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The map label for this gene is thiM [H]

Identifier: 238895672

GI number: 238895672

Start: 3595001

End: 3595774

Strand: Reverse

Name: thiM [H]

Synonym: KP1_3769

Alternate gene names: 238895672

Gene position: 3595774-3595001 (Counterclockwise)

Preceding gene: 238895673

Following gene: 238895671

Centisome position: 68.51

GC content: 70.03

Gene sequence:

>774_bases
ATGCCTGAGCTGTTGAATCCCGCGCCTGTCGCGCACCTGCGCCATCTGCTGCGCGCCCATTCCCCCCTTGTGCACTGCAT
GACTAATGACGTGGTGCAGACCTTTACCGCCAATGTTCTGCTGGCCGTCGGCGCCTCGCCGGCGATGGTGATCGATCCCC
GCGAAGCGGCGCAGTTTGCCGCTATCGCCGATGCGCTGTTAATTAACGTCGGTACCCTGACCGAAGATCGCGCCGTGGCG
ATGCGCGCTGCGGTGGAGCACGCCCGTCAGGCCGGCAAGCCCTGGACGCTGGATCCGGTGGCGGTCGGCGCCCTGACCGT
GCGCACGGCCTTTTGTCACGAGCTGCTGGCCCTCCAGCCGGCGGCCATTCGCGGCAATGCCTCTGAAATTCTGGCGCTGG
CCGGGATGAGCGCCGGCGGGCGCGGGGTGGATACCACCGATACGGCCGCCGCGGCGCTGCCGGCGGCCCAGGCGCTGGCT
CGTCGGCTGGCCACCGTGGTGGCGGTCACTGGCGAGGTGGACTACGTCACCGACGGCGAGCGGGTGCTCAGCGTGGCGGG
GGGCAATCCGCTGATGACCCGGGTGGTGGGCACCGGCTGCGCGCTGTCGGCGGTGGTGGCGGCGAGCGCGGCGCTGCCGG
GAGACCGGCTGGAAAACGTGGCCGCCGCCTGCGGGCTGATGAAGCAGGCCGGGGCGATCGCCGCCCGTCAGGGAGGCCCA
GGCAGCTTTATTCCGGCGTTTCTCGACGCGCTGTATCAGGAGGTGCAGGGATGA

Upstream 100 bases:

>100_bases
GGCTGAGAAATACCCGTACCACCTGATCTGGATAATGCCAGCGTAGGGAAGTCAGAGACCGCAGGGTCATTGCTTCTACC
TCGTCTGGCGGGAGCAAACT

Downstream 100 bases:

>100_bases
AACGCATCAACGCCCTGACCATCGCCGGCACCGATCCCAGCGGCGGGGCCGGTATCCAGGCCGATCTGAAAACCTTCTCC
GCGCTGGGGGCCTATGGCTG

Product: hydroxyethylthiazole kinase

Products: NA

Alternate protein names: 4-methyl-5-beta-hydroxyethylthiazole kinase; TH kinase; Thz kinase [H]

Number of amino acids: Translated: 257; Mature: 256

Protein sequence:

>257_residues
MPELLNPAPVAHLRHLLRAHSPLVHCMTNDVVQTFTANVLLAVGASPAMVIDPREAAQFAAIADALLINVGTLTEDRAVA
MRAAVEHARQAGKPWTLDPVAVGALTVRTAFCHELLALQPAAIRGNASEILALAGMSAGGRGVDTTDTAAAALPAAQALA
RRLATVVAVTGEVDYVTDGERVLSVAGGNPLMTRVVGTGCALSAVVAASAALPGDRLENVAAACGLMKQAGAIAARQGGP
GSFIPAFLDALYQEVQG

Sequences:

>Translated_257_residues
MPELLNPAPVAHLRHLLRAHSPLVHCMTNDVVQTFTANVLLAVGASPAMVIDPREAAQFAAIADALLINVGTLTEDRAVA
MRAAVEHARQAGKPWTLDPVAVGALTVRTAFCHELLALQPAAIRGNASEILALAGMSAGGRGVDTTDTAAAALPAAQALA
RRLATVVAVTGEVDYVTDGERVLSVAGGNPLMTRVVGTGCALSAVVAASAALPGDRLENVAAACGLMKQAGAIAARQGGP
GSFIPAFLDALYQEVQG
>Mature_256_residues
PELLNPAPVAHLRHLLRAHSPLVHCMTNDVVQTFTANVLLAVGASPAMVIDPREAAQFAAIADALLINVGTLTEDRAVAM
RAAVEHARQAGKPWTLDPVAVGALTVRTAFCHELLALQPAAIRGNASEILALAGMSAGGRGVDTTDTAAAALPAAQALAR
RLATVVAVTGEVDYVTDGERVLSVAGGNPLMTRVVGTGCALSAVVAASAALPGDRLENVAAACGLMKQAGAIAARQGGPG
SFIPAFLDALYQEVQG

Specific function: Thiamine biosynthesis. [C]

COG id: COG2145

COG function: function code H; Hydroxyethylthiazole kinase, sugar kinase family

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Thz kinase family [H]

Homologues:

Organism=Escherichia coli, GI1788421, Length=255, Percent_Identity=71.7647058823529, Blast_Score=351, Evalue=3e-98,
Organism=Saccharomyces cerevisiae, GI6325042, Length=285, Percent_Identity=32.9824561403509, Blast_Score=108, Evalue=1e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000417 [H]

Pfam domain/function: PF02110 HK [H]

EC number: =2.7.1.50 [H]

Molecular weight: Translated: 26117; Mature: 25986

Theoretical pI: Translated: 6.23; Mature: 6.23

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPELLNPAPVAHLRHLLRAHSPLVHCMTNDVVQTFTANVLLAVGASPAMVIDPREAAQFA
CCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHEEECCCCEEEECHHHHHHHH
AIADALLINVGTLTEDRAVAMRAAVEHARQAGKPWTLDPVAVGALTVRTAFCHELLALQP
HHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCC
AAIRGNASEILALAGMSAGGRGVDTTDTAAAALPAAQALARRLATVVAVTGEVDYVTDGE
HHHCCCHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCH
RVLSVAGGNPLMTRVVGTGCALSAVVAASAALPGDRLENVAAACGLMKQAGAIAARQGGP
HEEEECCCCHHHHHHHHCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCEECCCCC
GSFIPAFLDALYQEVQG
CCHHHHHHHHHHHHHCC
>Mature Secondary Structure 
PELLNPAPVAHLRHLLRAHSPLVHCMTNDVVQTFTANVLLAVGASPAMVIDPREAAQFA
CCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHEEECCCCEEEECHHHHHHHH
AIADALLINVGTLTEDRAVAMRAAVEHARQAGKPWTLDPVAVGALTVRTAFCHELLALQP
HHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCC
AAIRGNASEILALAGMSAGGRGVDTTDTAAAALPAAQALARRLATVVAVTGEVDYVTDGE
HHHCCCHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCH
RVLSVAGGNPLMTRVVGTGCALSAVVAASAALPGDRLENVAAACGLMKQAGAIAARQGGP
HEEEECCCCHHHHHHHHCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCEECCCCC
GSFIPAFLDALYQEVQG
CCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA