Click here to switch to the map view.

The map label for this gene is hisC [H]

Identifier: 238895598

GI number: 238895598

Start: 3502785

End: 3503846

Strand: Direct

Name: hisC [H]

Synonym: KP1_3681

Alternate gene names: 238895598

Gene position: 3502785-3503846 (Clockwise)

Preceding gene: 238895597

Following gene: 238895599

Centisome position: 66.74

GC content: 64.12

Gene sequence:

>1062_bases
ATGAGCATTGAAGATTTAGCCCGCGCCAACGTCCGCGCGCTGACCCCGTATCAATCCGCTCGCCGGCTGGGCGGCAAAGG
CGACGTCTGGCTCAACGCCAACGAATTCCCTACCGCCGTAGCCTTCCAGCTTACCGAACAGACGCTGAACCGCTATCCGG
AGCCGCAGCCGAAGGCCGTGATTGAGAGCTACGCCCGCTACGCCGAGGTCAAACCGGAGCAGGTGCTGGTCAGCCGCGGC
GCCGACGAAGGCATCGAGCTGCTGATCCGCGCCTTCTGCGAGCCCGGCGAAGACGCGGTGCTCTACTGCCCGCCGACCTA
CGGCATGTACAGCGTCAGCGCCGAGACCATCGGCGTCGAATGCCGCACCGTGCCGACGCTGGCCGACTGGCAGCTCGACC
TGCCGGGCATCGAGGCGCGGCTGGACGGCGTGAAGGTGGTCTTCGTCTGCAGCCCGAACAACCCGACCGGGCAGATTATC
GACCCGCAGTCGATGCGCGACCTGCTGGAGATGACCCGCGGCAAAGCCATCGTGGTGGCCGACGAAGCCTATATTGAATT
CTGCCCGCAGGCGACGCTCGCCGGCTGGCTCAGCGACTATCCGCACCTGGTGGTGCTGCGCACGCTGTCCAAAGCCTTCG
CCCTCGCCGGCCTGCGCTGCGGCTTCACCCTCGCCAACGCCGAGGTGATCAACGTGCTGCTGAAAGTGATCGCCCCGTAC
CCGCTCTCCACGCCGGTGGCCGATATCGCCGCCCAGGCCCTGAGCCCGGAGGGGATCGCCGCGATGCGCCAGCGCGTGGC
GCAGATCCTTGACGAGCGCCGCTACCTGGTGGAACAGCTGCGCGGCATCGCCTGCGTGGAGCAGGTCTTCGATTCCGAGA
CTAACTATGTGCTGGCGCGGATAACCGCCTCCAGCGCAGTGTTTAAATCTTTGTGGGATCAGGGCATTATCTTACGTGAC
CAGAATAAACAACCTTCATTAAGCGGCTGTTTGCGTATCACTATCGGTACCCGTGCCGAGAGCCAGCGCGTGATTGACGC
CTTGACTGCGGAGAATGTATGA

Upstream 100 bases:

>100_bases
CCGCCCTCGCCTCAACGATTGAGATCCTGGCCGCCGCCGAGCGCCTTGACGCCCACAAAAACGCCGTAACGCTGCGCGTT
GCCGCCCTGAAGGAGCAAGC

Downstream 100 bases:

>100_bases
CCCAGAAGTATCTCTTTATTGACCGTGACGGCACCCTGATTTCCGAACCGCCGGAGGATTTCCAGGTGGACCGGTTCGAC
AAGCTGGCGTTTGAGCCGCA

Product: histidinol-phosphate aminotransferase

Products: NA

Alternate protein names: Imidazole acetol-phosphate transaminase [H]

Number of amino acids: Translated: 353; Mature: 352

Protein sequence:

>353_residues
MSIEDLARANVRALTPYQSARRLGGKGDVWLNANEFPTAVAFQLTEQTLNRYPEPQPKAVIESYARYAEVKPEQVLVSRG
ADEGIELLIRAFCEPGEDAVLYCPPTYGMYSVSAETIGVECRTVPTLADWQLDLPGIEARLDGVKVVFVCSPNNPTGQII
DPQSMRDLLEMTRGKAIVVADEAYIEFCPQATLAGWLSDYPHLVVLRTLSKAFALAGLRCGFTLANAEVINVLLKVIAPY
PLSTPVADIAAQALSPEGIAAMRQRVAQILDERRYLVEQLRGIACVEQVFDSETNYVLARITASSAVFKSLWDQGIILRD
QNKQPSLSGCLRITIGTRAESQRVIDALTAENV

Sequences:

