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The map label for this gene is mutY [H]

Identifier: 238896493

GI number: 238896493

Start: 4471946

End: 4473157

Strand: Direct

Name: mutY [H]

Synonym: KP1_4673

Alternate gene names: 238896493

Gene position: 4471946-4473157 (Clockwise)

Preceding gene: 238896489

Following gene: 238896494

Centisome position: 85.2

GC content: 58.33

Gene sequence:

>1212_bases
ATGACGTCGTTTTTCATAAAAGTTTGGTCTGCTTGTGAATGTGTTCGGAAAACGGGCATTATCCAAAGTTACCCGGCGGA
TGCAAGGGTTTACAGCCACTCGCCCTTATGCTGCAATCTGCCCCCCTGTAATCGCGATCCCGGAGCCGTAGCTTTGACTT
TTCTCGCCACGCAATTTTCAGCCCAGGTTCTGGACTGGTACGACAAATACGGGCGTAAAACCCTGCCCTGGCAAATCGCC
AAGACGCCCTACAAAGTATGGCTCTCCGAAGTGATGTTGCAACAAACCCAGGTGACCACGGTAATCCCCTATTTTGAACG
CTTTATGGCGCGTTTCCCCACGGTGGTGGATCTCGCCAACGCGCCGCTGGATGAAGTGCTGCATCTGTGGACCGGTCTGG
GCTACTACGCGCGGGCGCGCAACTTACATAAAGCCGCACAGCAAGTCGCCACACTGCACGGCGGGGAATTCCCCCGGACC
TTTGACGAAGTGGCGGCGCTGCCCGGCGTCGGGCGCTCAACGGCGGGGGCGATTTTATCCCTTTCGCTCGGTCAGCATTA
TCCGATTCTCGACGGCAACGTGAAGCGCGTGCTCGCCCGCTGCTATGCTGTCAGCGGCTGGCCGGGGAAAAAAGAGGTGG
AAAAACGGCTGTGGGACATCAGCGAAGAGGTCACCCCGGCAGAGGGCGTCGAGCGCTTCAACCAGGCGATGATGGATCTC
GGGGCAATGGTTTGCACCCGCTCGAAGCCGAAGTGCGAGCTGTGTCCGCTGAGCAACGGCTGCGTGGCCTACGCGAACCA
TTCATGGGCGGAATATCCGGGCAAAAAACCGAAGCAGACCCTCCCGGAACGCACCGGCTACTTCCTGCTGATGCAGCACG
GCGACGAGGTGTTTCTTTCCCAGCGTCCGCCGGTGGGTCTGTGGGGCGGGTTGTTCTGTTTTCCGCAGTTTGCAGACGAA
GCGGAGCTACGCGAGTGGCTGGCGCAGCGCCAGATTAAGGCCGATAATCTGACGCAATTAACCGCTTTTCGCCACACTTT
CAGCCATTTCCACCTGGATATTGTGCCGATGTGGCTTACAGTGCACTCATCTGGCGCATGCATGGATGAAGGCAACGCAC
TCTGGTATAACTTAGCGCAGCCGCCGTCGGTCGGTCTGGCGGCCCCCGTGGAGCGCTTGTTGCAACAGCTAAAAGCCGGA
GCGCCGGTATAA

Upstream 100 bases:

>100_bases
ATCCAGCGCATGCTGCTGCCCTTTCGTCAGGCGGCCCTGGCGACGGACGAAGCTACGAATACGGCGCAGCGGGCGACCGT
TTTCATCGAATTCCGGAGAG

Downstream 100 bases:

>100_bases
ATTTTTCGGCTATCAAAGAGGATTAATTATGAGCAGAACCATTTTTTGTACCTTCCTGCAGCGTGAAGCGGACGGCCAGG
ATTTCCAGCTGTATCCGGGC

Product: adenine DNA glycosylase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 403; Mature: 402

Protein sequence:

>403_residues
MTSFFIKVWSACECVRKTGIIQSYPADARVYSHSPLCCNLPPCNRDPGAVALTFLATQFSAQVLDWYDKYGRKTLPWQIA
KTPYKVWLSEVMLQQTQVTTVIPYFERFMARFPTVVDLANAPLDEVLHLWTGLGYYARARNLHKAAQQVATLHGGEFPRT
FDEVAALPGVGRSTAGAILSLSLGQHYPILDGNVKRVLARCYAVSGWPGKKEVEKRLWDISEEVTPAEGVERFNQAMMDL
GAMVCTRSKPKCELCPLSNGCVAYANHSWAEYPGKKPKQTLPERTGYFLLMQHGDEVFLSQRPPVGLWGGLFCFPQFADE
AELREWLAQRQIKADNLTQLTAFRHTFSHFHLDIVPMWLTVHSSGACMDEGNALWYNLAQPPSVGLAAPVERLLQQLKAG
APV

Sequences:

>Translated_403_residues
MTSFFIKVWSACECVRKTGIIQSYPADARVYSHSPLCCNLPPCNRDPGAVALTFLATQFSAQVLDWYDKYGRKTLPWQIA
KTPYKVWLSEVMLQQTQVTTVIPYFERFMARFPTVVDLANAPLDEVLHLWTGLGYYARARNLHKAAQQVATLHGGEFPRT
FDEVAALPGVGRSTAGAILSLSLGQHYPILDGNVKRVLARCYAVSGWPGKKEVEKRLWDISEEVTPAEGVERFNQAMMDL
GAMVCTRSKPKCELCPLSNGCVAYANHSWAEYPGKKPKQTLPERTGYFLLMQHGDEVFLSQRPPVGLWGGLFCFPQFADE
AELREWLAQRQIKADNLTQLTAFRHTFSHFHLDIVPMWLTVHSSGACMDEGNALWYNLAQPPSVGLAAPVERLLQQLKAG
APV
>Mature_402_residues
TSFFIKVWSACECVRKTGIIQSYPADARVYSHSPLCCNLPPCNRDPGAVALTFLATQFSAQVLDWYDKYGRKTLPWQIAK
TPYKVWLSEVMLQQTQVTTVIPYFERFMARFPTVVDLANAPLDEVLHLWTGLGYYARARNLHKAAQQVATLHGGEFPRTF
DEVAALPGVGRSTAGAILSLSLGQHYPILDGNVKRVLARCYAVSGWPGKKEVEKRLWDISEEVTPAEGVERFNQAMMDLG
AMVCTRSKPKCELCPLSNGCVAYANHSWAEYPGKKPKQTLPERTGYFLLMQHGDEVFLSQRPPVGLWGGLFCFPQFADEA
ELREWLAQRQIKADNLTQLTAFRHTFSHFHLDIVPMWLTVHSSGACMDEGNALWYNLAQPPSVGLAAPVERLLQQLKAGA
PV

Specific function: Adenine glycosylase active on G-A mispairs. MutY also corrects error-prone DNA synthesis past GO lesions which are due to the oxidatively damaged form of guanine:7,8-dihydro-8- oxoguanine (8-oxo-dGTP) [H]

COG id: COG1194

COG function: function code L; A/G-specific DNA glycosylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Nth/MutY family [H]

Homologues:

Organism=Homo sapiens, GI190358497, Length=361, Percent_Identity=34.9030470914127, Blast_Score=194, Evalue=2e-49,
Organism=Homo sapiens, GI115298648, Length=361, Percent_Identity=34.9030470914127, Blast_Score=194, Evalue=2e-49,
Organism=Homo sapiens, GI6912520, Length=361, Percent_Identity=34.9030470914127, Blast_Score=193, Evalue=2e-49,
Organism=Homo sapiens, GI115298654, Length=361, Percent_Identity=34.9030470914127, Blast_Score=193, Evalue=2e-49,
Organism=Homo sapiens, GI115298652, Length=361, Percent_Identity=34.9030470914127, Blast_Score=193, Evalue=2e-49,
Organism=Homo sapiens, GI115298650, Length=361, Percent_Identity=34.9030470914127, Blast_Score=193, Evalue=2e-49,
Organism=Escherichia coli, GI1789331, Length=348, Percent_Identity=88.7931034482759, Blast_Score=653, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011257
- InterPro:   IPR004036
- InterPro:   IPR004035
- InterPro:   IPR003651
- InterPro:   IPR003265
- InterPro:   IPR000445
- InterPro:   IPR003583
- InterPro:   IPR023170
- InterPro:   IPR005760
- InterPro:   IPR000086
- InterPro:   IPR015797 [H]

Pfam domain/function: PF10576 EndIII_4Fe-2S; PF00633 HHH; PF00730 HhH-GPD [H]

EC number: 3.2.2.-

Molecular weight: Translated: 45124; Mature: 44993

Theoretical pI: Translated: 8.02; Mature: 8.02

Prosite motif: PS00764 ENDONUCLEASE_III_1 ; PS01155 ENDONUCLEASE_III_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
3.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSFFIKVWSACECVRKTGIIQSYPADARVYSHSPLCCNLPPCNRDPGAVALTFLATQFS
CCHHHHHHHHHHHHHHHCCCCCCCCCCCEEECCCCCEECCCCCCCCCCCEEHHHHHHHHH
AQVLDWYDKYGRKTLPWQIAKTPYKVWLSEVMLQQTQVTTVIPYFERFMARFPTVVDLAN
HHHHHHHHHHCCCCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCC
APLDEVLHLWTGLGYYARARNLHKAAQQVATLHGGEFPRTFDEVAALPGVGRSTAGAILS
CCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCHHHHEEE
LSLGQHYPILDGNVKRVLARCYAVSGWPGKKEVEKRLWDISEEVTPAEGVERFNQAMMDL
EECCCCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
GAMVCTRSKPKCELCPLSNGCVAYANHSWAEYPGKKPKQTLPERTGYFLLMQHGDEVFLS
HHHHHCCCCCCCEECCCCCCEEEECCCCHHHCCCCCCHHHCCCCCCEEEEEECCCEEEEC
QRPPVGLWGGLFCFPQFADEAELREWLAQRQIKADNLTQLTAFRHTFSHFHLDIVPMWLT
CCCCCCCCHHHHHHHCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHEEEEEEEE
VHSSGACMDEGNALWYNLAQPPSVGLAAPVERLLQQLKAGAPV
EECCCCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
TSFFIKVWSACECVRKTGIIQSYPADARVYSHSPLCCNLPPCNRDPGAVALTFLATQFS
CHHHHHHHHHHHHHHHCCCCCCCCCCCEEECCCCCEECCCCCCCCCCCEEHHHHHHHHH
AQVLDWYDKYGRKTLPWQIAKTPYKVWLSEVMLQQTQVTTVIPYFERFMARFPTVVDLAN
HHHHHHHHHHCCCCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCC
APLDEVLHLWTGLGYYARARNLHKAAQQVATLHGGEFPRTFDEVAALPGVGRSTAGAILS
CCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCHHHHEEE
LSLGQHYPILDGNVKRVLARCYAVSGWPGKKEVEKRLWDISEEVTPAEGVERFNQAMMDL
EECCCCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
GAMVCTRSKPKCELCPLSNGCVAYANHSWAEYPGKKPKQTLPERTGYFLLMQHGDEVFLS
HHHHHCCCCCCCEECCCCCCEEEECCCCHHHCCCCCCHHHCCCCCCEEEEEECCCEEEEC
QRPPVGLWGGLFCFPQFADEAELREWLAQRQIKADNLTQLTAFRHTFSHFHLDIVPMWLT
CCCCCCCCHHHHHHHCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHEEEEEEEE
VHSSGACMDEGNALWYNLAQPPSVGLAAPVERLLQQLKAGAPV
EECCCCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: 4Fe-4S Cluster [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Glycosylases; Hydrolysing N-glycosyl compounds [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2197596; 2001994; 9278503; 9846876 [H]