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The map label for this gene is thiD [H]

Identifier: 238895671

GI number: 238895671

Start: 3594204

End: 3595004

Strand: Reverse

Name: thiD [H]

Synonym: KP1_3768

Alternate gene names: 238895671

Gene position: 3595004-3594204 (Counterclockwise)

Preceding gene: 238895672

Following gene: 238895670

Centisome position: 68.5

GC content: 66.29

Gene sequence:

>801_bases
ATGAAACGCATCAACGCCCTGACCATCGCCGGCACCGATCCCAGCGGCGGGGCCGGTATCCAGGCCGATCTGAAAACCTT
CTCCGCGCTGGGGGCCTATGGCTGCTCGGCGATCACCGCCCTGGTGGCGCAGAATACCCGCGGCGTACAGTCGGTCTATC
GCATCGAACCGGATTTTGTGGCCGCGCAGCTCGACTCGGTGTTCAGCGATGTGCGTATCGATACCACCAAAATCGGCATG
CTGGCGGAGACCGATATTGTGGAAGCCGTGGCCGAGCGGCTGGCGCGCTACCGGGTGGCCAACGTGGTGCTGGATACCGT
CATGCTGGCGAAAAGCGGCGATCCGCTGCTGTCGGCCTCGGCGGTGGAGACCCTGCGTCAACGATTGTTGCCGCAGGTGT
CATTGATCACCCCGAACCTGCCGGAAGCGGCCGCGCTACTCGATGCCCCCCATGCGCGTAACGAACGGGAAATGCTGGAG
CAGGGGCGGGCGCTGCTGGCGCTGGGCTGCGGCGCGGTATTGATGAAGGGCGGCCATCTCGACGATGCCGAAAGCCCGGA
CTGGCTCTTCACCCGCGAAGGGGAACAGCGGTTCACCGCGCCGCGAGTGCAGACCAAAAATACCCACGGCACCGGCTGTA
CGCTCTCCGCCGCGCTGGCGGCGCTGCGCCCGCGTCACGCGGACTGGGCGGCCACCGTTATCGAGGCGAAGGCCTGGCTG
TCGGCGGCTCTGGCGCAGGCCGACTCTCTGGAGGTAGGCCACGGTATCGGGCCGGTGCACCATTTCCACGCCTGGTGGTA
A

Upstream 100 bases:

>100_bases
GCGGGCTGATGAAGCAGGCCGGGGCGATCGCCGCCCGTCAGGGAGGCCCAGGCAGCTTTATTCCGGCGTTTCTCGACGCG
CTGTATCAGGAGGTGCAGGG

Downstream 100 bases:

>100_bases
ATGGCAGCGCAACGGGACAGCAGAATCTCCTGAAAAAATGGCCCCCCGGCTGGAAAATAGGCTAAGTCGGTACCAGGCTT
AACCTGCCCAAAAAAATTGG

Product: phosphomethylpyrimidine kinase

Products: NA

Alternate protein names: Hydroxymethylpyrimidine kinase; HMP kinase; Hydroxymethylpyrimidine phosphate kinase; HMP-P kinase; HMP-phosphate kinase; HMPP kinase [H]

Number of amino acids: Translated: 266; Mature: 266

Protein sequence:

>266_residues
MKRINALTIAGTDPSGGAGIQADLKTFSALGAYGCSAITALVAQNTRGVQSVYRIEPDFVAAQLDSVFSDVRIDTTKIGM
LAETDIVEAVAERLARYRVANVVLDTVMLAKSGDPLLSASAVETLRQRLLPQVSLITPNLPEAAALLDAPHARNEREMLE
QGRALLALGCGAVLMKGGHLDDAESPDWLFTREGEQRFTAPRVQTKNTHGTGCTLSAALAALRPRHADWAATVIEAKAWL
SAALAQADSLEVGHGIGPVHHFHAWW

Sequences:

>Translated_266_residues
MKRINALTIAGTDPSGGAGIQADLKTFSALGAYGCSAITALVAQNTRGVQSVYRIEPDFVAAQLDSVFSDVRIDTTKIGM
LAETDIVEAVAERLARYRVANVVLDTVMLAKSGDPLLSASAVETLRQRLLPQVSLITPNLPEAAALLDAPHARNEREMLE
QGRALLALGCGAVLMKGGHLDDAESPDWLFTREGEQRFTAPRVQTKNTHGTGCTLSAALAALRPRHADWAATVIEAKAWL
SAALAQADSLEVGHGIGPVHHFHAWW
>Mature_266_residues
MKRINALTIAGTDPSGGAGIQADLKTFSALGAYGCSAITALVAQNTRGVQSVYRIEPDFVAAQLDSVFSDVRIDTTKIGM
LAETDIVEAVAERLARYRVANVVLDTVMLAKSGDPLLSASAVETLRQRLLPQVSLITPNLPEAAALLDAPHARNEREMLE
QGRALLALGCGAVLMKGGHLDDAESPDWLFTREGEQRFTAPRVQTKNTHGTGCTLSAALAALRPRHADWAATVIEAKAWL
SAALAQADSLEVGHGIGPVHHFHAWW

Specific function: Catalyzes the phosphorylation of hydroxymethylpyrimidine phosphate (HMP-P) to HMP-PP, and of HMP to HMP-P. Shows no activity with pyridoxal, pyridoxamine or pyridoxine [H]

COG id: COG0351

COG function: function code H; Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiD family [H]

Homologues:

Organism=Escherichia coli, GI1788420, Length=266, Percent_Identity=91.3533834586466, Blast_Score=503, Evalue=1e-144,
Organism=Saccharomyces cerevisiae, GI6325378, Length=271, Percent_Identity=29.8892988929889, Blast_Score=114, Evalue=1e-26,
Organism=Saccharomyces cerevisiae, GI6324997, Length=272, Percent_Identity=33.8235294117647, Blast_Score=108, Evalue=1e-24,
Organism=Saccharomyces cerevisiae, GI6324517, Length=272, Percent_Identity=33.8235294117647, Blast_Score=104, Evalue=1e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013749
- InterPro:   IPR004399 [H]

Pfam domain/function: PF08543 Phos_pyr_kin [H]

EC number: =2.7.1.49; =2.7.4.7 [H]

Molecular weight: Translated: 28378; Mature: 28378

Theoretical pI: Translated: 6.31; Mature: 6.31

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRINALTIAGTDPSGGAGIQADLKTFSALGAYGCSAITALVAQNTRGVQSVYRIEPDFV
CCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCHHH
AAQLDSVFSDVRIDTTKIGMLAETDIVEAVAERLARYRVANVVLDTVMLAKSGDPLLSAS
HHHHHHHHHHCCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHH
AVETLRQRLLPQVSLITPNLPEAAALLDAPHARNEREMLEQGRALLALGCGAVLMKGGHL
HHHHHHHHHCCCEEECCCCCCHHHHHHCCCCCCCHHHHHHCCCEEEEECHHHHHHCCCCC
DDAESPDWLFTREGEQRFTAPRVQTKNTHGTGCTLSAALAALRPRHADWAATVIEAKAWL
CCCCCCCEEEECCCCCHHCCCCCCCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHH
SAALAQADSLEVGHGIGPVHHFHAWW
HHHHHHHCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MKRINALTIAGTDPSGGAGIQADLKTFSALGAYGCSAITALVAQNTRGVQSVYRIEPDFV
CCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCHHH
AAQLDSVFSDVRIDTTKIGMLAETDIVEAVAERLARYRVANVVLDTVMLAKSGDPLLSAS
HHHHHHHHHHCCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHH
AVETLRQRLLPQVSLITPNLPEAAALLDAPHARNEREMLEQGRALLALGCGAVLMKGGHL
HHHHHHHHHCCCEEECCCCCCHHHHHHCCCCCCCHHHHHHCCCEEEEECHHHHHHCCCCC
DDAESPDWLFTREGEQRFTAPRVQTKNTHGTGCTLSAALAALRPRHADWAATVIEAKAWL
CCCCCCCEEEECCCCCHHCCCCCCCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHH
SAALAQADSLEVGHGIGPVHHFHAWW
HHHHHHHCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10075431; 9097040; 9278503 [H]