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The map label for this gene is adrB [H]

Identifier: 238895390

GI number: 238895390

Start: 3276370

End: 3277962

Strand: Direct

Name: adrB [H]

Synonym: KP1_3456

Alternate gene names: 238895390

Gene position: 3276370-3277962 (Clockwise)

Preceding gene: 238895389

Following gene: 238895392

Centisome position: 62.42

GC content: 58.76

Gene sequence:

>1593_bases
GTGTCGCACATGCAGACTGCACAAAAAGTCATTACGGCCTATCGTCACAAACGCATTATTGTCTGCCTGCTGGTAGCCCT
GGCGACCCTGGGCGCCACATTAGCCATCCGATTTATTTCGCAGCGCAGCGTAAATGAAGATTATATTCGCACGGCCGCCA
CCCAACGGGTGGCGGCGCTCAATGACATCTTGCGCCCGCTAAGCGCGCAGCGAGCCACCCTGCTCCCTCTGGTGGGCAAA
CCCTGCCCTGATATCCATCTGACGCTGCGCAAAATGGCGGCCTCGTTGCAAACCATTCGTTCCGTCGCCCTCGTCACGTC
AGGTATCGTTTACTGTTCCAGTATTTTTGGCCCGCGACAGGCAGACTTACATCGCCTGCAGCCCGCGCTTCCTGCGCCCC
GCCCTCTGCTGCTCTTCTCGAACGACAGCTCCTTGCTCAAAGGCTCGCCGGTACTGATCCAATGGTATCCAGCCGCGGAG
AGCGGCCTGGACGGCGTGATGCTGGTGGTGAATATTGAGCTGCTGGGAACCTTAATTCTTAATGAAAAATCGGCCCTGAT
CAGCGACGTCAGCCTGCAGGTTGGCGATCGTTATTTTAGCAGCCGCCATGGGCTTCTCGAAAAAGCGCATGTCCCGCAGG
GCACGGTGATTTATCGCCAGCGCTCTACGGAGTTTCCGTTTACTGTCAATATTAACGGCCCTGGCGCCTCGGCGATTGCG
CTTGAGGAGCTGCCCGGCGAGCTGCCGCTGGCGCTGATTTTTAGCCTGCTAATGACCGGCATCGCCTGGCTGGCCACCGC
CGGCAGAATGAGTTTCTCGCGGGAAATAAGCCTTGGCATTTCGGCCCGGGAGTTTGCCCTCTGGTGCCAGCCGCTGCAGG
ATGCGCGCAGCGGCCGCTGCTGCGGGGTGGAGATCCTGCTGCGCTGGAATAATCCCCGCCGTGGGACGATTTCGCCGGAG
GTATTTATCCCCATCGCCGAAGGCAATAATCTGATCATCCCTCTCACCCGCTATGTGATTGCCGAAACCGCTCGCCGCCT
GGACGCTTTTCCTCGCGACCGCCATTTTCACATCGCGATCAATGTCGCCGCGCGCCATTTCGCTAACGGACTCCTGCTGC
GCGACCTGCACAATTACTGGTTCAGCGTGGATCCGGTGCAGCAGCTGGTGGTCGAGCTAACCGAACGCGATGTCCTGCAG
GATGGCGACCAGCATATGGCCGAACATCTGCACTTTAAAGGCGTACAGCTGGCGATCGATGATTTTGGTACCGGCAATAC
TTCGCTCTCATGGCTGGAAAAGCTGCGCCCGGACGTCCTGAAGATCGACCGCTCGTTCACCAGCTCGGTCGGCATAGATA
GCGTGAACGCGACGGTGACAGATATTATTATCGCCCTCGCCAACCGCCTGCATATTGTTACCGTTGCCGAAGGGGTGGAG
ACGCTGGAGCAGGAAAACTACCTGCGTAGCCACGGCGTCGATGTGCTGCAGGGGTTTTATTATGCGCGGCCGATGCCGGT
GGAGGCGTTCCCGGCGTGGCTGGCCAGCAGGGAGGAGAGTGAGAGTGAGGGTGAGAGCGAGACGACAGAATAA

Upstream 100 bases:

>100_bases
CTTCAACGGCGCATTTTCTTTTTTCTATACCTGGCGATATTCTGCCACTACACTTGCTCTATAAAATAAGCCACGCTTAA
CCACTCGTCCTGTCGACAGG

Downstream 100 bases:

>100_bases
CTCGCCGGCCGCAGCGGCCGGCGAGCCTGGCGATTACTCTTCTTCGTCGCTCGGCGGACGAGTGACCACCGCGCGCACCA
GATCGACCCGGTAATCATTC

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 530; Mature: 529

Protein sequence:

>530_residues
MSHMQTAQKVITAYRHKRIIVCLLVALATLGATLAIRFISQRSVNEDYIRTAATQRVAALNDILRPLSAQRATLLPLVGK
PCPDIHLTLRKMAASLQTIRSVALVTSGIVYCSSIFGPRQADLHRLQPALPAPRPLLLFSNDSSLLKGSPVLIQWYPAAE
SGLDGVMLVVNIELLGTLILNEKSALISDVSLQVGDRYFSSRHGLLEKAHVPQGTVIYRQRSTEFPFTVNINGPGASAIA
LEELPGELPLALIFSLLMTGIAWLATAGRMSFSREISLGISAREFALWCQPLQDARSGRCCGVEILLRWNNPRRGTISPE
VFIPIAEGNNLIIPLTRYVIAETARRLDAFPRDRHFHIAINVAARHFANGLLLRDLHNYWFSVDPVQQLVVELTERDVLQ
DGDQHMAEHLHFKGVQLAIDDFGTGNTSLSWLEKLRPDVLKIDRSFTSSVGIDSVNATVTDIIIALANRLHIVTVAEGVE
TLEQENYLRSHGVDVLQGFYYARPMPVEAFPAWLASREESESEGESETTE

Sequences:

>Translated_530_residues
MSHMQTAQKVITAYRHKRIIVCLLVALATLGATLAIRFISQRSVNEDYIRTAATQRVAALNDILRPLSAQRATLLPLVGK
PCPDIHLTLRKMAASLQTIRSVALVTSGIVYCSSIFGPRQADLHRLQPALPAPRPLLLFSNDSSLLKGSPVLIQWYPAAE
SGLDGVMLVVNIELLGTLILNEKSALISDVSLQVGDRYFSSRHGLLEKAHVPQGTVIYRQRSTEFPFTVNINGPGASAIA
LEELPGELPLALIFSLLMTGIAWLATAGRMSFSREISLGISAREFALWCQPLQDARSGRCCGVEILLRWNNPRRGTISPE
VFIPIAEGNNLIIPLTRYVIAETARRLDAFPRDRHFHIAINVAARHFANGLLLRDLHNYWFSVDPVQQLVVELTERDVLQ
DGDQHMAEHLHFKGVQLAIDDFGTGNTSLSWLEKLRPDVLKIDRSFTSSVGIDSVNATVTDIIIALANRLHIVTVAEGVE
TLEQENYLRSHGVDVLQGFYYARPMPVEAFPAWLASREESESEGESETTE
>Mature_529_residues
SHMQTAQKVITAYRHKRIIVCLLVALATLGATLAIRFISQRSVNEDYIRTAATQRVAALNDILRPLSAQRATLLPLVGKP
CPDIHLTLRKMAASLQTIRSVALVTSGIVYCSSIFGPRQADLHRLQPALPAPRPLLLFSNDSSLLKGSPVLIQWYPAAES
GLDGVMLVVNIELLGTLILNEKSALISDVSLQVGDRYFSSRHGLLEKAHVPQGTVIYRQRSTEFPFTVNINGPGASAIAL
EELPGELPLALIFSLLMTGIAWLATAGRMSFSREISLGISAREFALWCQPLQDARSGRCCGVEILLRWNNPRRGTISPEV
FIPIAEGNNLIIPLTRYVIAETARRLDAFPRDRHFHIAINVAARHFANGLLLRDLHNYWFSVDPVQQLVVELTERDVLQD
GDQHMAEHLHFKGVQLAIDDFGTGNTSLSWLEKLRPDVLKIDRSFTSSVGIDSVNATVTDIIIALANRLHIVTVAEGVET
LEQENYLRSHGVDVLQGFYYARPMPVEAFPAWLASREESESEGESETTE

Specific function: May serve as a negative regulator of cellulose synthesis (as has been suggested for S.typhimurium); over-expression inhibits cell aggregation in strains able to produce adhesive curli fimbriae. Cyclic-di-GMP is a second messenger which controls cell surfa

COG id: COG2200

COG function: function code T; FOG: EAL domain

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 EAL domain [H]

Homologues:

Organism=Escherichia coli, GI87081980, Length=526, Percent_Identity=55.7034220532319, Blast_Score=577, Evalue=1e-166,
Organism=Escherichia coli, GI1788502, Length=520, Percent_Identity=29.0384615384615, Blast_Score=206, Evalue=3e-54,
Organism=Escherichia coli, GI87081845, Length=504, Percent_Identity=30.1587301587302, Blast_Score=167, Evalue=2e-42,
Organism=Escherichia coli, GI1786507, Length=240, Percent_Identity=36.25, Blast_Score=149, Evalue=3e-37,
Organism=Escherichia coli, GI1790496, Length=250, Percent_Identity=35.2, Blast_Score=146, Evalue=3e-36,
Organism=Escherichia coli, GI87081921, Length=257, Percent_Identity=34.2412451361868, Blast_Score=134, Evalue=1e-32,
Organism=Escherichia coli, GI1787541, Length=224, Percent_Identity=33.9285714285714, Blast_Score=131, Evalue=1e-31,
Organism=Escherichia coli, GI87081743, Length=271, Percent_Identity=33.5793357933579, Blast_Score=131, Evalue=1e-31,
Organism=Escherichia coli, GI226510982, Length=254, Percent_Identity=31.1023622047244, Blast_Score=114, Evalue=1e-26,
Organism=Escherichia coli, GI1787055, Length=265, Percent_Identity=30.9433962264151, Blast_Score=93, Evalue=3e-20,
Organism=Escherichia coli, GI1788849, Length=251, Percent_Identity=29.4820717131474, Blast_Score=89, Evalue=5e-19,
Organism=Escherichia coli, GI87082096, Length=206, Percent_Identity=29.6116504854369, Blast_Score=89, Evalue=7e-19,
Organism=Escherichia coli, GI1787410, Length=119, Percent_Identity=31.0924369747899, Blast_Score=62, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001633 [H]

Pfam domain/function: PF00563 EAL [H]

EC number: =3.1.4.52 [H]

Molecular weight: Translated: 58641; Mature: 58510

Theoretical pI: Translated: 6.80; Mature: 6.80

Prosite motif: PS50883 EAL

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSHMQTAQKVITAYRHKRIIVCLLVALATLGATLAIRFISQRSVNEDYIRTAATQRVAAL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
NDILRPLSAQRATLLPLVGKPCPDIHLTLRKMAASLQTIRSVALVTSGIVYCSSIFGPRQ
HHHHHHHCCCCCEECHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCH
ADLHRLQPALPAPRPLLLFSNDSSLLKGSPVLIQWYPAAESGLDGVMLVVNIELLGTLIL
HHHHHHCCCCCCCCEEEEECCCCCCCCCCCEEEEEECCCCCCCCCEEEEEEHHHHHHHHC
NEKSALISDVSLQVGDRYFSSRHGLLEKAHVPQGTVIYRQRSTEFPFTVNINGPGASAIA
CCCHHHHHHHHHHHHHHHHHHHCCCHHHCCCCCCEEEEEECCCCCCEEEEECCCCCCEEE
LEELPGELPLALIFSLLMTGIAWLATAGRMSFSREISLGISAREFALWCQPLQDARSGRC
HHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCHHHHHHHHHHHHHCCCCCC
CGVEILLRWNNPRRGTISPEVFIPIAEGNNLIIPLTRYVIAETARRLDAFPRDRHFHIAI
EEEEEEEEECCCCCCCCCCEEEEEEECCCCEEEHHHHHHHHHHHHHHHCCCCCCEEEEEE
NVAARHFANGLLLRDLHNYWFSVDPVQQLVVELTERDVLQDGDQHMAEHLHFKGVQLAID
EHHHHHHHCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCEEEEEE
DFGTGNTSLSWLEKLRPDVLKIDRSFTSSVGIDSVNATVTDIIIALANRLHIVTVAEGVE
CCCCCCCHHHHHHHHCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCEEEEEEHHHHH
TLEQENYLRSHGVDVLQGFYYARPMPVEAFPAWLASREESESEGESETTE
HHHHHHHHHHCCHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCCCCCCCC
>Mature Secondary Structure 
SHMQTAQKVITAYRHKRIIVCLLVALATLGATLAIRFISQRSVNEDYIRTAATQRVAAL
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
NDILRPLSAQRATLLPLVGKPCPDIHLTLRKMAASLQTIRSVALVTSGIVYCSSIFGPRQ
HHHHHHHCCCCCEECHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCH
ADLHRLQPALPAPRPLLLFSNDSSLLKGSPVLIQWYPAAESGLDGVMLVVNIELLGTLIL
HHHHHHCCCCCCCCEEEEECCCCCCCCCCCEEEEEECCCCCCCCCEEEEEEHHHHHHHHC
NEKSALISDVSLQVGDRYFSSRHGLLEKAHVPQGTVIYRQRSTEFPFTVNINGPGASAIA
CCCHHHHHHHHHHHHHHHHHHHCCCHHHCCCCCCEEEEEECCCCCCEEEEECCCCCCEEE
LEELPGELPLALIFSLLMTGIAWLATAGRMSFSREISLGISAREFALWCQPLQDARSGRC
HHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCHHHHHHHHHHHHHCCCCCC
CGVEILLRWNNPRRGTISPEVFIPIAEGNNLIIPLTRYVIAETARRLDAFPRDRHFHIAI
EEEEEEEEECCCCCCCCCCEEEEEEECCCCEEEHHHHHHHHHHHHHHHCCCCCCEEEEEE
NVAARHFANGLLLRDLHNYWFSVDPVQQLVVELTERDVLQDGDQHMAEHLHFKGVQLAID
EHHHHHHHCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCEEEEEE
DFGTGNTSLSWLEKLRPDVLKIDRSFTSSVGIDSVNATVTDIIIALANRLHIVTVAEGVE
CCCCCCCHHHHHHHHCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCEEEEEEHHHHH
TLEQENYLRSHGVDVLQGFYYARPMPVEAFPAWLASREESESEGESETTE
HHHHHHHHHHCCHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503 [H]