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The map label for this gene is fmt [H]

Identifier: 238896784

GI number: 238896784

Start: 4765662

End: 4766609

Strand: Direct

Name: fmt [H]

Synonym: KP1_5006

Alternate gene names: 238896784

Gene position: 4765662-4766609 (Clockwise)

Preceding gene: 238896783

Following gene: 238896785

Centisome position: 90.8

GC content: 57.91

Gene sequence:

>948_bases
GTGTCACAATCACTACGTATCATTTTCGCCGGCACCCCTGATTTTGCAGCGCGTCATCTTGATGCGCTGCTGTCGTCTGA
ACATCAGGTTGTTGGCGTATTCACTCAGCCTGATCGCCCTGCTGGTCGCGGCAAAAAATTGATGCCAAGCCCGGTAAAAG
TGCTGGCAGAAGCCCATAACTTACCTGTGTTCCAGCCATCCTCCCTGCGTCCGCAGGATAACCAGCGGTTAGTCGCCGAT
CTCGGCGCCGATATTATGGTGGTAGTGGCGTACGGTCTGATTCTGCCTAAAGCGGTGCTGGAGATGCCCCGTCTGGGCTG
TATCAACGTTCACGGCTCGCTGCTACCGCGCTGGCGTGGCGCAGCGCCTATTCAGCGTTCACTGTGGGCGGGGGATAGCG
AAACTGGCGTAACCATCATGCAGATGGACGTCGGCCTTGATACGGGGGATATGCTGTATAAGCTTTCCTGCCCCATTACC
GCAGAGGATACCAGCGGCAGCCTGTACGATAAGCTGGCCGAGCTCGGCCCTCAGGGGCTGCTGGCAACGTTAGCCCAACT
GGCCAACGGCACCGCACGGCCTGAAGTACAAGATGAATCGCTGGTGTGCCATGCCGAAAAGCTGAGTAAAGAAGAGGCTC
GTATCGATTGGTCGCTTTCCGCTGCGCAGTTGGAACGCTGCATCCGCGCGTTTAATCCGTGGCCAATGAGCTGGCTGGAA
ATTGACGGACAACCGGTAAAAGTGTGGCGGGCATCGGTCATCGCCGAAGCAGCTCACGCCGAACCGGGTACTATCGTGGC
AGCAACCAAACAGGGTATTCAGGTCGCCACGGGGGATGGGATCCTCAGCCTGGAGTCGCTACAGCCTGCGGGTAAAAAAG
CGATGAGCGCCCAGGACTTACTCAATTCCCGCCGGGAGTGGTTTATCCCTGGCACCCGTCTCGCCTGA

Upstream 100 bases:

>100_bases
TGTTTATTGACTATCTGTCACCACTCAAACAACAGCGCATTCGTCAGAAGGTAGAGAAACTGGATCGTTTACGTTCCCGT
GCCTGATAACAAGGAATACC

Downstream 100 bases:

>100_bases
CGGTCGTCTCTTCTGAAGCCCGGGTTCGCCGGGCATTTTTATTTTTGCGCTTATGAAAAAGAATATAAATTTACGCAGCC
TGGCCGCCCAGGCTATCGAA

Product: methionyl-tRNA formyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 315; Mature: 314

Protein sequence:

>315_residues
MSQSLRIIFAGTPDFAARHLDALLSSEHQVVGVFTQPDRPAGRGKKLMPSPVKVLAEAHNLPVFQPSSLRPQDNQRLVAD
LGADIMVVVAYGLILPKAVLEMPRLGCINVHGSLLPRWRGAAPIQRSLWAGDSETGVTIMQMDVGLDTGDMLYKLSCPIT
AEDTSGSLYDKLAELGPQGLLATLAQLANGTARPEVQDESLVCHAEKLSKEEARIDWSLSAAQLERCIRAFNPWPMSWLE
IDGQPVKVWRASVIAEAAHAEPGTIVAATKQGIQVATGDGILSLESLQPAGKKAMSAQDLLNSRREWFIPGTRLA

Sequences:

>Translated_315_residues
MSQSLRIIFAGTPDFAARHLDALLSSEHQVVGVFTQPDRPAGRGKKLMPSPVKVLAEAHNLPVFQPSSLRPQDNQRLVAD
LGADIMVVVAYGLILPKAVLEMPRLGCINVHGSLLPRWRGAAPIQRSLWAGDSETGVTIMQMDVGLDTGDMLYKLSCPIT
AEDTSGSLYDKLAELGPQGLLATLAQLANGTARPEVQDESLVCHAEKLSKEEARIDWSLSAAQLERCIRAFNPWPMSWLE
IDGQPVKVWRASVIAEAAHAEPGTIVAATKQGIQVATGDGILSLESLQPAGKKAMSAQDLLNSRREWFIPGTRLA
>Mature_314_residues
SQSLRIIFAGTPDFAARHLDALLSSEHQVVGVFTQPDRPAGRGKKLMPSPVKVLAEAHNLPVFQPSSLRPQDNQRLVADL
GADIMVVVAYGLILPKAVLEMPRLGCINVHGSLLPRWRGAAPIQRSLWAGDSETGVTIMQMDVGLDTGDMLYKLSCPITA
EDTSGSLYDKLAELGPQGLLATLAQLANGTARPEVQDESLVCHAEKLSKEEARIDWSLSAAQLERCIRAFNPWPMSWLEI
DGQPVKVWRASVIAEAAHAEPGTIVAATKQGIQVATGDGILSLESLQPAGKKAMSAQDLLNSRREWFIPGTRLA

Specific function: Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by:(I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-

COG id: COG0223

COG function: function code J; Methionyl-tRNA formyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the fmt family [H]

Homologues:

Organism=Homo sapiens, GI238814322, Length=319, Percent_Identity=30.4075235109718, Blast_Score=119, Evalue=3e-27,
Organism=Homo sapiens, GI21614513, Length=255, Percent_Identity=31.7647058823529, Blast_Score=112, Evalue=6e-25,
Organism=Homo sapiens, GI164663775, Length=317, Percent_Identity=28.7066246056782, Blast_Score=92, Evalue=8e-19,
Organism=Escherichia coli, GI1789683, Length=314, Percent_Identity=88.5350318471338, Blast_Score=573, Evalue=1e-165,
Organism=Escherichia coli, GI1788589, Length=295, Percent_Identity=27.7966101694915, Blast_Score=128, Evalue=6e-31,
Organism=Caenorhabditis elegans, GI133930964, Length=302, Percent_Identity=29.1390728476821, Blast_Score=102, Evalue=3e-22,
Organism=Drosophila melanogaster, GI45550868, Length=305, Percent_Identity=31.4754098360656, Blast_Score=110, Evalue=1e-24,
Organism=Drosophila melanogaster, GI28571984, Length=224, Percent_Identity=32.5892857142857, Blast_Score=100, Evalue=2e-21,
Organism=Drosophila melanogaster, GI24585660, Length=245, Percent_Identity=30.2040816326531, Blast_Score=91, Evalue=9e-19,

Paralogues:

None

Copy number: 400 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005794
- InterPro:   IPR005793
- InterPro:   IPR002376
- InterPro:   IPR011034
- InterPro:   IPR001555
- InterPro:   IPR015518 [H]

Pfam domain/function: PF02911 Formyl_trans_C; PF00551 Formyl_trans_N [H]

EC number: =2.1.2.9 [H]

Molecular weight: Translated: 34023; Mature: 33891

Theoretical pI: Translated: 6.25; Mature: 6.25

Prosite motif: PS00373 GART

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQSLRIIFAGTPDFAARHLDALLSSEHQVVGVFTQPDRPAGRGKKLMPSPVKVLAEAHN
CCCCEEEEEECCCHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCCCHHHHHHHHHC
LPVFQPSSLRPQDNQRLVADLGADIMVVVAYGLILPKAVLEMPRLGCINVHGSLLPRWRG
CCCCCCCCCCCCCCCHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCCCCCCC
AAPIQRSLWAGDSETGVTIMQMDVGLDTGDMLYKLSCPITAEDTSGSLYDKLAELGPQGL
CCCHHHHHCCCCCCCCEEEEEEECCCCCCCEEEEEECCEEECCCCCHHHHHHHHHCCCHH
LATLAQLANGTARPEVQDESLVCHAEKLSKEEARIDWSLSAAQLERCIRAFNPWPMSWLE
HHHHHHHHCCCCCCCCCCCCEEEEHHHHCHHHHHEEECCCHHHHHHHHHHCCCCCCCEEE
IDGQPVKVWRASVIAEAAHAEPGTIVAATKQGIQVATGDGILSLESLQPAGKKAMSAQDL
ECCCCHHHHHHHHHHHHHCCCCCEEEEEECCCEEEECCCCEEEECCCCCCHHHHHHHHHH
LNSRREWFIPGTRLA
HHCCCEEECCCCCCC
>Mature Secondary Structure 
SQSLRIIFAGTPDFAARHLDALLSSEHQVVGVFTQPDRPAGRGKKLMPSPVKVLAEAHN
CCCEEEEEECCCHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCCCHHHHHHHHHC
LPVFQPSSLRPQDNQRLVADLGADIMVVVAYGLILPKAVLEMPRLGCINVHGSLLPRWRG
CCCCCCCCCCCCCCCHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCCCCCCC
AAPIQRSLWAGDSETGVTIMQMDVGLDTGDMLYKLSCPITAEDTSGSLYDKLAELGPQGL
CCCHHHHHCCCCCCCCEEEEEEECCCCCCCEEEEEECCEEECCCCCHHHHHHHHHCCCHH
LATLAQLANGTARPEVQDESLVCHAEKLSKEEARIDWSLSAAQLERCIRAFNPWPMSWLE
HHHHHHHHCCCCCCCCCCCCEEEEHHHHCHHHHHEEECCCHHHHHHHHHHCCCCCCCEEE
IDGQPVKVWRASVIAEAAHAEPGTIVAATKQGIQVATGDGILSLESLQPAGKKAMSAQDL
ECCCCHHHHHHHHHHHHHCCCCCEEEEEECCCEEEECCCCEEEECCCCCCHHHHHHHHHH
LNSRREWFIPGTRLA
HHCCCEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA