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The map label for this gene is rnc [H]

Identifier: 238896018

GI number: 238896018

Start: 3979327

End: 3979941

Strand: Reverse

Name: rnc [H]

Synonym: KP1_4146

Alternate gene names: 238896018

Gene position: 3979941-3979327 (Counterclockwise)

Preceding gene: 238896019

Following gene: 238896017

Centisome position: 75.83

GC content: 56.91

Gene sequence:

>615_bases
TTGCAACAGGCATTAACTCACCGCAGTGCCAGCAGCAAACATAATGAGCGCCTGGAATTTTTAGGTGACTCCATTTTAAG
TTTCGTGATCGCGAATGCGCTGTATCATCGCTTTCCTCGTGTCGATGAAGGCGATATGAGCCGTATGCGCGCGACGCTGG
TGCGCGGCAACACGCTGGCGGAGATCGCCCGCGAGTTTGAGCTGGGCGAGTGTCTGCGCCTCGGGCCGGGAGAGCTGAAA
AGCGGCGGTTTCCGTCGCGAATCGATTCTCGCGGATACCGTTGAAGCGTTAATTGGCGGGGTTTTCCTCGACAGTGATAT
TCAGAACGTTGAACGCTTAATCCTCTCCTGGTACCAGACCCGTCTGGACGAAATCAGTCCGGGCGATAAGCAAAAGGATC
CGAAGACGCGTCTGCAGGAGTATCTGCAGGGACGTCATCTGCCGCTGCCGTCTTACCTGGTGGTCCAGGTTCGCGGCGAA
GCGCACGATCAGGAATTTACTATCCACTGCCAGGTCAGTGGCCTGAGTGAACCGGTGGTTGGCACAGGTTCCAGCCGTCG
TAAGGCGGAGCAGGCTGCCGCCGAACAGGCGCTGAAAAAGCTGGAGCTGGAATGA

Upstream 100 bases:

>100_bases
CTGCATCTTTGACGCATTCATTTATTGGTAACGCATGAACCCCATCGTAATTAATCGGCTTCAACGAAAGCTGGGCTACA
CTTTTCATCATCAGGAGCTG

Downstream 100 bases:

>100_bases
GCGAAGAAAAAAGTTATTGTGGGTTTGTCGCCATCGTGGGTCGTCCAAACGTTGGCAAATCCACGCTGTTGAACAAGCTG
CTTGGGCAGAAGATCTCGAT

Product: ribonuclease III

Products: NA

Alternate protein names: Ribonuclease III; RNase III [H]

Number of amino acids: Translated: 204; Mature: 204

Protein sequence:

>204_residues
MQQALTHRSASSKHNERLEFLGDSILSFVIANALYHRFPRVDEGDMSRMRATLVRGNTLAEIAREFELGECLRLGPGELK
SGGFRRESILADTVEALIGGVFLDSDIQNVERLILSWYQTRLDEISPGDKQKDPKTRLQEYLQGRHLPLPSYLVVQVRGE
AHDQEFTIHCQVSGLSEPVVGTGSSRRKAEQAAAEQALKKLELE

Sequences:

>Translated_204_residues
MQQALTHRSASSKHNERLEFLGDSILSFVIANALYHRFPRVDEGDMSRMRATLVRGNTLAEIAREFELGECLRLGPGELK
SGGFRRESILADTVEALIGGVFLDSDIQNVERLILSWYQTRLDEISPGDKQKDPKTRLQEYLQGRHLPLPSYLVVQVRGE
AHDQEFTIHCQVSGLSEPVVGTGSSRRKAEQAAAEQALKKLELE
>Mature_204_residues
MQQALTHRSASSKHNERLEFLGDSILSFVIANALYHRFPRVDEGDMSRMRATLVRGNTLAEIAREFELGECLRLGPGELK
SGGFRRESILADTVEALIGGVFLDSDIQNVERLILSWYQTRLDEISPGDKQKDPKTRLQEYLQGRHLPLPSYLVVQVRGE
AHDQEFTIHCQVSGLSEPVVGTGSSRRKAEQAAAEQALKKLELE

Specific function: Digests double-stranded RNA. Involved in the processing of ribosomal RNA precursors and of some mRNAs [H]

COG id: COG0571

COG function: function code K; dsRNA-specific ribonuclease

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RNase III domain [H]

Homologues:

Organism=Homo sapiens, GI155030234, Length=195, Percent_Identity=30.7692307692308, Blast_Score=94, Evalue=9e-20,
Organism=Homo sapiens, GI155030236, Length=195, Percent_Identity=30.7692307692308, Blast_Score=94, Evalue=9e-20,
Organism=Escherichia coli, GI1788920, Length=204, Percent_Identity=96.5686274509804, Blast_Score=389, Evalue=1e-110,
Organism=Caenorhabditis elegans, GI17506883, Length=213, Percent_Identity=30.0469483568075, Blast_Score=91, Evalue=4e-19,
Organism=Caenorhabditis elegans, GI193202651, Length=213, Percent_Identity=30.0469483568075, Blast_Score=91, Evalue=4e-19,
Organism=Saccharomyces cerevisiae, GI6323895, Length=204, Percent_Identity=28.921568627451, Blast_Score=64, Evalue=1e-11,
Organism=Drosophila melanogaster, GI17137682, Length=213, Percent_Identity=27.6995305164319, Blast_Score=75, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001159
- InterPro:   IPR014720
- InterPro:   IPR000999
- InterPro:   IPR011907 [H]

Pfam domain/function: PF00035 dsrm; PF00636 Ribonuclease_3 [H]

EC number: =3.1.26.3 [H]

Molecular weight: Translated: 22885; Mature: 22885

Theoretical pI: Translated: 6.25; Mature: 6.25

Prosite motif: PS50137 DS_RBD ; PS00517 RNASE_3_1 ; PS50142 RNASE_3_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQQALTHRSASSKHNERLEFLGDSILSFVIANALYHRFPRVDEGDMSRMRATLVRGNTLA
CCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCHHH
EIAREFELGECLRLGPGELKSGGFRRESILADTVEALIGGVFLDSDIQNVERLILSWYQT
HHHHHHCHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHH
RLDEISPGDKQKDPKTRLQEYLQGRHLPLPSYLVVQVRGEAHDQEFTIHCQVSGLSEPVV
HHHHCCCCCCCCCHHHHHHHHHCCCCCCCCCEEEEEECCCCCCCEEEEEEEECCCCCCCC
GTGSSRRKAEQAAAEQALKKLELE
CCCCHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MQQALTHRSASSKHNERLEFLGDSILSFVIANALYHRFPRVDEGDMSRMRATLVRGNTLA
CCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCHHH
EIAREFELGECLRLGPGELKSGGFRRESILADTVEALIGGVFLDSDIQNVERLILSWYQT
HHHHHHCHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHH
RLDEISPGDKQKDPKTRLQEYLQGRHLPLPSYLVVQVRGEAHDQEFTIHCQVSGLSEPVV
HHHHCCCCCCCCCHHHHHHHHHCCCCCCCCCEEEEEECCCCCCCEEEEEEEECCCCCCCC
GTGSSRRKAEQAAAEQALKKLELE
CCCCHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA