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The map label for this gene is hypC [H]

Identifier: 238896185

GI number: 238896185

Start: 4155830

End: 4156102

Strand: Direct

Name: hypC [H]

Synonym: KP1_4333

Alternate gene names: 238896185

Gene position: 4155830-4156102 (Clockwise)

Preceding gene: 238896184

Following gene: 238896186

Centisome position: 79.18

GC content: 62.27

Gene sequence:

>273_bases
ATGTGCATAGGCATTCCGGGACAAATTTGCGCCATCGACGGCGTGCTGGCGAAGGTGGAAGTTTGCGGTATTCAGCGCGA
CGTCGACCTGACGCTGGTCGGCGCCGTTGATGAGCAGGGCCAGCCGCGGCTCGGCCAGTGGGTGCTGGTGCACGTCGGCT
TCGCCATGAGCGTCATTAATGAATCCGAAGCCCGCGACACCCTCGAGGCGCTGCAAAATATGTTTGACGTGGAGCCGGAC
GTCGGCGCGCTGCTGTACGGCGAGGAGCGATAA

Upstream 100 bases:

>100_bases
CCTGCGCCCGCGAGGTCAATCCGCATATTGAAATTATTCTTGTCTCCGCCACCAGCGGCGAAGGCATGGAGCAATGGCTC
ACCTGGCTGGAGACGCAGCG

Downstream 100 bases:

>100_bases
TGCGTTACGTAGATGAATACCGCGCCCCCGAACAGGTGATGCAGCTGGTGGCCCATCTTCAGCAGCGTGCTCGTCTGCTG
CCGCACACCGCCGCGCGACC

Product: hydrogenase assembly chaperone

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 90; Mature: 90

Protein sequence:

>90_residues
MCIGIPGQICAIDGVLAKVEVCGIQRDVDLTLVGAVDEQGQPRLGQWVLVHVGFAMSVINESEARDTLEALQNMFDVEPD
VGALLYGEER

Sequences:

>Translated_90_residues
MCIGIPGQICAIDGVLAKVEVCGIQRDVDLTLVGAVDEQGQPRLGQWVLVHVGFAMSVINESEARDTLEALQNMFDVEPD
VGALLYGEER
>Mature_90_residues
MCIGIPGQICAIDGVLAKVEVCGIQRDVDLTLVGAVDEQGQPRLGQWVLVHVGFAMSVINESEARDTLEALQNMFDVEPD
VGALLYGEER

Specific function: Is required for the formation of all three hydrogenase isoenzymes. May bind to the precursor form of the large subunit of dehydrogenases to keep them in a conformation accessible for metal incorporation [H]

COG id: COG0298

COG function: function code O; Hydrogenase maturation factor

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the hupF/hypC family [H]

Homologues:

Organism=Escherichia coli, GI1789083, Length=90, Percent_Identity=85.5555555555556, Blast_Score=159, Evalue=3e-41,
Organism=Escherichia coli, GI1789364, Length=83, Percent_Identity=55.421686746988, Blast_Score=83, Evalue=3e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR019812
- InterPro:   IPR001109 [H]

Pfam domain/function: PF01455 HupF_HypC [H]

EC number: NA

Molecular weight: Translated: 9713; Mature: 9713

Theoretical pI: Translated: 3.87; Mature: 3.87

Prosite motif: PS01097 HUPF_HYPC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.3 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
6.7 %Cys+Met (Translated Protein)
3.3 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
6.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MCIGIPGQICAIDGVLAKVEVCGIQRDVDLTLVGAVDEQGQPRLGQWVLVHVGFAMSVIN
CEECCCCCEEEHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCCCCCEEEEHHHHHHHHHC
ESEARDTLEALQNMFDVEPDVGALLYGEER
CHHHHHHHHHHHHHHCCCCCCCEEEEECCC
>Mature Secondary Structure
MCIGIPGQICAIDGVLAKVEVCGIQRDVDLTLVGAVDEQGQPRLGQWVLVHVGFAMSVIN
CEECCCCCEEEHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCCCCCEEEEHHHHHHHHHC
ESEARDTLEALQNMFDVEPDVGALLYGEER
CHHHHHHHHHHHHHHCCCCCCCEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]