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The map label for this gene is degQ [H]

Identifier: 238896730

GI number: 238896730

Start: 4708886

End: 4710253

Strand: Direct

Name: degQ [H]

Synonym: KP1_4946

Alternate gene names: 238896730

Gene position: 4708886-4710253 (Clockwise)

Preceding gene: 238896729

Following gene: 238896731

Centisome position: 89.72

GC content: 58.63

Gene sequence:

>1368_bases
ATGAAGAAACAGACTTTGCTGTTGAGTGCGTTAGCGTTAAGCATTGGGTTATCGTTGTCGGTCCTGCCTCCGGCAGCGGC
ATCCTTACCGACTCAGGTGCCCGGCCAGGGCGCGTTACCAAGCCTGGCGCCGATGCTGGAAAAGGTTCTGCCGGCGGTAG
TTAGCGTACAGGTGGAAGGCACCGCCTCGCCGACGCTCAATATGCCGGAAGAGCTGAAAAAATATTTTGGCGATAACGCC
CCGCAGGAGCAGGCGCAGCCGTTTGAAGGGCTCGGCTCCGGCGTTATCATCGACGCGGCGAAAGGCTATGTGCTGACCAA
TAACCACGTCATCAATCAGGCGCAGAAGATCAGCGTCCAGCTGAACGATGGCCGTGAGTTCGATGCCAAACTGGTCGGGA
GCGATGAACAGAGCGATATCGCTCTGCTGCAGCTGATTAAGCCAGACCACCTGACGCAAATCGCCATTGCTGACTCTGAT
AAACTTCGCGTCGGCGACTTCGCCGTCGCCGTCGGCAACCCGTTCGGCCTTGGCCAGACCGCCACATCCGGCATTATCTC
TGCCCTTGGCCGCAGCGGCTTGAACCTTGAAGGGCTGGAGAATTTCATTCAGACCGACGCCTCGATTAACCGCGGCAACT
CCGGCGGCGCGCTGCTGAACCTCAACGGCGAGCTTATCGGGATCAACACCGCGATCCTCGCGCCGGGCGGCGGCAGCATC
GGCATCGGCTTTGCCATTCCAAGCAATATGGCGAAAACCCTCGCCGACCAGCTCATTCAGTTTGGCGAAATCAAGCGCGG
CCTGTTGGGCATTAAAGGCATGGAAATGAGCGCCGACATCGCCAAAGCGATGAATCTCAACGTTCAGCGCGGCGCCTTCG
TCAGTGAAGTCCTGCCAAACTCCGGCTCCGCCAAAGCGGGGATTAAATCCGGGGACGTCATCGTGAGTCTGAACGGCAAA
CCGCTGAACAGTTTCGCCGAACTGCGTTCGCGGATCGCCACCACCGAGCCGGGTACCAAGGTCAAACTGGGCCTGCTGCG
CGATGGAAAGCCGGTCGATGTCGAAGTGACCCTGGATAAGAGCACCTCCTCAACCGCCAGCGCGGAACTGATTATCCCGG
CGCTGCAGGGGGCCTCGTTCAGCGACGGCCAGATGAAAGATGGCACCAAAGGAGTGGTGATCGATAATGTGGATAAAGGC
AGCGCCGCCGCCCAGGTCGGCCTACATAAAGATGACATTATCATTGGCCTTAACCGGCAGCGTATTCACTCAATTGCCGA
ACTGCGCAAAGCGCTCGAAGGCAAACCGCCGGTCATCGCCCTGAACGTGATCCGCGGCAACGAAAGCATCTATCTGCTGC
TGCGCTGA

Upstream 100 bases:

>100_bases
TTAAACCAGTCCCCACGTTGTTACCTGTGCAAAAATTCAATAACATCAGGTTATTCAGGACATTTTTCCATACACCTCAG
GTTACGAGAGCCAGCATCTA

Downstream 100 bases:

>100_bases
TTGTCTCTCCGGGCATCGCCGCCATGTGCGATGTCCGGACAACTCATGCTATGCTGCGCCTGACCATTCATTAACGATAT
CTGCATCATGCCTGGAAAGT

Product: serine endoprotease

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 455; Mature: 455

Protein sequence:

>455_residues
MKKQTLLLSALALSIGLSLSVLPPAAASLPTQVPGQGALPSLAPMLEKVLPAVVSVQVEGTASPTLNMPEELKKYFGDNA
PQEQAQPFEGLGSGVIIDAAKGYVLTNNHVINQAQKISVQLNDGREFDAKLVGSDEQSDIALLQLIKPDHLTQIAIADSD
KLRVGDFAVAVGNPFGLGQTATSGIISALGRSGLNLEGLENFIQTDASINRGNSGGALLNLNGELIGINTAILAPGGGSI
GIGFAIPSNMAKTLADQLIQFGEIKRGLLGIKGMEMSADIAKAMNLNVQRGAFVSEVLPNSGSAKAGIKSGDVIVSLNGK
PLNSFAELRSRIATTEPGTKVKLGLLRDGKPVDVEVTLDKSTSSTASAELIIPALQGASFSDGQMKDGTKGVVIDNVDKG
SAAAQVGLHKDDIIIGLNRQRIHSIAELRKALEGKPPVIALNVIRGNESIYLLLR

Sequences:

>Translated_455_residues
MKKQTLLLSALALSIGLSLSVLPPAAASLPTQVPGQGALPSLAPMLEKVLPAVVSVQVEGTASPTLNMPEELKKYFGDNA
PQEQAQPFEGLGSGVIIDAAKGYVLTNNHVINQAQKISVQLNDGREFDAKLVGSDEQSDIALLQLIKPDHLTQIAIADSD
KLRVGDFAVAVGNPFGLGQTATSGIISALGRSGLNLEGLENFIQTDASINRGNSGGALLNLNGELIGINTAILAPGGGSI
GIGFAIPSNMAKTLADQLIQFGEIKRGLLGIKGMEMSADIAKAMNLNVQRGAFVSEVLPNSGSAKAGIKSGDVIVSLNGK
PLNSFAELRSRIATTEPGTKVKLGLLRDGKPVDVEVTLDKSTSSTASAELIIPALQGASFSDGQMKDGTKGVVIDNVDKG
SAAAQVGLHKDDIIIGLNRQRIHSIAELRKALEGKPPVIALNVIRGNESIYLLLR
>Mature_455_residues
MKKQTLLLSALALSIGLSLSVLPPAAASLPTQVPGQGALPSLAPMLEKVLPAVVSVQVEGTASPTLNMPEELKKYFGDNA
PQEQAQPFEGLGSGVIIDAAKGYVLTNNHVINQAQKISVQLNDGREFDAKLVGSDEQSDIALLQLIKPDHLTQIAIADSD
KLRVGDFAVAVGNPFGLGQTATSGIISALGRSGLNLEGLENFIQTDASINRGNSGGALLNLNGELIGINTAILAPGGGSI
GIGFAIPSNMAKTLADQLIQFGEIKRGLLGIKGMEMSADIAKAMNLNVQRGAFVSEVLPNSGSAKAGIKSGDVIVSLNGK
PLNSFAELRSRIATTEPGTKVKLGLLRDGKPVDVEVTLDKSTSSTASAELIIPALQGASFSDGQMKDGTKGVVIDNVDKG
SAAAQVGLHKDDIIIGLNRQRIHSIAELRKALEGKPPVIALNVIRGNESIYLLLR

Specific function: Protease with a shared specificity with degP [H]

COG id: COG0265

COG function: function code O; Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 PDZ (DHR) domains [H]

Homologues:

Organism=Homo sapiens, GI22129776, Length=314, Percent_Identity=37.5796178343949, Blast_Score=166, Evalue=4e-41,
Organism=Homo sapiens, GI4506141, Length=294, Percent_Identity=35.3741496598639, Blast_Score=155, Evalue=6e-38,
Organism=Homo sapiens, GI24308541, Length=305, Percent_Identity=30.4918032786885, Blast_Score=137, Evalue=3e-32,
Organism=Homo sapiens, GI7019477, Length=296, Percent_Identity=32.0945945945946, Blast_Score=126, Evalue=5e-29,
Organism=Escherichia coli, GI1789629, Length=455, Percent_Identity=81.5384615384615, Blast_Score=721, Evalue=0.0,
Organism=Escherichia coli, GI1786356, Length=440, Percent_Identity=58.8636363636364, Blast_Score=507, Evalue=1e-145,
Organism=Escherichia coli, GI1789630, Length=322, Percent_Identity=41.304347826087, Blast_Score=214, Evalue=7e-57,
Organism=Drosophila melanogaster, GI24646839, Length=288, Percent_Identity=32.2916666666667, Blast_Score=125, Evalue=4e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001478
- InterPro:   IPR009003
- InterPro:   IPR011782
- InterPro:   IPR001254
- InterPro:   IPR001940 [H]

Pfam domain/function: PF00595 PDZ; PF00089 Trypsin [H]

EC number: 3.4.21.-

Molecular weight: Translated: 47271; Mature: 47271

Theoretical pI: Translated: 6.18; Mature: 6.18

Prosite motif: PS50106 PDZ

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKQTLLLSALALSIGLSLSVLPPAAASLPTQVPGQGALPSLAPMLEKVLPAVVSVQVEG
CCCHHHHHHHHHHHHCCEEEECCCCHHCCCCCCCCCCCCCHHHHHHHHHHHHHEEEEECC
TASPTLNMPEELKKYFGDNAPQEQAQPFEGLGSGVIIDAAKGYVLTNNHVINQAQKISVQ
CCCCCCCCHHHHHHHHCCCCCHHHCCCHHCCCCCEEEECCCCEEEECCCEECCCEEEEEE
LNDGREFDAKLVGSDEQSDIALLQLIKPDHLTQIAIADSDKLRVGDFAVAVGNPFGLGQT
ECCCCCCCEEEECCCCCCCEEEEEEECCCCEEEEEEECCCCEEECEEEEEECCCCCCCHH
ATSGIISALGRSGLNLEGLENFIQTDASINRGNSGGALLNLNGELIGINTAILAPGGGSI
HHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCCCCCCEEEEECCEEEEEEEEEEECCCCCE
GIGFAIPSNMAKTLADQLIQFGEIKRGLLGIKGMEMSADIAKAMNLNVQRGAFVSEVLPN
EEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCCCCHHHHHCCC
SGSAKAGIKSGDVIVSLNGKPLNSFAELRSRIATTEPGTKVKLGLLRDGKPVDVEVTLDK
CCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHCCCCCCCEEEEEEECCCCCEEEEEEECC
STSSTASAELIIPALQGASFSDGQMKDGTKGVVIDNVDKGSAAAQVGLHKDDIIIGLNRQ
CCCCCCCEEEEEEEECCCCCCCCCCCCCCCCEEEECCCCCCCCEEECCCCCCEEEECCHH
RIHSIAELRKALEGKPPVIALNVIRGNESIYLLLR
HHHHHHHHHHHHCCCCCEEEEEEEECCCEEEEEEC
>Mature Secondary Structure
MKKQTLLLSALALSIGLSLSVLPPAAASLPTQVPGQGALPSLAPMLEKVLPAVVSVQVEG
CCCHHHHHHHHHHHHCCEEEECCCCHHCCCCCCCCCCCCCHHHHHHHHHHHHHEEEEECC
TASPTLNMPEELKKYFGDNAPQEQAQPFEGLGSGVIIDAAKGYVLTNNHVINQAQKISVQ
CCCCCCCCHHHHHHHHCCCCCHHHCCCHHCCCCCEEEECCCCEEEECCCEECCCEEEEEE
LNDGREFDAKLVGSDEQSDIALLQLIKPDHLTQIAIADSDKLRVGDFAVAVGNPFGLGQT
ECCCCCCCEEEECCCCCCCEEEEEEECCCCEEEEEEECCCCEEECEEEEEECCCCCCCHH
ATSGIISALGRSGLNLEGLENFIQTDASINRGNSGGALLNLNGELIGINTAILAPGGGSI
HHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCCCCCCEEEEECCEEEEEEEEEEECCCCCE
GIGFAIPSNMAKTLADQLIQFGEIKRGLLGIKGMEMSADIAKAMNLNVQRGAFVSEVLPN
EEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCCCCCHHHHHCCC
SGSAKAGIKSGDVIVSLNGKPLNSFAELRSRIATTEPGTKVKLGLLRDGKPVDVEVTLDK
CCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHCCCCCCCEEEEEEECCCCCEEEEEEECC
STSSTASAELIIPALQGASFSDGQMKDGTKGVVIDNVDKGSAAAQVGLHKDDIIIGLNRQ
CCCCCCCEEEEEEEECCCCCCCCCCCCCCCCEEEECCCCCCCCEEECCCCCCEEEECCHH
RIHSIAELRKALEGKPPVIALNVIRGNESIYLLLR
HHHHHHHHHHHHCCCCCEEEEEEEECCCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8576051; 9278503 [H]