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The map label for this gene is tdcC [H]

Identifier: 238895348

GI number: 238895348

Start: 3234616

End: 3235947

Strand: Reverse

Name: tdcC [H]

Synonym: KP1_3410

Alternate gene names: 238895348

Gene position: 3235947-3234616 (Counterclockwise)

Preceding gene: 238895349

Following gene: 238895347

Centisome position: 61.65

GC content: 57.06

Gene sequence:

>1332_bases
ATGAGTACGACTGAGAGCATTGCATCCAGCCAGACAAGCCTTTCGTCCTGGCGTAAATCTGACACCACCTGGACCCTGGG
CCTGTTTGGCACCGCTATCGGCGCCGGGGTGCTGTTTTTCCCGATCCGCGCAGGCTTCGGCGGGCTGATCCCGATCCTGG
TGATGCTGGTGCTGGCCTATCCCATCGCCTTTTATTGCCATCGGGCCCTGGCCCGGCTATGCCTGTCGGGGGCTAACCCC
TCCGGCAATATCACCGAAACGGTGGAAGAGCATTTTGGCAAAACCGGCGGGGTGGTGATCACCTTTCTGTACTTCTTCGC
CATCTGCCCACTGCTGTGGATTTATGGCGTCACGATCACCAATACCTTTATGACTTTCTGGGAGAACCAGCTGCAGATGC
CGGCTCTCAACCGCGGGGTGGTGGCGCTGCTCCTGCTGCTGCTGATGGCGTTTGTCATCTGGTTTGGTAAAGACCTGATG
GTCAAGGTGATGAGCTATCTGGTGTGGCCGTTTATCGCCAGCCTGGTGGTGATCTCCCTGTCCCTGATCCCCTACTGGAA
TAGCGCGGTGATTGACCAGGTCAACCTCAGCGATATCGCCTTAACCGGTCACGACGGCATTCTGGTGACGGTATGGCTGG
GCATCTCCATCATGGTGTTCTCCTTCAACTTCTCGCCGATCGTCTCCTCGTTTGTGGTCTCCAAACGCGAAGAGTATGAA
GCGCAGTTTGGCCGCGAGTATACCGAACGCAAATGCTCACAGATCATCTCCCGGGCCAGCATGCTGATGGTGGCGGTGGT
GATGTTCTTCGCCTTCAGCTGCCTGTTTACCCTCTCACCGCAGAACATGGCGGACGCCAAGGCGCAGAATATCCCGGTGC
TCTCCTATCTGGCGAACCACTTTGCCTCGATGTCGGGCACCAAATCCACCTTTGCCACCCTGCTGGAGTATGGCGCGTCG
ATCATCGCCCTGGTGGCCATCTTCAAATCGTTTTTCGGCCACTATCTCGGCACGCTCGAGGGGCTGAACGGTCTGATCCT
GCGCTTCGGCTATAAAGGGGATAAAACCCGGGTCTCCAGCGGCAAGCTCAATACCCTGAGCATGGTGTTCATCATGGGAT
CGACCTGGGTGGTGGCGTATGCCAACCCCAATATCCTCGACCTGATTGAGGCCATGGGCGCGCCGATTATCGCCTCGCTG
CTGTGCCTGCTGCCGATGTACGCCATTCGTAAAGCGCCTTCGCTGGCCAAATACCGTGGCCGTCTCGACAACCTCTTTGT
GACCGCTATCGGTCTGCTGACCATCCTCAACATTGCTTACAAACTGTTCTAA

Upstream 100 bases:

>100_bases
ACGGTCAGCCTGATTTCCGGGGGCAATATCGATCTCTCCCGGGTATCGCAAATTACCGGTTTTGTTGACGCTTAATTCAA
TACATAAGTGAGGACAGGAT

Downstream 100 bases:

>100_bases
TCCGGCTCAGGCCACGCGGAGTACAACATGACTGAATTTCCGGTAGTACTGGTGATTAACTGCGGCTCGTCGTCGATCAA
ATTTTCCGTCCTCGACGTCG

Product: threonine/serine transporter TdcC

Products: Proton [Cytoplasm]; D-serine [Cytoplasm]; L-threonine [Cytoplasm] [C]

Alternate protein names: H(+)/threonine-serine symporter [H]

Number of amino acids: Translated: 443; Mature: 442

Protein sequence:

>443_residues
MSTTESIASSQTSLSSWRKSDTTWTLGLFGTAIGAGVLFFPIRAGFGGLIPILVMLVLAYPIAFYCHRALARLCLSGANP
SGNITETVEEHFGKTGGVVITFLYFFAICPLLWIYGVTITNTFMTFWENQLQMPALNRGVVALLLLLLMAFVIWFGKDLM
VKVMSYLVWPFIASLVVISLSLIPYWNSAVIDQVNLSDIALTGHDGILVTVWLGISIMVFSFNFSPIVSSFVVSKREEYE
AQFGREYTERKCSQIISRASMLMVAVVMFFAFSCLFTLSPQNMADAKAQNIPVLSYLANHFASMSGTKSTFATLLEYGAS
IIALVAIFKSFFGHYLGTLEGLNGLILRFGYKGDKTRVSSGKLNTLSMVFIMGSTWVVAYANPNILDLIEAMGAPIIASL
LCLLPMYAIRKAPSLAKYRGRLDNLFVTAIGLLTILNIAYKLF

Sequences:

>Translated_443_residues
MSTTESIASSQTSLSSWRKSDTTWTLGLFGTAIGAGVLFFPIRAGFGGLIPILVMLVLAYPIAFYCHRALARLCLSGANP
SGNITETVEEHFGKTGGVVITFLYFFAICPLLWIYGVTITNTFMTFWENQLQMPALNRGVVALLLLLLMAFVIWFGKDLM
VKVMSYLVWPFIASLVVISLSLIPYWNSAVIDQVNLSDIALTGHDGILVTVWLGISIMVFSFNFSPIVSSFVVSKREEYE
AQFGREYTERKCSQIISRASMLMVAVVMFFAFSCLFTLSPQNMADAKAQNIPVLSYLANHFASMSGTKSTFATLLEYGAS
IIALVAIFKSFFGHYLGTLEGLNGLILRFGYKGDKTRVSSGKLNTLSMVFIMGSTWVVAYANPNILDLIEAMGAPIIASL
LCLLPMYAIRKAPSLAKYRGRLDNLFVTAIGLLTILNIAYKLF
>Mature_442_residues
STTESIASSQTSLSSWRKSDTTWTLGLFGTAIGAGVLFFPIRAGFGGLIPILVMLVLAYPIAFYCHRALARLCLSGANPS
GNITETVEEHFGKTGGVVITFLYFFAICPLLWIYGVTITNTFMTFWENQLQMPALNRGVVALLLLLLMAFVIWFGKDLMV
KVMSYLVWPFIASLVVISLSLIPYWNSAVIDQVNLSDIALTGHDGILVTVWLGISIMVFSFNFSPIVSSFVVSKREEYEA
QFGREYTERKCSQIISRASMLMVAVVMFFAFSCLFTLSPQNMADAKAQNIPVLSYLANHFASMSGTKSTFATLLEYGASI
IALVAIFKSFFGHYLGTLEGLNGLILRFGYKGDKTRVSSGKLNTLSMVFIMGSTWVVAYANPNILDLIEAMGAPIIASLL
CLLPMYAIRKAPSLAKYRGRLDNLFVTAIGLLTILNIAYKLF

Specific function: Involved in the import of threonine and serine into the cell, with the concomitant import of a proton (symport system) [H]

COG id: COG0814

COG function: function code E; Amino acid permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid/polyamine transporter 2 family. SdaC/TdcC subfamily [H]

Homologues:

Organism=Escherichia coli, GI1789504, Length=443, Percent_Identity=90.9706546275395, Blast_Score=806, Evalue=0.0,
Organism=Escherichia coli, GI1789160, Length=444, Percent_Identity=49.0990990990991, Blast_Score=422, Evalue=1e-119,
Organism=Escherichia coli, GI1789211, Length=425, Percent_Identity=30.5882352941176, Blast_Score=209, Evalue=3e-55,
Organism=Escherichia coli, GI145693183, Length=421, Percent_Identity=23.9904988123515, Blast_Score=102, Evalue=4e-23,
Organism=Escherichia coli, GI1789961, Length=414, Percent_Identity=23.4299516908213, Blast_Score=94, Evalue=1e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004694
- InterPro:   IPR018227 [H]

Pfam domain/function: PF03222 Trp_Tyr_perm [H]

EC number: NA

Molecular weight: Translated: 48754; Mature: 48623

Theoretical pI: Translated: 9.05; Mature: 9.05

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTTESIASSQTSLSSWRKSDTTWTLGLFGTAIGAGVLFFPIRAGFGGLIPILVMLVLAY
CCCHHHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
PIAFYCHRALARLCLSGANPSGNITETVEEHFGKTGGVVITFLYFFAICPLLWIYGVTIT
HHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
NTFMTFWENQLQMPALNRGVVALLLLLLMAFVIWFGKDLMVKVMSYLVWPFIASLVVISL
HHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHH
SLIPYWNSAVIDQVNLSDIALTGHDGILVTVWLGISIMVFSFNFSPIVSSFVVSKREEYE
HHHCCCCHHHHCCCCCCCEEEECCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
AQFGREYTERKCSQIISRASMLMVAVVMFFAFSCLFTLSPQNMADAKAQNIPVLSYLANH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCHHHHHHHHH
FASMSGTKSTFATLLEYGASIIALVAIFKSFFGHYLGTLEGLNGLILRFGYKGDKTRVSS
HHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHEEEECCCCCCCCCCC
GKLNTLSMVFIMGSTWVVAYANPNILDLIEAMGAPIIASLLCLLPMYAIRKAPSLAKYRG
CCCHHHHHHEEECCCEEEEECCCCHHHHHHHHCCHHHHHHHHHHHHHHHHCCCHHHHHHH
RLDNLFVTAIGLLTILNIAYKLF
HHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
STTESIASSQTSLSSWRKSDTTWTLGLFGTAIGAGVLFFPIRAGFGGLIPILVMLVLAY
CCHHHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH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HHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; D-serine [Periplasm]; L-threonine [Periplasm] [C]

Specific reaction: Proton [Periplasm] + D-serine [Periplasm] = Proton [Cytoplasm] + D-serine [Cytoplasm] Proton [Periplasm] + L-threonine [Periplasm] = Proton [Cytoplasm] + L-threonine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA