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The map label for this gene is tyrA [H]

Identifier: 238896045

GI number: 238896045

Start: 4014194

End: 4015315

Strand: Reverse

Name: tyrA [H]

Synonym: KP1_4177

Alternate gene names: 238896045

Gene position: 4015315-4014194 (Counterclockwise)

Preceding gene: 238896046

Following gene: 238896044

Centisome position: 76.5

GC content: 59.89

Gene sequence:

>1122_bases
ATGGTTGCTGAACTGACCGCGTTACGCGATCAAATTGATGAAGTGGATAAAGCGTTGCTTAGCCTGCTGGCTAAGCGTCT
GGAGCTGGTGGCCGAAGTCGGCGAGGTGAAGAGCCAGTATGGCCTGCCGATTTACGTCCCGGAGCGCGAGTCGGCGATGC
TCGCCTCCCGACGTGAAGAGGCGGCTGCGCTCGGCGTACCACCGGATCTGATCGAGGACGTTCTGCGTCGCGTGATGCGG
GAATCCTATTCCAGCGAAAACGACAAAGGCTTCAAAACCCTGCAGCCGAATCTGCGGCCGGTGGTCATCGTCGGCGGCGG
TGGGCAGATGGGCCGTCTGTTTGAGAAGATGTTAACGCTGTCCGGCTACCAGGTGCGTATTCTGGAAAAAGAGGATTGGG
CCCGGGCGGCGGATATCGTCGCCGATGCCGGCATGGTTATCGTCAGCGTACCGATTCACACCACCGTGGAGACGATCGCC
AGGCTGCCGCCCCTTCCGGCGGATTGCATTCTGGTTGACCTTGCCTCGGTGAAAGCGGAGCCGCTGCAGGCGATGCTGGC
GGCGCATCAGGGCCCGGTTCTTGGCCTGCACCCGATGTTCGGTCCGGACAGCGGCAGCCTGGCGAAGCAGGTGGTGGTCT
ATTGTGATGGCCGCCAGCCGGAGGCCTATCAGTGGTTCCTCGAACAAATTCAGGTCTGGGGCGCGCGGCTGCACCGCATC
AGCGCCGTTGAGCACGATCAGAACATGGCCTTTATTCAGGCGCTGCGCCACTTTGCCACCTTCGCCTATGGCCTGCACCT
GGCGGAAGAGAATGTACGTCTTGAGCAACTGCTGGCGCTCTCGTCGCCCATTTACCGACTGGAGCTGGCGATGGTAGGCC
GTCTGTTTGCCCAGGATCCGCAGCTGTACGCCGATATTATTATGTCATCGGAAAACAACCTGGCGCTGATTAAGCGCTAC
TACCAGCGTTTCGGAGAAGCGATCGGCCTGCTGGAGCAGGGCGATAAGCAGGCGTTTATCGACAGCTTCCGTAAAGTCGA
ACACTGGTTTGGCGATTACGCTCAGCGTTTCCAGAGCGAGAGCCGCACGCTGCTGCGTCAGGCGAACGATAATCGGCAGT
AA

Upstream 100 bases:

>100_bases
GGATGCCTGCATCAGCTGGGAGACTACCGAGGCGCTGCTGCGTGAACTGGATAAGGATCTCCGCGGCCACTTGGCGGCCC
GTTTGGTTTAAGAGGAAAGT

Downstream 100 bases:

>100_bases
AGCGAAAAAGATGTATACAATAAAGCCAGCGACCCGCTGGCTTTTTTTATAGGGATGACAACGATGGCTGAACCACAACC
GCTGTTTGACTACACCGGAT

Product: bifunctional chorismate mutase/prephenate dehydrogenase

Products: NA

Alternate protein names: Chorismate mutase; CM; Prephenate dehydrogenase; PDH [H]

Number of amino acids: Translated: 373; Mature: 373

Protein sequence:

>373_residues
MVAELTALRDQIDEVDKALLSLLAKRLELVAEVGEVKSQYGLPIYVPERESAMLASRREEAAALGVPPDLIEDVLRRVMR
ESYSSENDKGFKTLQPNLRPVVIVGGGGQMGRLFEKMLTLSGYQVRILEKEDWARAADIVADAGMVIVSVPIHTTVETIA
RLPPLPADCILVDLASVKAEPLQAMLAAHQGPVLGLHPMFGPDSGSLAKQVVVYCDGRQPEAYQWFLEQIQVWGARLHRI
SAVEHDQNMAFIQALRHFATFAYGLHLAEENVRLEQLLALSSPIYRLELAMVGRLFAQDPQLYADIIMSSENNLALIKRY
YQRFGEAIGLLEQGDKQAFIDSFRKVEHWFGDYAQRFQSESRTLLRQANDNRQ

Sequences:

>Translated_373_residues
MVAELTALRDQIDEVDKALLSLLAKRLELVAEVGEVKSQYGLPIYVPERESAMLASRREEAAALGVPPDLIEDVLRRVMR
ESYSSENDKGFKTLQPNLRPVVIVGGGGQMGRLFEKMLTLSGYQVRILEKEDWARAADIVADAGMVIVSVPIHTTVETIA
RLPPLPADCILVDLASVKAEPLQAMLAAHQGPVLGLHPMFGPDSGSLAKQVVVYCDGRQPEAYQWFLEQIQVWGARLHRI
SAVEHDQNMAFIQALRHFATFAYGLHLAEENVRLEQLLALSSPIYRLELAMVGRLFAQDPQLYADIIMSSENNLALIKRY
YQRFGEAIGLLEQGDKQAFIDSFRKVEHWFGDYAQRFQSESRTLLRQANDNRQ
>Mature_373_residues
MVAELTALRDQIDEVDKALLSLLAKRLELVAEVGEVKSQYGLPIYVPERESAMLASRREEAAALGVPPDLIEDVLRRVMR
ESYSSENDKGFKTLQPNLRPVVIVGGGGQMGRLFEKMLTLSGYQVRILEKEDWARAADIVADAGMVIVSVPIHTTVETIA
RLPPLPADCILVDLASVKAEPLQAMLAAHQGPVLGLHPMFGPDSGSLAKQVVVYCDGRQPEAYQWFLEQIQVWGARLHRI
SAVEHDQNMAFIQALRHFATFAYGLHLAEENVRLEQLLALSSPIYRLELAMVGRLFAQDPQLYADIIMSSENNLALIKRY
YQRFGEAIGLLEQGDKQAFIDSFRKVEHWFGDYAQRFQSESRTLLRQANDNRQ

Specific function: Tyrosine biosynthesis [C]

COG id: COG0287

COG function: function code E; Prephenate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 prephenate/arogenate dehydrogenase domain [H]

Homologues:

Organism=Escherichia coli, GI1788952, Length=373, Percent_Identity=91.9571045576407, Blast_Score=701, Evalue=0.0,

Paralogues:

None

Copy number: 500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR008244
- InterPro:   IPR002701
- InterPro:   IPR020822
- InterPro:   IPR011277
- InterPro:   IPR016040
- InterPro:   IPR003099 [H]

Pfam domain/function: PF01817 CM_2; PF02153 PDH [H]

EC number: =5.4.99.5; =1.3.1.12 [H]

Molecular weight: Translated: 41871; Mature: 41871

Theoretical pI: Translated: 5.30; Mature: 5.30

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVAELTALRDQIDEVDKALLSLLAKRLELVAEVGEVKSQYGLPIYVPERESAMLASRREE
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCHHHHHHHHHHH
AAALGVPPDLIEDVLRRVMRESYSSENDKGFKTLQPNLRPVVIVGGGGQMGRLFEKMLTL
HHHCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHC
SGYQVRILEKEDWARAADIVADAGMVIVSVPIHTTVETIARLPPLPADCILVDLASVKAE
CCCEEEEECCHHHHHHHHHHHCCCEEEEEECHHHHHHHHHHCCCCCHHHHHHHHHHHHHH
PLQAMLAAHQGPVLGLHPMFGPDSGSLAKQVVVYCDGRQPEAYQWFLEQIQVWGARLHRI
HHHHHHHHCCCCEEEECCCCCCCCCHHHHEEEEEECCCCCHHHHHHHHHHHHHHHHHHHH
SAVEHDQNMAFIQALRHFATFAYGLHLAEENVRLEQLLALSSPIYRLELAMVGRLFAQDP
HHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCHHHHHHHHHHHHHHCCH
QLYADIIMSSENNLALIKRYYQRFGEAIGLLEQGDKQAFIDSFRKVEHWFGDYAQRFQSE
HHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHH
SRTLLRQANDNRQ
HHHHHHHCCCCCC
>Mature Secondary Structure
MVAELTALRDQIDEVDKALLSLLAKRLELVAEVGEVKSQYGLPIYVPERESAMLASRREE
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCHHHHHHHHHHH
AAALGVPPDLIEDVLRRVMRESYSSENDKGFKTLQPNLRPVVIVGGGGQMGRLFEKMLTL
HHHCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHC
SGYQVRILEKEDWARAADIVADAGMVIVSVPIHTTVETIARLPPLPADCILVDLASVKAE
CCCEEEEECCHHHHHHHHHHHCCCEEEEEECHHHHHHHHHHCCCCCHHHHHHHHHHHHHH
PLQAMLAAHQGPVLGLHPMFGPDSGSLAKQVVVYCDGRQPEAYQWFLEQIQVWGARLHRI
HHHHHHHHCCCCEEEECCCCCCCCCHHHHEEEEEECCCCCHHHHHHHHHHHHHHHHHHHH
SAVEHDQNMAFIQALRHFATFAYGLHLAEENVRLEQLLALSSPIYRLELAMVGRLFAQDP
HHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCHHHHHHHHHHHHHHCCH
QLYADIIMSSENNLALIKRYYQRFGEAIGLLEQGDKQAFIDSFRKVEHWFGDYAQRFQSE
HHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHH
SRTLLRQANDNRQ
HHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 6396419; 9205837; 9278503 [H]