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The map label for this gene is lepB [H]

Identifier: 238896019

GI number: 238896019

Start: 3980257

End: 3981231

Strand: Reverse

Name: lepB [H]

Synonym: KP1_4148

Alternate gene names: 238896019

Gene position: 3981231-3980257 (Counterclockwise)

Preceding gene: 238896020

Following gene: 238896018

Centisome position: 75.85

GC content: 56.72

Gene sequence:

>975_bases
ATGGCGAACATGTTTGCCCTGATCCTGGTGATTGCAACCCTGGTGACGGGCGTTTTATGGTGCCTGGACAAGTTCATTTT
TGCACCGAAACGTCGTGAACGTCAGGCCGCTGCTCAGGCAGCGACCGGCGAGCAACTGGACAAGAAGACGCTGAAGAAAG
TCGGCCCGAAACCGGGCTGGCTGGAAACCGGCGCATCGGTTTTCCCGGTGCTGGCGATCGTTCTGGTGGTACGTTCATTT
ATTTATGAGCCTTTCCAGATCCCTTCAGGTTCGATGATGCCAACGCTGCTCATCGGCGATTTTATTCTGGTGGAGAAATT
TGCCTACGGCATTAAAGATCCTATCTACCAGAAAACGCTGATCGAGACCGGCCATCCGAAGCGCGGCGACATCGTGGTGT
TTAAATATCCGGAAGACCCGCGTCTGGACTACATTAAGCGCGCGGTGGGGTTACCGGGTGATAAGGTCACCTACGATCCG
GTTGCCAAACAGGTCACTATTCAGCCGGGCTGCAGTTCCGGACAGGCCTGCGGCAACGCGCTGCCGGTGACCTATTCCAA
CGTGGAGCCGAGCGATTTTGTTCAGACCTTCTCCCGCAGCAACGGCGGCGAAGCGAGCAGCGGTTTCTGGCAGTTGCCGA
AGGGCGAAACCAAAGCCGACGGCATTCGTCTTACCGAGCGTCAGGAGACGTTGGGCGACGTGACGCACCGAATTCTGATG
GTGCCGATTGCCCAGGATCAGGTTGGGATGTACTACCATCAGTCCGGTCTGCCGCTGGCCACCTGGATTGTGCCGCCCGG
TCAGTACTTCATGATGGGCGACAACCGGGATAACAGCGCCGACAGCCGGTACTGGGGCTTTGTGCCGGAAGCCAACCTGG
TCGGAAAAGCAACCGCTATCTGGATGAGTTTTGAAAAGCAGGAAGGTGAATGGCCGACCGGCGTGCGGTTATCGCGCATT
GGTGGAATTCATTAA

Upstream 100 bases:

>100_bases
GAAGCGTATGAAGCAGGTCGGTAACGTTGAGCTGCCGCAGGAAGCGTTCCTCGCCATTCTGCACGTTGGTAAAGACGGCA
AATAACCCTAAGGAGTTGGC

Downstream 100 bases:

>100_bases
TTTCCTCTGCTGAATTCACGTCGCTGCTGTTATCGCAGCGGCGTGAATTATTTAGTATTTAAATCCATTCAAACTAACGA
CATCCCGTGTCGTTGCGTAT

Product: signal peptidase I

Products: NA

Alternate protein names: SPase I; Leader peptidase I [H]

Number of amino acids: Translated: 324; Mature: 323

Protein sequence:

>324_residues
MANMFALILVIATLVTGVLWCLDKFIFAPKRRERQAAAQAATGEQLDKKTLKKVGPKPGWLETGASVFPVLAIVLVVRSF
IYEPFQIPSGSMMPTLLIGDFILVEKFAYGIKDPIYQKTLIETGHPKRGDIVVFKYPEDPRLDYIKRAVGLPGDKVTYDP
VAKQVTIQPGCSSGQACGNALPVTYSNVEPSDFVQTFSRSNGGEASSGFWQLPKGETKADGIRLTERQETLGDVTHRILM
VPIAQDQVGMYYHQSGLPLATWIVPPGQYFMMGDNRDNSADSRYWGFVPEANLVGKATAIWMSFEKQEGEWPTGVRLSRI
GGIH

Sequences:

>Translated_324_residues
MANMFALILVIATLVTGVLWCLDKFIFAPKRRERQAAAQAATGEQLDKKTLKKVGPKPGWLETGASVFPVLAIVLVVRSF
IYEPFQIPSGSMMPTLLIGDFILVEKFAYGIKDPIYQKTLIETGHPKRGDIVVFKYPEDPRLDYIKRAVGLPGDKVTYDP
VAKQVTIQPGCSSGQACGNALPVTYSNVEPSDFVQTFSRSNGGEASSGFWQLPKGETKADGIRLTERQETLGDVTHRILM
VPIAQDQVGMYYHQSGLPLATWIVPPGQYFMMGDNRDNSADSRYWGFVPEANLVGKATAIWMSFEKQEGEWPTGVRLSRI
GGIH
>Mature_323_residues
ANMFALILVIATLVTGVLWCLDKFIFAPKRRERQAAAQAATGEQLDKKTLKKVGPKPGWLETGASVFPVLAIVLVVRSFI
YEPFQIPSGSMMPTLLIGDFILVEKFAYGIKDPIYQKTLIETGHPKRGDIVVFKYPEDPRLDYIKRAVGLPGDKVTYDPV
AKQVTIQPGCSSGQACGNALPVTYSNVEPSDFVQTFSRSNGGEASSGFWQLPKGETKADGIRLTERQETLGDVTHRILMV
PIAQDQVGMYYHQSGLPLATWIVPPGQYFMMGDNRDNSADSRYWGFVPEANLVGKATAIWMSFEKQEGEWPTGVRLSRIG
GIH

Specific function: Unknown

COG id: COG0681

COG function: function code U; Signal peptidase I

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S26 family [H]

Homologues:

Organism=Escherichia coli, GI1788921, Length=324, Percent_Identity=90.1234567901235, Blast_Score=600, Evalue=1e-173,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000223
- InterPro:   IPR019758
- InterPro:   IPR019757
- InterPro:   IPR019756
- InterPro:   IPR019759
- InterPro:   IPR015927
- InterPro:   IPR011056
- InterPro:   IPR019533
- InterPro:   IPR019766 [H]

Pfam domain/function: PF00717 Peptidase_S24; PF10502 Peptidase_S26 [H]

EC number: =3.4.21.89 [H]

Molecular weight: Translated: 35790; Mature: 35658

Theoretical pI: Translated: 8.41; Mature: 8.41

Prosite motif: PS00501 SPASE_I_1 ; PS00760 SPASE_I_2 ; PS00761 SPASE_I_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MANMFALILVIATLVTGVLWCLDKFIFAPKRRERQAAAQAATGEQLDKKTLKKVGPKPGW
CCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
LETGASVFPVLAIVLVVRSFIYEPFQIPSGSMMPTLLIGDFILVEKFAYGIKDPIYQKTL
HHCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHH
IETGHPKRGDIVVFKYPEDPRLDYIKRAVGLPGDKVTYDPVAKQVTIQPGCSSGQACGNA
HHCCCCCCCCEEEEECCCCCCHHHHHHHHCCCCCCEECCCCCCEEEECCCCCCCCCCCCC
LPVTYSNVEPSDFVQTFSRSNGGEASSGFWQLPKGETKADGIRLTERQETLGDVTHRILM
CCEEECCCCHHHHHHHHHCCCCCCCCCCCEECCCCCCCCCCEEECHHHHHHHHHHHEEEE
VPIAQDQVGMYYHQSGLPLATWIVPPGQYFMMGDNRDNSADSRYWGFVPEANLVGKATAI
EEECCCCCCEEEECCCCCEEEEEECCCCEEEEECCCCCCCCCCEECCCCCCCCCCCCEEE
WMSFEKQEGEWPTGVRLSRIGGIH
EEEECCCCCCCCCCEEECCCCCCC
>Mature Secondary Structure 
ANMFALILVIATLVTGVLWCLDKFIFAPKRRERQAAAQAATGEQLDKKTLKKVGPKPGW
CHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
LETGASVFPVLAIVLVVRSFIYEPFQIPSGSMMPTLLIGDFILVEKFAYGIKDPIYQKTL
HHCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHH
IETGHPKRGDIVVFKYPEDPRLDYIKRAVGLPGDKVTYDPVAKQVTIQPGCSSGQACGNA
HHCCCCCCCCEEEEECCCCCCHHHHHHHHCCCCCCEECCCCCCEEEECCCCCCCCCCCCC
LPVTYSNVEPSDFVQTFSRSNGGEASSGFWQLPKGETKADGIRLTERQETLGDVTHRILM
CCEEECCCCHHHHHHHHHCCCCCCCCCCCEECCCCCCCCCCEEECHHHHHHHHHHHEEEE
VPIAQDQVGMYYHQSGLPLATWIVPPGQYFMMGDNRDNSADSRYWGFVPEANLVGKATAI
EEECCCCCCEEEECCCCCEEEEEECCCCEEEEECCCCCCCCCCEECCCCCCCCCCCCEEE
WMSFEKQEGEWPTGVRLSRIGGIH
EEEECCCCCCCCCCEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 6311837; 9278503; 2202591; 1618816; 1546969; 8394311; 2551889; 9823901 [H]