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The map label for this gene is frmA [H]

Identifier: 238894993

GI number: 238894993

Start: 2883427

End: 2884545

Strand: Reverse

Name: frmA [H]

Synonym: KP1_3020

Alternate gene names: 238894993

Gene position: 2884545-2883427 (Counterclockwise)

Preceding gene: 238894994

Following gene: 238894988

Centisome position: 54.96

GC content: 58.89

Gene sequence:

>1119_bases
ATGAAATCACGCGCAGCAGTGGCCTTCGGCCCCGGTCAGCCGTTAAAAATCGTTGAGATTGACGTCGCGCCGCCGAAAAA
AGGCGAAGTTCTGGTGAAAATCACCCACACCGGGGTGTGTCATACCGATGCCTTCACCCTCTCCGGTGACGATCCGGAAG
GTGTCTTCCCGGCGGTGCTGGGCCATGAGGGCGGCGGGATTGTCGTGGAAGTAGGCGAGGGCGTCACCAGCCTTAAGCCG
GGCGATCACGTCATTCCGCTGTATACCGCCGAATGTGGCGAGTGCAAATTCTGTAAGTCGGGTAAAACCAACCTCTGTCA
GGCGGTGCGTGCCACCCAGGGTAAAGGGCTGATGCCGGACGGCACCACTCGTTTCTCGTACAATGGCGAACCGATCTATC
ACTATATGGGCACCAGCACCTTCAGCGAATATACGGTTTGCGCCGAGATTTCGCTGGCGAAAGTCAATCCGCAGGCGCCT
TTGGATAAAGTGTGCCTGCTGGGCTGCGGCGTAACCACCGGTATCGGCGCGGTGCATAACACGGCGAAGGTCAAGGCCGG
GGATAGCGTCGCGGTCTTTGGTCTGGGCGGCATTGGTCTGGCGGTGATCCAGGGCGCGGTGCAGGCGCAGGCCGGGCGCA
TTCTGGCGGTTGATACCAACCCGGATAAATTCACTCTCGCTAAAGAGATGGGCGCGACCGATTTTATCAATCCGAACGAC
TACGATAAGCCGATTCAGGATGTGATTGTTGAGCTGACCGACGGCGGGGTGGATTTCAGCTTCGAGTGCATCGGCAATGT
AAATGTGATGCGCGCGGCGCTGGAGTGCTGCCATAAAGGCTGGGGTGAGAGCGTGATCATCGGTGTAGCCGGCGCCGGGC
AGGAGATCAAGACCCGTCCGTTCCAGCTGGTGACCGGCCGCGTGTGGCGCGGTTCCGCCTTCGGCGGCGTAAAAGGGCGC
AGTCAGCTGCCGGGCATGGTGGAAGACGCCATGGCGGGTAAAATTCGCCTCGATCCGTTTATTACCCATCGCCTGCCGCT
GGAGCAGATTAACGAGGCCTTTGATCTGATGCATGAAGGTAAATCGATTCGCACCGTGATCCACTTTGGCGACCAGTAA

Upstream 100 bases:

>100_bases
CGGCGACACCACCCCTGAGCAGCGGGCCGCGAGAATGGCAGAGGTCGGTCATCTGCTACGATCCTATTTAAAATAACATC
ACGACGAGGAAGAGACAGTT

Downstream 100 bases:

>100_bases
TCCCCGACGCTGAAGGCGAATCGTCACCCATAAAAAAAGGGCCCGGATGGGCCCTTTTGTTTATGTCGATCAGTGATGGT
CTGGGAGCGCGTAGGCGATG

Product: alcohol dehydrogenase class III

Products: NA

Alternate protein names: Alcohol dehydrogenase class-3; Alcohol dehydrogenase class-III; Glutathione-dependent formaldehyde dehydrogenase; FALDH; FDH; GSH-FDH [H]

Number of amino acids: Translated: 372; Mature: 372

Protein sequence:

>372_residues
MKSRAAVAFGPGQPLKIVEIDVAPPKKGEVLVKITHTGVCHTDAFTLSGDDPEGVFPAVLGHEGGGIVVEVGEGVTSLKP
GDHVIPLYTAECGECKFCKSGKTNLCQAVRATQGKGLMPDGTTRFSYNGEPIYHYMGTSTFSEYTVCAEISLAKVNPQAP
LDKVCLLGCGVTTGIGAVHNTAKVKAGDSVAVFGLGGIGLAVIQGAVQAQAGRILAVDTNPDKFTLAKEMGATDFINPND
YDKPIQDVIVELTDGGVDFSFECIGNVNVMRAALECCHKGWGESVIIGVAGAGQEIKTRPFQLVTGRVWRGSAFGGVKGR
SQLPGMVEDAMAGKIRLDPFITHRLPLEQINEAFDLMHEGKSIRTVIHFGDQ

Sequences:

>Translated_372_residues
MKSRAAVAFGPGQPLKIVEIDVAPPKKGEVLVKITHTGVCHTDAFTLSGDDPEGVFPAVLGHEGGGIVVEVGEGVTSLKP
GDHVIPLYTAECGECKFCKSGKTNLCQAVRATQGKGLMPDGTTRFSYNGEPIYHYMGTSTFSEYTVCAEISLAKVNPQAP
LDKVCLLGCGVTTGIGAVHNTAKVKAGDSVAVFGLGGIGLAVIQGAVQAQAGRILAVDTNPDKFTLAKEMGATDFINPND
YDKPIQDVIVELTDGGVDFSFECIGNVNVMRAALECCHKGWGESVIIGVAGAGQEIKTRPFQLVTGRVWRGSAFGGVKGR
SQLPGMVEDAMAGKIRLDPFITHRLPLEQINEAFDLMHEGKSIRTVIHFGDQ
>Mature_372_residues
MKSRAAVAFGPGQPLKIVEIDVAPPKKGEVLVKITHTGVCHTDAFTLSGDDPEGVFPAVLGHEGGGIVVEVGEGVTSLKP
GDHVIPLYTAECGECKFCKSGKTNLCQAVRATQGKGLMPDGTTRFSYNGEPIYHYMGTSTFSEYTVCAEISLAKVNPQAP
LDKVCLLGCGVTTGIGAVHNTAKVKAGDSVAVFGLGGIGLAVIQGAVQAQAGRILAVDTNPDKFTLAKEMGATDFINPND
YDKPIQDVIVELTDGGVDFSFECIGNVNVMRAALECCHKGWGESVIIGVAGAGQEIKTRPFQLVTGRVWRGSAFGGVKGR
SQLPGMVEDAMAGKIRLDPFITHRLPLEQINEAFDLMHEGKSIRTVIHFGDQ

Specific function: Has High Formaldehyde Dehydrogenase Activity In The Presence Of Glutathione And Catalyzes The Oxidation Of Normal Alcohols In A Reaction That Is Not Gsh-Dependent. In Addition, Hemithiolacetals Other Than Those Formed From Gsh, Including Omega-Thiol Fatty

COG id: COG1062

COG function: function code C; Zn-dependent alcohol dehydrogenases, class III

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily [H]

Homologues:

Organism=Homo sapiens, GI71565154, Length=369, Percent_Identity=66.1246612466125, Blast_Score=496, Evalue=1e-140,
Organism=Homo sapiens, GI34577061, Length=371, Percent_Identity=52.2911051212938, Blast_Score=403, Evalue=1e-112,
Organism=Homo sapiens, GI4501933, Length=371, Percent_Identity=51.2129380053908, Blast_Score=392, Evalue=1e-109,
Organism=Homo sapiens, GI4501929, Length=369, Percent_Identity=51.219512195122, Blast_Score=390, Evalue=1e-108,
Organism=Homo sapiens, GI71565152, Length=373, Percent_Identity=48.7935656836461, Blast_Score=374, Evalue=1e-104,
Organism=Homo sapiens, GI156523966, Length=367, Percent_Identity=48.2288828337875, Blast_Score=369, Evalue=1e-102,
Organism=Homo sapiens, GI4501939, Length=361, Percent_Identity=48.4764542936288, Blast_Score=363, Evalue=1e-100,
Organism=Homo sapiens, GI71743840, Length=369, Percent_Identity=47.9674796747967, Blast_Score=355, Evalue=3e-98,
Organism=Homo sapiens, GI262073058, Length=369, Percent_Identity=47.9674796747967, Blast_Score=355, Evalue=4e-98,
Organism=Homo sapiens, GI156627571, Length=372, Percent_Identity=26.0752688172043, Blast_Score=85, Evalue=1e-16,
Organism=Escherichia coli, GI1786552, Length=369, Percent_Identity=81.3008130081301, Blast_Score=608, Evalue=1e-175,
Organism=Escherichia coli, GI87082125, Length=384, Percent_Identity=26.0416666666667, Blast_Score=112, Evalue=4e-26,
Organism=Escherichia coli, GI87081918, Length=348, Percent_Identity=32.183908045977, Blast_Score=102, Evalue=5e-23,
Organism=Escherichia coli, GI1788073, Length=381, Percent_Identity=26.509186351706, Blast_Score=98, Evalue=8e-22,
Organism=Escherichia coli, GI1790045, Length=358, Percent_Identity=26.8156424581006, Blast_Score=97, Evalue=1e-21,
Organism=Escherichia coli, GI1787863, Length=356, Percent_Identity=25.561797752809, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI1786825, Length=247, Percent_Identity=30.3643724696356, Blast_Score=91, Evalue=2e-19,
Organism=Escherichia coli, GI226510992, Length=372, Percent_Identity=25.8064516129032, Blast_Score=80, Evalue=3e-16,
Organism=Escherichia coli, GI1790718, Length=328, Percent_Identity=25.9146341463415, Blast_Score=77, Evalue=3e-15,
Organism=Escherichia coli, GI1788407, Length=230, Percent_Identity=28.2608695652174, Blast_Score=76, Evalue=4e-15,
Organism=Escherichia coli, GI1786518, Length=371, Percent_Identity=27.4932614555256, Blast_Score=75, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI25146526, Length=373, Percent_Identity=59.5174262734584, Blast_Score=459, Evalue=1e-130,
Organism=Caenorhabditis elegans, GI71997431, Length=375, Percent_Identity=59.2, Blast_Score=454, Evalue=1e-128,
Organism=Caenorhabditis elegans, GI17565904, Length=343, Percent_Identity=59.1836734693878, Blast_Score=424, Evalue=1e-119,
Organism=Caenorhabditis elegans, GI17562584, Length=364, Percent_Identity=28.021978021978, Blast_Score=92, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI71988145, Length=371, Percent_Identity=27.2237196765499, Blast_Score=86, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI17562582, Length=373, Percent_Identity=27.3458445040214, Blast_Score=84, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6320033, Length=371, Percent_Identity=60.9164420485175, Blast_Score=479, Evalue=1e-136,
Organism=Saccharomyces cerevisiae, GI6323729, Length=355, Percent_Identity=29.2957746478873, Blast_Score=103, Evalue=4e-23,
Organism=Saccharomyces cerevisiae, GI6319621, Length=277, Percent_Identity=30.6859205776173, Blast_Score=100, Evalue=4e-22,
Organism=Saccharomyces cerevisiae, GI6323961, Length=275, Percent_Identity=30.1818181818182, Blast_Score=96, Evalue=1e-20,
Organism=Saccharomyces cerevisiae, GI6324486, Length=285, Percent_Identity=30.5263157894737, Blast_Score=94, Evalue=5e-20,
Organism=Saccharomyces cerevisiae, GI6323099, Length=377, Percent_Identity=28.6472148541114, Blast_Score=92, Evalue=9e-20,
Organism=Saccharomyces cerevisiae, GI6319257, Length=307, Percent_Identity=27.6872964169381, Blast_Score=70, Evalue=7e-13,
Organism=Drosophila melanogaster, GI17737895, Length=368, Percent_Identity=65.4891304347826, Blast_Score=504, Evalue=1e-143,
Organism=Drosophila melanogaster, GI17137530, Length=347, Percent_Identity=26.5129682997118, Blast_Score=85, Evalue=9e-17,
Organism=Drosophila melanogaster, GI17737897, Length=351, Percent_Identity=25.0712250712251, Blast_Score=74, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014183
- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.284; =1.1.1.1 [H]

Molecular weight: Translated: 39270; Mature: 39270

Theoretical pI: Translated: 6.18; Mature: 6.18

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
3.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKSRAAVAFGPGQPLKIVEIDVAPPKKGEVLVKITHTGVCHTDAFTLSGDDPEGVFPAVL
CCCCEEEEECCCCCEEEEEEECCCCCCCCEEEEEECCCEEECCEEEECCCCCCCCCCCEE
GHEGGGIVVEVGEGVTSLKPGDHVIPLYTAECGECKFCKSGKTNLCQAVRATQGKGLMPD
CCCCCEEEEECCCCCCCCCCCCEEEEEEECCCCCEEECCCCCHHHHHHHHHCCCCCCCCC
GTTRFSYNGEPIYHYMGTSTFSEYTVCAEISLAKVNPQAPLDKVCLLGCGVTTGIGAVHN
CCEEEECCCCEEEEEECCCCCCCEEEEEEEEEEECCCCCCHHHHHEEECCHHHCCCHHCC
TAKVKAGDSVAVFGLGGIGLAVIQGAVQAQAGRILAVDTNPDKFTLAKEMGATDFINPND
CEEEECCCCEEEEEECCHHHHHHHHHHHHCCCEEEEEECCCCCEEEHHHCCCCCCCCCCC
YDKPIQDVIVELTDGGVDFSFECIGNVNVMRAALECCHKGWGESVIIGVAGAGQEIKTRP
CCCCHHHHHEEEECCCCCEEEEEECCHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCC
FQLVTGRVWRGSAFGGVKGRSQLPGMVEDAMAGKIRLDPFITHRLPLEQINEAFDLMHEG
EEEEECEEEECCCCCCCCCCCCCCCHHHHHCCCEEEECHHEECCCCHHHHHHHHHHHHCC
KSIRTVIHFGDQ
CEEEEEEEECCC
>Mature Secondary Structure
MKSRAAVAFGPGQPLKIVEIDVAPPKKGEVLVKITHTGVCHTDAFTLSGDDPEGVFPAVL
CCCCEEEEECCCCCEEEEEEECCCCCCCCEEEEEECCCEEECCEEEECCCCCCCCCCCEE
GHEGGGIVVEVGEGVTSLKPGDHVIPLYTAECGECKFCKSGKTNLCQAVRATQGKGLMPD
CCCCCEEEEECCCCCCCCCCCCEEEEEEECCCCCEEECCCCCHHHHHHHHHCCCCCCCCC
GTTRFSYNGEPIYHYMGTSTFSEYTVCAEISLAKVNPQAPLDKVCLLGCGVTTGIGAVHN
CCEEEECCCCEEEEEECCCCCCCEEEEEEEEEEECCCCCCHHHHHEEECCHHHCCCHHCC
TAKVKAGDSVAVFGLGGIGLAVIQGAVQAQAGRILAVDTNPDKFTLAKEMGATDFINPND
CEEEECCCCEEEEEECCHHHHHHHHHHHHCCCEEEEEECCCCCEEEHHHCCCCCCCCCCC
YDKPIQDVIVELTDGGVDFSFECIGNVNVMRAALECCHKGWGESVIIGVAGAGQEIKTRP
CCCCHHHHHEEEECCCCCEEEEEECCHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCC
FQLVTGRVWRGSAFGGVKGRSQLPGMVEDAMAGKIRLDPFITHRLPLEQINEAFDLMHEG
EEEEECEEEECCCCCCCCCCCCCCCHHHHHCCCEEEECHHEECCCCHHHHHHHHHHHHCC
KSIRTVIHFGDQ
CEEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]