Click here to switch to the map view.

The map label for this gene is hisD [H]

Identifier: 238895597

GI number: 238895597

Start: 3501484

End: 3502788

Strand: Direct

Name: hisD [H]

Synonym: KP1_3680

Alternate gene names: 238895597

Gene position: 3501484-3502788 (Clockwise)

Preceding gene: 238895596

Following gene: 238895598

Centisome position: 66.71

GC content: 65.67

Gene sequence:

>1305_bases
ATGAGCTTCAACACAATCATCGACTGGAACGGCTGTAGCGCAGACCAACAACAGCAACTCTTAACGCGCCCGGCGATTTC
CGCCTCCGACAGCATCAGTAAAACGGTGACGGAGATCCTGAATAACGTCAAAGCCAACGGCGACGCGGCGCTGCGCGAAT
ACAGCGCGAAGTTTGATAAAACCACCGTCGCCGCGCTGCAGGTGAGCGAGGCGGAGATCGCCGCCGCCGGCGAGCGCCTC
AGCGATGAGCTGAAGCAGGCGATGGCGGTGGCGGTGAAAAACATCGAGACCTTTCACAACGCGCAACAGCTGCAGGCGGT
GGATGTCGAAACGCTGCCGGGGGTGCGCTGCCAGCAGGTCACCCGCCCTATCGCCTCCGTCGGACTGTACATTCCCGGCG
GCTCAGCGCCGCTGTTCTCCACGGTGCTGATGCTGGCGACGCCGGCGCGCATCGCCGGCTGTCAGCAGGTGGTGCTCTGC
TCGCCGCCGCCGATTGCCGATGAGATCCTCTATGCCGCACAGCTGTGCGGCGTAAAAACCATCTTTAACGTCGGCGGCGC
CCAGGCCATCGCCGCCCTCGCCCTCGGTACCGAGTCGGTGCCGAAGGTGGATAAAATCTTTGGCCCGGGCAACGCTTACG
TCACGGAAGCCAAACGCCAGGTCAGTCAGCGTCTGGACGGCGCAGCCATCGACATGCCGGCCGGCCCGTCGGAAGTGCTG
GTCATCGCCGACAGCGGCGCCAACCCGGACTTTGTCGCCTCCGACCTGCTGTCGCAGGCGGAACACGGCCCGGACTCGCA
GGTGATCCTCCTGACCCCGGACGCCGACATGGGCAGCCGCGTCGCCGAAGCCGTGGAGCGCCAGCTGGCCGCCCTGCCGC
GCGCGGAAACCGCCCGCGTGGCGCTCTCCGCCAGCCGGATCATCGTGGCCCGCGATCTGGCGCAGTGCGTGGCTATCTCC
AACCTGTACGGCCCGGAGCACCTGATCATTCAGACCCGTCAGGCCCGCGAGCTGGTGGACAGCATCACCAGCGCCGGTTC
CGTTTTTCTTGGCGACTGGTCACCGGAATCCGCGGGCGACTACGCCTCGGGCACCAACCACGTCCTGCCGACCTATGGTT
ACACCGCCACCTGCTCAAGCCTCGGCCTGGCCGACTTCCAGAAGCGGATGACCGTGCAGGAGCTGTCGCGCGACGGCTTT
GCCGCCCTCGCCTCAACGATTGAGATCCTGGCCGCCGCCGAGCGCCTTGACGCCCACAAAAACGCCGTAACGCTGCGCGT
TGCCGCCCTGAAGGAGCAAGCATGA

Upstream 100 bases:

>100_bases
ACTGAAGGCGCTGGGCGCCAGCTCCATTCTGGTGCTGCCGATTGAGAAAATGATGGAGTAATCGGCCAGCCGGTCACGGG
ACACACAGGGGAATACAATC

Downstream 100 bases:

>100_bases
GCATTGAAGATTTAGCCCGCGCCAACGTCCGCGCGCTGACCCCGTATCAATCCGCTCGCCGGCTGGGCGGCAAAGGCGAC
GTCTGGCTCAACGCCAACGA

Product: histidinol dehydrogenase

Products: NA

Alternate protein names: HDH [H]

Number of amino acids: Translated: 434; Mature: 433

Protein sequence:

>434_residues
MSFNTIIDWNGCSADQQQQLLTRPAISASDSISKTVTEILNNVKANGDAALREYSAKFDKTTVAALQVSEAEIAAAGERL
SDELKQAMAVAVKNIETFHNAQQLQAVDVETLPGVRCQQVTRPIASVGLYIPGGSAPLFSTVLMLATPARIAGCQQVVLC
SPPPIADEILYAAQLCGVKTIFNVGGAQAIAALALGTESVPKVDKIFGPGNAYVTEAKRQVSQRLDGAAIDMPAGPSEVL
VIADSGANPDFVASDLLSQAEHGPDSQVILLTPDADMGSRVAEAVERQLAALPRAETARVALSASRIIVARDLAQCVAIS
NLYGPEHLIIQTRQARELVDSITSAGSVFLGDWSPESAGDYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSRDGF
AALASTIEILAAAERLDAHKNAVTLRVAALKEQA

Sequences:

>Translated_434_residues
MSFNTIIDWNGCSADQQQQLLTRPAISASDSISKTVTEILNNVKANGDAALREYSAKFDKTTVAALQVSEAEIAAAGERL
SDELKQAMAVAVKNIETFHNAQQLQAVDVETLPGVRCQQVTRPIASVGLYIPGGSAPLFSTVLMLATPARIAGCQQVVLC
SPPPIADEILYAAQLCGVKTIFNVGGAQAIAALALGTESVPKVDKIFGPGNAYVTEAKRQVSQRLDGAAIDMPAGPSEVL
VIADSGANPDFVASDLLSQAEHGPDSQVILLTPDADMGSRVAEAVERQLAALPRAETARVALSASRIIVARDLAQCVAIS
NLYGPEHLIIQTRQARELVDSITSAGSVFLGDWSPESAGDYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSRDGF
AALASTIEILAAAERLDAHKNAVTLRVAALKEQA
>Mature_433_residues
SFNTIIDWNGCSADQQQQLLTRPAISASDSISKTVTEILNNVKANGDAALREYSAKFDKTTVAALQVSEAEIAAAGERLS
DELKQAMAVAVKNIETFHNAQQLQAVDVETLPGVRCQQVTRPIASVGLYIPGGSAPLFSTVLMLATPARIAGCQQVVLCS
PPPIADEILYAAQLCGVKTIFNVGGAQAIAALALGTESVPKVDKIFGPGNAYVTEAKRQVSQRLDGAAIDMPAGPSEVLV
IADSGANPDFVASDLLSQAEHGPDSQVILLTPDADMGSRVAEAVERQLAALPRAETARVALSASRIIVARDLAQCVAISN
LYGPEHLIIQTRQARELVDSITSAGSVFLGDWSPESAGDYASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSRDGFA
ALASTIEILAAAERLDAHKNAVTLRVAALKEQA

Specific function: Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine [H]

COG id: COG0141

COG function: function code E; Histidinol dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the histidinol dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI1788331, Length=434, Percent_Identity=88.2488479262673, Blast_Score=785, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6319819, Length=422, Percent_Identity=45.0236966824645, Blast_Score=355, Evalue=6e-99,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016161
- InterPro:   IPR022695
- InterPro:   IPR001692
- InterPro:   IPR012131 [H]

Pfam domain/function: PF00815 Histidinol_dh [H]

EC number: =1.1.1.23 [H]

Molecular weight: Translated: 45626; Mature: 45495

Theoretical pI: Translated: 4.63; Mature: 4.63

Prosite motif: PS00611 HISOL_DEHYDROGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSFNTIIDWNGCSADQQQQLLTRPAISASDSISKTVTEILNNVKANGDAALREYSAKFDK
CCCCEEEECCCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCC
TTVAALQVSEAEIAAAGERLSDELKQAMAVAVKNIETFHNAQQLQAVDVETLPGVRCQQV
CEEEHEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECHHHCCCCHHHHH
TRPIASVGLYIPGGSAPLFSTVLMLATPARIAGCQQVVLCSPPPIADEILYAAQLCGVKT
HHHHHHCEEECCCCCCHHHHHHHHHHCCHHHHCCCEEEEECCCCHHHHHHHHHHHHHHHH
IFNVGGAQAIAALALGTESVPKVDKIFGPGNAYVTEAKRQVSQRLDGAAIDMPAGPSEVL
HHHCCHHHHHHHHHHCCCCCCCHHHHCCCCCHHHHHHHHHHHHHCCCCEEECCCCCCCEE
VIADSGANPDFVASDLLSQAEHGPDSQVILLTPDADMGSRVAEAVERQLAALPRAETARV
EEECCCCCCHHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHCCCCHHHHE
ALSASRIIVARDLAQCVAISNLYGPEHLIIQTRQARELVDSITSAGSVFLGDWSPESAGD
EHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECHHHHHHHHHHHCCCCEEEECCCCCCCCC
YASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSRDGFAALASTIEILAAAERLDAHK
CCCCCCCCCCCCCCHHHHHHCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCC
NAVTLRVAALKEQA
CEEEEEEEHHCCCC
>Mature Secondary Structure 
SFNTIIDWNGCSADQQQQLLTRPAISASDSISKTVTEILNNVKANGDAALREYSAKFDK
CCCEEEECCCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCC
TTVAALQVSEAEIAAAGERLSDELKQAMAVAVKNIETFHNAQQLQAVDVETLPGVRCQQV
CEEEHEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECHHHCCCCHHHHH
TRPIASVGLYIPGGSAPLFSTVLMLATPARIAGCQQVVLCSPPPIADEILYAAQLCGVKT
HHHHHHCEEECCCCCCHHHHHHHHHHCCHHHHCCCEEEEECCCCHHHHHHHHHHHHHHHH
IFNVGGAQAIAALALGTESVPKVDKIFGPGNAYVTEAKRQVSQRLDGAAIDMPAGPSEVL
HHHCCHHHHHHHHHHCCCCCCCHHHHCCCCCHHHHHHHHHHHHHCCCCEEECCCCCCCEE
VIADSGANPDFVASDLLSQAEHGPDSQVILLTPDADMGSRVAEAVERQLAALPRAETARV
EEECCCCCCHHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHCCCCHHHHE
ALSASRIIVARDLAQCVAISNLYGPEHLIIQTRQARELVDSITSAGSVFLGDWSPESAGD
EHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECHHHHHHHHHHHCCCCEEEECCCCCCCCC
YASGTNHVLPTYGYTATCSSLGLADFQKRMTVQELSRDGFAALASTIEILAAAERLDAHK
CCCCCCCCCCCCCCHHHHHHCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCC
NAVTLRVAALKEQA
CEEEEEEEHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10222209; 11206551; 11258796 [H]