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The map label for this gene is mdtO [H]

Identifier: 238896411

GI number: 238896411

Start: 4390673

End: 4392610

Strand: Direct

Name: mdtO [H]

Synonym: KP1_4586

Alternate gene names: 238896411

Gene position: 4390673-4392610 (Clockwise)

Preceding gene: 238896410

Following gene: 238896412

Centisome position: 83.66

GC content: 65.53

Gene sequence:

>1938_bases
ATGTTTCCTCTCGCCCATTTTTTACGCCAGGAACTGCGCGACGCGCCGGGACGCGCCAGCTACACGCTGCGCCTGACGCT
AAGCTGCGCGGTGCTCATCACCCTGTTTATGACCCTGCAGATCCCTTTCCTGGCCGTTGCGCTGATCGTCGTGTTCTACG
TCAGCCAGCCTAACGTGTTGATGATTAAGCTGGTCAGCGTGGTCTTTTTTGTCACCGTCACCGTGGCGCTCGGCGGCGTG
CTGCTGATCATCAAGTGGACCTATGACTACCCGCTGATCCGCCTGGCGGCCTCCGTGGCGCTCTTTTTCTGCGCCCTCTA
TCTGATGCGGGTGCTGGGCAAGCTGGGACTGGCCTTTTTCGTGGTGGCGCTGGCGGTGATTTACGCTCAGACCTTCCCGT
CGATGACCAGCCAGAGCGAGATCCTGGTGCGGCTGCTGCTTTGGCTGTGGGTGGCGATTAACACCGCGATCCTCGTCACC
CTGCTGGTCAACGCCTGCTTTCAGCAGGCCTTTCCCGGTAACCAGTTTAAGGCGCGTCTGGCCGGGATGCTGCACGAGGT
CGCCCGGCGGCTGGCGGCCCCGGACGCTGAAGCGCCACCGACCTTCGGCGAGACCGCCGCGCAGTTCAATCAGCTGCAGT
CGCTATTCGCCCAGGCCAGCCGGGCGACACCGGAGATCGCCGCCGATCCCCAGGCCTGGCGCTCGCGGCTGGCCGCCACT
TTGCGCTGCTACCAGCTGGCGGCCCTGCTGCAAGCAGACGAGGCGGATAGTGACGATCGCCAGCAGCTGTCGCAGGCGGT
ACTTCAGCTGAAGAACGCCCTTAGCGAGGGGCCGTTTGACGGCGCTATTCCTCCCCTGACGCTCAGCGGTCGCGGCGTCA
ATCGCGCTGTTCTGCAGGAGATGGCTACCACTCTGCAGCGGCTGGCGCAGGGTGAGCCGGTTGCCCTGCCGCAGGGTGAG
GTGGAGAAGGCGCCCCTGCTGGCGCCGGACGCCTGGCGCAACCCGGCATATCTCCATTTTGCGCTCAAGACCCTGCTGGC
GACCCTAATCTGCTATGTCTTCTATACCGCTGCCGACTGGCAGGGTCTACATACCATTATGCTGAGCTGCGTGATCGTCG
CCCAGCCCGGGCTGGGCGCCACGATGCAAAAGACATGGCTGCGCATCGGCGGGGCGCTGCTCGCCTCCCTGCTGGCGCTG
CTGTTAATCGTCTTTGTCCAGCCCTGGACCGATTCGCTGACGGGCCTGCTGGCGATGTCCCTGCCGGTGCTGGCGCTGGC
GGCGTGGATTGCCGCCGGCTCGGAGCGTATCGCCTACGCCGGGATCCAGATTGGTTTCACCTTTGCGCTGGCCTTTCTCA
GCTGGTTTGCTCCGCTGACGAACCTCACCGAGCTGCGGGATCGGGTGCTGGGCATCCTGCTCGGGGTGCTGGTCTCCTCC
ATTGTTCATTTGTATCTCTGGCCGGACAGCGAAGCGCCGCAGCTGAAAACCCGCCTTGCGGCACTTTATCGCCGGCTGGC
GGACTGCCTCGCCGCCCCGAAGGAGGCGGTTCCGCTGGCTCCCCTGCTTGTCGCCTTCACCGACAGCGAAGCGCTGATCC
ACCGGGTTCGCGCCGAACCGCTGGGCACGTATGCTCACCCCTGGCCCCAGGCGAAAGGCTGGCCGATGCGCGCCACCCTC
GCCCAGGCCGAGGAGATCGCCCGCCTCAGCGAAGGCTACCGACTCAACGCCGCGCCGGGAGACCCGCCCCTGACCCGCTG
CGCCGAACAGCTGCGGCGCTACGCTGAACGTATCGAACAGGAGGCGACGGCGCCTGGCGAACAGCTGACCGCCGACCTGA
CTAACCCCTTTGGCCCGGCGCTGGCCGCCGCGCTGGCCGCCCTGCCCGACTGGGGGCCGACACCGATAGCGACTGAGCAA
CAGGCTAAAACGTCATGA

Upstream 100 bases:

>100_bases
GCGCTTCCCGGTGAAAATCGCCGTCAGCGATCCCGACCCGGAACTGTTCCGCATGGGCGCCTCGGCCAGCGCCGTGCTGC
AGCCGTAGCCGGGCGACGCT

Downstream 100 bases:

>100_bases
TGATCCTTCCTTTCTCCGCGCGCCTGCGCGGCACTCTTTTTACCCTGACGCTGACGCTGCTCAGCGGCTGCGCGCTGATC
CAGGATGAGCCTGCCCAGGT

Product: multidrug efflux system protein MdtO

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 645; Mature: 645

Protein sequence:

>645_residues
MFPLAHFLRQELRDAPGRASYTLRLTLSCAVLITLFMTLQIPFLAVALIVVFYVSQPNVLMIKLVSVVFFVTVTVALGGV
LLIIKWTYDYPLIRLAASVALFFCALYLMRVLGKLGLAFFVVALAVIYAQTFPSMTSQSEILVRLLLWLWVAINTAILVT
LLVNACFQQAFPGNQFKARLAGMLHEVARRLAAPDAEAPPTFGETAAQFNQLQSLFAQASRATPEIAADPQAWRSRLAAT
LRCYQLAALLQADEADSDDRQQLSQAVLQLKNALSEGPFDGAIPPLTLSGRGVNRAVLQEMATTLQRLAQGEPVALPQGE
VEKAPLLAPDAWRNPAYLHFALKTLLATLICYVFYTAADWQGLHTIMLSCVIVAQPGLGATMQKTWLRIGGALLASLLAL
LLIVFVQPWTDSLTGLLAMSLPVLALAAWIAAGSERIAYAGIQIGFTFALAFLSWFAPLTNLTELRDRVLGILLGVLVSS
IVHLYLWPDSEAPQLKTRLAALYRRLADCLAAPKEAVPLAPLLVAFTDSEALIHRVRAEPLGTYAHPWPQAKGWPMRATL
AQAEEIARLSEGYRLNAAPGDPPLTRCAEQLRRYAERIEQEATAPGEQLTADLTNPFGPALAAALAALPDWGPTPIATEQ
QAKTS

Sequences:

>Translated_645_residues
MFPLAHFLRQELRDAPGRASYTLRLTLSCAVLITLFMTLQIPFLAVALIVVFYVSQPNVLMIKLVSVVFFVTVTVALGGV
LLIIKWTYDYPLIRLAASVALFFCALYLMRVLGKLGLAFFVVALAVIYAQTFPSMTSQSEILVRLLLWLWVAINTAILVT
LLVNACFQQAFPGNQFKARLAGMLHEVARRLAAPDAEAPPTFGETAAQFNQLQSLFAQASRATPEIAADPQAWRSRLAAT
LRCYQLAALLQADEADSDDRQQLSQAVLQLKNALSEGPFDGAIPPLTLSGRGVNRAVLQEMATTLQRLAQGEPVALPQGE
VEKAPLLAPDAWRNPAYLHFALKTLLATLICYVFYTAADWQGLHTIMLSCVIVAQPGLGATMQKTWLRIGGALLASLLAL
LLIVFVQPWTDSLTGLLAMSLPVLALAAWIAAGSERIAYAGIQIGFTFALAFLSWFAPLTNLTELRDRVLGILLGVLVSS
IVHLYLWPDSEAPQLKTRLAALYRRLADCLAAPKEAVPLAPLLVAFTDSEALIHRVRAEPLGTYAHPWPQAKGWPMRATL
AQAEEIARLSEGYRLNAAPGDPPLTRCAEQLRRYAERIEQEATAPGEQLTADLTNPFGPALAAALAALPDWGPTPIATEQ
QAKTS
>Mature_645_residues
MFPLAHFLRQELRDAPGRASYTLRLTLSCAVLITLFMTLQIPFLAVALIVVFYVSQPNVLMIKLVSVVFFVTVTVALGGV
LLIIKWTYDYPLIRLAASVALFFCALYLMRVLGKLGLAFFVVALAVIYAQTFPSMTSQSEILVRLLLWLWVAINTAILVT
LLVNACFQQAFPGNQFKARLAGMLHEVARRLAAPDAEAPPTFGETAAQFNQLQSLFAQASRATPEIAADPQAWRSRLAAT
LRCYQLAALLQADEADSDDRQQLSQAVLQLKNALSEGPFDGAIPPLTLSGRGVNRAVLQEMATTLQRLAQGEPVALPQGE
VEKAPLLAPDAWRNPAYLHFALKTLLATLICYVFYTAADWQGLHTIMLSCVIVAQPGLGATMQKTWLRIGGALLASLLAL
LLIVFVQPWTDSLTGLLAMSLPVLALAAWIAAGSERIAYAGIQIGFTFALAFLSWFAPLTNLTELRDRVLGILLGVLVSS
IVHLYLWPDSEAPQLKTRLAALYRRLADCLAAPKEAVPLAPLLVAFTDSEALIHRVRAEPLGTYAHPWPQAKGWPMRATL
AQAEEIARLSEGYRLNAAPGDPPLTRCAEQLRRYAERIEQEATAPGEQLTADLTNPFGPALAAALAALPDWGPTPIATEQ
QAKTS

Specific function: Could be involved in resistance to puromycin, acriflavine and tetraphenylarsonium chloride [H]

COG id: COG1289

COG function: function code S; Predicted membrane protein

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MdtO family [H]

Homologues:

Organism=Escherichia coli, GI87082367, Length=558, Percent_Identity=36.7383512544803, Blast_Score=304, Evalue=1e-83,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006726 [H]

Pfam domain/function: PF04632 FUSC [H]

EC number: NA

Molecular weight: Translated: 70206; Mature: 70206

Theoretical pI: Translated: 7.74; Mature: 7.74

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFPLAHFLRQELRDAPGRASYTLRLTLSCAVLITLFMTLQIPFLAVALIVVFYVSQPNVL
CCCHHHHHHHHHHCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHH
MIKLVSVVFFVTVTVALGGVLLIIKWTYDYPLIRLAASVALFFCALYLMRVLGKLGLAFF
HHHHHHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VVALAVIYAQTFPSMTSQSEILVRLLLWLWVAINTAILVTLLVNACFQQAFPGNQFKARL
HHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHH
AGMLHEVARRLAAPDAEAPPTFGETAAQFNQLQSLFAQASRATPEIAADPQAWRSRLAAT
HHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHH
LRCYQLAALLQADEADSDDRQQLSQAVLQLKNALSEGPFDGAIPPLTLSGRGVNRAVLQE
HHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEECCCCCCHHHHHH
MATTLQRLAQGEPVALPQGEVEKAPLLAPDAWRNPAYLHFALKTLLATLICYVFYTAADW
HHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCC
QGLHTIMLSCVIVAQPGLGATMQKTWLRIGGALLASLLALLLIVFVQPWTDSLTGLLAMS
CHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHH
LPVLALAAWIAAGSERIAYAGIQIGFTFALAFLSWFAPLTNLTELRDRVLGILLGVLVSS
HHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IVHLYLWPDSEAPQLKTRLAALYRRLADCLAAPKEAVPLAPLLVAFTDSEALIHRVRAEP
HHHEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHEECCCHHHHHHHHHCC
LGTYAHPWPQAKGWPMRATLAQAEEIARLSEGYRLNAAPGDPPLTRCAEQLRRYAERIEQ
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCEECCCCCCCHHHHHHHHHHHHHHHHHH
EATAPGEQLTADLTNPFGPALAAALAALPDWGPTPIATEQQAKTS
HCCCCHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MFPLAHFLRQELRDAPGRASYTLRLTLSCAVLITLFMTLQIPFLAVALIVVFYVSQPNVL
CCCHHHHHHHHHHCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHH
MIKLVSVVFFVTVTVALGGVLLIIKWTYDYPLIRLAASVALFFCALYLMRVLGKLGLAFF
HHHHHHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VVALAVIYAQTFPSMTSQSEILVRLLLWLWVAINTAILVTLLVNACFQQAFPGNQFKARL
HHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHH
AGMLHEVARRLAAPDAEAPPTFGETAAQFNQLQSLFAQASRATPEIAADPQAWRSRLAAT
HHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHH
LRCYQLAALLQADEADSDDRQQLSQAVLQLKNALSEGPFDGAIPPLTLSGRGVNRAVLQE
HHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEECCCCCCHHHHHH
MATTLQRLAQGEPVALPQGEVEKAPLLAPDAWRNPAYLHFALKTLLATLICYVFYTAADW
HHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCC
QGLHTIMLSCVIVAQPGLGATMQKTWLRIGGALLASLLALLLIVFVQPWTDSLTGLLAMS
CHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHH
LPVLALAAWIAAGSERIAYAGIQIGFTFALAFLSWFAPLTNLTELRDRVLGILLGVLVSS
HHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IVHLYLWPDSEAPQLKTRLAALYRRLADCLAAPKEAVPLAPLLVAFTDSEALIHRVRAEP
HHHEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHEECCCHHHHHHHHHCC
LGTYAHPWPQAKGWPMRATLAQAEEIARLSEGYRLNAAPGDPPLTRCAEQLRRYAERIEQ
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCEECCCCCCCHHHHHHHHHHHHHHHHHH
EATAPGEQLTADLTNPFGPALAAALAALPDWGPTPIATEQQAKTS
HCCCCHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]