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The map label for this gene is tdcB [H]

Identifier: 238895349

GI number: 238895349

Start: 3235973

End: 3236962

Strand: Reverse

Name: tdcB [H]

Synonym: KP1_3411

Alternate gene names: 238895349

Gene position: 3236962-3235973 (Counterclockwise)

Preceding gene: 238895350

Following gene: 238895348

Centisome position: 61.67

GC content: 53.64

Gene sequence:

>990_bases
ATGCATATTACCTACGATCTTCCGGTATCTATTGACGATATTCTCGAAGCGAAACAACGCCTCGCGGGAAAAATATATAA
AACAGGCATGCCCCGTTCGAATTATTTTAGCGAGCGCTGCCAGGGCGAAATATTTCTTAAATTCGAAAATATGCAGCGCA
CGGGTTCATTTAAAATTCGCGGCGCCTTTAATAAACTGTGCGGTTTAACCGCGGCGGAAAAACGCAAAGGGGTGGTGGCC
TGCTCAGCGGGCAACCACGCCCAGGGCGTCTCGCTCTCCTGCGCCATGCTCGGCATTGACGGGAAAGTGGTGATGCCGAA
AGGGGCGCCGAAATCGAAAGTTGCCGCCACCTGTGATTATTCGGCGGAAGTGGTGCTACATGGCGATAACTTTAACGATA
CCCTCGCCAAAGCCAGCGATATTGTTGAACTTGAGGGCCGCATTTTTATTCCCCCCTATGACGACCCGCAGGTTATCGCC
GGGCAGGGGACGATTGGACTCGAAATATTAGAAGATCTGTATGACGTGGATAATGTCATCGTGCCCATTGGCGGCGGCGG
CTTAATTGCCGGTATCGCGATTGCGATTAAATCCATTAACCCGACAATCCGCATTATCGGCGTGCAGTCGGAGAATGTTC
ACGGCATGGCCGCCTCCTGGTATGCCGGGGAAATCACCAGCCATCGCCACGCCGGCACCTTAGCCGATGGTTGCGACGTC
GCCCGCCCGGGGAAACTGACCTATGAAATCGCCCGCCAGCTGGTGGATGACATCGTCCTGGTGAGTGAGGACGACATTCG
CCAGAGCATGGTCGCCTTAATTCAGCGCAATAAAGTGATCACCGAAGGGGCCGGGGCGTTAGCCTGCGCCGCGTTATTAA
GCGGCAAACTCGACAGCTATATCCAGAACCGCAAAACGGTCAGCCTGATTTCCGGGGGCAATATCGATCTCTCCCGGGTA
TCGCAAATTACCGGTTTTGTTGACGCTTAA

Upstream 100 bases:

>100_bases
TGCGTAACTGAAAGTCGTTAAATAATCCAACACACGTCCTCGCTGTTATCAGCAGGATGACGCCCGGTCATTGACTTTAT
ATTCAGATACAGAGGCCATA

Downstream 100 bases:

>100_bases
TTCAATACATAAGTGAGGACAGGATATGAGTACGACTGAGAGCATTGCATCCAGCCAGACAAGCCTTTCGTCCTGGCGTA
AATCTGACACCACCTGGACC

Product: threonine dehydratase

Products: NA

Alternate protein names: Threonine deaminase [H]

Number of amino acids: Translated: 329; Mature: 329

Protein sequence:

>329_residues
MHITYDLPVSIDDILEAKQRLAGKIYKTGMPRSNYFSERCQGEIFLKFENMQRTGSFKIRGAFNKLCGLTAAEKRKGVVA
CSAGNHAQGVSLSCAMLGIDGKVVMPKGAPKSKVAATCDYSAEVVLHGDNFNDTLAKASDIVELEGRIFIPPYDDPQVIA
GQGTIGLEILEDLYDVDNVIVPIGGGGLIAGIAIAIKSINPTIRIIGVQSENVHGMAASWYAGEITSHRHAGTLADGCDV
ARPGKLTYEIARQLVDDIVLVSEDDIRQSMVALIQRNKVITEGAGALACAALLSGKLDSYIQNRKTVSLISGGNIDLSRV
SQITGFVDA

Sequences:

>Translated_329_residues
MHITYDLPVSIDDILEAKQRLAGKIYKTGMPRSNYFSERCQGEIFLKFENMQRTGSFKIRGAFNKLCGLTAAEKRKGVVA
CSAGNHAQGVSLSCAMLGIDGKVVMPKGAPKSKVAATCDYSAEVVLHGDNFNDTLAKASDIVELEGRIFIPPYDDPQVIA
GQGTIGLEILEDLYDVDNVIVPIGGGGLIAGIAIAIKSINPTIRIIGVQSENVHGMAASWYAGEITSHRHAGTLADGCDV
ARPGKLTYEIARQLVDDIVLVSEDDIRQSMVALIQRNKVITEGAGALACAALLSGKLDSYIQNRKTVSLISGGNIDLSRV
SQITGFVDA
>Mature_329_residues
MHITYDLPVSIDDILEAKQRLAGKIYKTGMPRSNYFSERCQGEIFLKFENMQRTGSFKIRGAFNKLCGLTAAEKRKGVVA
CSAGNHAQGVSLSCAMLGIDGKVVMPKGAPKSKVAATCDYSAEVVLHGDNFNDTLAKASDIVELEGRIFIPPYDDPQVIA
GQGTIGLEILEDLYDVDNVIVPIGGGGLIAGIAIAIKSINPTIRIIGVQSENVHGMAASWYAGEITSHRHAGTLADGCDV
ARPGKLTYEIARQLVDDIVLVSEDDIRQSMVALIQRNKVITEGAGALACAALLSGKLDSYIQNRKTVSLISGGNIDLSRV
SQITGFVDA

Specific function: Acts on both serine and threonine, and properly considered as a hydroxy amino acid deaminase [H]

COG id: COG1171

COG function: function code E; Threonine dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the serine/threonine dehydratase family [H]

Homologues:

Organism=Homo sapiens, GI11345492, Length=317, Percent_Identity=34.0694006309148, Blast_Score=171, Evalue=1e-42,
Organism=Escherichia coli, GI1789505, Length=329, Percent_Identity=90.5775075987842, Blast_Score=571, Evalue=1e-164,
Organism=Escherichia coli, GI1790207, Length=297, Percent_Identity=37.037037037037, Blast_Score=185, Evalue=4e-48,
Organism=Caenorhabditis elegans, GI71991565, Length=314, Percent_Identity=38.5350318471338, Blast_Score=179, Evalue=2e-45,
Organism=Caenorhabditis elegans, GI17537387, Length=304, Percent_Identity=39.4736842105263, Blast_Score=155, Evalue=4e-38,
Organism=Caenorhabditis elegans, GI17508781, Length=326, Percent_Identity=29.4478527607362, Blast_Score=135, Evalue=4e-32,
Organism=Saccharomyces cerevisiae, GI6322631, Length=311, Percent_Identity=37.2990353697749, Blast_Score=191, Evalue=1e-49,
Organism=Saccharomyces cerevisiae, GI6320930, Length=296, Percent_Identity=36.1486486486487, Blast_Score=172, Evalue=5e-44,
Organism=Saccharomyces cerevisiae, GI6319788, Length=281, Percent_Identity=25.9786476868327, Blast_Score=89, Evalue=1e-18,
Organism=Drosophila melanogaster, GI21355833, Length=310, Percent_Identity=39.6774193548387, Blast_Score=160, Evalue=1e-39,
Organism=Drosophila melanogaster, GI24645328, Length=214, Percent_Identity=40.1869158878505, Blast_Score=105, Evalue=3e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001926
- InterPro:   IPR000634 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =4.3.1.19 [H]

Molecular weight: Translated: 35082; Mature: 35082

Theoretical pI: Translated: 6.25; Mature: 6.25

Prosite motif: PS00165 DEHYDRATASE_SER_THR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHITYDLPVSIDDILEAKQRLAGKIYKTGMPRSNYFSERCQGEIFLKFENMQRTGSFKIR
CEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHCCCEEEEEEECCCCCCCEEEE
GAFNKLCGLTAAEKRKGVVACSAGNHAQGVSLSCAMLGIDGKVVMPKGAPKSKVAATCDY
EHHHHHHCCCHHHHCCCEEEECCCCCCCCCEEEEEEEECCCEEEECCCCCCCCEEEEECC
SAEVVLHGDNFNDTLAKASDIVELEGRIFIPPYDDPQVIAGQGTIGLEILEDLYDVDNVI
CEEEEEECCCCCHHHHHHCCEEEECCEEEECCCCCCCEEECCCCCHHHHHHHHHCCCCEE
VPIGGGGLIAGIAIAIKSINPTIRIIGVQSENVHGMAASWYAGEITSHRHAGTLADGCDV
EEECCCHHHHHHHHHEECCCCEEEEEEECCCCCCCEEEEEEECCCCCCCCCCCCCCCCCC
ARPGKLTYEIARQLVDDIVLVSEDDIRQSMVALIQRNKVITEGAGALACAALLSGKLDSY
CCCCCHHHHHHHHHHHHEEEECCHHHHHHHHHHHHCCCEEECCCCHHHHHHHHHHHHHHH
IQNRKTVSLISGGNIDLSRVSQITGFVDA
HHCCCEEEEEECCCCCHHHHHHHHHCCCC
>Mature Secondary Structure
MHITYDLPVSIDDILEAKQRLAGKIYKTGMPRSNYFSERCQGEIFLKFENMQRTGSFKIR
CEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHCCCEEEEEEECCCCCCCEEEE
GAFNKLCGLTAAEKRKGVVACSAGNHAQGVSLSCAMLGIDGKVVMPKGAPKSKVAATCDY
EHHHHHHCCCHHHHCCCEEEECCCCCCCCCEEEEEEEECCCEEEECCCCCCCCEEEEECC
SAEVVLHGDNFNDTLAKASDIVELEGRIFIPPYDDPQVIAGQGTIGLEILEDLYDVDNVI
CEEEEEECCCCCHHHHHHCCEEEECCEEEECCCCCCCEEECCCCCHHHHHHHHHCCCCEE
VPIGGGGLIAGIAIAIKSINPTIRIIGVQSENVHGMAASWYAGEITSHRHAGTLADGCDV
EEECCCHHHHHHHHHEECCCCEEEEEEECCCCCCCEEEEEEECCCCCCCCCCCCCCCCCC
ARPGKLTYEIARQLVDDIVLVSEDDIRQSMVALIQRNKVITEGAGALACAALLSGKLDSY
CCCCCHHHHHHHHHHHHEEEECCHHHHHHHHHHHHCCCEEECCCCHHHHHHHHHHHHHHH
IQNRKTVSLISGGNIDLSRVSQITGFVDA
HHCCCEEEEEECCCCCHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]