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The map label for this gene is btuD [H]

Identifier: 238895221

GI number: 238895221

Start: 3103200

End: 3103949

Strand: Reverse

Name: btuD [H]

Synonym: KP1_3269

Alternate gene names: 238895221

Gene position: 3103949-3103200 (Counterclockwise)

Preceding gene: 238895222

Following gene: 238895220

Centisome position: 59.14

GC content: 64.13

Gene sequence:

>750_bases
ATGTCGTTTCTGATGCAGCTACAGGATGTAGAAGCGGCGGGGCGCCTGGCCCCGTTTTCTGCGGCCTTTCGCGCCGGGGA
GATTGTCCATCTGGTGGGGCCGAACGGCGCAGGGAAGAGCACGCTGCTGACCCGCATGGCGGGGCTGTCCGACGGCCCCG
GCACGGTTCATTTTAACGGCCGGCTGCTTGACGAGTGGCCGGCGAGGGAGCTGGCGCGCCGTCGCGGATATCTGAGTCAA
CACCAGACCCCGCCGTTCGCCATGCCGGTATGGCACTACCTGGCGCTGCATATGCAGCAGCAGGGTGATAGCGCCCGTCT
GAGCGATATCGCGGCCAGGCTTGGTCTGGACAATAAGCTGGGCCGTCCGGTCAATCAGCTGTCGGGCGGCGAGTGGCAGC
GCGTGCGGCTGGCGGCAGTGATCCTGCAGATCGATCCCTTGAGTAATTCCGCGGGTCAGCTGCTGCTGCTGGATGAGCCG
ATGAACAGTCTGGATGTGGCTCAGCAGGCGGCGCTGGATCGGCTGTTACACGAGCTGAGCGCGGCGGGGATTGCGGTGGT
GATGAGCAGCCACGATCTCAACCATACCCTGCGCCACGCCGGTCAGAGCTGGCTGCTCTGCCAGGGGGAAGCCATCGCCT
GCGGGGAGACCGCCGAGGTGCTGAATGAGGAAAATTTAACCGCCGCCTATGCGATCCCGTTCCAGCGCGTTGAGGTGGCC
GGTCATATTATGCTCATCGCGTCACAGTAG

Upstream 100 bases:

>100_bases
TCATCGATCGCCAGGGCAACGTCATTCAGCGCTTCTCTCCGGATATGACGCCGGACGATCCGCAGCTGGTGGCGGCGATT
AAAGGAGCGCTGGCGCAATA

Downstream 100 bases:

>100_bases
CACGCAGTTATCTTGTCACTATATTGATAAACAAGCTAAATTATTGCGATAAAGAGACTAGGGACAGAGGGATCATCTGA
AATGCGCTTCTGGTTCATGT

Product: vitamin B12-transporter ATPase

Products: NA

Alternate protein names: Vitamin B12-transporting ATPase [H]

Number of amino acids: Translated: 249; Mature: 248

Protein sequence:

>249_residues
MSFLMQLQDVEAAGRLAPFSAAFRAGEIVHLVGPNGAGKSTLLTRMAGLSDGPGTVHFNGRLLDEWPARELARRRGYLSQ
HQTPPFAMPVWHYLALHMQQQGDSARLSDIAARLGLDNKLGRPVNQLSGGEWQRVRLAAVILQIDPLSNSAGQLLLLDEP
MNSLDVAQQAALDRLLHELSAAGIAVVMSSHDLNHTLRHAGQSWLLCQGEAIACGETAEVLNEENLTAAYAIPFQRVEVA
GHIMLIASQ

Sequences:

>Translated_249_residues
MSFLMQLQDVEAAGRLAPFSAAFRAGEIVHLVGPNGAGKSTLLTRMAGLSDGPGTVHFNGRLLDEWPARELARRRGYLSQ
HQTPPFAMPVWHYLALHMQQQGDSARLSDIAARLGLDNKLGRPVNQLSGGEWQRVRLAAVILQIDPLSNSAGQLLLLDEP
MNSLDVAQQAALDRLLHELSAAGIAVVMSSHDLNHTLRHAGQSWLLCQGEAIACGETAEVLNEENLTAAYAIPFQRVEVA
GHIMLIASQ
>Mature_248_residues
SFLMQLQDVEAAGRLAPFSAAFRAGEIVHLVGPNGAGKSTLLTRMAGLSDGPGTVHFNGRLLDEWPARELARRRGYLSQH
QTPPFAMPVWHYLALHMQQQGDSARLSDIAARLGLDNKLGRPVNQLSGGEWQRVRLAAVILQIDPLSNSAGQLLLLDEPM
NSLDVAQQAALDRLLHELSAAGIAVVMSSHDLNHTLRHAGQSWLLCQGEAIACGETAEVLNEENLTAAYAIPFQRVEVAG
HIMLIASQ

Specific function: Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system [H]

COG id: COG4138

COG function: function code H; ABC-type cobalamin transport system, ATPase component

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transporter domain [H]

Homologues:

Organism=Homo sapiens, GI46592978, Length=215, Percent_Identity=27.906976744186, Blast_Score=69, Evalue=3e-12,
Organism=Homo sapiens, GI46592915, Length=215, Percent_Identity=27.906976744186, Blast_Score=69, Evalue=3e-12,
Organism=Homo sapiens, GI46592898, Length=215, Percent_Identity=27.906976744186, Blast_Score=69, Evalue=3e-12,
Organism=Homo sapiens, GI46592956, Length=215, Percent_Identity=27.906976744186, Blast_Score=69, Evalue=3e-12,
Organism=Homo sapiens, GI46592964, Length=215, Percent_Identity=27.906976744186, Blast_Score=69, Evalue=3e-12,
Organism=Homo sapiens, GI46592971, Length=215, Percent_Identity=27.906976744186, Blast_Score=69, Evalue=3e-12,
Organism=Escherichia coli, GI1788002, Length=248, Percent_Identity=62.0967741935484, Blast_Score=315, Evalue=1e-87,
Organism=Escherichia coli, GI1786345, Length=248, Percent_Identity=33.8709677419355, Blast_Score=108, Evalue=3e-25,
Organism=Escherichia coli, GI1790739, Length=228, Percent_Identity=32.4561403508772, Blast_Score=96, Evalue=2e-21,
Organism=Escherichia coli, GI1786803, Length=218, Percent_Identity=29.8165137614679, Blast_Score=86, Evalue=2e-18,
Organism=Escherichia coli, GI1788165, Length=228, Percent_Identity=32.4561403508772, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI1789593, Length=219, Percent_Identity=27.8538812785388, Blast_Score=77, Evalue=8e-16,
Organism=Escherichia coli, GI1788450, Length=211, Percent_Identity=32.2274881516588, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1786253, Length=214, Percent_Identity=32.2429906542056, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI1789873, Length=193, Percent_Identity=31.6062176165803, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI1786698, Length=219, Percent_Identity=33.7899543378995, Blast_Score=71, Evalue=6e-14,
Organism=Escherichia coli, GI87081791, Length=227, Percent_Identity=30.3964757709251, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI1790544, Length=226, Percent_Identity=28.7610619469027, Blast_Score=68, Evalue=6e-13,
Organism=Escherichia coli, GI1789891, Length=224, Percent_Identity=31.6964285714286, Blast_Score=67, Evalue=9e-13,
Organism=Escherichia coli, GI1788761, Length=196, Percent_Identity=30.6122448979592, Blast_Score=66, Evalue=3e-12,
Organism=Escherichia coli, GI1787105, Length=212, Percent_Identity=30.188679245283, Blast_Score=65, Evalue=3e-12,
Organism=Escherichia coli, GI87081834, Length=192, Percent_Identity=32.8125, Blast_Score=64, Evalue=8e-12,
Organism=Escherichia coli, GI1789963, Length=231, Percent_Identity=29.004329004329, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI1786703, Length=181, Percent_Identity=33.7016574585635, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI48995001, Length=209, Percent_Identity=24.4019138755981, Blast_Score=63, Evalue=1e-11,
Organism=Escherichia coli, GI1789864, Length=229, Percent_Identity=25.764192139738, Blast_Score=63, Evalue=2e-11,
Organism=Escherichia coli, GI1786398, Length=209, Percent_Identity=27.2727272727273, Blast_Score=62, Evalue=4e-11,
Organism=Escherichia coli, GI1786563, Length=201, Percent_Identity=30.8457711442786, Blast_Score=62, Evalue=5e-11,
Organism=Escherichia coli, GI1787792, Length=221, Percent_Identity=28.5067873303167, Blast_Score=61, Evalue=7e-11,
Organism=Escherichia coli, GI1788506, Length=218, Percent_Identity=30.2752293577982, Blast_Score=60, Evalue=1e-10,
Organism=Drosophila melanogaster, GI85726357, Length=211, Percent_Identity=28.9099526066351, Blast_Score=65, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003439
- InterPro:   IPR017871
- InterPro:   IPR003593 [H]

Pfam domain/function: PF00005 ABC_tran [H]

EC number: =3.6.3.33 [H]

Molecular weight: Translated: 26974; Mature: 26843

Theoretical pI: Translated: 6.34; Mature: 6.34

Prosite motif: PS00639 THIOL_PROTEASE_HIS ; PS00211 ABC_TRANSPORTER_1 ; PS50893 ABC_TRANSPORTER_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSFLMQLQDVEAAGRLAPFSAAFRAGEIVHLVGPNGAGKSTLLTRMAGLSDGPGTVHFNG
CCHHHHHHHHHHCCCCCCHHHHHCCCCEEEEECCCCCCHHHHHHHHHCCCCCCCEEEECC
RLLDEWPARELARRRGYLSQHQTPPFAMPVWHYLALHMQQQGDSARLSDIAARLGLDNKL
EECCCCCHHHHHHHCCCHHHCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCC
GRPVNQLSGGEWQRVRLAAVILQIDPLSNSAGQLLLLDEPMNSLDVAQQAALDRLLHELS
CCCHHHCCCCCHHHEEEEEEEEEEECCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHH
AAGIAVVMSSHDLNHTLRHAGQSWLLCQGEAIACGETAEVLNEENLTAAYAIPFQRVEVA
HCCEEEEEECCCHHHHHHHCCCCEEEECCCEEECCCHHHHHCCCCCEEEEECCHHHEEEC
GHIMLIASQ
CEEEEEECC
>Mature Secondary Structure 
SFLMQLQDVEAAGRLAPFSAAFRAGEIVHLVGPNGAGKSTLLTRMAGLSDGPGTVHFNG
CHHHHHHHHHHCCCCCCHHHHHCCCCEEEEECCCCCCHHHHHHHHHCCCCCCCEEEECC
RLLDEWPARELARRRGYLSQHQTPPFAMPVWHYLALHMQQQGDSARLSDIAARLGLDNKL
EECCCCCHHHHHHHCCCHHHCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCC
GRPVNQLSGGEWQRVRLAAVILQIDPLSNSAGQLLLLDEPMNSLDVAQQAALDRLLHELS
CCCHHHCCCCCHHHEEEEEEEEEEECCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHH
AAGIAVVMSSHDLNHTLRHAGQSWLLCQGEAIACGETAEVLNEENLTAAYAIPFQRVEVA
HCCEEEEEECCCHHHHHHHCCCCEEEECCCEEECCCHHHHHCCCCCEEEEECCHHHEEEC
GHIMLIASQ
CEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA