltransferase; rRNA (cytosine-C(5)-)-methyltransferase rsmB [H]

Number of amino acids: Translated: 431; Mature: 431

Protein sequence:

>431_residues
MKKNINLRSLAAQAIEQVVEKGQSLSNVLPPLQQKVSDKDKALLQELCFGVLRTLSQLEWLISKLMARPMTGKQRTVHFL
IMVGLYQLLYTRIPPHAALAETVEGAVAIKRPQLKGLINGVLRQFQRQQEALLAEFAEHENRYLHPKWLLKRLQQAWPQQ
WQEIVEANNQRPPMWLRVNRNHHSRDEWLALLNETGLEGFTHPDYPDAVRLATPAPVHALPGFAEGWVTVQDASAQGCMR
YLQPENGERILDLCAAPGGKTTHILEVAPQAQVMAVDIDEQRLSRVYDNLKRLGVKAEVKQGDGRFPEQWCGNEQFDRIL
LDAPCSATGVIRRHPDIKWLRRDRDIAELAQLQAEILNATWTHLKPGGTLVYATCSILPEENSQQIAAFLARTPDAELHA
TGTPASPGQQNLPGVEEGDGFFYAKLIKRRN

Sequences:

>Translated_431_residues
MKKNINLRSLAAQAIEQVVEKGQSLSNVLPPLQQKVSDKDKALLQELCFGVLRTLSQLEWLISKLMARPMTGKQRTVHFL
IMVGLYQLLYTRIPPHAALAETVEGAVAIKRPQLKGLINGVLRQFQRQQEALLAEFAEHENRYLHPKWLLKRLQQAWPQQ
WQEIVEANNQRPPMWLRVNRNHHSRDEWLALLNETGLEGFTHPDYPDAVRLATPAPVHALPGFAEGWVTVQDASAQGCMR
YLQPENGERILDLCAAPGGKTTHILEVAPQAQVMAVDIDEQRLSRVYDNLKRLGVKAEVKQGDGRFPEQWCGNEQFDRIL
LDAPCSATGVIRRHPDIKWLRRDRDIAELAQLQAEILNATWTHLKPGGTLVYATCSILPEENSQQIAAFLARTPDAELHA
TGTPASPGQQNLPGVEEGDGFFYAKLIKRRN
>Mature_431_residues
MKKNINLRSLAAQAIEQVVEKGQSLSNVLPPLQQKVSDKDKALLQELCFGVLRTLSQLEWLISKLMARPMTGKQRTVHFL
IMVGLYQLLYTRIPPHAALAETVEGAVAIKRPQLKGLINGVLRQFQRQQEALLAEFAEHENRYLHPKWLLKRLQQAWPQQ
WQEIVEANNQRPPMWLRVNRNHHSRDEWLALLNETGLEGFTHPDYPDAVRLATPAPVHALPGFAEGWVTVQDASAQGCMR
YLQPENGERILDLCAAPGGKTTHILEVAPQAQVMAVDIDEQRLSRVYDNLKRLGVKAEVKQGDGRFPEQWCGNEQFDRIL
LDAPCSATGVIRRHPDIKWLRRDRDIAELAQLQAEILNATWTHLKPGGTLVYATCSILPEENSQQIAAFLARTPDAELHA
TGTPASPGQQNLPGVEEGDGFFYAKLIKRRN

Specific function: Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA [H]

COG id: COG0144

COG function: function code J; tRNA and rRNA cytosine-C5-methylases

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. RsmB/NOP family [H]

Homologues:

Organism=Homo sapiens, GI76150625, Length=351, Percent_Identity=33.9031339031339, Blast_Score=142, Evalue=8e-34,
Organism=Homo sapiens, GI76150623, Length=351, Percent_Identity=33.9031339031339, Blast_Score=142, Evalue=8e-34,
Organism=Homo sapiens, GI32698918, Length=203, Percent_Identity=33.9901477832512, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI39995082, Length=185, Percent_Identity=32.4324324324324, Blast_Score=82, Evalue=1e-15,
Organism=Homo sapiens, GI301336155, Length=185, Percent_Identity=32.4324324324324, Blast_Score=82, Evalue=1e-15,
Organism=Homo sapiens, GI11545785, Length=282, Percent_Identity=27.6595744680851, Blast_Score=78, Evalue=2e-14,
Organism=Homo sapiens, GI270288816, Length=247, Percent_Identity=29.1497975708502, Blast_Score=73, Evalue=4e-13,
Organism=Homo sapiens, GI8922322, Length=247, Percent_Identity=29.1497975708502, Blast_Score=73, Evalue=4e-13,
Organism=Homo sapiens, GI23199998, Length=247, Percent_Identity=29.1497975708502, Blast_Score=73, Evalue=6e-13,
Organism=Homo sapiens, GI270288818, Length=247, Percent_Identity=29.1497975708502, Blast_Score=72, Evalue=7e-13,
Organism=Homo sapiens, GI40316918, Length=145, Percent_Identity=33.1034482758621, Blast_Score=72, Evalue=1e-12,
Organism=Escherichia coli, GI2367212, Length=429, Percent_Identity=85.0815850815851, Blast_Score=765, Evalue=0.0,
Organism=Escherichia coli, GI87081985, Length=218, Percent_Identity=32.1100917431193, Blast_Score=96, Evalue=4e-21,
Organism=Caenorhabditis elegans, GI17536757, Length=317, Percent_Identity=29.9684542586751, Blast_Score=121, Evalue=7e-28,
Organism=Caenorhabditis elegans, GI25143471, Length=163, Percent_Identity=36.8098159509202, Blast_Score=87, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6324268, Length=335, Percent_Identity=31.044776119403, Blast_Score=120, Evalue=4e-28,
Organism=Saccharomyces cerevisiae, GI6319447, Length=280, Percent_Identity=28.9285714285714, Blast_Score=75, Evalue=2e-14,
Organism=Drosophila melanogaster, GI22024126, Length=250, Percent_Identity=34, Blast_Score=125, Evalue=7e-29,
Organism=Drosophila melanogaster, GI19920494, Length=153, Percent_Identity=35.2941176470588, Blast_Score=89, Evalue=8e-18,
Organism=Drosophila melanogaster, GI24668781, Length=206, Percent_Identity=33.495145631068, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI21356513, Length=168, Percent_Identity=34.5238095238095, Blast_Score=87, Evalue=3e-17,
Organism=Drosophila melanogaster, GI21355201, Length=189, Percent_Identity=30.6878306878307, Blast_Score=77, Evalue=3e-14,
Organism=Drosophila melanogaster, GI21356579, Length=304, Percent_Identity=25, Blast_Score=70, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001678
- InterPro:   IPR018314
- InterPro:   IPR006027
- InterPro:   IPR004573 [H]

Pfam domain/function: PF01189 Nol1_Nop2_Fmu; PF01029 NusB [H]

EC number: =2.1.1.176 [H]

Molecular weight: Translated: 48617; Mature: 48617

Theoretical pI: Translated: 8.15; Mature: 8.15

Prosite motif: PS01153 NOL1_NOP2_SUN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKNINLRSLAAQAIEQVVEKGQSLSNVLPPLQQKVSDKDKALLQELCFGVLRTLSQLEW
CCCCCCHHHHHHHHHHHHHHCCCHHHHHCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHH
LISKLMARPMTGKQRTVHFLIMVGLYQLLYTRIPPHAALAETVEGAVAIKRPQLKGLING
HHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHEECCHHHHHHHHH
VLRQFQRQQEALLAEFAEHENRYLHPKWLLKRLQQAWPQQWQEIVEANNQRPPMWLRVNR
HHHHHHHHHHHHHHHHHHHCCCEECHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECC
NHHSRDEWLALLNETGLEGFTHPDYPDAVRLATPAPVHALPGFAEGWVTVQDASAQGCMR
CCCCHHHHHHHHHHCCCCCCCCCCCCCCEEECCCCCHHHCCCCCCCEEEEECCCHHHHHH
YLQPENGERILDLCAAPGGKTTHILEVAPQAQVMAVDIDEQRLSRVYDNLKRLGVKAEVK
HHCCCCCCHHHHHHCCCCCCCEEEEEECCCCEEEEEECCHHHHHHHHHHHHHCCCCEEEC
QGDGRFPEQWCGNEQFDRILLDAPCSATGVIRRHPDIKWLRRDRDIAELAQLQAEILNAT
CCCCCCCHHHCCCHHHHHEEEECCCCCCCHHHCCCCHHHHHCCCCHHHHHHHHHHHHHHH
WTHLKPGGTLVYATCSILPEENSQQIAAFLARTPDAELHATGTPASPGQQNLPGVEEGDG
HHEECCCCEEEEEEEEECCCCCHHHHHHHHHCCCCCCEEECCCCCCCCCCCCCCCCCCCC
FFYAKLIKRRN
HHHHHHHHHCC
>Mature Secondary Structure
MKKNINLRSLAAQAIEQVVEKGQSLSNVLPPLQQKVSDKDKALLQELCFGVLRTLSQLEW
CCCCCCHHHHHHHHHHHHHHCCCHHHHHCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHH
LISKLMARPMTGKQRTVHFLIMVGLYQLLYTRIPPHAALAETVEGAVAIKRPQLKGLING
HHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHEECCHHHHHHHHH
VLRQFQRQQEALLAEFAEHENRYLHPKWLLKRLQQAWPQQWQEIVEANNQRPPMWLRVNR
HHHHHHHHHHHHHHHHHHHCCCEECHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECC
NHHSRDEWLALLNETGLEGFTHPDYPDAVRLATPAPVHALPGFAEGWVTVQDASAQGCMR
CCCCHHHHHHHHHHCCCCCCCCCCCCCCEEECCCCCHHHCCCCCCCEEEEECCCHHHHHH
YLQPENGERILDLCAAPGGKTTHILEVAPQAQVMAVDIDEQRLSRVYDNLKRLGVKAEVK
HHCCCCCCHHHHHHCCCCCCCEEEEEECCCCEEEEEECCHHHHHHHHHHHHHCCCCEEEC
QGDGRFPEQWCGNEQFDRILLDAPCSATGVIRRHPDIKWLRRDRDIAELAQLQAEILNAT
CCCCCCCHHHCCCHHHHHEEEECCCCCCCHHHCCCCHHHHHCCCCHHHHHHHHHHHHHHH
WTHLKPGGTLVYATCSILPEENSQQIAAFLARTPDAELHATGTPASPGQQNLPGVEEGDG
HHEECCCCEEEEEEEEECCCCCHHHHHHHHHCCCCCCEEECCCCCCCCCCCCCCCCCCCC
FFYAKLIKRRN
HHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA