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The map label for this gene is mdtN [H]

Identifier: 238896410

GI number: 238896410

Start: 4389635

End: 4390660

Strand: Direct

Name: mdtN [H]

Synonym: KP1_4584

Alternate gene names: 238896410

Gene position: 4389635-4390660 (Clockwise)

Preceding gene: 238896409

Following gene: 238896411

Centisome position: 83.64

GC content: 64.04

Gene sequence:

>1026_bases
ATGACAACTTCCCGCACTCCCCTGTTACGCAAAAAGTGGCCTCTGCTGGCGCTGGTCCTTGCCGCCATCCTGGCGCTGAT
CCTCGTTATCTGGCAGTTGCAAACCTCGCCGGAGACCAATGACGCCTATGTCTATGCCGATACCATCGATGTAGTGCCCG
AGGTCAGCGGACGCATCGTGGAGATGCCCATTCGCGATAACCAGCGGGTGAAAAAAGGCGATCTGTTGTTCCGCATCGAC
CCCCGCCCCTATCAGGCAATGCTCGATGACGCGAAAGCCCGGCTGACGACCCTCGACGCGCAGATCATGCTGACCCAGCG
CACCATCAAAGCGCAGGAGTATAACGCCCAGTCGGTGGCGGCCGCCGTCGAGCGCGCCAGAGCGCTGGTTAAGCAGACCA
CCTCCACGCGTATCCGCCTTGAGCCGCTGGTGCCGCAGGGGTTCGCTTCCCAGGAAGATCTCGATCAGGCGCGCACCGCT
GAGAAAGCGGCGCGGGCGGAGCTGGAGGCCACGCTGCTGCAGGCCAAACAGGCCTCGGCGGCCGTGACCGGCGTGGATGC
CATGGTGGCGCAACGCGCCGGGGTCCTGGCGCAAATCGCCCTCGCTGAACTGCATCTGGAATTTACCGAAGTGCGCGCGC
CGTTCAACGGCGTGGTGGTGGCGCTGAAAACCACCGTCGGCCAGTACGCCTCGGCGCTGAAGCCGGTCTTCACCCTGCTG
GATGACGACCGCTGGTATGTGATCGCGAACTTCCGCGAAACCGACCTGAACAACGTGCGCCCCGGCGTGGCGGCGCGGAT
CACCGTGATGACCAACCACAACCGGACCTTTAACGGGGTGGTGGATTCGGTCGGCTCCGGGGTCCTGCCCGAAGGTGGGA
GCGTCATCGAAGGGCTGCCGCTGATCCAGAAAAGCATTAACTGGGTCCACGTCTCGCAGCGCTTCCCGGTGAAAATCGCC
GTCAGCGATCCCGACCCGGAACTGTTCCGCATGGGCGCCTCGGCCAGCGCCGTGCTGCAGCCGTAG

Upstream 100 bases:

>100_bases
CTGGCAGCCGCGCTTTTCTCCCCTGGTCTTCAGCTACGTCGCGCTGATGTTCCTGTTCGCCACGTTGCTGTGGTTTCTGT
TTTTTGTTCACTGATCGCTT

Downstream 100 bases:

>100_bases
CCGGGCGACGCTATGTTTCCTCTCGCCCATTTTTTACGCCAGGAACTGCGCGACGCGCCGGGACGCGCCAGCTACACGCT
GCGCCTGACGCTAAGCTGCG

Product: multidrug resistance protein MdtN

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 341; Mature: 340

Protein sequence:

>341_residues
MTTSRTPLLRKKWPLLALVLAAILALILVIWQLQTSPETNDAYVYADTIDVVPEVSGRIVEMPIRDNQRVKKGDLLFRID
PRPYQAMLDDAKARLTTLDAQIMLTQRTIKAQEYNAQSVAAAVERARALVKQTTSTRIRLEPLVPQGFASQEDLDQARTA
EKAARAELEATLLQAKQASAAVTGVDAMVAQRAGVLAQIALAELHLEFTEVRAPFNGVVVALKTTVGQYASALKPVFTLL
DDDRWYVIANFRETDLNNVRPGVAARITVMTNHNRTFNGVVDSVGSGVLPEGGSVIEGLPLIQKSINWVHVSQRFPVKIA
VSDPDPELFRMGASASAVLQP

Sequences:

>Translated_341_residues
MTTSRTPLLRKKWPLLALVLAAILALILVIWQLQTSPETNDAYVYADTIDVVPEVSGRIVEMPIRDNQRVKKGDLLFRID
PRPYQAMLDDAKARLTTLDAQIMLTQRTIKAQEYNAQSVAAAVERARALVKQTTSTRIRLEPLVPQGFASQEDLDQARTA
EKAARAELEATLLQAKQASAAVTGVDAMVAQRAGVLAQIALAELHLEFTEVRAPFNGVVVALKTTVGQYASALKPVFTLL
DDDRWYVIANFRETDLNNVRPGVAARITVMTNHNRTFNGVVDSVGSGVLPEGGSVIEGLPLIQKSINWVHVSQRFPVKIA
VSDPDPELFRMGASASAVLQP
>Mature_340_residues
TTSRTPLLRKKWPLLALVLAAILALILVIWQLQTSPETNDAYVYADTIDVVPEVSGRIVEMPIRDNQRVKKGDLLFRIDP
RPYQAMLDDAKARLTTLDAQIMLTQRTIKAQEYNAQSVAAAVERARALVKQTTSTRIRLEPLVPQGFASQEDLDQARTAE
KAARAELEATLLQAKQASAAVTGVDAMVAQRAGVLAQIALAELHLEFTEVRAPFNGVVVALKTTVGQYASALKPVFTLLD
DDRWYVIANFRETDLNNVRPGVAARITVMTNHNRTFNGVVDSVGSGVLPEGGSVIEGLPLIQKSINWVHVSQRFPVKIAV
SDPDPELFRMGASASAVLQP

Specific function: Could be involved in resistance to puromycin, acriflavine and tetraphenylarsonium chloride [H]

COG id: COG1566

COG function: function code V; Multidrug resistance efflux pump

Gene ontology:

Cell location: Cell inner membrane; Single-pass type II membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

Organism=Escherichia coli, GI1790519, Length=333, Percent_Identity=61.8618618618619, Blast_Score=411, Evalue=1e-116,
Organism=Escherichia coli, GI87081951, Length=310, Percent_Identity=32.258064516129, Blast_Score=135, Evalue=5e-33,
Organism=Escherichia coli, GI1789637, Length=336, Percent_Identity=29.7619047619048, Blast_Score=119, Evalue=3e-28,
Organism=Escherichia coli, GI1788711, Length=338, Percent_Identity=27.5147928994083, Blast_Score=103, Evalue=2e-23,
Organism=Escherichia coli, GI1790012, Length=293, Percent_Identity=28.6689419795222, Blast_Score=97, Evalue=1e-21,
Organism=Escherichia coli, GI1790024, Length=302, Percent_Identity=27.4834437086093, Blast_Score=96, Evalue=3e-21,
Organism=Escherichia coli, GI1789041, Length=303, Percent_Identity=27.7227722772277, Blast_Score=94, Evalue=1e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005694
- InterPro:   IPR006143 [H]

Pfam domain/function: PF00529 HlyD [H]

EC number: NA

Molecular weight: Translated: 37312; Mature: 37181

Theoretical pI: Translated: 8.79; Mature: 8.79

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTSRTPLLRKKWPLLALVLAAILALILVIWQLQTSPETNDAYVYADTIDVVPEVSGRIV
CCCCCCCCHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEEEECCCCCCCEEE
EMPIRDNQRVKKGDLLFRIDPRPYQAMLDDAKARLTTLDAQIMLTQRTIKAQEYNAQSVA
EECCCCCCCEECCCEEEEECCCHHHHHHHHHHHHHEEECCEEEEEHHHHHHHHCCHHHHH
AAVERARALVKQTTSTRIRLEPLVPQGFASQEDLDQARTAEKAARAELEATLLQAKQASA
HHHHHHHHHHHHHCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AVTGVDAMVAQRAGVLAQIALAELHLEFTEVRAPFNGVVVALKTTVGQYASALKPVFTLL
HHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCEEEEEEHHHHHHHHHHHHHHHHC
DDDRWYVIANFRETDLNNVRPGVAARITVMTNHNRTFNGVVDSVGSGVLPEGGSVIEGLP
CCCCEEEEEECCCCCCCCCCCCCEEEEEEEECCCCCHHHHHHHHCCCCCCCCCCHHHCCH
LIQKSINWVHVSQRFPVKIAVSDPDPELFRMGASASAVLQP
HHHHCCCEEEECCCCCEEEEECCCCHHHHCCCCCCCCCCCC
>Mature Secondary Structure 
TTSRTPLLRKKWPLLALVLAAILALILVIWQLQTSPETNDAYVYADTIDVVPEVSGRIV
CCCCCCCHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEEEECCCCCCCEEE
EMPIRDNQRVKKGDLLFRIDPRPYQAMLDDAKARLTTLDAQIMLTQRTIKAQEYNAQSVA
EECCCCCCCEECCCEEEEECCCHHHHHHHHHHHHHEEECCEEEEEHHHHHHHHCCHHHHH
AAVERARALVKQTTSTRIRLEPLVPQGFASQEDLDQARTAEKAARAELEATLLQAKQASA
HHHHHHHHHHHHHCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AVTGVDAMVAQRAGVLAQIALAELHLEFTEVRAPFNGVVVALKTTVGQYASALKPVFTLL
HHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCEEEEEEHHHHHHHHHHHHHHHHC
DDDRWYVIANFRETDLNNVRPGVAARITVMTNHNRTFNGVVDSVGSGVLPEGGSVIEGLP
CCCCEEEEEECCCCCCCCCCCCCEEEEEEEECCCCCHHHHHHHHCCCCCCCCCCHHHCCH
LIQKSINWVHVSQRFPVKIAVSDPDPELFRMGASASAVLQP
HHHHCCCEEEECCCCCEEEEECCCCHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]