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The map label for this gene is sufS [H]

Identifier: 238895187

GI number: 238895187

Start: 3067529

End: 3068749

Strand: Reverse

Name: sufS [H]

Synonym: KP1_3233

Alternate gene names: 238895187

Gene position: 3068749-3067529 (Counterclockwise)

Preceding gene: 238895188

Following gene: 238895186

Centisome position: 58.47

GC content: 64.05

Gene sequence:

>1221_bases
ATGACATTTTCAGTAGAACAGGTTCGCGCCGATTTTCCGGTACTGAACCGGGAGGTCAACGGTCAGCCGTTGGTCTATCT
CGACAGCGCCGCCAGCGCCCAGAAGCCGGAGGCAGTGATCGGCGCCGAAGCGGAATTCTATCGCCACGGCTACGCGGCGG
TGCACCGCGGCATCCATACCCTCAGCGCGGAAGCCACCGCGCGGATGGAAGCCGTGCGTCAGCAGGCGGCCACCTTCCTT
AACGCCGGGTCGGCGGAGGAAGTGGTGTTCGTCCGCGGCACCACCGAGGGTATCAACCTGGTGGCCAACAGCTGGGGAAA
CGCCAACGTCGGCGCCGGGGATAACATCATCATCAGCGAAATGGAGCACCACGCCAATATTGTGCCGTGGCAGATGCTGT
GCGCCCGCGTCGGGGCTGAGCTGCGGGTGATCCCCCTGAACCCGGACGGTACGCTGCAACTGGATGTTGTCCCGGGACTG
TTTGACCCGCGCACCCGCCTGCTGGCGATAACCGAGGTCTCCAACGTGCTGGGGACGGAAAACCCGCTGGCGGCGCTGAT
TGCTCTTGCGCATCAGCATGGCGCGAAAGTGCTGGTGGATGGCGCCCAGGCGGTGATGCACCACCCGGTGGACGTCCAGG
CGCTGGGCTGCGATTTTTATGTTTTCTCCGCCCACAAGCTGTATGGGCCGACCGGGATCGGCGTGCTCTACGCCCGGTCC
GAGCTGCTGCAGACGATGGCGCCTTGGGAAGGGGGCGGGTCGATGATCGCCACCGTCAGCCTGACGGAGGGCACCACCTG
GAATCAGGCGCCGTGGCGCTTTGAGGCCGGCACGCCGAATACCGGGGGGATCATTGGACTCGGCGCGGCGCTGACCTACG
TCAGCCAGCTGGGACTGACGCAGATTGCCGAGTATGAGCAGACGCTGATGCGCTACGCGCTCGATGCCCTGCGCGCGGTA
CCGGATCTGATCCTTTACGGCCCGGCGCAGCGTAAAGGGGTAATTGCTTTCAACCTCGGTCAGCATCACGCCTATGACGT
CGGCAGCTTCCTCGATAACTACGGGATCGCCGTGCGGACCGGACACCACTGCGCGATGCCGTTGATGGCCCGGTATCAGG
TACCGGCTATGTGTCGGGCATCGCTGGCGATGTACAATACCACGGAAGAGGTGGACCGCCTGGTGGCCGGCCTCCAGCGG
ATCCGCAAACTGTTAGGGTAA

Upstream 100 bases:

>100_bases
TCTACGCCTTTGCCGCCGAGCTCACCGAGGCTATCCGCAGCGACGCGCTCAAAGAGCAGGTGCTGGCGCGTATTGGACAG
CGTTTGCCGGGAGGCACTGT

Downstream 100 bases:

>100_bases
AGGACGGGACAATGGCGGCACTACCGGACAAAGACAAACTGTTGCGTAACTTTAGCCGTTGCGCCAACTGGGAAGAGAAG
TATCTCTATATCATCGAGCT

Product: bifunctional cysteine desulfurase/selenocysteine lyase

Products: NA

Alternate protein names: Selenocysteine beta-lyase; SCL; Selenocysteine lyase; Selenocysteine reductase [H]

Number of amino acids: Translated: 406; Mature: 405

Protein sequence:

>406_residues
MTFSVEQVRADFPVLNREVNGQPLVYLDSAASAQKPEAVIGAEAEFYRHGYAAVHRGIHTLSAEATARMEAVRQQAATFL
NAGSAEEVVFVRGTTEGINLVANSWGNANVGAGDNIIISEMEHHANIVPWQMLCARVGAELRVIPLNPDGTLQLDVVPGL
FDPRTRLLAITEVSNVLGTENPLAALIALAHQHGAKVLVDGAQAVMHHPVDVQALGCDFYVFSAHKLYGPTGIGVLYARS
ELLQTMAPWEGGGSMIATVSLTEGTTWNQAPWRFEAGTPNTGGIIGLGAALTYVSQLGLTQIAEYEQTLMRYALDALRAV
PDLILYGPAQRKGVIAFNLGQHHAYDVGSFLDNYGIAVRTGHHCAMPLMARYQVPAMCRASLAMYNTTEEVDRLVAGLQR
IRKLLG

Sequences:

>Translated_406_residues
MTFSVEQVRADFPVLNREVNGQPLVYLDSAASAQKPEAVIGAEAEFYRHGYAAVHRGIHTLSAEATARMEAVRQQAATFL
NAGSAEEVVFVRGTTEGINLVANSWGNANVGAGDNIIISEMEHHANIVPWQMLCARVGAELRVIPLNPDGTLQLDVVPGL
FDPRTRLLAITEVSNVLGTENPLAALIALAHQHGAKVLVDGAQAVMHHPVDVQALGCDFYVFSAHKLYGPTGIGVLYARS
ELLQTMAPWEGGGSMIATVSLTEGTTWNQAPWRFEAGTPNTGGIIGLGAALTYVSQLGLTQIAEYEQTLMRYALDALRAV
PDLILYGPAQRKGVIAFNLGQHHAYDVGSFLDNYGIAVRTGHHCAMPLMARYQVPAMCRASLAMYNTTEEVDRLVAGLQR
IRKLLG
>Mature_405_residues
TFSVEQVRADFPVLNREVNGQPLVYLDSAASAQKPEAVIGAEAEFYRHGYAAVHRGIHTLSAEATARMEAVRQQAATFLN
AGSAEEVVFVRGTTEGINLVANSWGNANVGAGDNIIISEMEHHANIVPWQMLCARVGAELRVIPLNPDGTLQLDVVPGLF
DPRTRLLAITEVSNVLGTENPLAALIALAHQHGAKVLVDGAQAVMHHPVDVQALGCDFYVFSAHKLYGPTGIGVLYARSE
LLQTMAPWEGGGSMIATVSLTEGTTWNQAPWRFEAGTPNTGGIIGLGAALTYVSQLGLTQIAEYEQTLMRYALDALRAVP
DLILYGPAQRKGVIAFNLGQHHAYDVGSFLDNYGIAVRTGHHCAMPLMARYQVPAMCRASLAMYNTTEEVDRLVAGLQRI
RKLLG

Specific function: Cysteine desulfurases mobilize the sulfur from L- cysteine to yield L-alanine, an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Component of the suf operon, which is activated and required under speci

COG id: COG0520

COG function: function code E; Selenocysteine lyase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. Csd subfamily [H]

Homologues:

Organism=Homo sapiens, GI32307132, Length=399, Percent_Identity=23.5588972431078, Blast_Score=106, Evalue=4e-23,
Organism=Homo sapiens, GI156713448, Length=258, Percent_Identity=28.6821705426357, Blast_Score=69, Evalue=8e-12,
Organism=Escherichia coli, GI1787970, Length=406, Percent_Identity=83.743842364532, Blast_Score=710, Evalue=0.0,
Organism=Escherichia coli, GI1789175, Length=403, Percent_Identity=45.6575682382134, Blast_Score=343, Evalue=2e-95,
Organism=Escherichia coli, GI48994898, Length=360, Percent_Identity=25.2777777777778, Blast_Score=93, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI25143064, Length=233, Percent_Identity=27.0386266094421, Blast_Score=92, Evalue=6e-19,
Organism=Caenorhabditis elegans, GI193211090, Length=380, Percent_Identity=24.2105263157895, Blast_Score=91, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6319831, Length=229, Percent_Identity=26.2008733624454, Blast_Score=92, Evalue=2e-19,
Organism=Drosophila melanogaster, GI20129463, Length=422, Percent_Identity=25.1184834123223, Blast_Score=108, Evalue=5e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000192
- InterPro:   IPR020578
- InterPro:   IPR010970
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00266 Aminotran_5 [H]

