Click here to switch to the map view.

The map label for this gene is nuoM [H]

Identifier: 238895794

GI number: 238895794

Start: 3739990

End: 3741519

Strand: Reverse

Name: nuoM [H]

Synonym: KP1_3909

Alternate gene names: 238895794

Gene position: 3741519-3739990 (Counterclockwise)

Preceding gene: 238895795

Following gene: 238895793

Centisome position: 71.29

GC content: 58.24

Gene sequence:

>1530_bases
ATGTTACTACCCTGGCTAATATTAATTCCCTTTATCGGCGGCTTCCTGTGCTGGCAGACCGAACGCTTTGGCGTGAAAGT
GCCGCGCTGGATCGCGCTGATTACCATGGGACTGACGCTGGTGCTTGGCCTGCAGCTGTGGATGCAGGGCGGCTATTCTC
TGACGCAATCCGCGGGTATTCCGCAATGGCAGTCGGAATTCGTGCTGCCGTGGATCCCACGCTTCGGCATTAGCATCCAT
CTGGCGATCGACGGCCTGTCGCTGCTGATGGTGGTGCTGACCGGTCTCCTCGGCGTGCTGGCGGTGCTCTGTTCGTGGCG
TGAAATCGAAAAATACCAGGGCTTCTTCCACCTCAACCTGATGTGGATCCTGGGCGGCGTTATCGGCGTGTTCCTCGCCA
TCGACATGTTCCTGTTCTTCTTCTTCTGGGAAATGATGTTGGTGCCGATGTACTTCCTGATCGCGCTGTGGGGCCACAAA
GCCTCGGACGGTAAAACGCGCATCACAGCGGCCACCAAGTTCTTCATCTATACCCAGGCGAGCGGCCTGGTGATGCTGAT
TGCCATTCTGGCGCTGGCCTTCGTCCACTTCAACGCCACCGGCGTGTGGACCTTCAACTATGAAGATCTGCTGAAAACCC
CAATGTCTCACGGCGTGGAATACCTGCTGATGCTCGGCTTCTTCATCGCCTTCGCGGTGAAAATGCCGGTGGTGCCGCTG
CACGGCTGGCTGCCGGACGCTCACTCCCAGGCGCCGACCGCCGGCTCTGTCGACCTCGCGGGGATCCTGCTGAAAACCGC
CGCCTACGGTCTGCTGCGCTTTGCGCTGCCGCTGTTCCCGAATGCCTCCGCCGAGTTTGCGCCCATCGCCATGTGGCTGG
GCGTGATTGGTATCTTCTACGGCGCGTGGATGGCCTTCGCCCAGACCGATATTAAACGCCTGATCGCCTACACCTCCGTG
TCCCACATGGGCTTCGTGCTGATTGCTATCTACACCGGCAGCCAGCTGGCCTATCAGGGAGCGGTGATCCAGATGATTGC
TCACGGTCTGTCCGCGGCGGGTCTGTTTATTCTCTGCGGCCAGCTGTACGAACGTCTGCATACCCGCGATATGCGCCAGA
TGGGCGGTCTGTGGAGCAAAATTAAATGGCTGCCGGCGATGTCGATGTTCTTCGCGGTCGCCACTCTGGGGATGCCGGGC
ACCGGTAACTTCGTCGGCGAATTTATGATCCTGTTCGGCAGCTATAAAGTGGTGCCGACGATCACCGTCATCTCCACCTT
TGGTCTGGTATTCGCGTCCGTTTACTCGCTGTCGATGTTACATCGCGCTTACTTCGGTAAAGCGAAGAGCGAAGCGGCGG
CGAAAGAGTTGCCGGGGATGTCCCTGCGTGAACTGTCTATCATCCTGCTGCTGGTGGTGCTGCTGGTGCTGTTGGGCTTC
TTCCCGCAGCCGATCCTCGACACCTCGCATGCTGCGATGAGCAACATTCAGCAGTGGTTTGTTAATTCTGTTTCTACTAC
AAGGCCGTAA

Upstream 100 bases:

>100_bases
AAGCGCCACCCGACACAACAAACCGCACTCAAACGTGAATGTAGTCGAATTCGTTGAAAATCGGTCCTGAACGGGACTTT
AACAAGGAATAAAAATCGCC

Downstream 100 bases:

>100_bases
TTCGCCATGACAATAACTCCACAACAACTGATCGCACTGCTACCGCTGCTGATCGTCGGCTTGACGGTGGTGGTTGTGAT
GCTCTCCATTGCGTGGCGAC

Product: NADH dehydrogenase subunit M

Products: NA

Alternate protein names: NADH dehydrogenase I subunit M; NDH-1 subunit M; NUO13 [H]

Number of amino acids: Translated: 509; Mature: 509

Protein sequence:

>509_residues
MLLPWLILIPFIGGFLCWQTERFGVKVPRWIALITMGLTLVLGLQLWMQGGYSLTQSAGIPQWQSEFVLPWIPRFGISIH
LAIDGLSLLMVVLTGLLGVLAVLCSWREIEKYQGFFHLNLMWILGGVIGVFLAIDMFLFFFFWEMMLVPMYFLIALWGHK
ASDGKTRITAATKFFIYTQASGLVMLIAILALAFVHFNATGVWTFNYEDLLKTPMSHGVEYLLMLGFFIAFAVKMPVVPL
HGWLPDAHSQAPTAGSVDLAGILLKTAAYGLLRFALPLFPNASAEFAPIAMWLGVIGIFYGAWMAFAQTDIKRLIAYTSV
SHMGFVLIAIYTGSQLAYQGAVIQMIAHGLSAAGLFILCGQLYERLHTRDMRQMGGLWSKIKWLPAMSMFFAVATLGMPG
TGNFVGEFMILFGSYKVVPTITVISTFGLVFASVYSLSMLHRAYFGKAKSEAAAKELPGMSLRELSIILLLVVLLVLLGF
FPQPILDTSHAAMSNIQQWFVNSVSTTRP

Sequences:

>Translated_509_residues
MLLPWLILIPFIGGFLCWQTERFGVKVPRWIALITMGLTLVLGLQLWMQGGYSLTQSAGIPQWQSEFVLPWIPRFGISIH
LAIDGLSLLMVVLTGLLGVLAVLCSWREIEKYQGFFHLNLMWILGGVIGVFLAIDMFLFFFFWEMMLVPMYFLIALWGHK
ASDGKTRITAATKFFIYTQASGLVMLIAILALAFVHFNATGVWTFNYEDLLKTPMSHGVEYLLMLGFFIAFAVKMPVVPL
HGWLPDAHSQAPTAGSVDLAGILLKTAAYGLLRFALPLFPNASAEFAPIAMWLGVIGIFYGAWMAFAQTDIKRLIAYTSV
SHMGFVLIAIYTGSQLAYQGAVIQMIAHGLSAAGLFILCGQLYERLHTRDMRQMGGLWSKIKWLPAMSMFFAVATLGMPG
TGNFVGEFMILFGSYKVVPTITVISTFGLVFASVYSLSMLHRAYFGKAKSEAAAKELPGMSLRELSIILLLVVLLVLLGF
FPQPILDTSHAAMSNIQQWFVNSVSTTRP
>Mature_509_residues
MLLPWLILIPFIGGFLCWQTERFGVKVPRWIALITMGLTLVLGLQLWMQGGYSLTQSAGIPQWQSEFVLPWIPRFGISIH
LAIDGLSLLMVVLTGLLGVLAVLCSWREIEKYQGFFHLNLMWILGGVIGVFLAIDMFLFFFFWEMMLVPMYFLIALWGHK
ASDGKTRITAATKFFIYTQASGLVMLIAILALAFVHFNATGVWTFNYEDLLKTPMSHGVEYLLMLGFFIAFAVKMPVVPL
HGWLPDAHSQAPTAGSVDLAGILLKTAAYGLLRFALPLFPNASAEFAPIAMWLGVIGIFYGAWMAFAQTDIKRLIAYTSV
SHMGFVLIAIYTGSQLAYQGAVIQMIAHGLSAAGLFILCGQLYERLHTRDMRQMGGLWSKIKWLPAMSMFFAVATLGMPG
TGNFVGEFMILFGSYKVVPTITVISTFGLVFASVYSLSMLHRAYFGKAKSEAAAKELPGMSLRELSIILLLVVLLVLLGF
FPQPILDTSHAAMSNIQQWFVNSVSTTRP

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1008

COG function: function code C; NADH:ubiquinone oxidoreductase subunit 4 (chain M)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 4 family [H]

Homologues:

Organism=Homo sapiens, GI251831116, Length=367, Percent_Identity=32.6975476839237, Blast_Score=161, Evalue=1e-39,
Organism=Escherichia coli, GI1788613, Length=509, Percent_Identity=93.713163064833, Blast_Score=947, Evalue=0.0,
Organism=Escherichia coli, GI1788827, Length=452, Percent_Identity=25.6637168141593, Blast_Score=119, Evalue=3e-28,
Organism=Escherichia coli, GI1788831, Length=418, Percent_Identity=27.0334928229665, Blast_Score=105, Evalue=8e-24,
Organism=Escherichia coli, GI1788614, Length=525, Percent_Identity=25.5238095238095, Blast_Score=96, Evalue=8e-21,
Organism=Escherichia coli, GI145693160, Length=440, Percent_Identity=26.3636363636364, Blast_Score=76, Evalue=6e-15,
Organism=Escherichia coli, GI1788829, Length=345, Percent_Identity=26.6666666666667, Blast_Score=67, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010227
- InterPro:   IPR001750
- InterPro:   IPR003918 [H]

Pfam domain/function: PF00361 Oxidored_q1 [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 56441; Mature: 56441

Theoretical pI: Translated: 9.31; Mature: 9.31

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
5.1 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
5.1 %Met     (Mature Protein)
5.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLLPWLILIPFIGGFLCWQTERFGVKVPRWIALITMGLTLVLGLQLWMQGGYSLTQSAGI
CCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHCCCC
PQWQSEFVLPWIPRFGISIHLAIDGLSLLMVVLTGLLGVLAVLCSWREIEKYQGFFHLNL
CCCCCCCCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHH
MWILGGVIGVFLAIDMFLFFFFWEMMLVPMYFLIALWGHKASDGKTRITAATKFFIYTQA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEEEEEEEECC
SGLVMLIAILALAFVHFNATGVWTFNYEDLLKTPMSHGVEYLLMLGFFIAFAVKMPVVPL
CHHHHHHHHHHHHHHHCCCEEEEEECHHHHHHCHHHHHHHHHHHHHHHHHHHHHCCCEEC
HGWLPDAHSQAPTAGSVDLAGILLKTAAYGLLRFALPLFPNASAEFAPIAMWLGVIGIFY
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHH
GAWMAFAQTDIKRLIAYTSVSHMGFVLIAIYTGSQLAYQGAVIQMIAHGLSAAGLFILCG
HHHHHHHHHHHHHHHHHHHHHHHHEEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHH
QLYERLHTRDMRQMGGLWSKIKWLPAMSMFFAVATLGMPGTGNFVGEFMILFGSYKVVPT
HHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCHHHHH
ITVISTFGLVFASVYSLSMLHRAYFGKAKSEAAAKELPGMSLRELSIILLLVVLLVLLGF
HHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHC
FPQPILDTSHAAMSNIQQWFVNSVSTTRP
CCCCCCCCHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MLLPWLILIPFIGGFLCWQTERFGVKVPRWIALITMGLTLVLGLQLWMQGGYSLTQSAGI
CCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHCCCC
PQWQSEFVLPWIPRFGISIHLAIDGLSLLMVVLTGLLGVLAVLCSWREIEKYQGFFHLNL
CCCCCCCCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHH
MWILGGVIGVFLAIDMFLFFFFWEMMLVPMYFLIALWGHKASDGKTRITAATKFFIYTQA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEEEEEEEECC
SGLVMLIAILALAFVHFNATGVWTFNYEDLLKTPMSHGVEYLLMLGFFIAFAVKMPVVPL
CHHHHHHHHHHHHHHHCCCEEEEEECHHHHHHCHHHHHHHHHHHHHHHHHHHHHCCCEEC
HGWLPDAHSQAPTAGSVDLAGILLKTAAYGLLRFALPLFPNASAEFAPIAMWLGVIGIFY
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHH
GAWMAFAQTDIKRLIAYTSVSHMGFVLIAIYTGSQLAYQGAVIQMIAHGLSAAGLFILCG
HHHHHHHHHHHHHHHHHHHHHHHHEEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHH
QLYERLHTRDMRQMGGLWSKIKWLPAMSMFFAVATLGMPGTGNFVGEFMILFGSYKVVPT
HHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCHHHHH
ITVISTFGLVFASVYSLSMLHRAYFGKAKSEAAAKELPGMSLRELSIILLLVVLLVLLGF
HHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHC
FPQPILDTSHAAMSNIQQWFVNSVSTTRP
CCCCCCCCHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]