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The map label for this gene is clpB [H]

Identifier: 238896038

GI number: 238896038

Start: 4005960

End: 4008545

Strand: Reverse

Name: clpB [H]

Synonym: KP1_4170

Alternate gene names: 238896038

Gene position: 4008545-4005960 (Counterclockwise)

Preceding gene: 238896039

Following gene: 238896036

Centisome position: 76.37

GC content: 56.81

Gene sequence:

>2586_bases
ATGGGAGGAGTTATGCGTCTGGATCGTCTTACCAATAAATTCCAGCTTGCTCTTGCCGATGCCCAGTCACTCGCACTCGG
GCACGACAACCAATTCATCGAACCTCTTCATTTAATGAGCGCCTTGCTGAATCAGGAAGGGGGATCGGTACGTCCTTTAT
TAACCTCGGCGGGCGTGAATGCCGGGAAACTACGCACTGACATCGAACAGGCCTTGAGCCGTTTACCGCAGGTGGAAGGC
ACCGGCGGCGATGTACAACCTTCTCAGGATTTAGTGCGGATCCTGAACCTTTGCGACAAGCTGGCGCAAAAGAAAAAGGA
CAACTTTATTTCGTCGGAACTGTTCGTTCTGGCGGCGCTTGAATCACGCGGTACGCTGACCGACCTTTTAAAATCCGCCG
GAGCAACAACCGCCAACGTGACTCAGGCGATTGAACAAATGCGCGGAGGGGAAAGCGTGAACGATCAGGGTGCCGAAGAC
CAACGTCAGGCATTGAAGAAATTTACCGTCGATCTCACCGAGCGTGCCGAGCAGGGCAAGCTGGATCCGGTGATCGGCCG
TGATGAAGAGATTCGCCGTACCATTCAGGTACTGCAGCGTCGTACCAAAAACAACCCGGTGCTGATCGGTGAACCCGGGG
TGGGTAAAACGGCAATCGTCGAAGGCCTGGCGCAGCGTATCGTCAACGGCGAAGTACCAGAAGGGCTGAAAGGCCGTCGG
GTATTGGCGCTGGATATGGGGGCGCTGGTGGCCGGGGCGAAATACCGCGGTGAGTTTGAAGAGCGTCTGAAAGGCGTGCT
GACCGACCTGTCCAAACAGGAAGGCAACGTCATTCTATTTATCGACGAACTGCATACCATGGTTGGCGCTGGTAAAGCCG
ACGGCGCGATGGATGCGGGTAACATGCTGAAGCCGGCGCTGGCGCGTGGTGAACTGCACTGCGTCGGGGCGACGACGCTT
GATGAATACCGTCAGTACATCGAAAAAGACGCCGCGCTGGAACGTCGCTTCCAGAAAGTGTTCGTTGCCGAGCCTTCGGT
AGAAGATACCATCGCGATTCTGCGCGGTCTGAAAGAACGTTATGAGCTGCACCACCACGTGCAGATCACTGACCCGGCTA
TCGTGGCGGCGGCGACCTTATCGCATCGCTATATTGCCGACCGTCAGCTGCCGGATAAAGCCATCGACCTCATCGATGAG
GCGGCATCCAGCATCCGTATGCAGATTGACTCCAAACCGGAAGAGCTGGACCGTCTCGATCGGCGTATTATCCAGCTGAA
ACTGGAACAGCAGGCGCTGAAGAAAGAGTCTGATGAGGCGAGCCTGAAGCGTCTCGATATGCTCAACGAGGAGCTGGCGG
ATAAAGAACGGCAGTACTCGGTGCTGGAAGAAGAGTGGAAAGCGGAAAAAGCGTCGCTCTCCGGCACCCAGACCATCAAA
GCTGAGCTGGAGCAGGCGAAAATCGCCATCGAACAGGCGCGCCGCGTCGGCGATCTGGCGCGGATGTCCGAGCTGCAGTA
CGGCAAAATTCCGGAACTGGAGAAACAGCTGGCGGCGGCCACGCAGGCCGAAGGGAAAACCATGCGTCTGCTGCGTAATA
AAGTGACGGATGCTGAAATCGCCGAAGTGCTGGCCCGCTGGACCGGTATCCCGGTCTCCCGCATGATGGAAAGCGAGCGC
GACAAACTGCTGCGTATGGAGCAGGAGCTGCATCATCGGGTGATTGGCCAGGATGAGGCGGTTGAAGCGGTATCCAACGC
CATTCGCCGCAGCCGCGCCGGGCTGTCCGATCCGAACCGGCCGATTGGTTCGTTCCTGTTCCTCGGTCCAACCGGGGTCG
GTAAAACCGAGCTGTGTAAAACGCTGGCTAACTTTATGTTCGACAGCGACGACGCAATGGTGCGTATCGATATGTCCGAG
TTTATGGAGAAACACTCCGTCTCGCGTCTGGTCGGTGCGCCTCCGGGATACGTCGGCTATGAAGAGGGCGGTTACCTGAC
CGAGGCGGTGCGCCGTCGTCCTTATTCCGTCATCCTGCTGGATGAAGTGGAAAAAGCGCACCCGGATGTGTTCAACATTC
TGCTGCAGGTACTCGACGACGGGCGTCTCACCGACGGGCAGGGGAGAACGGTCGACTTCCGTAATACGGTAGTCATCATG
ACCTCGAACCTCGGTTCCGATCTGATTCAGGAACGGTTCGGCGAGCTGGACTACGGACATATGAAGGACCTGGTGCTGGG
GGTAGTCAGCCAGAACTTCCGTCCGGAGTTCATCAACCGTATCGACGAAGTGGTGGTCTTCCATCCGCTGGGCGAGAAAC
ATATTGCCTCTATTGCCCAGATCCAGCTGCAGCGTCTGTATAAACGTCTGGAAGAGCGCGGATATGAAGTGCAGATGTCC
GATGAGGCGCTGAAGCTGCTGAGCGCCAACGGTTACGATCCGGTATACGGCGCGCGGCCATTGAAACGTGCTATTCAGCA
GCAGATTGAGAACCCGTTAGCCCAGCAGATCCTTTCCGGTGAGCTGGTTCCGGGTAAAACCATCGAGCTGGTAGTAAAAG
ACGACCGCATTGTGGCAGTGCAGTAA

Upstream 100 bases:

>100_bases
ATCCAGAAGGCAAACTTATTTTTCGCATAGTTCAGGTCTTTAACCTTGAATAATTGAGGGATGACCTCATTTAATCTCCA
GTAGCAAATTTGACCTGTTT

Downstream 100 bases:

>100_bases
ATCACAAAACGACAAAAACGAGCCCAGCGGGCTCGTTTTTGTTTAAAAACCAGGCAAGAATTAAAACTCAATACCTGATT
TGGTTGAAAAGTGAGCGGTT

Product: protein disaggregation chaperone

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 861; Mature: 860

Protein sequence:

>861_residues
MGGVMRLDRLTNKFQLALADAQSLALGHDNQFIEPLHLMSALLNQEGGSVRPLLTSAGVNAGKLRTDIEQALSRLPQVEG
TGGDVQPSQDLVRILNLCDKLAQKKKDNFISSELFVLAALESRGTLTDLLKSAGATTANVTQAIEQMRGGESVNDQGAED
QRQALKKFTVDLTERAEQGKLDPVIGRDEEIRRTIQVLQRRTKNNPVLIGEPGVGKTAIVEGLAQRIVNGEVPEGLKGRR
VLALDMGALVAGAKYRGEFEERLKGVLTDLSKQEGNVILFIDELHTMVGAGKADGAMDAGNMLKPALARGELHCVGATTL
DEYRQYIEKDAALERRFQKVFVAEPSVEDTIAILRGLKERYELHHHVQITDPAIVAAATLSHRYIADRQLPDKAIDLIDE
AASSIRMQIDSKPEELDRLDRRIIQLKLEQQALKKESDEASLKRLDMLNEELADKERQYSVLEEEWKAEKASLSGTQTIK
AELEQAKIAIEQARRVGDLARMSELQYGKIPELEKQLAAATQAEGKTMRLLRNKVTDAEIAEVLARWTGIPVSRMMESER
DKLLRMEQELHHRVIGQDEAVEAVSNAIRRSRAGLSDPNRPIGSFLFLGPTGVGKTELCKTLANFMFDSDDAMVRIDMSE
FMEKHSVSRLVGAPPGYVGYEEGGYLTEAVRRRPYSVILLDEVEKAHPDVFNILLQVLDDGRLTDGQGRTVDFRNTVVIM
TSNLGSDLIQERFGELDYGHMKDLVLGVVSQNFRPEFINRIDEVVVFHPLGEKHIASIAQIQLQRLYKRLEERGYEVQMS
DEALKLLSANGYDPVYGARPLKRAIQQQIENPLAQQILSGELVPGKTIELVVKDDRIVAVQ