EC number: =2.8.1.7; =4.4.1.16 [H]

Molecular weight: Translated: 43751; Mature: 43619

Theoretical pI: Translated: 6.14; Mature: 6.14

Prosite motif: PS00595 AA_TRANSFER_CLASS_5

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTFSVEQVRADFPVLNREVNGQPLVYLDSAASAQKPEAVIGAEAEFYRHGYAAVHRGIHT
CCCCHHHHHCCCCHHCCCCCCCCEEEEECCCCCCCCCEEECCCHHHHHHHHHHHHHCHHH
LSAEATARMEAVRQQAATFLNAGSAEEVVFVRGTTEGINLVANSWGNANVGAGDNIIISE
HHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCEEECCCCCCCCCCCCCEEEEE
MEHHANIVPWQMLCARVGAELRVIPLNPDGTLQLDVVPGLFDPRTRLLAITEVSNVLGTE
HHHCCCCCCHHHHHHHCCCCEEEEEECCCCEEEEEEECCCCCCCHHEEEEEHHHHHHCCC
NPLAALIALAHQHGAKVLVDGAQAVMHHPVDVQALGCDFYVFSAHKLYGPTGIGVLYARS
CHHHHHHHHHHHCCCEEEEECHHHHHCCCCCEEEECCEEEEEECCEECCCCCCHHHHHHH
ELLQTMAPWEGGGSMIATVSLTEGTTWNQAPWRFEAGTPNTGGIIGLGAALTYVSQLGLT
HHHHHHCCCCCCCCEEEEEEEECCCCCCCCCEEEECCCCCCCCEEEHHHHHHHHHHHHHH
QIAEYEQTLMRYALDALRAVPDLILYGPAQRKGVIAFNLGQHHAYDVGSFLDNYGIAVRT
HHHHHHHHHHHHHHHHHHHCCHHEEECCCCCCCEEEEECCCCCHHHHHHHHHCCCEEEEC
GHHCAMPLMARYQVPAMCRASLAMYNTTEEVDRLVAGLQRIRKLLG
CCCHHCHHHHHCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHC
>Mature Secondary Structure 
TFSVEQVRADFPVLNREVNGQPLVYLDSAASAQKPEAVIGAEAEFYRHGYAAVHRGIHT
CCCHHHHHCCCCHHCCCCCCCCEEEEECCCCCCCCCEEECCCHHHHHHHHHHHHHCHHH
LSAEATARMEAVRQQAATFLNAGSAEEVVFVRGTTEGINLVANSWGNANVGAGDNIIISE
HHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCEEECCCCCCCCCCCCCEEEEE
MEHHANIVPWQMLCARVGAELRVIPLNPDGTLQLDVVPGLFDPRTRLLAITEVSNVLGTE
HHHCCCCCCHHHHHHHCCCCEEEEEECCCCEEEEEEECCCCCCCHHEEEEEHHHHHHCCC
NPLAALIALAHQHGAKVLVDGAQAVMHHPVDVQALGCDFYVFSAHKLYGPTGIGVLYARS
CHHHHHHHHHHHCCCEEEEECHHHHHCCCCCEEEECCEEEEEECCEECCCCCCHHHHHHH
ELLQTMAPWEGGGSMIATVSLTEGTTWNQAPWRFEAGTPNTGGIIGLGAALTYVSQLGLT
HHHHHHCCCCCCCCEEEEEEEECCCCCCCCCEEEECCCCCCCCEEEHHHHHHHHHHHHHH
QIAEYEQTLMRYALDALRAVPDLILYGPAQRKGVIAFNLGQHHAYDVGSFLDNYGIAVRT
HHHHHHHHHHHHHHHHHHHCCHHEEECCCCCCCEEEEECCCCCHHHHHHHHHCCCEEEEC
GHHCAMPLMARYQVPAMCRASLAMYNTTEEVDRLVAGLQRIRKLLG
CCCHHCHHHHHCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA