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The map label for this gene is ftsI [H]

Identifier: 238895398

GI number: 238895398

Start: 3285060

End: 3286829

Strand: Reverse

Name: ftsI [H]

Synonym: KP1_3464

Alternate gene names: 238895398

Gene position: 3286829-3285060 (Counterclockwise)

Preceding gene: 238895399

Following gene: 238895397

Centisome position: 62.62

GC content: 59.83

Gene sequence:

>1770_bases
TTGCAAAACAATGCCGGAGCTATGGTGCTAAAGAAAAAAACGAAGTCCGCCGCCAGTTTCACCCCGATTCGCTTCGGGTT
ACTGTGTGTGGCCATTCTCGGTTGTCTGGGGCTGCTGCTGGTCCGCGTGGGCTGGCTACAAATTATCTCCCCCGATAACC
TGGTAAAACAAGAAGATATGCGCTCCCTGCGCGAAGAACCCGTAGCGGTTGAGCGGGGGATGATCAGCGACCGGGAAGGA
CGGCCGCTGGCGGTGAGCGTTCCGGTCAGTGCTATCTGGATCGACCCGCAGACCACTATGGAGAAGGGCGGTGTGGGCTA
TGGACCCCGCTGGCAGGCGATGGCCGAAGCGCTGCACCTCAACCTCGGAGAGCTGGCCCAGCGGGTACAGAGTCATCCCC
ACGCTCGCTTTCTCTATCTGGCGCGTCAGATCAATCCCGAGCAGGCAGAGTGGATTGATAAACTGCATCTGCCGGGCGTT
TACCTGCGCGATGAATCGCGACGGTTCTACCCGGCGGGCCACGTGGCTGCCAATCTGCTGGGCTTTACCAATGTTGATAA
TCAGGGCATCGAAGGGGTGGAGAAAAGCTTTAACGCCCAGTTGACCGGTAAACCCGGGCGACGTCTGGTGCGTAAAGATA
AACATGGTAATGTCATTGAGAACATTACCGAAGTGCCGCCGGTACCGGCGCATAATCTGCAGCTGAGTATTGATGAACGC
CTGCAGACGGTGACGGAAGACGCCCTCGACAACGCCGTCCGCTGGAACAAAGCAGAGTCCGGGGCGGCGGTATTGATCAA
AATTGATACCGGCGAGATCCTGGCGATGGCCAGCTATCCGGACTTCAATCCGAACAATCGCGATAGCGCGACGCTGGATG
ATTTTCGCAACCGGGCCATCAGCGACACCTTCGAGCCCGGGTCGACGGTCAAACCGCTGGTGATCATGACTGCGCTACAG
CAGGGGATTGTCCAGCCAGACAGCGTGGTGGATACCCATCCGTTCGTCCTCGATGGCCATCGTATTCGCGATGTGGGCTA
TTATCCGGAGCTGAGCCTGACCGGGATCCTGCAGAAATCCAGCGATACCGGCGTGTCCCATCTCTCGCTCGCCATGCCGG
TGCAGCATCTGATCGATACCTATAAAGCTTTCGGCTTTGGCGAACCGACGGGGCTGGGGTTGACCGGCGAAAGCGCCGGG
CTGATGCCGCATCGCCGCTACTGGGGGCAACTGGATCGCGCCACCTTCGCCTTCGGCTATGGTTTGATGGTCACCCCGCT
CCAGCTCGCCCACGTCTACGCCACCATCGGCGGCTTCGGCATTGCGCGACCACTGTCGATTACCCGCATCGATCCGCCGG
TGATGGGCACGCGGGTGATGCCGGAGAGTATTGTGCATAGCGTGGAACATATGATGGAGAGCGTGGCGCTCCCGGGCGGG
GGCGGTACCAAAGCGGCGGTACGCGACTACCGGGTGGCGGTAAAAACCGGCACGGCGAAGAAAATCGGCCCGGACGGCAA
ATATATCGATAAGTATGTGGCCTATACCGCCGGCGTGGCGCCCGCCAGTCGACCACAGTTTGCGCTGGTTGTGGTGATGA
ACGATCCGAGCAATGGTTCCTATTACGGCGGCGCTGTGTCCGCGCCGGTCTTCAGCCAGATCATGGGCGATGTCCTGCGG
CTGGAGAACGTCATGCCGGACGGCATGCCGCAAGGGGCGGAGAATCTGATCGTAATGCACGATAGCCACCCACAGGGGCC
GGCGCTGTAA

Upstream 100 bases:

>100_bases
ATGTCATTTTTCCCCCTCCCGTCGCGTCTTGTTGCAAATACTCATCTTTATTAGCATTGTGTAGCAGTCTGTTTTGCTAA
TTTTCTGTTAAATCAGTTGG

Downstream 100 bases:

>100_bases
CAGTGGTCTGCAGGGGCGAATAGCGCTACACTTTCGCCCTTTCAGCAACACCGGAGCCGTCATGTCATACAGTTGCCCCC
TTTGTCACGCGCCGCTCAGC

Product: division-specific transpeptidase

Products: NA

Alternate protein names: Penicillin-binding protein 3; PBP-3; Peptidoglycan glycosyltransferase 3 [H]

Number of amino acids: Translated: 589; Mature: 589

Protein sequence:

>589_residues
MQNNAGAMVLKKKTKSAASFTPIRFGLLCVAILGCLGLLLVRVGWLQIISPDNLVKQEDMRSLREEPVAVERGMISDREG
RPLAVSVPVSAIWIDPQTTMEKGGVGYGPRWQAMAEALHLNLGELAQRVQSHPHARFLYLARQINPEQAEWIDKLHLPGV
YLRDESRRFYPAGHVAANLLGFTNVDNQGIEGVEKSFNAQLTGKPGRRLVRKDKHGNVIENITEVPPVPAHNLQLSIDER
LQTVTEDALDNAVRWNKAESGAAVLIKIDTGEILAMASYPDFNPNNRDSATLDDFRNRAISDTFEPGSTVKPLVIMTALQ
QGIVQPDSVVDTHPFVLDGHRIRDVGYYPELSLTGILQKSSDTGVSHLSLAMPVQHLIDTYKAFGFGEPTGLGLTGESAG
LMPHRRYWGQLDRATFAFGYGLMVTPLQLAHVYATIGGFGIARPLSITRIDPPVMGTRVMPESIVHSVEHMMESVALPGG
GGTKAAVRDYRVAVKTGTAKKIGPDGKYIDKYVAYTAGVAPASRPQFALVVVMNDPSNGSYYGGAVSAPVFSQIMGDVLR
LENVMPDGMPQGAENLIVMHDSHPQGPAL

Sequences:

>Translated_589_residues
MQNNAGAMVLKKKTKSAASFTPIRFGLLCVAILGCLGLLLVRVGWLQIISPDNLVKQEDMRSLREEPVAVERGMISDREG
RPLAVSVPVSAIWIDPQTTMEKGGVGYGPRWQAMAEALHLNLGELAQRVQSHPHARFLYLARQINPEQAEWIDKLHLPGV
YLRDESRRFYPAGHVAANLLGFTNVDNQGIEGVEKSFNAQLTGKPGRRLVRKDKHGNVIENITEVPPVPAHNLQLSIDER
LQTVTEDALDNAVRWNKAESGAAVLIKIDTGEILAMASYPDFNPNNRDSATLDDFRNRAISDTFEPGSTVKPLVIMTALQ
QGIVQPDSVVDTHPFVLDGHRIRDVGYYPELSLTGILQKSSDTGVSHLSLAMPVQHLIDTYKAFGFGEPTGLGLTGESAG
LMPHRRYWGQLDRATFAFGYGLMVTPLQLAHVYATIGGFGIARPLSITRIDPPVMGTRVMPESIVHSVEHMMESVALPGG
GGTKAAVRDYRVAVKTGTAKKIGPDGKYIDKYVAYTAGVAPASRPQFALVVVMNDPSNGSYYGGAVSAPVFSQIMGDVLR
LENVMPDGMPQGAENLIVMHDSHPQGPAL
>Mature_589_residues
MQNNAGAMVLKKKTKSAASFTPIRFGLLCVAILGCLGLLLVRVGWLQIISPDNLVKQEDMRSLREEPVAVERGMISDREG
RPLAVSVPVSAIWIDPQTTMEKGGVGYGPRWQAMAEALHLNLGELAQRVQSHPHARFLYLARQINPEQAEWIDKLHLPGV
YLRDESRRFYPAGHVAANLLGFTNVDNQGIEGVEKSFNAQLTGKPGRRLVRKDKHGNVIENITEVPPVPAHNLQLSIDER
LQTVTEDALDNAVRWNKAESGAAVLIKIDTGEILAMASYPDFNPNNRDSATLDDFRNRAISDTFEPGSTVKPLVIMTALQ
QGIVQPDSVVDTHPFVLDGHRIRDVGYYPELSLTGILQKSSDTGVSHLSLAMPVQHLIDTYKAFGFGEPTGLGLTGESAG
LMPHRRYWGQLDRATFAFGYGLMVTPLQLAHVYATIGGFGIARPLSITRIDPPVMGTRVMPESIVHSVEHMMESVALPGG
GGTKAAVRDYRVAVKTGTAKKIGPDGKYIDKYVAYTAGVAPASRPQFALVVVMNDPSNGSYYGGAVSAPVFSQIMGDVLR
LENVMPDGMPQGAENLIVMHDSHPQGPAL

Specific function: Cell wall formation. Essential for the formation of a septum of the murein sacculus. Synthesis of cross-linked peptidoglycan from the lipid intermediates [H]

COG id: COG0768

COG function: function code M; Cell division protein FtsI/penicillin-binding protein 2

Gene ontology:

Cell location: Cell inner membrane; Single-pass membrane protein; Periplasmic side. Note=The bulk of the molecule, except for the N-terminal membrane anchor region, protrudes into the periplasmic space, where it acts on murein (By similarity) [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transpeptidase family [H]

Homologues:

Organism=Escherichia coli, GI1786272, Length=575, Percent_Identity=61.2173913043478, Blast_Score=748, Evalue=0.0,
Organism=Escherichia coli, GI1786854, Length=618, Percent_Identity=26.2135922330097, Blast_Score=140, Evalue=2e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR005311
- InterPro:   IPR001460 [H]

Pfam domain/function: PF03717 PBP_dimer; PF00905 Transpeptidase [H]

EC number: =2.4.1.129 [H]

Molecular weight: Translated: 64055; Mature: 64055

Theoretical pI: Translated: 7.01; Mature: 7.01

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQNNAGAMVLKKKTKSAASFTPIRFGLLCVAILGCLGLLLVRVGWLQIISPDNLVKQEDM
CCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCHHHHHHHH
RSLREEPVAVERGMISDREGRPLAVSVPVSAIWIDPQTTMEKGGVGYGPRWQAMAEALHL
HHHHHCCCHHHCCCCCCCCCCEEEEECCEEEEEECCHHHHHCCCCCCCCHHHHHHHHHHC
NLGELAQRVQSHPHARFLYLARQINPEQAEWIDKLHLPGVYLRDESRRFYPAGHVAANLL
CHHHHHHHHHHCCCCEEEHHHHHCCHHHHHHHHHHCCCCEEEECCCCCCCCCHHHHHHHH
GFTNVDNQGIEGVEKSFNAQLTGKPGRRLVRKDKHGNVIENITEVPPVPAHNLQLSIDER
HCCCCCCCCHHHHHHHCCCEECCCCCHHHHHCCCCCCHHHHHHHCCCCCCCCEEEEHHHH
LQTVTEDALDNAVRWNKAESGAAVLIKIDTGEILAMASYPDFNPNNRDSATLDDFRNRAI
HHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCEEEEECCCCCCCCCCCCCCHHHHHHHHC
SDTFEPGSTVKPLVIMTALQQGIVQPDSVVDTHPFVLDGHRIRDVGYYPELSLTGILQKS
CCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCEEECCCEEEECCCCCCCCEEEEEECC
SDTGVSHLSLAMPVQHLIDTYKAFGFGEPTGLGLTGESAGLMPHRRYWGQLDRATFAFGY
CCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHCCCCCHHHHHCC
GLMVTPLQLAHVYATIGGFGIARPLSITRIDPPVMGTRVMPESIVHSVEHMMESVALPGG
CHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCCCCCCCHHHHHHHHHHHHHHHCCCCC
GGTKAAVRDYRVAVKTGTAKKIGPDGKYIDKYVAYTAGVAPASRPQFALVVVMNDPSNGS
CCCCHHHHHEEEEEECCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCEEEEEEEECCCCCC
YYGGAVSAPVFSQIMGDVLRLENVMPDGMPQGAENLIVMHDSHPQGPAL
CCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCCCCCC
>Mature Secondary Structure
MQNNAGAMVLKKKTKSAASFTPIRFGLLCVAILGCLGLLLVRVGWLQIISPDNLVKQEDM
CCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCHHHHHHHH
RSLREEPVAVERGMISDREGRPLAVSVPVSAIWIDPQTTMEKGGVGYGPRWQAMAEALHL
HHHHHCCCHHHCCCCCCCCCCEEEEECCEEEEEECCHHHHHCCCCCCCCHHHHHHHHHHC
NLGELAQRVQSHPHARFLYLARQINPEQAEWIDKLHLPGVYLRDESRRFYPAGHVAANLL
CHHHHHHHHHHCCCCEEEHHHHHCCHHHHHHHHHHCCCCEEEECCCCCCCCCHHHHHHHH
GFTNVDNQGIEGVEKSFNAQLTGKPGRRLVRKDKHGNVIENITEVPPVPAHNLQLSIDER
HCCCCCCCCHHHHHHHCCCEECCCCCHHHHHCCCCCCHHHHHHHCCCCCCCCEEEEHHHH
LQTVTEDALDNAVRWNKAESGAAVLIKIDTGEILAMASYPDFNPNNRDSATLDDFRNRAI
HHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCEEEEECCCCCCCCCCCCCCHHHHHHHHC
SDTFEPGSTVKPLVIMTALQQGIVQPDSVVDTHPFVLDGHRIRDVGYYPELSLTGILQKS
CCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCEEECCCEEEECCCCCCCCEEEEEECC
SDTGVSHLSLAMPVQHLIDTYKAFGFGEPTGLGLTGESAGLMPHRRYWGQLDRATFAFGY
CCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHCCCCCHHHHHCC
GLMVTPLQLAHVYATIGGFGIARPLSITRIDPPVMGTRVMPESIVHSVEHMMESVALPGG
CHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCCCCCCCHHHHHHHHHHHHHHHCCCCC
GGTKAAVRDYRVAVKTGTAKKIGPDGKYIDKYVAYTAGVAPASRPQFALVVVMNDPSNGS
CCCCHHHHHEEEEEECCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCEEEEEEEECCCCCC
YYGGAVSAPVFSQIMGDVLRLENVMPDGMPQGAENLIVMHDSHPQGPAL
CCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]