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The map label for this gene is fdhF [H]

Identifier: 238895138

GI number: 238895138

Start: 3017444

End: 3019594

Strand: Direct

Name: fdhF [H]

Synonym: KP1_3178

Alternate gene names: 238895138

Gene position: 3017444-3019594 (Clockwise)

Preceding gene: 238895137

Following gene: 238895140

Centisome position: 57.49

GC content: 62.76

Gene sequence:

>2151_bases
ATGAAAAAAATCACGAGCGTGTGCCCCTACTGCGGGGCGGGTTGCAAACTTAAACTGGTTGTCGACAACAATAAAATCAT
TCGCGCGGAGGCCGCCGACGGCGTCACCAACCAGAACCAGCTGTGCCTGAAAGGCTACTACGGCTGGGATTTTCTTAACG
ATACGCAGCTCCTGACGCCCCGTCTTAAACAACCGATGATCCGCTACCAGAAAGGCGGCGCCTTCACGCCGGTCAGCTGG
CAGGAGGCGATTCGCTATACCGCCAGCAAGCTCAGGGAGATCAAAGAGAAGCATGGCCCGCGCGCCATCATGACCACCGG
CTCCTCGCGCGGCACCGGCAACGAAACCAACTATGTGATGCAAAAGTTCGCCCGCGCGGTGCTGAACACCAATAACGTCG
ACTGCTGCGCCCGCGTCTGCCACGGCCCCTCCGTCGCCGGGCTACAGCAGGCGCTGGGCAACGGGGCGATGAGCAACTCG
ATTAGCGACATCGAAAACTCGAAGTGCCTGCTGATTTTTGGCTACAACTGCGCCGACTCCCATCCCATCGTCGCCCGCCG
GGTAATCAAGGCCCGGGACAACGGCGCCAAAATCATCGTCTGCGATCCGCGGCGCATTGAAACCGCGCGCATTGCCGATC
GTCATCTGCAGCTCAACAACGGCAGCAACATGGCGCTGGTAAATGCCTTCGGCTATGTGCTGCTGGAGGAGGAGCTGTAC
AACAAAACCTATGTCGAACGCTATACCGAAGGGCTGGATGCTTACCGCGAGGCGGTGAAGGATTACGCCCCGGAAGCGGT
GGAAGGGATTGTCGGGGTCAGCGCGCGGGAAATCCGGGAGGCGATGCGCATGTTCGCCGCCGCCCCATCCGCCACCATTA
TGTGGGGCATGGGGGTCACCCAGTTTGGCCAGGCGGTGGACGTGGTGCGCGGCCTGGCAAGCCTGGCGCTGCTCACCGGC
AACCTGGGACGGCCCAACGTCGGCGTGGGGCCGGTCCGCGGGCAAAACAACGTACAGGGCGCCTGCGATATGGGCGTGCT
GCCGAACCTGTTCCCCGGCTATCAGGAGGTCACCGACCCCGCCGTGCGGGCGAAATTCGCCGCCGCCTGGGGCATCGACC
CGGCGCTGATGGACGACCAGGTCGGCACCCGCATCACCGAGGTGCCGCATAAAGCGCTGACCGGCGAGATCAAAGCCTAT
TACATCATGGGCGAAGATCCGCTGCAGACCGAAGCCGACCTCGGCCTGGTGCGCAAAGGCATCGAGGCGCTGGACTTTGT
CATCGTGCAGGACATCTTCATGACCAAAACAGCGGAAATGGCCGATGTCCTGCTGCCGGCCACCTCCTGGGGCGAGCACG
GCGGCGTCTTCACCTGCGCCGACCGCGGGTTCCAGCGGTTTGAACAGGCGATCCCTCCGGCGGGGAATGTGAAGCGCGAC
TGGGAGATCATTAGCCTGCTGGCCAGCGAATTGGGCTATCCGATGCACTATGAGAACAACCAGCAGATCTGGGACGAGAT
GCGCGAGCTCTGCCCGCTGTTCTACGGCGTGACCTGGGAGAAAATGGGCGATATGGGCCATGTCCAGTGGCCGTGCCCGA
CCCTCGATCATCCCGGCACGCCGTGGCTGTATAAAGACAACCGCTTCGACACCCCCTCGGGTAAAGGGCAGCTGTTCGCC
ACCGCCTGGCGCGCGCCGGCGGAGCGCCCGGATGACGAGTGGCCGCTGGTGCTCTGCACCGTGCGGGAAGTCGGGCATTA
TTCCTGCCGCTCGATGACCGGCAACTGCGCCGCGCTGCAGTCGCTGGCCGACGAGCCGGGACGGGTGCAGATGAATCCCG
CGGATGCGCAACGACTGGGGATCGCCGACAAACAGCTGGTGTGGGTCAGCTCCCGGCGCGGGAAGGTGATCTCCCGCGCC
GACCTCAGCGATCGCATCAATCCGGGGGCGGTCTATATGACCTATCAGTGGTGGGTGGGCGCCTGCAATGAGCTGACCCA
GGATAACCTCGATCCGATCTCCAAAACGCCGGAAACCAAATACTGTGCGGTGAAAGTGGAAGCGATTGCCGACCAGCAAT
GGGCGGAGCGCTATGCCTGGACGGCCTACAGCGACATGAAAGCGCGACTGAAAGCCGCTGCCGACGTCTGA

Upstream 100 bases:

>100_bases
AGGCCTGCGTCTGCATCACCACCAGGCGATACCGCGATCGTTGCCCGTCGGGCCCGGCGCGACAGCGATCCTCAGTTCAC
TGTTAACAGGTCTGTTACTG

Downstream 100 bases:

>100_bases
CCTCAGGGAGCGCAGCGCGCTCCCTCTGCCGCTGCCGGTGGGTTACGCCGCCGGCAGCTGTTTCTCCACCAGCCCCACCC
ACATGGCGACGCCGGGGCCG

Product: formate dehydrogenase H selenopolypeptide subunit

Products: NA

Alternate protein names: Formate dehydrogenase-H subunit alpha; FDH-H; Formate-hydrogen-lyase-linked, selenocysteine-containing polypeptide [H]

Number of amino acids: Translated: 716; Mature: 716

Protein sequence:

>716_residues
MKKITSVCPYCGAGCKLKLVVDNNKIIRAEAADGVTNQNQLCLKGYYGWDFLNDTQLLTPRLKQPMIRYQKGGAFTPVSW
QEAIRYTASKLREIKEKHGPRAIMTTGSSRGTGNETNYVMQKFARAVLNTNNVDCCARVCHGPSVAGLQQALGNGAMSNS
ISDIENSKCLLIFGYNCADSHPIVARRVIKARDNGAKIIVCDPRRIETARIADRHLQLNNGSNMALVNAFGYVLLEEELY
NKTYVERYTEGLDAYREAVKDYAPEAVEGIVGVSAREIREAMRMFAAAPSATIMWGMGVTQFGQAVDVVRGLASLALLTG
NLGRPNVGVGPVRGQNNVQGACDMGVLPNLFPGYQEVTDPAVRAKFAAAWGIDPALMDDQVGTRITEVPHKALTGEIKAY
YIMGEDPLQTEADLGLVRKGIEALDFVIVQDIFMTKTAEMADVLLPATSWGEHGGVFTCADRGFQRFEQAIPPAGNVKRD
WEIISLLASELGYPMHYENNQQIWDEMRELCPLFYGVTWEKMGDMGHVQWPCPTLDHPGTPWLYKDNRFDTPSGKGQLFA
TAWRAPAERPDDEWPLVLCTVREVGHYSCRSMTGNCAALQSLADEPGRVQMNPADAQRLGIADKQLVWVSSRRGKVISRA
DLSDRINPGAVYMTYQWWVGACNELTQDNLDPISKTPETKYCAVKVEAIADQQWAERYAWTAYSDMKARLKAAADV

Sequences:

>Translated_716_residues
MKKITSVCPYCGAGCKLKLVVDNNKIIRAEAADGVTNQNQLCLKGYYGWDFLNDTQLLTPRLKQPMIRYQKGGAFTPVSW
QEAIRYTASKLREIKEKHGPRAIMTTGSSRGTGNETNYVMQKFARAVLNTNNVDCCARVCHGPSVAGLQQALGNGAMSNS
ISDIENSKCLLIFGYNCADSHPIVARRVIKARDNGAKIIVCDPRRIETARIADRHLQLNNGSNMALVNAFGYVLLEEELY
NKTYVERYTEGLDAYREAVKDYAPEAVEGIVGVSAREIREAMRMFAAAPSATIMWGMGVTQFGQAVDVVRGLASLALLTG
NLGRPNVGVGPVRGQNNVQGACDMGVLPNLFPGYQEVTDPAVRAKFAAAWGIDPALMDDQVGTRITEVPHKALTGEIKAY
YIMGEDPLQTEADLGLVRKGIEALDFVIVQDIFMTKTAEMADVLLPATSWGEHGGVFTCADRGFQRFEQAIPPAGNVKRD
WEIISLLASELGYPMHYENNQQIWDEMRELCPLFYGVTWEKMGDMGHVQWPCPTLDHPGTPWLYKDNRFDTPSGKGQLFA
TAWRAPAERPDDEWPLVLCTVREVGHYSCRSMTGNCAALQSLADEPGRVQMNPADAQRLGIADKQLVWVSSRRGKVISRA
DLSDRINPGAVYMTYQWWVGACNELTQDNLDPISKTPETKYCAVKVEAIADQQWAERYAWTAYSDMKARLKAAADV
>Mature_716_residues
MKKITSVCPYCGAGCKLKLVVDNNKIIRAEAADGVTNQNQLCLKGYYGWDFLNDTQLLTPRLKQPMIRYQKGGAFTPVSW
QEAIRYTASKLREIKEKHGPRAIMTTGSSRGTGNETNYVMQKFARAVLNTNNVDCCARVCHGPSVAGLQQALGNGAMSNS
ISDIENSKCLLIFGYNCADSHPIVARRVIKARDNGAKIIVCDPRRIETARIADRHLQLNNGSNMALVNAFGYVLLEEELY
NKTYVERYTEGLDAYREAVKDYAPEAVEGIVGVSAREIREAMRMFAAAPSATIMWGMGVTQFGQAVDVVRGLASLALLTG
NLGRPNVGVGPVRGQNNVQGACDMGVLPNLFPGYQEVTDPAVRAKFAAAWGIDPALMDDQVGTRITEVPHKALTGEIKAY
YIMGEDPLQTEADLGLVRKGIEALDFVIVQDIFMTKTAEMADVLLPATSWGEHGGVFTCADRGFQRFEQAIPPAGNVKRD
WEIISLLASELGYPMHYENNQQIWDEMRELCPLFYGVTWEKMGDMGHVQWPCPTLDHPGTPWLYKDNRFDTPSGKGQLFA
TAWRAPAERPDDEWPLVLCTVREVGHYSCRSMTGNCAALQSLADEPGRVQMNPADAQRLGIADKQLVWVSSRRGKVISRA
DLSDRINPGAVYMTYQWWVGACNELTQDNLDPISKTPETKYCAVKVEAIADQQWAERYAWTAYSDMKARLKAAADV

Specific function: Decomposes formic acid to hydrogen and carbon dioxide under anaerobic conditions in the absence of exogenous electron acceptors [H]

COG id: COG0243

COG function: function code C; Anaerobic dehydrogenases, typically selenocysteine-containing

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the prokaryotic molybdopterin-containing oxidoreductase family [H]

Homologues:

Organism=Escherichia coli, GI3868721, Length=716, Percent_Identity=66.2011173184357, Blast_Score=1014, Evalue=0.0,
Organism=Escherichia coli, GI1788534, Length=790, Percent_Identity=24.9367088607595, Blast_Score=215, Evalue=1e-56,
Organism=Escherichia coli, GI3868720, Length=432, Percent_Identity=28.4722222222222, Blast_Score=168, Evalue=1e-42,
Organism=Escherichia coli, GI3868719, Length=622, Percent_Identity=24.5980707395498, Blast_Score=164, Evalue=2e-41,
Organism=Escherichia coli, GI87081797, Length=796, Percent_Identity=24.4974874371859, Blast_Score=135, Evalue=9e-33,
Organism=Escherichia coli, GI171474008, Length=794, Percent_Identity=25.5667506297229, Blast_Score=127, Evalue=3e-30,
Organism=Escherichia coli, GI1787778, Length=682, Percent_Identity=23.0205278592375, Blast_Score=125, Evalue=1e-29,
Organism=Escherichia coli, GI1787870, Length=789, Percent_Identity=23.9543726235741, Blast_Score=125, Evalue=1e-29,
Organism=Escherichia coli, GI87081994, Length=701, Percent_Identity=22.9671897289586, Blast_Score=102, Evalue=1e-22,
Organism=Escherichia coli, GI1787231, Length=687, Percent_Identity=22.9985443959243, Blast_Score=100, Evalue=4e-22,
Organism=Escherichia coli, GI145693196, Length=681, Percent_Identity=21.43906020558, Blast_Score=96, Evalue=8e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009010
- InterPro:   IPR006478
- InterPro:   IPR006657
- InterPro:   IPR006656
- InterPro:   IPR006963
- InterPro:   IPR006655 [H]

Pfam domain/function: PF04879 Molybdop_Fe4S4; PF00384 Molybdopterin; PF01568 Molydop_binding [H]

EC number: =1.2.1.2 [H]

Molecular weight: Translated: 79227; Mature: 79227

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: PS00490 MOLYBDOPTERIN_PROK_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.7 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
5.9 %Cys+Met (Translated Protein)
2.7 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
5.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKITSVCPYCGAGCKLKLVVDNNKIIRAEAADGVTNQNQLCLKGYYGWDFLNDTQLLTP
CCCHHHHCCCCCCCCEEEEEECCCEEEEEECCCCCCCCCCEEEEEECCCCCCCCCHHHCH
RLKQPMIRYQKGGAFTPVSWQEAIRYTASKLREIKEKHGPRAIMTTGSSRGTGNETNYVM
HHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCHHHHHH
QKFARAVLNTNNVDCCARVCHGPSVAGLQQALGNGAMSNSISDIENSKCLLIFGYNCADS
HHHHHHHHCCCCHHHHHHHHCCCCHHHHHHHHCCCHHCCCHHHCCCCCEEEEEECCCCCC
HPIVARRVIKARDNGAKIIVCDPRRIETARIADRHLQLNNGSNMALVNAFGYVLLEEELY
CCHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHEEEECCCCCEEEEEHHHHHEEHHHHH
NKTYVERYTEGLDAYREAVKDYAPEAVEGIVGVSAREIREAMRMFAAAPSATIMWGMGVT
HHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCHHHHHHHHHHHHCCCCCEEEECCCHH
QFGQAVDVVRGLASLALLTGNLGRPNVGVGPVRGQNNVQGACDMGVLPNLFPGYQEVTDP
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHCCH
AVRAKFAAAWGIDPALMDDQVGTRITEVPHKALTGEIKAYYIMGEDPLQTEADLGLVRKG
HHHHHHHHHCCCCHHHCCCHHCCHHHHCCHHHHCCCEEEEEEECCCCCCCHHHHHHHHHH
IEALDFVIVQDIFMTKTAEMADVLLPATSWGEHGGVFTCADRGFQRFEQAIPPAGNVKRD
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEHHHHHHHHHHHCCCCCCCCHH
WEIISLLASELGYPMHYENNQQIWDEMRELCPLFYGVTWEKMGDMGHVQWPCPTLDHPGT
HHHHHHHHHHCCCCEEECCCHHHHHHHHHHHHHHHCCCHHHHCCCCCCCCCCCCCCCCCC
PWLYKDNRFDTPSGKGQLFATAWRAPAERPDDEWPLVLCTVREVGHYSCRSMTGNCAALQ
CCEEECCCCCCCCCCCCEEEEECCCCCCCCCCCCCEEEEEEHHHCCHHHHCCCCCHHHHH
SLADEPGRVQMNPADAQRLGIADKQLVWVSSRRGKVISRADLSDRINPGAVYMTYQWWVG
HHCCCCCEEEECCCCHHHHCCCCCEEEEEECCCCCEEEECCCCCCCCCCEEEEEEEHHHH
ACNELTQDNLDPISKTPETKYCAVKVEAIADQQWAERYAWTAYSDMKARLKAAADV
HHHHHHCCCCCCCCCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKKITSVCPYCGAGCKLKLVVDNNKIIRAEAADGVTNQNQLCLKGYYGWDFLNDTQLLTP
CCCHHHHCCCCCCCCEEEEEECCCEEEEEECCCCCCCCCCEEEEEECCCCCCCCCHHHCH
RLKQPMIRYQKGGAFTPVSWQEAIRYTASKLREIKEKHGPRAIMTTGSSRGTGNETNYVM
HHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCHHHHHH
QKFARAVLNTNNVDCCARVCHGPSVAGLQQALGNGAMSNSISDIENSKCLLIFGYNCADS
HHHHHHHHCCCCHHHHHHHHCCCCHHHHHHHHCCCHHCCCHHHCCCCCEEEEEECCCCCC
HPIVARRVIKARDNGAKIIVCDPRRIETARIADRHLQLNNGSNMALVNAFGYVLLEEELY
CCHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHEEEECCCCCEEEEEHHHHHEEHHHHH
NKTYVERYTEGLDAYREAVKDYAPEAVEGIVGVSAREIREAMRMFAAAPSATIMWGMGVT
HHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCHHHHHHHHHHHHCCCCCEEEECCCHH
QFGQAVDVVRGLASLALLTGNLGRPNVGVGPVRGQNNVQGACDMGVLPNLFPGYQEVTDP
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHCCH
AVRAKFAAAWGIDPALMDDQVGTRITEVPHKALTGEIKAYYIMGEDPLQTEADLGLVRKG
HHHHHHHHHCCCCHHHCCCHHCCHHHHCCHHHHCCCEEEEEEECCCCCCCHHHHHHHHHH
IEALDFVIVQDIFMTKTAEMADVLLPATSWGEHGGVFTCADRGFQRFEQAIPPAGNVKRD
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEHHHHHHHHHHHCCCCCCCCHH
WEIISLLASELGYPMHYENNQQIWDEMRELCPLFYGVTWEKMGDMGHVQWPCPTLDHPGT
HHHHHHHHHHCCCCEEECCCHHHHHHHHHHHHHHHCCCHHHHCCCCCCCCCCCCCCCCCC
PWLYKDNRFDTPSGKGQLFATAWRAPAERPDDEWPLVLCTVREVGHYSCRSMTGNCAALQ
CCEEECCCCCCCCCCCCEEEEECCCCCCCCCCCCCEEEEEEHHHCCHHHHCCCCCHHHHH
SLADEPGRVQMNPADAQRLGIADKQLVWVSSRRGKVISRADLSDRINPGAVYMTYQWWVG
HHCCCCCEEEECCCCHHHHCCCCCEEEEEECCCCCEEEECCCCCCCCCCEEEEEEEHHHH
ACNELTQDNLDPISKTPETKYCAVKVEAIADQQWAERYAWTAYSDMKARLKAAADV
HHHHHHCCCCCCCCCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2941757; 8265357; 9278503; 2211698; 9036855 [H]