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The map label for this gene is dctA [H]

Identifier: 238895645

GI number: 238895645

Start: 3559438

End: 3560712

Strand: Reverse

Name: dctA [H]

Synonym: KP1_3740

Alternate gene names: 238895645

Gene position: 3560712-3559438 (Counterclockwise)

Preceding gene: 238895655

Following gene: 238895639

Centisome position: 67.84

GC content: 59.37

Gene sequence:

>1275_bases
GTGGCAAACGCAAACAAACTCACGCTCTTCATCGTCGTTTTTATGCTGATGGGGATCCTCTCCGGCGCGGCTATCCATGC
CTACGCGACGCCAACCACCGTTTCCGCCTGGGCGGACAATATTACGCTGCTCACCGATCTGTTTCTGCGGTTGATCAAAA
TGGTCATCGCGCCGTTGGTGTTCAGCACCCTGACGGTCGGCATTATGCGCCTCGGCGAGACGGCGACCATCGGCCGGGTA
GGCGGCAAGGCGATGGTCTGGTTCATCACCTCCTCGGTATTATCCATTCTCGTCGGGCTGGTGATCGTCACCTTCCAGCA
CCCGGGCGCCGGGTTAAACCTGGCGGTGCCGAAAGAGGCGGTGGATACCGGCCTGGCGGTCAGCGGCATGAGCCTGAAAG
GGTTCCTGTCGCACACCATCCCCACCAGCATCACCGAGGCGATGGCCAACAACGAGATCCTGCAGATCGTGGTGTTCTCG
ATGTTCTTCGGCATCGCCGGCGCGTCGCTGGGGGAGAAGTTTAATGCTCCGCTGGTGGCGGCCCTTAACGTGGTGTCGCA
CATTATGCTGAAGGTGACGGGCTATGTGATGTACGTTGCGCCGCTGGCCATCTTCGCCGCCATCTCGTCGGTGATTGCCT
CCCAGGGGCTGGGGATCCTGCTCAACTATGCTTCGTTCATCGGCGGCTACTACCTGGCGGTGCTGTTGACCAGCGCGGTG
CTGATTGCCGTCGGCTATATGGTGCTGAAAAAAGAGGTTTTCCGCCTGCTGAACATGCTGAAAGATCCGGTGCTGGTGGC
CTTTACCACCAGCAGCTCGGAAGCGGCCTATCCGAAGACCCTTGAGCGACTGGTGAAGTTTGGCTGCTCGCGCAATATCG
TCTCGTTCGTCCTGCCGATTGGCTACTCGTTCAACCTCGTTGGCTCGATGGTCTACTGCTCCTTCGCCGCGATGTTTATC
GCCCAGGCCTATAACGTGCCGCTGAGCTTTAGCGAGATTACGGTCATGATGCTGACCCTGATGCTGGCCTCGAAAGGTAT
CGCCGGGGTGCCGCGTTCTGCGCTGGTGGTGCTGGCGGCGACGATCCCCAGCTTCAATATACCGGTCGCCGGGATCCTTC
TGCTGATGGGTATCGACCATTTCCTCGACATGGGGCGCTCTGCCATCAACGTGCTGGGTAATGGCATCGCCACCGCGATG
CTGTCGAAAAATGAAGGGTTGCTGACCGACGAGGAAGCGCAGCCGGACTGGGAAGTGGAGAAAGCGGAAGCCTGA

Upstream 100 bases:

>100_bases
GGCTTTAATTAGATTTATGCGGTGAATAAATCAGTGCATTCCCATAATAATAAAATATGCACTTAAAAATCAACATGTTA
AATAATCAGGGGTCATTGCT

Downstream 100 bases:

>100_bases
TCCTGCCGCGCCCTTTCACTGAGGGCGCTATTCCACACGGAAAAAAAGACCCCTGACAGGCACGTCAGGGGCAATGTGAC
GAAGTATCAGTTTTCCTCGT

Product: glutamate-aspartate symport protein

Products: L-aspartate [Cytoplasm]; Proton [Cytoplasm]; L-glutamate [Cytoplasm] [C]

Alternate protein names: C4-dicarboxylate permease [H]

Number of amino acids: Translated: 424; Mature: 423

Protein sequence:

>424_residues
MANANKLTLFIVVFMLMGILSGAAIHAYATPTTVSAWADNITLLTDLFLRLIKMVIAPLVFSTLTVGIMRLGETATIGRV
GGKAMVWFITSSVLSILVGLVIVTFQHPGAGLNLAVPKEAVDTGLAVSGMSLKGFLSHTIPTSITEAMANNEILQIVVFS
MFFGIAGASLGEKFNAPLVAALNVVSHIMLKVTGYVMYVAPLAIFAAISSVIASQGLGILLNYASFIGGYYLAVLLTSAV
LIAVGYMVLKKEVFRLLNMLKDPVLVAFTTSSSEAAYPKTLERLVKFGCSRNIVSFVLPIGYSFNLVGSMVYCSFAAMFI
AQAYNVPLSFSEITVMMLTLMLASKGIAGVPRSALVVLAATIPSFNIPVAGILLLMGIDHFLDMGRSAINVLGNGIATAM
LSKNEGLLTDEEAQPDWEVEKAEA

Sequences:

>Translated_424_residues
MANANKLTLFIVVFMLMGILSGAAIHAYATPTTVSAWADNITLLTDLFLRLIKMVIAPLVFSTLTVGIMRLGETATIGRV
GGKAMVWFITSSVLSILVGLVIVTFQHPGAGLNLAVPKEAVDTGLAVSGMSLKGFLSHTIPTSITEAMANNEILQIVVFS
MFFGIAGASLGEKFNAPLVAALNVVSHIMLKVTGYVMYVAPLAIFAAISSVIASQGLGILLNYASFIGGYYLAVLLTSAV
LIAVGYMVLKKEVFRLLNMLKDPVLVAFTTSSSEAAYPKTLERLVKFGCSRNIVSFVLPIGYSFNLVGSMVYCSFAAMFI
AQAYNVPLSFSEITVMMLTLMLASKGIAGVPRSALVVLAATIPSFNIPVAGILLLMGIDHFLDMGRSAINVLGNGIATAM
LSKNEGLLTDEEAQPDWEVEKAEA
>Mature_423_residues
ANANKLTLFIVVFMLMGILSGAAIHAYATPTTVSAWADNITLLTDLFLRLIKMVIAPLVFSTLTVGIMRLGETATIGRVG
GKAMVWFITSSVLSILVGLVIVTFQHPGAGLNLAVPKEAVDTGLAVSGMSLKGFLSHTIPTSITEAMANNEILQIVVFSM
FFGIAGASLGEKFNAPLVAALNVVSHIMLKVTGYVMYVAPLAIFAAISSVIASQGLGILLNYASFIGGYYLAVLLTSAVL
IAVGYMVLKKEVFRLLNMLKDPVLVAFTTSSSEAAYPKTLERLVKFGCSRNIVSFVLPIGYSFNLVGSMVYCSFAAMFIA
QAYNVPLSFSEITVMMLTLMLASKGIAGVPRSALVVLAATIPSFNIPVAGILLLMGIDHFLDMGRSAINVLGNGIATAML
SKNEGLLTDEEAQPDWEVEKAEA

Specific function: Responsible for the transport of succinate and fumarate, but not malate, across the membrane (Probable) [H]

COG id: COG1301

COG function: function code C; Na+/H+-dicarboxylate symporters

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2.A.23) family [H]

Homologues:

Organism=Homo sapiens, GI169790839, Length=418, Percent_Identity=26.7942583732057, Blast_Score=124, Evalue=2e-28,
Organism=Homo sapiens, GI21314632, Length=423, Percent_Identity=26.241134751773, Blast_Score=115, Evalue=9e-26,
Organism=Homo sapiens, GI4827012, Length=277, Percent_Identity=29.2418772563177, Blast_Score=111, Evalue=1e-24,
Organism=Homo sapiens, GI66773030, Length=462, Percent_Identity=24.4588744588745, Blast_Score=110, Evalue=2e-24,
Organism=Homo sapiens, GI223468564, Length=280, Percent_Identity=28.9285714285714, Blast_Score=109, Evalue=4e-24,
Organism=Homo sapiens, GI223468566, Length=280, Percent_Identity=28.9285714285714, Blast_Score=109, Evalue=5e-24,
Organism=Homo sapiens, GI5032093, Length=280, Percent_Identity=28.9285714285714, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI194239697, Length=258, Percent_Identity=30.6201550387597, Blast_Score=102, Evalue=9e-22,
Organism=Homo sapiens, GI40254478, Length=278, Percent_Identity=28.4172661870504, Blast_Score=98, Evalue=1e-20,
Organism=Homo sapiens, GI262359914, Length=343, Percent_Identity=25.3644314868805, Blast_Score=83, Evalue=4e-16,
Organism=Homo sapiens, GI301601644, Length=176, Percent_Identity=27.2727272727273, Blast_Score=73, Evalue=5e-13,
Organism=Escherichia coli, GI1790514, Length=409, Percent_Identity=35.9413202933985, Blast_Score=253, Evalue=2e-68,
Organism=Escherichia coli, GI1789947, Length=375, Percent_Identity=34.6666666666667, Blast_Score=222, Evalue=4e-59,
Organism=Escherichia coli, GI1788024, Length=394, Percent_Identity=24.3654822335025, Blast_Score=77, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI71996953, Length=476, Percent_Identity=24.5798319327731, Blast_Score=123, Evalue=2e-28,
Organism=Caenorhabditis elegans, GI71983106, Length=403, Percent_Identity=26.302729528536, Blast_Score=121, Evalue=6e-28,
Organism=Caenorhabditis elegans, GI71983099, Length=403, Percent_Identity=26.302729528536, Blast_Score=121, Evalue=6e-28,
Organism=Caenorhabditis elegans, GI17537407, Length=460, Percent_Identity=24.7826086956522, Blast_Score=120, Evalue=1e-27,
Organism=Caenorhabditis elegans, GI193206505, Length=428, Percent_Identity=26.4018691588785, Blast_Score=119, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI193206654, Length=407, Percent_Identity=24.3243243243243, Blast_Score=108, Evalue=4e-24,
Organism=Caenorhabditis elegans, GI17541374, Length=394, Percent_Identity=23.0964467005076, Blast_Score=88, Evalue=9e-18,
Organism=Drosophila melanogaster, GI24583025, Length=462, Percent_Identity=24.4588744588745, Blast_Score=122, Evalue=6e-28,
Organism=Drosophila melanogaster, GI17137668, Length=462, Percent_Identity=24.4588744588745, Blast_Score=122, Evalue=6e-28,
Organism=Drosophila melanogaster, GI24583023, Length=462, Percent_Identity=24.4588744588745, Blast_Score=122, Evalue=6e-28,
Organism=Drosophila melanogaster, GI281360481, Length=452, Percent_Identity=26.5486725663717, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI281360483, Length=452, Percent_Identity=26.5486725663717, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI17137666, Length=452, Percent_Identity=26.5486725663717, Blast_Score=84, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001991
- InterPro:   IPR018107 [H]

Pfam domain/function: PF00375 SDF [H]

EC number: NA

Molecular weight: Translated: 44956; Mature: 44825

Theoretical pI: Translated: 7.61; Mature: 7.61

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
5.0 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
4.7 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MANANKLTLFIVVFMLMGILSGAAIHAYATPTTVSAWADNITLLTDLFLRLIKMVIAPLV
CCCCHHHHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHCCHHHHHHHHHHHHHHHHHHHH
FSTLTVGIMRLGETATIGRVGGKAMVWFITSSVLSILVGLVIVTFQHPGAGLNLAVPKEA
HHHHHHHHHHCCCCCCHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEECCCHHH
VDTGLAVSGMSLKGFLSHTIPTSITEAMANNEILQIVVFSMFFGIAGASLGEKFNAPLVA
HHCCCEECCCCHHHHHHHCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCHHCCCHHHH
ALNVVSHIMLKVTGYVMYVAPLAIFAAISSVIASQGLGILLNYASFIGGYYLAVLLTSAV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHH
LIAVGYMVLKKEVFRLLNMLKDPVLVAFTTSSSEAAYPKTLERLVKFGCSRNIVSFVLPI
HHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCHHHHHHHHHHCCCCCHHHHHHHC
GYSFNLVGSMVYCSFAAMFIAQAYNVPLSFSEITVMMLTLMLASKGIAGVPRSALVVLAA
CCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHH
TIPSFNIPVAGILLLMGIDHFLDMGRSAINVLGNGIATAMLSKNEGLLTDEEAQPDWEVE
HCCCCCCCHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC
KAEA
CCCC
>Mature Secondary Structure 
ANANKLTLFIVVFMLMGILSGAAIHAYATPTTVSAWADNITLLTDLFLRLIKMVIAPLV
CCCHHHHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHCCHHHHHHHHHHHHHHHHHHHH
FSTLTVGIMRLGETATIGRVGGKAMVWFITSSVLSILVGLVIVTFQHPGAGLNLAVPKEA
HHHHHHHHHHCCCCCCHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEECCCHHH
VDTGLAVSGMSLKGFLSHTIPTSITEAMANNEILQIVVFSMFFGIAGASLGEKFNAPLVA
HHCCCEECCCCHHHHHHHCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCHHCCCHHHH
ALNVVSHIMLKVTGYVMYVAPLAIFAAISSVIASQGLGILLNYASFIGGYYLAVLLTSAV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHH
LIAVGYMVLKKEVFRLLNMLKDPVLVAFTTSSSEAAYPKTLERLVKFGCSRNIVSFVLPI
HHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCHHHHHHHHHHCCCCCHHHHHHHC
GYSFNLVGSMVYCSFAAMFIAQAYNVPLSFSEITVMMLTLMLASKGIAGVPRSALVVLAA
CCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHH
TIPSFNIPVAGILLLMGIDHFLDMGRSAINVLGNGIATAMLSKNEGLLTDEEAQPDWEVE
HCCCCCCCHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC
KAEA
CCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: L-aspartate [Periplasm]; Proton [Periplasm]; L-glutamate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-aspartate [Periplasm] = Proton [Cytoplasm] + L-aspartate [Cytoplasm] Proton [Periplasm] + L-glutamate [Periplasm] = Proton [Cytoplasm] + L-glutamate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9384377; 10708364 [H]