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The map label for this gene is cynR [H]

Identifier: 238895862

GI number: 238895862

Start: 3806232

End: 3807140

Strand: Reverse

Name: cynR [H]

Synonym: KP1_3982

Alternate gene names: 238895862

Gene position: 3807140-3806232 (Counterclockwise)

Preceding gene: 238895865

Following gene: 238895858

Centisome position: 72.54

GC content: 59.19

Gene sequence:

>909_bases
ATGCTTCTGCGCCAACTTTCCTACTTTATCGCTGTGGCTGAACATTGTGGCTTTTCCCGCGCCGCCGCGGCGCTGCATGT
CTCCCAGCCTGCGCTGTCACAGCAGATACGCCAGCTGGAAGCGATGCTGGAGGTTCAGCTTTTCGACCGCTCTGGCCGAC
GTATTCGCCTGACCGATGCTGGAGAGATCTGGCTGGAGTATGCCCGTCGCGCGTTACGCGAGCTTGAGGAAGGTCGGCGC
GCCTTGCATGACGCAGAAGATCTCCAGCACGGTAAACTCCGCATTGCTATGACGCCAACTTTCACTACCTATATGCTGGG
CCCGCTGATGGAGGCGTACTACCGACGCTATCCTGGAGTAAAAGTGCTTATCCAGGAGATGAACCAGGAGCGGATGGAGG
CGATGCTGCTGGAGGATGAACTGGATGTGGGGATTGCCTTTGACGACAGCCGGTCACAGGAAATTGTGGTTCAGCCGCTG
CTGACGGAAACGCTTGCGCTGGTGGTGAGCCGTGCGCATCCGCTGGCAGGAGAGCGCGACTTGCAACTGCAGGCTCTCGA
CGCCCAGCCGCTAATTTTACTGAGCAGCGAGTTTGCTACCCGCGAGCAGATTGATCGTTATTGCCGCCTTCATCGGCTCG
AACCAGACGTGCGGATGGAGGCCAACTCCATCGGGGCCGTTCTGTCGGTTATTCGAAGCACAACGTTAGCAACGCTGCTG
CCGGCGGCGATCGCCGGACAGTTTGATGATGTGGTGGCGATTGAGCTAAGACCTGCGCTGCTGCAGCGCACGGCCTGTTT
ATTGCAGCGGCAGGGCGCCTGGCAGAGCGCCGCAGCGCGCGAATTCATCACCCTGGCCCGAGAGAACGCGATAACGATTG
AGCAGGAAAACCGCCAGTCCCTTGACTGA

Upstream 100 bases:

>100_bases
AAATATGTTGAGGGTCGTGCGAAGAGGGTACGTCTCTTGTTTCATAAGTTAAAAGACTTATTTATGATAATGCCTATTGG
AATTTCTTATAGGTGGGCCG

Downstream 100 bases:

>100_bases
AGGACTGCGTTACTCGCCGGCGAACTGCGACTCACGGCTGGCTTCGCTGCCGATATCGCCTTCATCGGGCTGGGCATTCT
CTATAAGCATGCCTTCTTCC

Product: DNA-binding transcriptional regulator CynR

Products: NA

Alternate protein names: Cyn operon transcriptional activator [H]

Number of amino acids: Translated: 302; Mature: 302

Protein sequence:

>302_residues
MLLRQLSYFIAVAEHCGFSRAAAALHVSQPALSQQIRQLEAMLEVQLFDRSGRRIRLTDAGEIWLEYARRALRELEEGRR
ALHDAEDLQHGKLRIAMTPTFTTYMLGPLMEAYYRRYPGVKVLIQEMNQERMEAMLLEDELDVGIAFDDSRSQEIVVQPL
LTETLALVVSRAHPLAGERDLQLQALDAQPLILLSSEFATREQIDRYCRLHRLEPDVRMEANSIGAVLSVIRSTTLATLL
PAAIAGQFDDVVAIELRPALLQRTACLLQRQGAWQSAAAREFITLARENAITIEQENRQSLD

Sequences:

>Translated_302_residues
MLLRQLSYFIAVAEHCGFSRAAAALHVSQPALSQQIRQLEAMLEVQLFDRSGRRIRLTDAGEIWLEYARRALRELEEGRR
ALHDAEDLQHGKLRIAMTPTFTTYMLGPLMEAYYRRYPGVKVLIQEMNQERMEAMLLEDELDVGIAFDDSRSQEIVVQPL
LTETLALVVSRAHPLAGERDLQLQALDAQPLILLSSEFATREQIDRYCRLHRLEPDVRMEANSIGAVLSVIRSTTLATLL
PAAIAGQFDDVVAIELRPALLQRTACLLQRQGAWQSAAAREFITLARENAITIEQENRQSLD
>Mature_302_residues
MLLRQLSYFIAVAEHCGFSRAAAALHVSQPALSQQIRQLEAMLEVQLFDRSGRRIRLTDAGEIWLEYARRALRELEEGRR
ALHDAEDLQHGKLRIAMTPTFTTYMLGPLMEAYYRRYPGVKVLIQEMNQERMEAMLLEDELDVGIAFDDSRSQEIVVQPL
LTETLALVVSRAHPLAGERDLQLQALDAQPLILLSSEFATREQIDRYCRLHRLEPDVRMEANSIGAVLSVIRSTTLATLL
PAAIAGQFDDVVAIELRPALLQRTACLLQRQGAWQSAAAREFITLARENAITIEQENRQSLD

Specific function: Positively regulates the cynTSX operon, and negatively regulates its own transcription. Binds specifically to the cynR- cynTSX intergenic region [H]

COG id: COG0583

COG function: function code K; Transcriptional regulator

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI157672245, Length=299, Percent_Identity=59.866220735786, Blast_Score=349, Evalue=1e-97,
Organism=Escherichia coli, GI145693105, Length=289, Percent_Identity=29.4117647058824, Blast_Score=121, Evalue=7e-29,
Organism=Escherichia coli, GI1790399, Length=276, Percent_Identity=29.3478260869565, Blast_Score=117, Evalue=1e-27,
Organism=Escherichia coli, GI1788297, Length=251, Percent_Identity=31.0756972111554, Blast_Score=111, Evalue=6e-26,
Organism=Escherichia coli, GI1787879, Length=297, Percent_Identity=29.96632996633, Blast_Score=105, Evalue=3e-24,
Organism=Escherichia coli, GI1788887, Length=292, Percent_Identity=28.4246575342466, Blast_Score=97, Evalue=1e-21,
Organism=Escherichia coli, GI1787530, Length=235, Percent_Identity=27.6595744680851, Blast_Score=97, Evalue=1e-21,
Organism=Escherichia coli, GI1788748, Length=243, Percent_Identity=27.1604938271605, Blast_Score=92, Evalue=5e-20,
Organism=Escherichia coli, GI2367136, Length=239, Percent_Identity=30.5439330543933, Blast_Score=89, Evalue=2e-19,
Organism=Escherichia coli, GI87081904, Length=205, Percent_Identity=30.2439024390244, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI1789173, Length=247, Percent_Identity=30.7692307692308, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI1787601, Length=292, Percent_Identity=25.3424657534247, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI1788481, Length=233, Percent_Identity=29.1845493562232, Blast_Score=81, Evalue=8e-17,
Organism=Escherichia coli, GI1786448, Length=169, Percent_Identity=33.7278106508876, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1789639, Length=120, Percent_Identity=35, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI87082132, Length=296, Percent_Identity=26.3513513513513, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1788296, Length=198, Percent_Identity=31.3131313131313, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI1789204, Length=238, Percent_Identity=26.0504201680672, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI1790262, Length=202, Percent_Identity=28.2178217821782, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI87081684, Length=290, Percent_Identity=23.448275862069, Blast_Score=68, Evalue=9e-13,
Organism=Escherichia coli, GI1786401, Length=167, Percent_Identity=28.1437125748503, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI87082024, Length=119, Percent_Identity=36.1344537815126, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI48994962, Length=188, Percent_Identity=30.8510638297872, Blast_Score=66, Evalue=2e-12,
Organism=Escherichia coli, GI1787806, Length=279, Percent_Identity=24.0143369175627, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI145693193, Length=152, Percent_Identity=29.6052631578947, Blast_Score=63, Evalue=2e-11,
Organism=Escherichia coli, GI1790208, Length=246, Percent_Identity=23.9837398373984, Blast_Score=62, Evalue=3e-11,
Organism=Escherichia coli, GI1788706, Length=168, Percent_Identity=29.1666666666667, Blast_Score=62, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 34191; Mature: 34191

Theoretical pI: Translated: 5.12; Mature: 5.12

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLLRQLSYFIAVAEHCGFSRAAAALHVSQPALSQQIRQLEAMLEVQLFDRSGRRIRLTDA
CHHHHHHHHHHHHHHCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEECH
GEIWLEYARRALRELEEGRRALHDAEDLQHGKLRIAMTPTFTTYMLGPLMEAYYRRYPGV
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHHHHHCCCH
KVLIQEMNQERMEAMLLEDELDVGIAFDDSRSQEIVVQPLLTETLALVVSRAHPLAGERD
HHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCC
LQLQALDAQPLILLSSEFATREQIDRYCRLHRLEPDVRMEANSIGAVLSVIRSTTLATLL
CEEEEECCCCEEEECCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
PAAIAGQFDDVVAIELRPALLQRTACLLQRQGAWQSAAAREFITLARENAITIEQENRQS
HHHHHCCCCCEEEEEECHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCEEEECCCCCC
LD
CC
>Mature Secondary Structure
MLLRQLSYFIAVAEHCGFSRAAAALHVSQPALSQQIRQLEAMLEVQLFDRSGRRIRLTDA
CHHHHHHHHHHHHHHCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEECH
GEIWLEYARRALRELEEGRRALHDAEDLQHGKLRIAMTPTFTTYMLGPLMEAYYRRYPGV
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHHHHHCCCH
KVLIQEMNQERMEAMLLEDELDVGIAFDDSRSQEIVVQPLLTETLALVVSRAHPLAGERD
HHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCC
LQLQALDAQPLILLSSEFATREQIDRYCRLHRLEPDVRMEANSIGAVLSVIRSTTLATLL
CEEEEECCCCEEEECCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
PAAIAGQFDDVVAIELRPALLQRTACLLQRQGAWQSAAAREFITLARENAITIEQENRQS
HHHHHCCCCCEEEEEECHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCEEEECCCCCC
LD
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]