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The map label for this gene is uvrY [H]

Identifier: 238895472

GI number: 238895472

Start: 3359327

End: 3359983

Strand: Reverse

Name: uvrY [H]

Synonym: KP1_3542

Alternate gene names: 238895472

Gene position: 3359983-3359327 (Counterclockwise)

Preceding gene: 238895474

Following gene: 238895471

Centisome position: 64.02

GC content: 53.27

Gene sequence:

>657_bases
TTGATCAACGTTCTTCTTGTTGATGACCACGAACTGGTGCGCGCAGGGATACGACGCATTCTGGAAGATATAAAAGGGAT
TAAAGTCGCTGGCGAAGCCTGCTGCGGCGAGGACGCCGTCAAGTGGTGCCGGGCTAATTCCGCAGATGTCGTCCTGATGG
ACATGAACATGCCTGGGATCGGTGGTCTTGAAGCGACGCGCAAAATCGCGCGCTCCGTGGCGGGCACCAAAGTGATCATG
TTAACCGTGCATACCGAGAATCCTTTACCTGCCAAGGTCATGCAGGCGGGCGCGGCGGGTTATCTCAGTAAAGGCGCCGC
GCCGCAGGAAGTGGTGAATGCCATCCGCTGCGTCGCGTCCGGGCAGCGCTATATTGCCTCCGATATTGCCCAGCAAATGG
CGTTAAGTCAGATTGAACCCGATAAGACAGAATCGCCGTTTGCCAGTTTGTCTGAACGCGAATTGCAGATTATGCTGATG
ATCACCAAAGGTCAGAAGGTGAATGAGATCTCAGAGCAGCTAAATCTGAGTCCTAAAACGGTTAACAGCTACCGCTATCG
GATGTTCAGTAAATTAAACATTCATGGCGATGTCGAGCTGACCCACCTGGCAATTCGCCATGGCCTGTGTAATGCGGAGT
CGTTAGCAAGCCAGTGA

Upstream 100 bases:

>100_bases
GCGAGGGCATTTTTTTGCCTTTTAAAATAGCAATAAAACCCGGTAATATGTGGGAGATAAAGTATCAGTAGCGTTATCCC
TCATTCTGGAGATTATTCCT

Downstream 100 bases:

>100_bases
GTGATGTTTTTGACGCAAAAGCTTTCCTGAAAACGGTGACCAGCCAGCCCGGTGTGTATCGGATGTATGATGCTGGCGGA
ACCGTCATCTATGTTGGCAA

Product: response regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 218; Mature: 218

Protein sequence:

>218_residues
MINVLLVDDHELVRAGIRRILEDIKGIKVAGEACCGEDAVKWCRANSADVVLMDMNMPGIGGLEATRKIARSVAGTKVIM
LTVHTENPLPAKVMQAGAAGYLSKGAAPQEVVNAIRCVASGQRYIASDIAQQMALSQIEPDKTESPFASLSERELQIMLM
ITKGQKVNEISEQLNLSPKTVNSYRYRMFSKLNIHGDVELTHLAIRHGLCNAESLASQ

Sequences:

>Translated_218_residues
MINVLLVDDHELVRAGIRRILEDIKGIKVAGEACCGEDAVKWCRANSADVVLMDMNMPGIGGLEATRKIARSVAGTKVIM
LTVHTENPLPAKVMQAGAAGYLSKGAAPQEVVNAIRCVASGQRYIASDIAQQMALSQIEPDKTESPFASLSERELQIMLM
ITKGQKVNEISEQLNLSPKTVNSYRYRMFSKLNIHGDVELTHLAIRHGLCNAESLASQ
>Mature_218_residues
MINVLLVDDHELVRAGIRRILEDIKGIKVAGEACCGEDAVKWCRANSADVVLMDMNMPGIGGLEATRKIARSVAGTKVIM
LTVHTENPLPAKVMQAGAAGYLSKGAAPQEVVNAIRCVASGQRYIASDIAQQMALSQIEPDKTESPFASLSERELQIMLM
ITKGQKVNEISEQLNLSPKTVNSYRYRMFSKLNIHGDVELTHLAIRHGLCNAESLASQ

Specific function: Member of the two-component regulatory system UvrY/BarA involved in the regulation of carbon metabolism via the CsrA/CsrB regulatory system. UvrY activates the transcription of the untranslated csrB RNA and of barA, in an autoregulatory loop. Mediates the

COG id: COG2197

COG function: function code TK; Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1788222, Length=218, Percent_Identity=92.6605504587156, Blast_Score=421, Evalue=1e-119,
Organism=Escherichia coli, GI1790102, Length=200, Percent_Identity=35.5, Blast_Score=121, Evalue=5e-29,
Organism=Escherichia coli, GI1788521, Length=206, Percent_Identity=32.0388349514563, Blast_Score=112, Evalue=2e-26,
Organism=Escherichia coli, GI1786747, Length=205, Percent_Identity=26.3414634146341, Blast_Score=95, Evalue=5e-21,
Organism=Escherichia coli, GI1788712, Length=209, Percent_Identity=26.3157894736842, Blast_Score=86, Evalue=2e-18,
Organism=Escherichia coli, GI1787473, Length=185, Percent_Identity=28.6486486486486, Blast_Score=81, Evalue=5e-17,
Organism=Escherichia coli, GI1788546, Length=206, Percent_Identity=26.6990291262136, Blast_Score=77, Evalue=7e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001789
- InterPro:   IPR000792
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00196 GerE; PF00072 Response_reg [H]

EC number: NA

Molecular weight: Translated: 23701; Mature: 23701

Theoretical pI: Translated: 7.46; Mature: 7.46

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00622 HTH_LUXR_1 ; PS50043 HTH_LUXR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
4.6 %Met     (Translated Protein)
6.9 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
4.6 %Met     (Mature Protein)
6.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MINVLLVDDHELVRAGIRRILEDIKGIKVAGEACCGEDAVKWCRANSADVVLMDMNMPGI
CEEEEEECCHHHHHHHHHHHHHHHCCCEECCHHHCCHHHHHHHCCCCCCEEEEECCCCCC
GGLEATRKIARSVAGTKVIMLTVHTENPLPAKVMQAGAAGYLSKGAAPQEVVNAIRCVAS
CCHHHHHHHHHHHCCCEEEEEEEECCCCCCHHHHHHCCCHHHHCCCCHHHHHHHHHHHHC
GQRYIASDIAQQMALSQIEPDKTESPFASLSERELQIMLMITKGQKVNEISEQLNLSPKT
CCHHHHHHHHHHHHHHHCCCCCCCCCHHHHCCCCEEEEEEEECCCHHHHHHHHHCCCCCH
VNSYRYRMFSKLNIHGDVELTHLAIRHGLCNAESLASQ
HHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCHHHHCCC
>Mature Secondary Structure
MINVLLVDDHELVRAGIRRILEDIKGIKVAGEACCGEDAVKWCRANSADVVLMDMNMPGI
CEEEEEECCHHHHHHHHHHHHHHHCCCEECCHHHCCHHHHHHHCCCCCCEEEEECCCCCC
GGLEATRKIARSVAGTKVIMLTVHTENPLPAKVMQAGAAGYLSKGAAPQEVVNAIRCVAS
CCHHHHHHHHHHHCCCEEEEEEEECCCCCCHHHHHHCCCHHHHCCCCHHHHHHHHHHHHC
GQRYIASDIAQQMALSQIEPDKTESPFASLSERELQIMLMITKGQKVNEISEQLNLSPKT
CCHHHHHHHHHHHHHHHCCCCCCCCCHHHHCCCCEEEEEEEECCCHHHHHHHHHCCCCCH
VNSYRYRMFSKLNIHGDVELTHLAIRHGLCNAESLASQ
HHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]