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The map label for this gene is rrmA [H]

Identifier: 238895397

GI number: 238895397

Start: 3284204

End: 3284998

Strand: Reverse

Name: rrmA [H]

Synonym: KP1_3463

Alternate gene names: 238895397

Gene position: 3284998-3284204 (Counterclockwise)

Preceding gene: 238895398

Following gene: 238895391

Centisome position: 62.59

GC content: 62.77

Gene sequence:

>795_bases
ATGTCATACAGTTGCCCCCTTTGTCACGCGCCGCTCAGCCGTAGCGACAACCACTATTCCTGCCCGCAGCGGCACCAGTT
CGATCTGGCGAAAGAGGGGTACGTCAATCTGCTACCGGTGCAGTTCAAGCGGTCGCGCGATCCCGGCGATAGCGCCGAAA
TGATGCAGGCCCGGCGGGCGTTCCTCGACGCCGGACATTATCAGCCGCTACGGGATGCTATCGCTGAGCGTCTGCGACAT
TACGCCCCTACGGATTTACTGGATATCGGCTGTGGCGAGGGGTATTACACCCACGCGTTTGCCGCCATCGCCAGCCGCAG
CTGGGGGCTGGACGTGTCGAAGCCGGCGATCCGCGCGGCGGCAAAACGCTACCCGCAGGTGAATTTTTGCGTGGCCTCCA
GCCAGCGCCTGCCATTTTCCGACGCTAGCTTCGACGCGGTAGTGCGCATTTACGCGCCCTGCAACGCCGAAGAGCTGGCG
CGGGTGGTGCGTCCCGGTGGTTGGGTGATCACCGCCACGCCGGGTCCCCGTCACCTACTGGAGCTGAAAGGGCTGATTTA
CGATGAAGTTCGCCTGCATGAGCTGAAGACGGAAGCGATGCCGGGGTTCCGCCTGGAGGCTCAGCAGCAGCTGGCTTACC
CGATGATCCTGACGGGAAGTGAAGCGCAGGCCCTGCTGCAGATGACGCCGTTCGCATGGCGGGCTAAAGCCGAAGTGCAC
GCCGCGCTGCGTCAGCAGCCGACCTTTGGTTGCCAGACCGATTTTATGATCCACTGCTGGCAGCGCGAAGCGTAA

Upstream 100 bases:

>100_bases
GTAATGCACGATAGCCACCCACAGGGGCCGGCGCTGTAACAGTGGTCTGCAGGGGCGAATAGCGCTACACTTTCGCCCTT
TCAGCAACACCGGAGCCGTC

Downstream 100 bases:

>100_bases
AGCTTAACCGGCGAAATGGCTCCAGAGGATTTCGCTGCCGATGCCAATCAGCACGATACCGCCGAGAATTTCGGCTCGTT
TGCCCAGCAGCGGGCCGATA

Product: ribosomal RNA large subunit methyltransferase A

Products: NA

Alternate protein names: 23S rRNA m1G745 methyltransferase; rRNA (guanine-N(1)-)-methyltransferase [H]

Number of amino acids: Translated: 264; Mature: 263

Protein sequence:

>264_residues
MSYSCPLCHAPLSRSDNHYSCPQRHQFDLAKEGYVNLLPVQFKRSRDPGDSAEMMQARRAFLDAGHYQPLRDAIAERLRH
YAPTDLLDIGCGEGYYTHAFAAIASRSWGLDVSKPAIRAAAKRYPQVNFCVASSQRLPFSDASFDAVVRIYAPCNAEELA
RVVRPGGWVITATPGPRHLLELKGLIYDEVRLHELKTEAMPGFRLEAQQQLAYPMILTGSEAQALLQMTPFAWRAKAEVH
AALRQQPTFGCQTDFMIHCWQREA

Sequences:

>Translated_264_residues
MSYSCPLCHAPLSRSDNHYSCPQRHQFDLAKEGYVNLLPVQFKRSRDPGDSAEMMQARRAFLDAGHYQPLRDAIAERLRH
YAPTDLLDIGCGEGYYTHAFAAIASRSWGLDVSKPAIRAAAKRYPQVNFCVASSQRLPFSDASFDAVVRIYAPCNAEELA
RVVRPGGWVITATPGPRHLLELKGLIYDEVRLHELKTEAMPGFRLEAQQQLAYPMILTGSEAQALLQMTPFAWRAKAEVH
AALRQQPTFGCQTDFMIHCWQREA
>Mature_263_residues
SYSCPLCHAPLSRSDNHYSCPQRHQFDLAKEGYVNLLPVQFKRSRDPGDSAEMMQARRAFLDAGHYQPLRDAIAERLRHY
APTDLLDIGCGEGYYTHAFAAIASRSWGLDVSKPAIRAAAKRYPQVNFCVASSQRLPFSDASFDAVVRIYAPCNAEELAR
VVRPGGWVITATPGPRHLLELKGLIYDEVRLHELKTEAMPGFRLEAQQQLAYPMILTGSEAQALLQMTPFAWRAKAEVHA
ALRQQPTFGCQTDFMIHCWQREA

Specific function: Specifically methylates the guanosine in position 745 of 23S rRNA [H]

COG id: COG0500

COG function: function code QR; SAM-dependent methyltransferases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. RlmA family [H]

Homologues:

Organism=Escherichia coli, GI1788125, Length=267, Percent_Identity=73.0337078651685, Blast_Score=395, Evalue=1e-111,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013216
- InterPro:   IPR016718 [H]

Pfam domain/function: PF08241 Methyltransf_11 [H]

EC number: =2.1.1.187 [H]

Molecular weight: Translated: 29723; Mature: 29592

Theoretical pI: Translated: 8.02; Mature: 8.02

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.0 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
3.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSYSCPLCHAPLSRSDNHYSCPQRHQFDLAKEGYVNLLPVQFKRSRDPGDSAEMMQARRA
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEEECCCCCCCHHHHHHHHHH
FLDAGHYQPLRDAIAERLRHYAPTDLLDIGCGEGYYTHAFAAIASRSWGLDVSKPAIRAA
HHHCCCCCHHHHHHHHHHHHCCCCCCEECCCCCCHHHHHHHHHHHCCCCCCCCCHHHHHH
AKRYPQVNFCVASSQRLPFSDASFDAVVRIYAPCNAEELARVVRPGGWVITATPGPRHLL
HHHCCCEEEEEECCCCCCCCCCCCEEEEEEECCCCHHHHHHHHCCCCEEEECCCCHHHHH
ELKGLIYDEVRLHELKTEAMPGFRLEAQQQLAYPMILTGSEAQALLQMTPFAWRAKAEVH
HHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHCCCEEEECCHHHHHHHHCCCHHHHHHHHH
AALRQQPTFGCQTDFMIHCWQREA
HHHHCCCCCCCCCCCEEEEECCCC
>Mature Secondary Structure 
SYSCPLCHAPLSRSDNHYSCPQRHQFDLAKEGYVNLLPVQFKRSRDPGDSAEMMQARRA
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEEECCCCCCCHHHHHHHHHH
FLDAGHYQPLRDAIAERLRHYAPTDLLDIGCGEGYYTHAFAAIASRSWGLDVSKPAIRAA
HHHCCCCCHHHHHHHHHHHHCCCCCCEECCCCCCHHHHHHHHHHHCCCCCCCCCHHHHHH
AKRYPQVNFCVASSQRLPFSDASFDAVVRIYAPCNAEELARVVRPGGWVITATPGPRHLL
HHHCCCEEEEEECCCCCCCCCCCCEEEEEEECCCCHHHHHHHHCCCCEEEECCCCHHHHH
ELKGLIYDEVRLHELKTEAMPGFRLEAQQQLAYPMILTGSEAQALLQMTPFAWRAKAEVH
HHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHCCCEEEECCHHHHHHHHCCCHHHHHHHHH
AALRQQPTFGCQTDFMIHCWQREA
HHHHCCCCCCCCCCCEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7984109; 9097040; 9278503; 9440525 [H]