Sequences:

>Translated_861_residues
MGGVMRLDRLTNKFQLALADAQSLALGHDNQFIEPLHLMSALLNQEGGSVRPLLTSAGVNAGKLRTDIEQALSRLPQVEG
TGGDVQPSQDLVRILNLCDKLAQKKKDNFISSELFVLAALESRGTLTDLLKSAGATTANVTQAIEQMRGGESVNDQGAED
QRQALKKFTVDLTERAEQGKLDPVIGRDEEIRRTIQVLQRRTKNNPVLIGEPGVGKTAIVEGLAQRIVNGEVPEGLKGRR
VLALDMGALVAGAKYRGEFEERLKGVLTDLSKQEGNVILFIDELHTMVGAGKADGAMDAGNMLKPALARGELHCVGATTL
DEYRQYIEKDAALERRFQKVFVAEPSVEDTIAILRGLKERYELHHHVQITDPAIVAAATLSHRYIADRQLPDKAIDLIDE
AASSIRMQIDSKPEELDRLDRRIIQLKLEQQALKKESDEASLKRLDMLNEELADKERQYSVLEEEWKAEKASLSGTQTIK
AELEQAKIAIEQARRVGDLARMSELQYGKIPELEKQLAAATQAEGKTMRLLRNKVTDAEIAEVLARWTGIPVSRMMESER
DKLLRMEQELHHRVIGQDEAVEAVSNAIRRSRAGLSDPNRPIGSFLFLGPTGVGKTELCKTLANFMFDSDDAMVRIDMSE
FMEKHSVSRLVGAPPGYVGYEEGGYLTEAVRRRPYSVILLDEVEKAHPDVFNILLQVLDDGRLTDGQGRTVDFRNTVVIM
TSNLGSDLIQERFGELDYGHMKDLVLGVVSQNFRPEFINRIDEVVVFHPLGEKHIASIAQIQLQRLYKRLEERGYEVQMS
DEALKLLSANGYDPVYGARPLKRAIQQQIENPLAQQILSGELVPGKTIELVVKDDRIVAVQ
>Mature_860_residues
GGVMRLDRLTNKFQLALADAQSLALGHDNQFIEPLHLMSALLNQEGGSVRPLLTSAGVNAGKLRTDIEQALSRLPQVEGT
GGDVQPSQDLVRILNLCDKLAQKKKDNFISSELFVLAALESRGTLTDLLKSAGATTANVTQAIEQMRGGESVNDQGAEDQ
RQALKKFTVDLTERAEQGKLDPVIGRDEEIRRTIQVLQRRTKNNPVLIGEPGVGKTAIVEGLAQRIVNGEVPEGLKGRRV
LALDMGALVAGAKYRGEFEERLKGVLTDLSKQEGNVILFIDELHTMVGAGKADGAMDAGNMLKPALARGELHCVGATTLD
EYRQYIEKDAALERRFQKVFVAEPSVEDTIAILRGLKERYELHHHVQITDPAIVAAATLSHRYIADRQLPDKAIDLIDEA
ASSIRMQIDSKPEELDRLDRRIIQLKLEQQALKKESDEASLKRLDMLNEELADKERQYSVLEEEWKAEKASLSGTQTIKA
ELEQAKIAIEQARRVGDLARMSELQYGKIPELEKQLAAATQAEGKTMRLLRNKVTDAEIAEVLARWTGIPVSRMMESERD
KLLRMEQELHHRVIGQDEAVEAVSNAIRRSRAGLSDPNRPIGSFLFLGPTGVGKTELCKTLANFMFDSDDAMVRIDMSEF
MEKHSVSRLVGAPPGYVGYEEGGYLTEAVRRRPYSVILLDEVEKAHPDVFNILLQVLDDGRLTDGQGRTVDFRNTVVIMT
SNLGSDLIQERFGELDYGHMKDLVLGVVSQNFRPEFINRIDEVVVFHPLGEKHIASIAQIQLQRLYKRLEERGYEVQMSD
EALKLLSANGYDPVYGARPLKRAIQQQIENPLAQQILSGELVPGKTIELVVKDDRIVAVQ

Specific function: Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE. Acts before DnaK, in the processing of protein aggregates. Protein binding stimulates the ATPase

COG id: COG0542

COG function: function code O; ATPases with chaperone activity, ATP-binding subunit

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the clpA/clpB family [H]

Homologues:

Organism=Homo sapiens, GI13540606, Length=318, Percent_Identity=37.4213836477987, Blast_Score=219, Evalue=8e-57,
Organism=Escherichia coli, GI1788943, Length=857, Percent_Identity=94.9824970828471, Blast_Score=1661, Evalue=0.0,
Organism=Escherichia coli, GI1787109, Length=484, Percent_Identity=38.2231404958678, Blast_Score=285, Evalue=1e-77,
Organism=Saccharomyces cerevisiae, GI6320464, Length=727, Percent_Identity=52.9573590096286, Blast_Score=780, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6323002, Length=851, Percent_Identity=43.5957696827262, Blast_Score=703, Evalue=0.0,

Paralogues:

None

Copy number: 560 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR013093
- InterPro:   IPR003959
- InterPro:   IPR018368
- InterPro:   IPR017730
- InterPro:   IPR001270
- InterPro:   IPR019489
- InterPro:   IPR004176
- InterPro:   IPR023150 [H]

Pfam domain/function: PF00004 AAA; PF07724 AAA_2; PF02861 Clp_N; PF10431 ClpB_D2-small [H]

EC number: NA

Molecular weight: Translated: 95736; Mature: 95605

Theoretical pI: Translated: 5.29; Mature: 5.29

Prosite motif: PS00870 CLPAB_1 ; PS00871 CLPAB_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGGVMRLDRLTNKFQLALADAQSLALGHDNQFIEPLHLMSALLNQEGGSVRPLLTSAGVN
CCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHCCCC
AGKLRTDIEQALSRLPQVEGTGGDVQPSQDLVRILNLCDKLAQKKKDNFISSELFVLAAL
CHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHEEEH
ESRGTLTDLLKSAGATTANVTQAIEQMRGGESVNDQGAEDQRQALKKFTVDLTERAEQGK
HCCCHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCC
LDPVIGRDEEIRRTIQVLQRRTKNNPVLIGEPGVGKTAIVEGLAQRIVNGEVPEGLKGRR
CCCCCCCCHHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHHCCCCCCCCCCCE
VLALDMGALVAGAKYRGEFEERLKGVLTDLSKQEGNVILFIDELHTMVGAGKADGAMDAG
EEEEEHHHHHHCCHHCCCHHHHHHHHHHHHHCCCCCEEEEHHHHHHHHCCCCCCCCCCCC
NMLKPALARGELHCVGATTLDEYRQYIEKDAALERRFQKVFVAEPSVEDTIAILRGLKER
HHHHHHHHCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
YELHHHVQITDPAIVAAATLSHRYIADRQLPDKAIDLIDEAASSIRMQIDSKPEELDRLD
HHHHHCEEECCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHEECCCCCHHHHHHHH
RRIIQLKLEQQALKKESDEASLKRLDMLNEELADKERQYSVLEEEWKAEKASLSGTQTIK
HHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHH
AELEQAKIAIEQARRVGDLARMSELQYGKIPELEKQLAAATQAEGKTMRLLRNKVTDAEI
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHCCHHHH
AEVLARWTGIPVSRMMESERDKLLRMEQELHHRVIGQDEAVEAVSNAIRRSRAGLSDPNR
HHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCC
PIGSFLFLGPTGVGKTELCKTLANFMFDSDDAMVRIDMSEFMEKHSVSRLVGAPPGYVGY
CCCCEEEECCCCCCHHHHHHHHHHHHCCCCCCEEEECHHHHHHHHHHHHHHCCCCCCCCC
EEGGYLTEAVRRRPYSVILLDEVEKAHPDVFNILLQVLDDGRLTDGQGRTVDFRNTVVIM
CCCCHHHHHHHCCCCEEEEECCHHHHCCHHHHHHHHHHCCCCCCCCCCCEEEECCEEEEE
TSNLGSDLIQERFGELDYGHMKDLVLGVVSQNFRPEFINRIDEVVVFHPLGEKHIASIAQ
ECCCCHHHHHHHHCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHEEEECCCCHHHHHHHHH
IQLQRLYKRLEERGYEVQMSDEALKLLSANGYDPVYGARPLKRAIQQQIENPLAQQILSG
HHHHHHHHHHHHCCCEEEECHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCC
ELVPGKTIELVVKDDRIVAVQ
CCCCCCEEEEEEECCEEEEEC
>Mature Secondary Structure 
GGVMRLDRLTNKFQLALADAQSLALGHDNQFIEPLHLMSALLNQEGGSVRPLLTSAGVN
CCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHCCCC
AGKLRTDIEQALSRLPQVEGTGGDVQPSQDLVRILNLCDKLAQKKKDNFISSELFVLAAL
CHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHEEEH
ESRGTLTDLLKSAGATTANVTQAIEQMRGGESVNDQGAEDQRQALKKFTVDLTERAEQGK
HCCCHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCC
LDPVIGRDEEIRRTIQVLQRRTKNNPVLIGEPGVGKTAIVEGLAQRIVNGEVPEGLKGRR
CCCCCCCCHHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHHCCCCCCCCCCCE
VLALDMGALVAGAKYRGEFEERLKGVLTDLSKQEGNVILFIDELHTMVGAGKADGAMDAG
EEEEEHHHHHHCCHHCCCHHHHHHHHHHHHHCCCCCEEEEHHHHHHHHCCCCCCCCCCCC
NMLKPALARGELHCVGATTLDEYRQYIEKDAALERRFQKVFVAEPSVEDTIAILRGLKER
HHHHHHHHCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
YELHHHVQITDPAIVAAATLSHRYIADRQLPDKAIDLIDEAASSIRMQIDSKPEELDRLD
HHHHHCEEECCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHEECCCCCHHHHHHHH
RRIIQLKLEQQALKKESDEASLKRLDMLNEELADKERQYSVLEEEWKAEKASLSGTQTIK
HHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHH
AELEQAKIAIEQARRVGDLARMSELQYGKIPELEKQLAAATQAEGKTMRLLRNKVTDAEI
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHCCHHHH
AEVLARWTGIPVSRMMESERDKLLRMEQELHHRVIGQDEAVEAVSNAIRRSRAGLSDPNR
HHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCC
PIGSFLFLGPTGVGKTELCKTLANFMFDSDDAMVRIDMSEFMEKHSVSRLVGAPPGYVGY
CCCCEEEECCCCCCHHHHHHHHHHHHCCCCCCEEEECHHHHHHHHHHHHHHCCCCCCCCC
EEGGYLTEAVRRRPYSVILLDEVEKAHPDVFNILLQVLDDGRLTDGQGRTVDFRNTVVIM
CCCCHHHHHHHCCCCEEEEECCHHHHCCHHHHHHHHHHCCCCCCCCCCCEEEECCEEEEE
TSNLGSDLIQERFGELDYGHMKDLVLGVVSQNFRPEFINRIDEVVVFHPLGEKHIASIAQ
ECCCCHHHHHHHHCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHEEEECCCCHHHHHHHHH
IQLQRLYKRLEERGYEVQMSDEALKLLSANGYDPVYGARPLKRAIQQQIENPLAQQILSG
HHHHHHHHHHHHCCCEEEECHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCC
ELVPGKTIELVVKDDRIVAVQ
CCCCCCEEEEEEECCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases); Serine endopeptidases [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]