>Translated_353_residues
MSIEDLARANVRALTPYQSARRLGGKGDVWLNANEFPTAVAFQLTEQTLNRYPEPQPKAVIESYARYAEVKPEQVLVSRG
ADEGIELLIRAFCEPGEDAVLYCPPTYGMYSVSAETIGVECRTVPTLADWQLDLPGIEARLDGVKVVFVCSPNNPTGQII
DPQSMRDLLEMTRGKAIVVADEAYIEFCPQATLAGWLSDYPHLVVLRTLSKAFALAGLRCGFTLANAEVINVLLKVIAPY
PLSTPVADIAAQALSPEGIAAMRQRVAQILDERRYLVEQLRGIACVEQVFDSETNYVLARITASSAVFKSLWDQGIILRD
QNKQPSLSGCLRITIGTRAESQRVIDALTAENV
>Mature_352_residues
SIEDLARANVRALTPYQSARRLGGKGDVWLNANEFPTAVAFQLTEQTLNRYPEPQPKAVIESYARYAEVKPEQVLVSRGA
DEGIELLIRAFCEPGEDAVLYCPPTYGMYSVSAETIGVECRTVPTLADWQLDLPGIEARLDGVKVVFVCSPNNPTGQIID
PQSMRDLLEMTRGKAIVVADEAYIEFCPQATLAGWLSDYPHLVVLRTLSKAFALAGLRCGFTLANAEVINVLLKVIAPYP
LSTPVADIAAQALSPEGIAAMRQRVAQILDERRYLVEQLRGIACVEQVFDSETNYVLARITASSAVFKSLWDQGIILRDQ
NKQPSLSGCLRITIGTRAESQRVIDALTAENV

Specific function: Histidine biosynthesis; seventh step. [C]

COG id: COG0079

COG function: function code E; Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788332, Length=353, Percent_Identity=84.4192634560906, Blast_Score=623, Evalue=1e-180,
Organism=Escherichia coli, GI1788722, Length=255, Percent_Identity=27.843137254902, Blast_Score=62, Evalue=7e-11,
Organism=Saccharomyces cerevisiae, GI6322075, Length=375, Percent_Identity=34.1333333333333, Blast_Score=189, Evalue=8e-49,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR005861
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.6.1.9 [H]

Molecular weight: Translated: 38732; Mature: 38601

Theoretical pI: Translated: 4.66; Mature: 4.66

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSIEDLARANVRALTPYQSARRLGGKGDVWLNANEFPTAVAFQLTEQTLNRYPEPQPKAV
CCHHHHHHCCCEEECCHHHHHHCCCCCCEEECCCCCCCHHHHHHHHHHHHCCCCCCHHHH
IESYARYAEVKPEQVLVSRGADEGIELLIRAFCEPGEDAVLYCPPTYGMYSVSAETIGVE
HHHHHHHHHCCHHHHHHHCCCCHHHHHHHHHHCCCCCCCEEECCCCCCEEEECHHHCCEE
CRTVPTLADWQLDLPGIEARLDGVKVVFVCSPNNPTGQIIDPQSMRDLLEMTRGKAIVVA
EEECCCCCCCEECCCCCCEEECCEEEEEEECCCCCCCCEECHHHHHHHHHHHCCCEEEEE
DEAYIEFCPQATLAGWLSDYPHLVVLRTLSKAFALAGLRCGFTLANAEVINVLLKVIAPY
CHHHHHHCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCEEEHHHHHHHHHHHHHCCC
PLSTPVADIAAQALSPEGIAAMRQRVAQILDERRYLVEQLRGIACVEQVFDSETNYVLAR
CCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEE
ITASSAVFKSLWDQGIILRDQNKQPSLSGCLRITIGTRAESQRVIDALTAENV
EEHHHHHHHHHHHCCCEEECCCCCCCCCCEEEEEECCCCHHHHHHHHHHHCCC
>Mature Secondary Structure 
SIEDLARANVRALTPYQSARRLGGKGDVWLNANEFPTAVAFQLTEQTLNRYPEPQPKAV
CHHHHHHCCCEEECCHHHHHHCCCCCCEEECCCCCCCHHHHHHHHHHHHCCCCCCHHHH
IESYARYAEVKPEQVLVSRGADEGIELLIRAFCEPGEDAVLYCPPTYGMYSVSAETIGVE
HHHHHHHHHCCHHHHHHHCCCCHHHHHHHHHHCCCCCCCEEECCCCCCEEEECHHHCCEE
CRTVPTLADWQLDLPGIEARLDGVKVVFVCSPNNPTGQIIDPQSMRDLLEMTRGKAIVVA
EEECCCCCCCEECCCCCCEEECCEEEEEEECCCCCCCCEECHHHHHHHHHHHCCCEEEEE
DEAYIEFCPQATLAGWLSDYPHLVVLRTLSKAFALAGLRCGFTLANAEVINVLLKVIAPY
CHHHHHHCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCEEEHHHHHHHHHHHHHCCC
PLSTPVADIAAQALSPEGIAAMRQRVAQILDERRYLVEQLRGIACVEQVFDSETNYVLAR
CCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEE
ITASSAVFKSLWDQGIILRDQNKQPSLSGCLRITIGTRAESQRVIDALTAENV
EEHHHHHHHHHHHCCCEEECCCCCCCCCCEEEEEECCCCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA