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The map label for this gene is aas [H]

Identifier: 238896353

GI number: 238896353

Start: 4332621

End: 4334780

Strand: Reverse

Name: aas [H]

Synonym: KP1_4517

Alternate gene names: 238896353

Gene position: 4334780-4332621 (Counterclockwise)

Preceding gene: 238896354

Following gene: 238896352

Centisome position: 82.59

GC content: 60.69

Gene sequence:

>2160_bases
ATGCTTTTGGGATTTTTCAGACTGCTGTTCAAGGGGTTATACCGGGTCAGACTGACCGGCGACACGCAGGCTTTATACCA
GCAAAAGGTCTTAATCACCCCGAACCACGTCTCTTTCCTCGACGGCATTCTGCTGGCGCTGTTTTTGCCGGTCCGACCGG
TTTTTGCGGTCTATACCTCAATCAGCCAGCGCTGGTTTATGCGCGCGCTGACGCCGATTATCGATTTTGTGCCGCTGGAC
CCGACCAAGCCGATGTCGATCAAACATCTGGTGCGCCTGATTGAGCAGGGGCGGCCGGTGGTTATTTTCCCGGAAGGGCG
AATTTCGGTCAGCGGCTCGCTGATGAAAATTTATGACGGCGCCGCCTTTGTCGCCGCCAAATCGCAGGCGACCATTGTGC
CGCTGCGTATTGAAGGCGCCGAACTGACGCCCTTCAGCCGGTTGAAGGGGCTGGTGAAACGTCGCCTGTTCCCGCGTATT
CAGCTGCATCTCCTGCCGCCCACCCATCTGCCGATGCCCGAGGCGCCGCGCGCCCGCGACCGGCGCAAAATCGCCGGGGA
GATGCTGCATCAGATCATGATGGAAGCCCGGATGGCGGTGCGCCCGCGGGAAACCCTGTATGAGTCGCTGCTGGCGGCGC
AGGACCGCTTCGGCGCGCGCAAACCCTGCGTGGAGGATATCAACTTCCAGCCGGATACCTATCGCAAGCTGCTGACCAAA
ACCCTGTTTGTCGCCCGCATTCTGGAAAAATACAGCCAGCCGGGCGAGAAGATCGGCCTGATGCTGCCTAACGCCGGCAT
CAGCGCGGCGGTGATTTTCGGCGCTATCGCCCGCGGGCGTATTCCGGCGATGATGAACTATACCGCCGGGGTGAAAGGGC
TCAGCAGCGCGATAGCCGCCGCGGAGCTCAACACCATTTTCACCTCGCGCACCTTCCTCGATAAAGGCAAACTCTGGCAC
CTGCCGGAGCAACTGACCCAGGTGCGCTGGGTATTCCTGGAAGATCTTAAAGGCGATATCACCCTCGCTGACAAACTGTG
GATTTTTGCTCATCTGCTGGCGCCGCGTCTGGCGCAGGTTAAGCAGCAGCCGGAAGACGCGGCGATGATCCTCTTCACCT
CCGGTTCAGAGGGCAATCCGAAAGGGGTGGTGCACAGCCATAAGAGTCTGCTGTCCAACGTCGAGCAGATCAAAACTATC
GCCGACTTTACCGCCAATGACCGCTTTATGTCGGCGCTGCCGCTGTTCCACTCTTTTGGCCTCACCGTCGGCCTGCTGAC
GCCGCTGCTTACCGGGGCGGAAGTGTTTCTCTATCCCAGCCCGCTGCACTATCGCGTGGTGCCGGAGCTGGTCTACGATC
GCAACTGTACGGTGCTGTTCGGCACTTCGACCTTCCTCGCCAACTATGCCCGTTTCGCCAATCCGTACGATTTCTACCGC
CTGCGCTACGTGGTCGCCGGGGCGGAGAAGCTGCAGGAGAGCACCAAACAGCTGTGGCAGGATAAATTCGGCCTGCGCAT
TCTCGAAGGCTATGGCGTGACCGAGTGCGCGCCGGTGGTCTCGATTAACGTGCCGATGGCGGCGAAGGTCGGCACCGTGG
GCCGCATCCTGCCGGGGATGGACGCCCGCCTGCTGGCGATGCCAGGCATTGAGCAAGGGGGGCGGCTGCAGCTGAAAGGG
CCGAACATCATGAAAGGCTACCTGCGGGTGGAAAACCCCGGCGTGCTGGAAGCGCCTGCGGCGGAAAACCAGCACGGCGA
GATGGAAGCGGGCTGGTATGACACCGGGGATATCGTTACCTTCGACGAGCAGGGCTATGTCCGCATTCAGGGCCGCGCGA
AGCGCTTCGCCAAAATCGCCGGCGAGATGATCTCCCTCGAGATGGTGGAGCAGGTGGCCCTCGGCGCGTCGCCGGACAAA
ATGCACGCCACGGCGATTAAACAGGACGCCAGCAAAGGCGAGGCGCTGGTGCTGTTTACCACCGATAATGAACTGACTCG
TGAAGCCCTGCTGCGCTACGCTCGCCAGCACGGCGTACCGGAGCTGGCGGTGCCGCGAGATATACGCTGGCTGAAACAGC
TACCGGTGCTCGGCAGCGGCAAGCCAGACTATGTCACCCTGAAAAATATGGTCGACGAGGCGGAAACAACCCATGAGTGA

Upstream 100 bases:

>100_bases
CGCAGGTTTTTTTTATTCCGAAAATCCCCCCGCTGCACTGCTTTCCCATGCCTTCTCGTGTAACCTGCTTTGACTCATCA
ACCGGTCACATGGAGTTGTT

Downstream 100 bases:

>100_bases
GTCAGTACATGCTAACCCTTCGCTGTACTCGAAAGGGATGGTGGCGGTGATCTGCGCCCAGTTCCTGTCGGCCTTCGGCG
ACAATGCGCTTCTTTTCGCC

Product: bifunctional acyl-[acyl carrier protein] synthetase/2-acylglycerophosphoethanolamine acyltransferase

Products: NA

Alternate protein names: 2-acylglycerophosphoethanolamine acyltransferase; 2-acyl-GPE acyltransferase; Acyl-[acyl-carrier-protein]--phospholipid O-acyltransferase; Acyl-[acyl-carrier-protein] synthetase; Acyl-ACP synthetase; Long-chain-fatty-acid--[acyl-carrier-protein] ligase [H]

Number of amino acids: Translated: 719; Mature: 719

Protein sequence:

>719_residues
MLLGFFRLLFKGLYRVRLTGDTQALYQQKVLITPNHVSFLDGILLALFLPVRPVFAVYTSISQRWFMRALTPIIDFVPLD
PTKPMSIKHLVRLIEQGRPVVIFPEGRISVSGSLMKIYDGAAFVAAKSQATIVPLRIEGAELTPFSRLKGLVKRRLFPRI
QLHLLPPTHLPMPEAPRARDRRKIAGEMLHQIMMEARMAVRPRETLYESLLAAQDRFGARKPCVEDINFQPDTYRKLLTK
TLFVARILEKYSQPGEKIGLMLPNAGISAAVIFGAIARGRIPAMMNYTAGVKGLSSAIAAAELNTIFTSRTFLDKGKLWH
LPEQLTQVRWVFLEDLKGDITLADKLWIFAHLLAPRLAQVKQQPEDAAMILFTSGSEGNPKGVVHSHKSLLSNVEQIKTI
ADFTANDRFMSALPLFHSFGLTVGLLTPLLTGAEVFLYPSPLHYRVVPELVYDRNCTVLFGTSTFLANYARFANPYDFYR
LRYVVAGAEKLQESTKQLWQDKFGLRILEGYGVTECAPVVSINVPMAAKVGTVGRILPGMDARLLAMPGIEQGGRLQLKG
PNIMKGYLRVENPGVLEAPAAENQHGEMEAGWYDTGDIVTFDEQGYVRIQGRAKRFAKIAGEMISLEMVEQVALGASPDK
MHATAIKQDASKGEALVLFTTDNELTREALLRYARQHGVPELAVPRDIRWLKQLPVLGSGKPDYVTLKNMVDEAETTHE

Sequences:

>Translated_719_residues
MLLGFFRLLFKGLYRVRLTGDTQALYQQKVLITPNHVSFLDGILLALFLPVRPVFAVYTSISQRWFMRALTPIIDFVPLD
PTKPMSIKHLVRLIEQGRPVVIFPEGRISVSGSLMKIYDGAAFVAAKSQATIVPLRIEGAELTPFSRLKGLVKRRLFPRI
QLHLLPPTHLPMPEAPRARDRRKIAGEMLHQIMMEARMAVRPRETLYESLLAAQDRFGARKPCVEDINFQPDTYRKLLTK
TLFVARILEKYSQPGEKIGLMLPNAGISAAVIFGAIARGRIPAMMNYTAGVKGLSSAIAAAELNTIFTSRTFLDKGKLWH
LPEQLTQVRWVFLEDLKGDITLADKLWIFAHLLAPRLAQVKQQPEDAAMILFTSGSEGNPKGVVHSHKSLLSNVEQIKTI
ADFTANDRFMSALPLFHSFGLTVGLLTPLLTGAEVFLYPSPLHYRVVPELVYDRNCTVLFGTSTFLANYARFANPYDFYR
LRYVVAGAEKLQESTKQLWQDKFGLRILEGYGVTECAPVVSINVPMAAKVGTVGRILPGMDARLLAMPGIEQGGRLQLKG
PNIMKGYLRVENPGVLEAPAAENQHGEMEAGWYDTGDIVTFDEQGYVRIQGRAKRFAKIAGEMISLEMVEQVALGASPDK
MHATAIKQDASKGEALVLFTTDNELTREALLRYARQHGVPELAVPRDIRWLKQLPVLGSGKPDYVTLKNMVDEAETTHE
>Mature_719_residues
MLLGFFRLLFKGLYRVRLTGDTQALYQQKVLITPNHVSFLDGILLALFLPVRPVFAVYTSISQRWFMRALTPIIDFVPLD
PTKPMSIKHLVRLIEQGRPVVIFPEGRISVSGSLMKIYDGAAFVAAKSQATIVPLRIEGAELTPFSRLKGLVKRRLFPRI
QLHLLPPTHLPMPEAPRARDRRKIAGEMLHQIMMEARMAVRPRETLYESLLAAQDRFGARKPCVEDINFQPDTYRKLLTK
TLFVARILEKYSQPGEKIGLMLPNAGISAAVIFGAIARGRIPAMMNYTAGVKGLSSAIAAAELNTIFTSRTFLDKGKLWH
LPEQLTQVRWVFLEDLKGDITLADKLWIFAHLLAPRLAQVKQQPEDAAMILFTSGSEGNPKGVVHSHKSLLSNVEQIKTI
ADFTANDRFMSALPLFHSFGLTVGLLTPLLTGAEVFLYPSPLHYRVVPELVYDRNCTVLFGTSTFLANYARFANPYDFYR
LRYVVAGAEKLQESTKQLWQDKFGLRILEGYGVTECAPVVSINVPMAAKVGTVGRILPGMDARLLAMPGIEQGGRLQLKG
PNIMKGYLRVENPGVLEAPAAENQHGEMEAGWYDTGDIVTFDEQGYVRIQGRAKRFAKIAGEMISLEMVEQVALGASPDK
MHATAIKQDASKGEALVLFTTDNELTREALLRYARQHGVPELAVPRDIRWLKQLPVLGSGKPDYVTLKNMVDEAETTHE

Specific function: Plays a role in lysophospholipid acylation. Transfers fatty acids to the 1-position via an enzyme-bound acyl-ACP intermediate in the presence of ATP and magnesium. Its physiological function is to regenerate phosphatidylethanolamine from 2-acyl-glycero-3-

COG id: COG0318

COG function: function code IQ; Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the ATP- dependent AMP-binding enzyme family [H]

Homologues:

Organism=Homo sapiens, GI187761345, Length=387, Percent_Identity=26.8733850129199, Blast_Score=100, Evalue=7e-21,
Organism=Homo sapiens, GI187761343, Length=387, Percent_Identity=26.8733850129199, Blast_Score=100, Evalue=7e-21,
Organism=Homo sapiens, GI156151445, Length=367, Percent_Identity=25.8855585831063, Blast_Score=100, Evalue=9e-21,
Organism=Homo sapiens, GI42544132, Length=361, Percent_Identity=24.9307479224377, Blast_Score=78, Evalue=3e-14,
Organism=Escherichia coli, GI1789201, Length=719, Percent_Identity=84.9791376912378, Blast_Score=1270, Evalue=0.0,
Organism=Escherichia coli, GI1788107, Length=524, Percent_Identity=27.6717557251908, Blast_Score=148, Evalue=1e-36,
Organism=Escherichia coli, GI145693145, Length=360, Percent_Identity=29.7222222222222, Blast_Score=127, Evalue=3e-30,
Organism=Escherichia coli, GI1786810, Length=500, Percent_Identity=22.2, Blast_Score=87, Evalue=4e-18,
Organism=Escherichia coli, GI1786801, Length=318, Percent_Identity=27.0440251572327, Blast_Score=67, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI17558820, Length=354, Percent_Identity=29.0960451977401, Blast_Score=129, Evalue=6e-30,
Organism=Caenorhabditis elegans, GI32563687, Length=288, Percent_Identity=29.5138888888889, Blast_Score=114, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI71994703, Length=371, Percent_Identity=25.6064690026954, Blast_Score=104, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI71994694, Length=371, Percent_Identity=25.6064690026954, Blast_Score=104, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI71994690, Length=371, Percent_Identity=25.6064690026954, Blast_Score=103, Evalue=3e-22,
Organism=Caenorhabditis elegans, GI17510401, Length=333, Percent_Identity=25.2252252252252, Blast_Score=90, Evalue=4e-18,
Organism=Caenorhabditis elegans, GI17531443, Length=383, Percent_Identity=25.8485639686684, Blast_Score=86, Evalue=8e-17,
Organism=Caenorhabditis elegans, GI17560308, Length=320, Percent_Identity=24.0625, Blast_Score=85, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI71985884, Length=369, Percent_Identity=24.6612466124661, Blast_Score=82, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17559526, Length=364, Percent_Identity=24.4505494505494, Blast_Score=79, Evalue=7e-15,
Organism=Caenorhabditis elegans, GI17538037, Length=410, Percent_Identity=22.6829268292683, Blast_Score=70, Evalue=4e-12,
Organism=Saccharomyces cerevisiae, GI6319699, Length=361, Percent_Identity=26.0387811634349, Blast_Score=102, Evalue=2e-22,
Organism=Saccharomyces cerevisiae, GI6320852, Length=346, Percent_Identity=24.2774566473988, Blast_Score=81, Evalue=7e-16,
Organism=Drosophila melanogaster, GI21355181, Length=538, Percent_Identity=24.1635687732342, Blast_Score=103, Evalue=4e-22,
Organism=Drosophila melanogaster, GI24581924, Length=541, Percent_Identity=23.8447319778189, Blast_Score=97, Evalue=3e-20,
Organism=Drosophila melanogaster, GI18859661, Length=298, Percent_Identity=26.1744966442953, Blast_Score=92, Evalue=9e-19,
Organism=Drosophila melanogaster, GI19922652, Length=301, Percent_Identity=27.2425249169435, Blast_Score=84, Evalue=3e-16,
Organism=Drosophila melanogaster, GI24648260, Length=369, Percent_Identity=25.4742547425474, Blast_Score=72, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002123
- InterPro:   IPR020845
- InterPro:   IPR000873 [H]

Pfam domain/function: PF01553 Acyltransferase; PF00501 AMP-binding [H]

EC number: =2.3.1.40; =6.2.1.20 [H]

Molecular weight: Translated: 80229; Mature: 80229

Theoretical pI: Translated: 9.89; Mature: 9.89

Prosite motif: PS00455 AMP_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLLGFFRLLFKGLYRVRLTGDTQALYQQKVLITPNHVSFLDGILLALFLPVRPVFAVYTS
CHHHHHHHHHHHHEEEEECCCHHHHHHCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHH
ISQRWFMRALTPIIDFVPLDPTKPMSIKHLVRLIEQGRPVVIFPEGRISVSGSLMKIYDG
HHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCCCEEEECCCCEEECCCEEEEECC
AAFVAAKSQATIVPLRIEGAELTPFSRLKGLVKRRLFPRIQLHLLPPTHLPMPEAPRARD
EEEEEECCCCEEEEEEECCCCCCHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCHHH
RRKIAGEMLHQIMMEARMAVRPRETLYESLLAAQDRFGARKPCVEDINFQPDTYRKLLTK
HHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCHHCCCCCCHHHHHHHHH
TLFVARILEKYSQPGEKIGLMLPNAGISAAVIFGAIARGRIPAMMNYTAGVKGLSSAIAA
HHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHH
AELNTIFTSRTFLDKGKLWHLPEQLTQVRWVFLEDLKGDITLADKLWIFAHLLAPRLAQV
HHHHHHHHHHHHHCCCCEECCHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHH
KQQPEDAAMILFTSGSEGNPKGVVHSHKSLLSNVEQIKTIADFTANDRFMSALPLFHSFG
HCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHH
LTVGLLTPLLTGAEVFLYPSPLHYRVVPELVYDRNCTVLFGTSTFLANYARFANPYDFYR
HHHHHHHHHHCCCEEEEECCCCCEEECHHHHHCCCCEEEEECHHHHHHHHHHCCCHHHHH
LRYVVAGAEKLQESTKQLWQDKFGLRILEGYGVTECAPVVSINVPMAAKVGTVGRILPGM
HHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCCCEEEECCCCHHCCCCHHHHCCCC
DARLLAMPGIEQGGRLQLKGPNIMKGYLRVENPGVLEAPAAENQHGEMEAGWYDTGDIVT
CCEEEECCCCCCCCEEEECCCCEEEEEEEECCCCCEECCCCCCCCCCCCCCEECCCCEEE
FDEQGYVRIQGRAKRFAKIAGEMISLEMVEQVALGASPDKMHATAIKQDASKGEALVLFT
ECCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCEEEEEE
TDNELTREALLRYARQHGVPELAVPRDIRWLKQLPVLGSGKPDYVTLKNMVDEAETTHE
CCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCCCCCCCEEEHHHHHHHHHHCCC
>Mature Secondary Structure
MLLGFFRLLFKGLYRVRLTGDTQALYQQKVLITPNHVSFLDGILLALFLPVRPVFAVYTS
CHHHHHHHHHHHHEEEEECCCHHHHHHCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHH
ISQRWFMRALTPIIDFVPLDPTKPMSIKHLVRLIEQGRPVVIFPEGRISVSGSLMKIYDG
HHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCCCEEEECCCCEEECCCEEEEECC
AAFVAAKSQATIVPLRIEGAELTPFSRLKGLVKRRLFPRIQLHLLPPTHLPMPEAPRARD
EEEEEECCCCEEEEEEECCCCCCHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCHHH
RRKIAGEMLHQIMMEARMAVRPRETLYESLLAAQDRFGARKPCVEDINFQPDTYRKLLTK
HHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCHHCCCCCCHHHHHHHHH
TLFVARILEKYSQPGEKIGLMLPNAGISAAVIFGAIARGRIPAMMNYTAGVKGLSSAIAA
HHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHH
AELNTIFTSRTFLDKGKLWHLPEQLTQVRWVFLEDLKGDITLADKLWIFAHLLAPRLAQV
HHHHHHHHHHHHHCCCCEECCHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHH
KQQPEDAAMILFTSGSEGNPKGVVHSHKSLLSNVEQIKTIADFTANDRFMSALPLFHSFG
HCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHH
LTVGLLTPLLTGAEVFLYPSPLHYRVVPELVYDRNCTVLFGTSTFLANYARFANPYDFYR
HHHHHHHHHHCCCEEEEECCCCCEEECHHHHHCCCCEEEEECHHHHHHHHHHCCCHHHHH
LRYVVAGAEKLQESTKQLWQDKFGLRILEGYGVTECAPVVSINVPMAAKVGTVGRILPGM
HHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCCCEEEECCCCHHCCCCHHHHCCCC
DARLLAMPGIEQGGRLQLKGPNIMKGYLRVENPGVLEAPAAENQHGEMEAGWYDTGDIVT
CCEEEECCCCCCCCEEEECCCCEEEEEEEECCCCCEECCCCCCCCCCCCCCEECCCCEEE
FDEQGYVRIQGRAKRFAKIAGEMISLEMVEQVALGASPDKMHATAIKQDASKGEALVLFT
ECCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCEEEEEE
TDNELTREALLRYARQHGVPELAVPRDIRWLKQLPVLGSGKPDYVTLKNMVDEAETTHE
CCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCCCCCCCEEEHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA