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The map label for this gene is sdaA [H]

Identifier: 238895389

GI number: 238895389

Start: 3274832

End: 3276196

Strand: Direct

Name: sdaA [H]

Synonym: KP1_3455

Alternate gene names: 238895389

Gene position: 3274832-3276196 (Clockwise)

Preceding gene: 238895388

Following gene: 238895390

Centisome position: 62.4

GC content: 59.34

Gene sequence:

>1365_bases
GTGATTAGTCTATTCGACATGTTCAAGGTGGGGATTGGTCCCTCATCTTCCCACACTGTTGGCCCGATGAAGGCCGGAAA
ACAGTTCGTCGATGACCTGGTCGAAAAAGGATTGCTTAATGCAGTGACTCGTGTGGCGGTTGACGTCTACGGTTCACTGT
CATTAACCGGCAAAGGCCACCATACGGACATCGCCATTATCATGGGACTGGCGGGCAATCAGCCCGATACGGTCGATATT
GACGCGATCCCGGCTTTTATCCGTGACGTCGAAGCGCGCGGTCGTCTGCTGCTGGCCAACGGCCAGCATGAGGTCGACTT
CCCGGCGGATGACGGCATGCGTTTTCGCAGCGACAACCTGCCGCTGCACGAAAACGGCATGACCATTCACGCCTGGGCCG
GCGAGAAAGAGATCTACTGCAAGACCTACTACTCGATCGGCGGCGGCTTTATTGTCGACGAAGAGCACTTCGGTAAGGAA
AACGCCAACGAACTGCAGGTGCCCTACCCATTTAAATCGGCGCAGGAAATGCTGGCCTACTGCAAAGAGACTGGCCTGTC
GCTCTCCGGGATGGTGATGCAGAACGAGCTGGCTCTGCACAGCAAAAAAGAGATCGAGGATTATTTCGCCAACGTTTGGC
AGACCATGCGCGCCTGTATCGACCGTGGGATGAACACCGAGGGCGTGCTGCCTGGCCCGCTGCGCGTACCGCGTCGCGCC
TCGGCGCTGCGTCGTCTGCTGGTGGCCAGCGATAAGCTCTCCAGCGATCCAATGAACGTTGTTGACTGGGTCAATATGTT
CGCGCTGGCGGTCAATGAAGAGAACGCCGCCGGCGGTCGCGTGGTAACCGCGCCGACCAACGGCGCCTGCGGCATCGTTC
CGGCGGTACTCGCCTATTACGATCACTTTATCGAGTCCGTCAGCCCGGAGATCTATATTCGCTACTTTATGGCCTGCGGG
GCGATCGGCGCGCTGTATAAGATGAATGCGTCCATTTCCGGCGCGGAAGTCGGCTGTCAGGGCGAGGTGGGCGTCGCCTG
CTCGATGGCGGCGGCGGGACTGGCTGAACTGCTCGGCGCCAGCCCGGAACAGGTTTGCGTGGCGGCGGAGATCGGCATGG
AACACAACCTCGGCCTGACCTGTGATCCGGTCGCCGGCCAGGTGCAGGTGCCATGCATTGAACGTAACGCCATCGCCTCC
GTCAAGGCGATCAACGCCGCGCGAATGGCGATGCGCCGCACCAGCGAACCGCGCGTCTCGCTCGATAAGGTGATCGAGAC
CATGTATGAAACCGGTAAAGACATGAACGCCAAGTACCGCGAAACCTCGCGCGGCGGCCTGGCGATTAAAGTTCAGTGTG
ACTAA

Upstream 100 bases:

>100_bases
TTCATGTGAATAGTTGAACTGACAGGGCGCTTCCCTCTTACACTATGCGCAGTTATTACATCGTTACCGCACCCGCGGTA
ACCCTGTCAGGAGTATTATC

Downstream 100 bases:

>100_bases
ACTATTCGTGTCCCTCTGCGCCTGCAAAGCGCGCAGGGGGTTAACCCTGGTGACTGAAATCTCCCTGATGCGCCTTCAAC
GGCGCATTTTCTTTTTTCTA

Product: L-serine deaminase

Products: NA

Alternate protein names: SDH 1; L-serine deaminase 1; L-SD1 [H]

Number of amino acids: Translated: 454; Mature: 454

Protein sequence:

>454_residues
MISLFDMFKVGIGPSSSHTVGPMKAGKQFVDDLVEKGLLNAVTRVAVDVYGSLSLTGKGHHTDIAIIMGLAGNQPDTVDI
DAIPAFIRDVEARGRLLLANGQHEVDFPADDGMRFRSDNLPLHENGMTIHAWAGEKEIYCKTYYSIGGGFIVDEEHFGKE
NANELQVPYPFKSAQEMLAYCKETGLSLSGMVMQNELALHSKKEIEDYFANVWQTMRACIDRGMNTEGVLPGPLRVPRRA
SALRRLLVASDKLSSDPMNVVDWVNMFALAVNEENAAGGRVVTAPTNGACGIVPAVLAYYDHFIESVSPEIYIRYFMACG
AIGALYKMNASISGAEVGCQGEVGVACSMAAAGLAELLGASPEQVCVAAEIGMEHNLGLTCDPVAGQVQVPCIERNAIAS
VKAINAARMAMRRTSEPRVSLDKVIETMYETGKDMNAKYRETSRGGLAIKVQCD

Sequences:

>Translated_454_residues
MISLFDMFKVGIGPSSSHTVGPMKAGKQFVDDLVEKGLLNAVTRVAVDVYGSLSLTGKGHHTDIAIIMGLAGNQPDTVDI
DAIPAFIRDVEARGRLLLANGQHEVDFPADDGMRFRSDNLPLHENGMTIHAWAGEKEIYCKTYYSIGGGFIVDEEHFGKE
NANELQVPYPFKSAQEMLAYCKETGLSLSGMVMQNELALHSKKEIEDYFANVWQTMRACIDRGMNTEGVLPGPLRVPRRA
SALRRLLVASDKLSSDPMNVVDWVNMFALAVNEENAAGGRVVTAPTNGACGIVPAVLAYYDHFIESVSPEIYIRYFMACG
AIGALYKMNASISGAEVGCQGEVGVACSMAAAGLAELLGASPEQVCVAAEIGMEHNLGLTCDPVAGQVQVPCIERNAIAS
VKAINAARMAMRRTSEPRVSLDKVIETMYETGKDMNAKYRETSRGGLAIKVQCD
>Mature_454_residues
MISLFDMFKVGIGPSSSHTVGPMKAGKQFVDDLVEKGLLNAVTRVAVDVYGSLSLTGKGHHTDIAIIMGLAGNQPDTVDI
DAIPAFIRDVEARGRLLLANGQHEVDFPADDGMRFRSDNLPLHENGMTIHAWAGEKEIYCKTYYSIGGGFIVDEEHFGKE
NANELQVPYPFKSAQEMLAYCKETGLSLSGMVMQNELALHSKKEIEDYFANVWQTMRACIDRGMNTEGVLPGPLRVPRRA
SALRRLLVASDKLSSDPMNVVDWVNMFALAVNEENAAGGRVVTAPTNGACGIVPAVLAYYDHFIESVSPEIYIRYFMACG
AIGALYKMNASISGAEVGCQGEVGVACSMAAAGLAELLGASPEQVCVAAEIGMEHNLGLTCDPVAGQVQVPCIERNAIAS
VKAINAARMAMRRTSEPRVSLDKVIETMYETGKDMNAKYRETSRGGLAIKVQCD

Specific function: Deaminates also threonine, particularly when it is present in high concentration [H]

COG id: COG1760

COG function: function code E; L-serine deaminase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the iron-sulfur dependent L-serine dehydratase family [H]

Homologues:

Organism=Escherichia coli, GI1788116, Length=454, Percent_Identity=89.4273127753304, Blast_Score=852, Evalue=0.0,
Organism=Escherichia coli, GI1789161, Length=455, Percent_Identity=77.3626373626374, Blast_Score=748, Evalue=0.0,
Organism=Escherichia coli, GI48994925, Length=453, Percent_Identity=72.6269315673289, Blast_Score=677, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004644
- InterPro:   IPR005130
- InterPro:   IPR005131 [H]

Pfam domain/function: PF03313 SDH_alpha; PF03315 SDH_beta [H]

EC number: =4.3.1.17 [H]

Molecular weight: Translated: 48997; Mature: 48997

Theoretical pI: Translated: 5.09; Mature: 5.09

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
4.6 %Met     (Translated Protein)
7.0 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
4.6 %Met     (Mature Protein)
7.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MISLFDMFKVGIGPSSSHTVGPMKAGKQFVDDLVEKGLLNAVTRVAVDVYGSLSLTGKGH
CCCHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEECCCCC
HTDIAIIMGLAGNQPDTVDIDAIPAFIRDVEARGRLLLANGQHEVDFPADDGMRFRSDNL
CCEEEEEEEECCCCCCEEEHHHHHHHHHHHHHCCCEEEECCCCCCCCCCCCCCEEECCCC
PLHENGMTIHAWAGEKEIYCKTYYSIGGGFIVDEEHFGKENANELQVPYPFKSAQEMLAY
CEECCCCEEEEECCCCEEEEEEEEECCCCEEEEHHHCCCCCCCCEECCCCCHHHHHHHHH
CKETGLSLSGMVMQNELALHSKKEIEDYFANVWQTMRACIDRGMNTEGVLPGPLRVPRRA
HHHHCCCEECEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHH
SALRRLLVASDKLSSDPMNVVDWVNMFALAVNEENAAGGRVVTAPTNGACGIVPAVLAYY
HHHHHHHHHHCCCCCCCCHHHHHHHHHEEEECCCCCCCCEEEECCCCCCCHHHHHHHHHH
DHFIESVSPEIYIRYFMACGAIGALYKMNASISGAEVGCQGEVGVACSMAAAGLAELLGA
HHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCC
SPEQVCVAAEIGMEHNLGLTCDPVAGQVQVPCIERNAIASVKAINAARMAMRRTSEPRVS
CHHHEEEEEECCCCCCCCEEECCCCCCEECCEECCCHHHHHHHHHHHHHHHHHCCCCCHH
LDKVIETMYETGKDMNAKYRETSRGGLAIKVQCD
HHHHHHHHHHCCCCCCCHHHCCCCCCEEEEEEEC
>Mature Secondary Structure
MISLFDMFKVGIGPSSSHTVGPMKAGKQFVDDLVEKGLLNAVTRVAVDVYGSLSLTGKGH
CCCHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEECCCCC
HTDIAIIMGLAGNQPDTVDIDAIPAFIRDVEARGRLLLANGQHEVDFPADDGMRFRSDNL
CCEEEEEEEECCCCCCEEEHHHHHHHHHHHHHCCCEEEECCCCCCCCCCCCCCEEECCCC
PLHENGMTIHAWAGEKEIYCKTYYSIGGGFIVDEEHFGKENANELQVPYPFKSAQEMLAY
CEECCCCEEEEECCCCEEEEEEEEECCCCEEEEHHHCCCCCCCCEECCCCCHHHHHHHHH
CKETGLSLSGMVMQNELALHSKKEIEDYFANVWQTMRACIDRGMNTEGVLPGPLRVPRRA
HHHHCCCEECEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHH
SALRRLLVASDKLSSDPMNVVDWVNMFALAVNEENAAGGRVVTAPTNGACGIVPAVLAYY
HHHHHHHHHHCCCCCCCCHHHHHHHHHEEEECCCCCCCCEEEECCCCCCCHHHHHHHHHH
DHFIESVSPEIYIRYFMACGAIGALYKMNASISGAEVGCQGEVGVACSMAAAGLAELLGA
HHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCC
SPEQVCVAAEIGMEHNLGLTCDPVAGQVQVPCIERNAIASVKAINAARMAMRRTSEPRVS
CHHHEEEEEECCCCCCCCEEECCCCCCEECCEECCCHHHHHHHHHHHHHHHHHCCCCCHH
LDKVIETMYETGKDMNAKYRETSRGGLAIKVQCD
HHHHHHHHHHCCCCCCCHHHCCCCCCEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2504697; 8436113; 9097040; 9278503 [H]